Conserved Protein Domain Family
AKR_AKR13C1_2
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cd19078: AKR_AKR13C1_2 
AKR13C family of aldo-keto reductase (AKR)
The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
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Statistics
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PSSM-Id: 381304
Aligned: 28 rows
Threshold Bit Score: 465.169
Created: 19-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ###                                #    #                              
AHD19084   10 GPEVSAIGLGCMRMSFGQkk--lpDRKEMIKLIRTAVELGiNFFDTAEVYGPy-------tNEELVGEALEp-fKGEVVI 79  Thermotoga maritim...
EPY21235    6 GLMVSQIGLGCMGMSFGIgdlsqlTEEGNIEVIHEAYRLGiNFFDTAEVYGPh-------aNEILVGKALHqfpRESLVI 78  Angomonas deanei
OUP77187    9 DLEVSAVGLGCMGMTHAYgk--paNKEEMKKLIIQAVEQGcNFFDTAECYVAenedgtieyNEELVGEALAp-yRDQVII 85  Erysipelatoclostri...
ANU54206    8 NLTVSEIGMGCMGFSHGYgq--ipSEEYSIEALRKALDYGcDFLDTSEAYGPymse--tghNEKIVGKAIKg-rREDVVL 82  Ruminococcaceae
CDE60724    8 DIEVSAVGIGCMGFSHGYga--ipTEEESIRLMHKAYDLGcTLFDTAEAYGPf-------tNETLVGKAVKp-fRDKIIL 77  Fusobacterium sp. ...
SNU98879    9 NLKVSAVGLGCMGLSHAYge--pvDKDTAVKFIQKAVEAGyTFFDTAEIYGTadd---phiNEKIVGEALKp-yRDKVVI 82  Megamonas hypermegale
KXT40289   10 GLRVSAIGLGCMGMSHAYgk--paDKHEMKELLTYAVDMGyTFFDTAEVYGTpdr---phhNEELLGEALKp-fRDRIVI 83  Bacteroides intest...
PNC65524   10 GLKVSAIGLGCMGMSHAYga--paDKKEMTELLARAVDMGyTFFDTAEAYGThgc---phdNEELLGKALAp-yRDKIVI 83  Akkermansia mucini...
PSN29041   72 AMKVSTLGFGCMGLNYHRsq--hpNKQAAINLVHEAIERGiNLFDTAESYGPy-------tNETLVGEALKg-yRDRVFV 141 German cockroach
NP_810028  62 AFTVSAMGYGCMGLNHNRsq--ypSREKEIALVHEAVERGvTLFDTAESYGYh-------iNEKLVGEALKg-yTDRVFV 131 Bacteroidales

Feature 1       #                                              ##                            #
AHD19084   80 ATKFGFelyedgr--pgwkglNSNPEHIKKAVEGSLRRLrvEAIDILYQHRVDPnvPIEEVAGAVKELIEEGKVKHFGLC 157 Thermotoga maritim...
EPY21235   79 ATKCGIysneq------gsyaDSSRETIRKAIAGSLERLqtSYVDLYYIHRIDKtiPIEEVAKTMLELKEEGKIRHWGLS 152 Angomonas deanei
OUP77187   86 ATKCGVhhqgt------nlvmDARPETIKKAIEGSLKRLktDYIDLYYLHRIDPnvPIETVAKTMKELMEAGKIRYWGIS 159 Erysipelatoclostri...
ANU54206   83 ATKLFIgtg---------earRSAYDALRKHLEASLKRLqtDYVDLYYLHRINPdvPVERVAEGMGRLIDEGLIRGWGLS 153 Ruminococcaceae
CDE60724   78 TTKFVPvfqpgq----eipegKLRKKGVTNALNDSLKRLqtDYIDIYYEHRVPLdsNVEEVAQWMGEFIKEGKIRAWGQS 153 Fusobacterium sp. ...
SNU98879   83 ATKFGItfdhdsgiiplplvtDSRPEVIRKSVEGSLKRLqtDHIDLYYQHRLDKnvPIEEVAGVMADLIKEGKILHWGLS 162 Megamonas hypermegale
KXT40289   84 ASKFGLrfdspqssgphalipDSRPEMIRYSVEESLRRLqtDRIDLYYQHRIDPniSPEEVAGVMAELIQEGKILHWGIS 163 Bacteroides intest...
PNC65524   84 ATKFGIrfsgtagtgpsplitDSRPGTIRQSVEGSLKRLgvERIGLYYQHRMDDsvPPEEVAGVMQELIREGKIAHWGIS 163 Akkermansia mucini...
PSN29041  142 TTKFGHkfvngk---rvmteeDSSPANIRKVCEESLRRLgiETIDLFYQHRADPhtPIEEVAETVKELIKEGKVKRFGLC 218 German cockroach
NP_810028 132 SSKFGHkfvngv---qikteeDSTPANIRRVCENSLRNLgvETLGMFYQHRIDPntPIEAVAETCSKLIKEGKILHWGMC 208 Bacteroidales

