Conserved Protein Domain Family
GlyDH-like

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cd08172: GlyDH-like 
Glycerol_dehydrogenase-like
This family contains glycerol dehydrogenase (GlyDH)-like proteins that have yet to be characterized, but show sequence homology with glycerol dehydrogenase. Glycerol dehydrogenases (GlyDH) is a key enzyme in the glycerol dissimilation pathway. In anaerobic conditions, many microorganisms utilize glycerol as a source of carbon through coupled oxidative and reductive pathways. One of the pathways involves the oxidation of glycerol to dihydroxyacetone with the reduction of NAD+ to NADH catalyzed by glycerol dehydrogenases. Dihydroxyacetone is then phosphorylated by dihydroxyacetone kinase and enters the glycolytic pathway for further degradation. The activity of GlyDH is zinc-dependent; the zinc ion plays a role in stabilizing an alkoxide intermediate at the active site.
Statistics
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PSSM-Id: 341451
Aligned: 65 rows
Threshold Bit Score: 311.759
Created: 12-Jul-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   #                                                 
CCG45732   10 PTFYCCEPGvLGRLPKFIEehtfeEGAVISGEQSWeaaePFFPDLNv--dLIYKKYRGECTHAEVDRLCKEis--gsDVI 85  Halobacillus halop...
SDG87668   13 AANYFSYEGaLGEIERFFPaerlgQVLWIGGRRALeaaaPYLPALYqdsrSRRKVFAGHCSEREVAAYVEEgr--qaDLV 90  Propionivibrio dic...
EHS59277   11 PQEYYHSKGiLNQLPQLISerkinRLFVIHGERSLqaamPYLPSLEnf-eIQYEKYRGECSLNEIKRISAIakqykaEGL 89  Paenibacillus sp. ...
KLV26657    6 PQNYYHYAGvINTLPKFLEdnhiqFPLIIHGEKSWqavqPYWPETEfqnpYKEILFAGECSYEEIDRIWNEalhhqhDAI 85  Bacillus circulans
OOK77961   12 PANYFSHPGsLAHLDDFFTpeqlsRAVWIYGERAIegarPYLPQSFnatgAKHLLFKGHCSESDVTHLVNEsgs-etSVV 90  Pedobacter himalay...
P45579     12 PANYFSHPGsFNHLHDFFTdeqlsRAVWIYGKRAIaaaqTKLPPAFglpgAKHILFRGHCSESDVQQLAAEsgd-drSVV 90  Escherichia coli K-12
EHM00400   10 PVEYVNEPGiLMQLNQIIVdkgyqRPIILTDNTVIkatsAYLPKGFyd-hHDVIIFNGNCTYPEAERIQSLik--nsDVL 86  Lactobacillus para...
KRL26330   10 PGIYVNEPSaLKKLPELINeftlkSPVILTDQTVLkiipQYLPADFvt-rYPVEIFNGSCEFAEIDRLTEQlr--syDGI 86  Lactobacillus muco...
EMP72853   10 PAEYINQVGiLKKLPEIIKqhgyqNPVVLTDTTVReiipDYLPDNFld-nYPLSLFSGNATKKEIKRLTGLlk--gyDLI 86  Streptococcus sobr...
KRM00363   10 PGEYVNEPGiLKHLPDYLSqhklsHPVIITDETVKkvipPYLPDGFld-qYPLMLFHGNCTYEEADRLADLcq--pyDGI 86  Lactobacillus gast...
Feature 1         ###  #  #              ## #                   ##                 #       #  
CCG45732   86 FGVGGGKVLDLCKACGnelnlPVILIPTLASNCAGWTSLSVFYDea-gnFIEYTIfq-ksTLMLIVDPALLVhsPVDFLR 163 Halobacillus halop...
SDG87668   91 IGVGGGSVLDTAKAVAhrlqrPFVAVPTIAATCAAWTPLSVWYDdd-grALGYELfp-laSQLVLVEPRLLAaaPPDYLR 168 Propionivibrio dic...
