5JHO,4KY9


Conserved Protein Domain Family
Band_3_cyto
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pfam07565: Band_3_cyto 
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Band 3 cytoplasmic domain
This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).
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Statistics
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PSSM-Id: 429542
Aligned: 14 rows
Threshold Bit Score: 340.851
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5JHO_B     92 DVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQN 171  human
AAX34415   67 DVEQGGNRWSKPHVATLSLHSLFQLRSCIMNGHFMNDLAETDIPSIFNAVIENLEKSGDLPSENREELREILLRKHVHQY 146 
Q1A708    152 DVDVDADRWSKPHVATLPLHSLFELRTCLINGTVCLDMEADNIVQIADLVLDKLIMSEQLDESKREQVREALLRKHHHQS 231  purple sea urchin
CAG09337  149 DVEDGGERWSKPYVATLSLHSLFELRSCIFNGTVLLDMRANTIEEIADMVLDHREIYSPLGNEVRKKVRATLLKQHHHQN 228 
Q9BY07    141 KVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQT 220  human
P04920    352 DVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPS 431  human
P15575     89 ESMEPGGAWG-SHLPLLTYHSLLELHRAFAKGVVLLDVAANSLAAVAHVLLDQLIYEGQLKPQHRDDVLRALLLRHKHPS 167  chicken
P04919    100 ENLREDGVWGRPHLSYLTFWSLLELQKVFSKGTFLLGLAETSLAGVANHLLDCFIYEDQIRPQDREELLRALLLKRSHAE 179  house mouse
Q2Z1P9    102 enlgEDGAWGRPHLSYLNFWSLLDLQRAFAKGSVLLDLSETSLAGVAEKLLDRFIYDGLIRPQYREDLLWVLLLKHSHAR 181  horse
4KY9_P     36 ENLGENGAWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAG 115  human

5JHO_B    172 E--------KKRNNLIPIVRSFAEVGKKQSDPHlm---------------------------dKHGQTVSPQSVPTTNLE 216  human
AAX34415  147 EqakkngagGEKGGFLSTVRSISDIGKSFSHGKnl--------------------------skIEEKPEGPVTSQTAGAP 200 
Q1A708    232 Hkkh---rdKRGSSLLPMIRSLTDIGRSLSQGGahntsmeqqaaaqsgiqtshgsspniqnsqTSPSSLMVKGNSGDLGK 308  purple sea urchin
CAG09337  229 Q--------KKLANRLPIVRSIADMGRRASELHl-----------------------------DKSDQMTSSQSQLAGPE 271 
Q9BY07    221 K--------------KPIHRSLADIGKSVSTTNrsparsp-----------------gagpslHHSTEDLRMRQSANYGR 269  human
P04920    432 De-------KDFS--FPRNISAGSLGSLLGHHHg-----------------------------QGAESDPHVTEPLMGGV 473  human
P15575    168 E--------AESVWTLPAAQLQCSDGEQKD---------------------------------ADERALLRDQRAVEMRE 206  chicken
P04919    180 Dl-------GNLEGVKPAVLTRSG---------------------------------------GASEPLLPHQPSLETQL 213  house mouse
Q2Z1P9    182 Dl-------KELDGVKPTVLTPSG---------------------------------------GTLQPLLPEHPSLETQL 215  horse
4KY9_P    116 El-------EALGGVKPAVLTRSG---------------------------------------DPSQPLLPQHSSLETQL 149  human

5JHO_B    217 VKNGVNCEHS---------------------PVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLS 275  human
AAX34415  201 SGSSNQLTLPtvesv-----------pkdisSEESSKGNLHFLKKLPAGVEASNVLIGEVDFLTRHICCFIRLKNANQLG 269 
Q1A708    309 SETSGSLPKVsshhslkkrlsearlsiphnlAGHSLSARHSFMRKIPQGAEASNVLIGEVDFLSRPIIAFVRLQSAVSLG 388  purple sea urchin
CAG09337  272 GKAEASKENS---------------------FVDFSKIDLHFMKKIPVGAEACNVLVGELDFLNRPVVAFVRLSPAVLLS 330 
Q9BY07    270 LCHAQSRSMNdi-----------------slTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLG 332  human
P04920    474 PETRLE--VErerelpp-------pappagiTRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELD 544  human
P15575    207 LHGAGQSP-------------------------SRAQLGPQLHQQLPEDTEATLVLVACAAFLEQPLLALVRLGAPCP-D 260  chicken
P04919    214 YCGQAEGG-------------------------SEGPSTSGTL-KIPPDSETTLVLVGRANFLEKPVLGFVRLKEAVPLE 267  house mouse
Q2Z1P9    216 FCAQGEGD-------------------------TEESSPSGILEKISPDSEAALVLVGRISFLEKPVLGFVRLREAVELE 270  horse
4KY9_P    150 FCEQGDGG-------------------------TEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELE 204  human

5JHO_B    276 GLTEVPIPTRFLFILLGP-VGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLP 344  human
AAX34415  270 DLTEVPVPTRFIFLLLGP-TGHGQQYREIGRAIATLMADEIFHDVAYGARDVDDLLDGIDEFLDQVTVLP 338 
Q1A708    389 DPTEVPIPRRFLFILLGPqSGETKRYHEIGRCVATIMSDKVFHDVAYKAKSTKDLLAGIDEFIDSVTVLP 458  purple sea urchin
CAG09337  331 GLAEVPIATRFLFILLGP-TGRGPQYHEIGRSMATLMTDEVFHDVAYKAKDRNDLIAGIDEFLDQVTVLP 399 
Q9BY07    333 GVTEVPVPTRFLFILLGP-SGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLP 401  human
P04920    545 AVLEVPVPVRFLFLLLGP-SSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLP 613  human
P15575    261 AVLAVPLPVRFVLTVLGP-DSPRLSYHEIRRAAATVMADRVFRRDAYLCGGRAELLGGLQGFLEASIVLP 329  chicken
P04919    268 DLV-LPEPVGFLLVLLGP-EAPHVDYTQLGRAAATLMTERVFRITASMAHNREELLRSLESFLDCSLVLP 335  house mouse
Q2Z1P9    271 ATVEPSVPVRFLLVLLGP-EAPHTDYTQLGRAAATLMSERVFLNEANTAQSKEELVRSLEGFLDCSLVLP 339  horse
4KY9_P    205 AV-ELPVPIRFLFVLLGP-EAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLP 272  human
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