1UIX,1S1C


Conserved Protein Domain Family
Rho_Binding
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pfam08912: Rho_Binding 
Rho Binding
Rho Binding Domain is responsible for the recognition and binding of Rho binding domain-containing proteins (such as ROCK) to Rho, resulting in activation of the GTPase which in turn modulates the phosphorylation of various signalling proteins. This domain is within an amphipathic alpha-helical coiled-coil and interacts with Rho through predominantly hydrophobic interactions.
Links
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Statistics
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PSSM-Id: 462630
Aligned: 37 rows
Threshold Bit Score: 45.3405
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1UIX_A          3 TSDVANLANEKEELNNKL----KEAQEQLSRLKd----eEISAAAIKaqfeKQLLTERTLKTQAVNKLAEIXNRKE 70  
XP_002411616  845 EKDRAVRDLELEQLHKQLvserSSHESALEQERaeraaeAARQEQLQ----KQLHQERLLKQVAVNKLAEVMNRKD 916 
ETN67237      883 NKNLTNKSYELDDLMQQC----KKLQDELYVLRl----eQGELDKCK----TKLLNETILKQQAVNKLAEIMNRKD 946 
KYB27402      942 KKMNEHLSKEREDINRQL----KQLQEEFSKKSg----nNEEIDKLK----SKLQTESLLKQQAVNKLHEVLNRKD 1005
NP_001265264  943 KKNVDQYLKEKEDLNKRF----KELQDQLSKAQs----nAEEIEKLS----SKLKTEQLLKQQAVNKLAEIMNRKD 1006
EEB18276      944 KKQLDQMSKEREEMTRQL----RHVQEDMKKRTn----qDEEVERLN----RVLKQEIVLKQQAVNKLAEIMNRKD 1007
EFX79573      956 KKTFDLVTQENQDLGAKL----KSAQEELAQASta---sVDEVERLR----VKLKQEQLLKMQAVNKLAEIMNRKD 1020
XP_001945269  945 KKKMEQLIKDNEELKNQL----TIIQEESKKNf------IEELEKLR----KQLKQEQLLKAQAVNKLAEIMNRKD 1006
XP_002117911  144 KNDKYEMALRITQLKAEV----RFVEDSEENAIl-----SKQIEKLR----ESLSAEQLLKTQAVNKLVETLNCKL 206 
2_pfamImport    2 KKRIDELIKDNEETNNQK----KIMEEDIRNAKa----cMEESERLH----KQLKQEQLLKAQAVNKLAEIMNRKD 65
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