EHS59277   90 LGIGGGKVADLVKAVAyqlqiPEILVPTLASNCAAFSAVSIIYNdegihVDSLSFpk--aTNLVLIEPEIILnsPVEYTI 167 Paenibacillus sp. ...
KLV26657   86 IGVGGGKVLDTVKAVAskakiPCILIPTLPSNCASFTPISIVYSae-gdHLGTIRhs-qsNYMVMVEPELLVkaPIEHLT 163 Bacillus circulans
OOK77961   91 IGVGGGAVMDTVKAVArrlgvPFVGIPTIAATCAAWTPLSVWYNda-gqALQFEIfd-daNFLVLVEPQIILnaPAEYLL 168 Pedobacter himalay...
P45579     91 IGVGGGALLDTAKALArrlglPFVAVPTIAATCAAWTPLSVWYNda-gqALHYEIfd-daNFMVLVEPEIILnaPQQYLL 168 Escherichia coli K-12
EHM00400   87 IALGGGQLLDTAKNVAdklriDLINVPTIPSNCASITTKSMVYSegsheMIGRQRhp-vaVQLVLVDPTLLRhsPTNYLL 165 Lactobacillus para...
KRL26330   87 IAFGGGQLMDTAKVVSdrlnnVLINVQTVPSNCSAFTTKSIVYSpt-heMIASIRek-kpVDAVILEPELLKnaPLEYLR 164 Lactobacillus muco...
EMP72853   87 LAFGGGQLMDTAKVVAdnlriALINIPTLPSNCAALTTKSILYSeq-ghEMIGAHrqsqaVTMVLLEPKLLQnaPEPYVL 165 Streptococcus sobr...
KRM00363   87 IAFGGGQLLDNVKLVAdklniKLFNIPTVPSNCAALTTKSIVYAegdheMVANHRtg-itISVVLVEPELLRvaPQHYIL 165 Lactobacillus gast...
Feature 1         #   #                                                                       
CCG45732  164 AGIGDTIAKWYEadvltrnl--ptkpipldIALHAAKLCRDVLIEDGNEALGYlrqtktdpVLTRVVETIILSAGMVGGF 241 Halobacillus halop...
SDG87668  169 AGIGDTLAKWYEarvlcdae--svlpltasIGLSVAAQIRDVLLVDGASAVPAntdglvtpALVRVIDAVIAGGGLVGGL 246 Propionivibrio dic...
EHS59277  168 AGIGDTLAKWYEgvsrlnqi--qtktvpmqLSFEMMHKCREFLFEFGEQSIKDaqtgklteAFINVIDTNIAVAGLVGGF 245 Paenibacillus sp. ...
KLV26657  164 SGIGDTLAKWYEskirfkkltseeisipleLSHTAAKQCRDNILKWGEAAVIAaeakksnaDFSRMIDTIYAVAGLVGGL 243 Bacillus circulans
OOK77961  169 AGIGDTLAKWYEaavlapqp--eslpltvrLGLNGALAIRDVLLERSEEALADqqrgeqtqAFRDVVDAIIAGGGMVGGL 246 Pedobacter himalay...
P45579    169 AGIGDTLAKWYEavvlapqp--etlpltvrLGINNAQAIRDVLLNSSEQALSDqqnqqltqSFCDVVDAIIAGGGMVGGL 246 Escherichia coli K-12
EHM00400  166 SGIGDTLAKWYEirrrlnvae-aqgaildiARKTIEISRDRTLAIRNLDQIDDk-------TFSNLLDTIFLVAASVDGF 237 Lactobacillus para...
KRL26330  165 SGIGDTLAKYYEirrrltdd--qmhslslsLARDMIERCREEMLNVDNPRSLNg------lDLQNFIDTIFLAASLVDGF 236 Lactobacillus muco...
EMP72853  166 SGIGDTLAKFYEirlrltdd--kldlvtaaISRQYLDICRDEILKVGDYRELDr------tQLINFLDTIFLIAASVDGL 237 Streptococcus sobr...