Feature 1     #                  #                            #######                         
AHD19084  158 EAsaETIRRAHKVcPVDVVQYEYSMWWRKPEe-eILPTCEELGIGFVAYSPLGKGFLTGAIGENSKFdeedi-rsriPRF 235 Thermotoga maritim...
EPY21235  153 EAsvKTIRRAHAVfPLTAVQSEFSIVHRDPQa-eLLPTLEELGIGFVPFSPLCRALLAGAIDATTTFpkgd--irgtMPR 229 Angomonas deanei
OUP77187  160 EAdeDTIRRAHAIcPLTAIQNRYSMMYRDYEt--LFPVLEELNISLVAFSPLANGLLSDAYNKDVKFtdkddfrtrmPQF 237 Erysipelatoclostri...
ANU54206  154 MVtvDFIDRAHKVtPVSAVQNIYSMMERDYEk-kVLPYCQANNIGFVAFSPIASGFLSGKVTADTKFvgddv-rrwvPQL 231 Ruminococcaceae
CDE60724  154 QStpEQIKKAHAVtPLTAIQSEYSMMERMFEg-dVIPLCKELNIGFVAFSPMASGFLSGKYNKNTQYkgddv-rrviTRF 231 Fusobacterium sp. ...
SNU98879  163 EAteETIRRAHKIcPLTAIQNRYHMMYRNYEn--LFSVLEELNIGFVAFSPLANGFLSGRYTADSRFtekgdyravmPQF 240 Megamonas hypermegale
KXT40289  164 EAteEYLRRAHKVcPVTAVQNRYSMMARWHEs--LFPTLEELGVGFVAFSPLANGLLTDCYTADTQFdaktdyrasmPQF 241 Bacteroides intest...
PNC65524  164 EAteEAIRRAHGTcPITAVQNRYSMMARHHEs--LFPVLEELGIGFVAFSPLANGLLSGRYDQNSTFepgtdyrssmPQF 241 Akkermansia mucini...
PSN29041  219 EVnvDTIRRAHAIqPITAIQSEYHLMFRRVEd-sILNLCEELGIGFVPYSPLNRGFLSGALNEYTRFdttndnraalPRF 297 German cockroach
NP_810028 209 EVnvDTIRRAHKIcPVTAIQSEYHLMHRMVEtngVLELCEDLGIGFVPYSPLNRGFLGGMINEYTKFdvtndnrqtlPRF 288 Bacteroidales

Feature 1                               #                ######  #  ##                    
AHD19084  236 QKENLKENLALVELLKKIAERKgATPSQIALAWLLAQkPWIVPIPGTTKLSHLLENIGGafVELTPEELQEINDAL 311 Thermotoga maritima MSB8
EPY21235  230 YNEGREQNLKYLEVVDDFAKRKgATRAQISLAWVNAQkPFIAPIPGTTKVARLRENAESvkVQFTPEEIQEFNDRL 305 Angomonas deanei
OUP77187  238 TPEAYDANQELMEMIRAISKEKnCTPAQLSLAWMINKkPYIIPIPGTRKSNRLKENLESanVYLTEEEVAKIDSLL 313 Erysipelatoclostridium...
ANU54206  232 SQRNIAANQPFIDLVSGVAERKgCTNAQISLAWMLHKySCVVPLPGSKNQERILENLRAseVELTDAEFRELENGL 307 Ruminococcaceae
CDE60724  232 APENVEKNQPLLDLLNEVADKKgITPAQISLAWMLHKyPHVVPIPGMRKDERVIENLGAadIILTDEEFNNIENEL 307 Fusobacterium sp. CAG:439
SNU98879  241 QPEAYESNRKLLQLINDMAEEKqATPAQISLVWMICKkPYIVPIPGTRKENRLIENIGAadINLTAQEIAQIDKAL 316 Megamonas hypermegale
KXT40289  242 SKESFEQNQDLLSLIEHLADEYhATPSQIALAWMINKhPWIVPIPGTRRLSRLKENIGAadIHLTMEEIQHIDKKL 317 Bacteroides intestinalis
PNC65524  242 KPESFAANKDLFLLLRRLAEEKqAAPAQISLAWMLCKkPWIVPIPGTRKFSRLKENAEAahVILSADEVRQIDAAL 317 Akkermansia muciniphila
PSN29041  298 THEAMRANLRIVDVLYDFGRTRgITPAQLAQAWLMNKkPWIVPITGTTKLSHLEENIRStdILFTAEEMNEIETRT 373 German cockroach
NP_810028 289 QPEAIRANYRIVEVLNAFGRTRgITPAQIALAWLMNKkPFIVPIPGTTKLSHLEENLRAcdIRFTAEEIEELETAV 364 Bacteroidales

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