KRM00363  166 SGIGDTIAKYYEirrrlpkd--nlplvtqqVARNFIEVCHREMLHVKNVATLSe------iELKNLWDTIFLIAASVDNF 237 Lactobacillus gast...
Feature 1               #   #            #                                                    
CCG45732  242 gdrLGRIAGAHSIHNGLTKVNETHqyLHGDKVAYGILIQLLLEKren-evqTLLSYYKEMNLPIHLSDLGvdvvseeiVD 320 Halobacillus halop...
SDG87668  247 gerFTRLAAAHSVHNGLTVVAGTErfLHGAKVAYGILVQLALEKrqg-ellNLYGALGALGLPRRLSDLGvdp---hdEN 322 Propionivibrio dic...
EHS59277  246 gsiFAKSVGAHAFFNAATAIPGTKtiLHGSLVAFGILVQLALEKktd-eleSILPFYRKIGLPTTLQDIHlddsnteaLQ 324 Paenibacillus sp. ...
KLV26657  244 ggkFGQSVGAHAFNYGYVSLGKKRh-LHGSLVAYGILFQLSLEEnye-eikQLVPLYKKLKLPICWRDLHlspe-kgdLE 320 Bacillus circulans
OOK77961  247 gerYTRVAAAHAVHNGLTVLPQTEkyLHGTKVAYGILVQSALLGqdd-vlaQLVAAYQRFNLPTTLRELDvdihnrdeLD 325 Pedobacter himalay...
P45579    247 gdrFTRVAAAHAVHNGLTVLPQTEkfLHGTKVAYGILVQSALLGqdd-vlaQLTGAYQRFHLPTTLAELEvdinnqaeID 325 Escherichia coli K-12
EHM00400  238 aaaRGRSVAAHSFHNGYLKVTDHPqkTHGEIVALGILVQLAIEGetd-eliKLIAFYRRIGLPYQLSDLGlapn-tsdIQ 315 Lactobacillus para...
KRL26330  237 adlDGRSVAAHTFYNAYVKVIGPQrfTHGEIVALGNLFQVTLENdta-linEIRAYYPRVGLPLSLADLDitq--geqLN 313 Lactobacillus muco...
EMP72853  238 anlDGRSVLAHAFYNAYMKYQTGKkkTHGEVVALGNLFQLHLEGnqvellkELEDYHQRIGLPLTIKDIYlds---qyLE 314 Streptococcus sobr...
KRM00363  238 addDGRSLAAHTFYKAYVKIKDHPdwTHGEIVALGNLFQVTLEGndk-latEIRQFYPTIGLPVKLADLDite---aeIH 313 Lactobacillus gast...
Feature 1                                        
CCG45732  321 TISSYSTapnesi----hlmgiSDNNKVKRAIYRL 351 Halobacillus halophilus DSM 2266
SDG87668  323 GIAAFVAhtlraqesihflpgaVDAERLRAALFTV 357 Propionivibrio dicarboxylicus
EHS59277  325 LIAAKMTsqtsri---hslpfkVTADDALWAILTV 356 Paenibacillus sp. Aloe-11
KLV26657  321 NMADQILrpssri---yalpmeLTKQKVIDGLEKL 352 Bacillus circulans
OOK77961  326 KVIAHTLrpvesi---hylpvtLTPEVLRAAFAKV 357 Pedobacter himalayensis
P45579    326 KVIAHTLrpvesi---hylpvtLTPDTLRAAFKKV 357 Escherichia coli K-12
EHM00400  316 TIAADMVkpdnari--qtvfhnLTQQTVTNAINSL 348 Lactobacillus parafarraginis F0439
KRL26330  314 SLAEYMAkpdnvrm--qsifpdITATTIRKTLTKL 346 Lactobacillus mucosae DSM 13345
EMP72853  315 DMANYIAqpdnirv--qtifpnINSQEILSALEKL 347 Streptococcus sobrinus DSM 20742 = ATCC 33478
KRM00363  314 PIAEYIClkkntrm--qsvfpdVQVTAVEAALRKM 346 Lactobacillus gastricus DSM 16045

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