Conserved Protein Domain Family
HDC_protein

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cd21416: HDC_protein 
histidine decarboxylase (HDC) gene cluster protein
This model includes an uncharacterized histidine decarboxylase (HDC) gene cluster protein. Lactobacillus parabuchneri is one of the major causes of elevated histamine levels in cheese. Histamine positive strain FAM21731 from L. parabuchneri has been shown to contain a histidine decarboxylase gene cluster present on a genomic island, which seems to have undergone transfer within the same species as well as between other lactobacilli.
Statistics
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PSSM-Id: 411065
Aligned: 210 rows
Threshold Bit Score: 217.677
Created: 27-Jan-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_057911190   9 VVMVFMFIGEWVSTMSHAfIPSVFISALLFVIGFWTi-LPKDVVTQASYgnefvsICVSMLLVHLGTLMGLKELVAQWKA 87  Lactobacillus p...
WP_087218291  12 TVFIVMYIAEIVTKKTKArVPSLLVVSIIFLAGYWSglFPRDILDVAFVnqm-rqIMLLFVLINIGTMFDIKEIRQEWRT 90  Lachnoclostridi...
WP_006780616  11 VVMVVMALGEAVSKKSKGrIPSLLIVAICFLTGYWTi-FPKDILNISMVmsv-rtITMSVILLQVGAMFSLHELKKEWRA 88  Hungatella hath...
WP_078710973  10 VIAIIMLVGEIISSKTGGkLPQMFIVATLFLFGYWTf-LPKDILTISGLsvv-aeICKIFILIHVGSMFNVKSLIKDWRV 87  Anaerorhabdus f...
WP_092591315  11 LVIAIIFVSETISAKLKGkIPALFLMTVITLIGYWTv-IPMDIVEVSGLgav-knIMMMIILIHMGTLLELEQLKREWKT 88  Acidaminobacter...
WP_073051186  11 MVVCIVFVAEFISAKFNGkVPALFLMTVMTLIGYWTi-LPKDIVAVSGLgav-knIMMMIILIHMGTLLEIEQLKKEWKT 88  Dethiosulfatiba...
WP_109732958  11 LFCVIVLIAEVISKKTSArIPSVFLVGAIFMVLFVGkiIPSDFIDSSYMelv-grITLTMLIINMGTTFDIMQIKKEWKT 89  Clostridiales
WP_109732605  15 VFLAIAFVSLAIAAKLKSmIPMPLIYGVIFAIGFGTgvLPKDMLLSANMiav-gtIAFNVLVIHSGTMINLKMLKAKKKE 93  Faecalicatena o...
WP_047915670  10 IVCLIMYIGEFISIRSSGlIPQMLIVTLLFLIGFWTi-LPHDILDKSGImil-skIIFSIILIDVGTSLDLKEIFKNRQV 87  Lactococcus pis...
WP_087164400  14 VFLLIAFTSMALAEKLRSlIPMPFIYGVIFILGFAFdlLPKDLLLSANMiav-gtIAFNVLVVHSGTMVNFRLLRDRWRE 92  Lachnoclostridi...
WP_057911190  88 VCIALLGVc-gTMLLCLTIGs-lIFDWKTVVAAVPPLtGGLVSALLMTDGLKAQGvtaLVALPVSMFVIHSVVGYPLTSL 165 Lactobacillus p...
WP_087218291  91 VVVILAAVg-gIVALVTPLGs-aLFGNQMALAAVPPLtGGGMATIIMSDQAAAMGlpeIAMLATLIFVFQGFFGFPLTSY 168 Lachnoclostridi...
WP_006780616  89 VIITLLSVa-gVIVFAGIAGa-lFFDVNTALVAIPPLtGGGIATIIMSDAAAAQGlteLAMLSSIIYIMQGFVGFPLTSY 166 Hungatella hath...
WP_078710973  88 VVTTLCAIv-gILALVLTIGt-vIFGKDMAIIAAAPLtGGGMAAMIMNEGAIAIGksaLGVVAFVIFIMQGFVGFPVTAF 165 Anaerorhabdus f...
WP_092591315  89 VATALAAVa-gIALIFLSVGgliLGDKLLSLTAIAPLaGGGMAGILTSQALTNGGytdLAVWPILLITLQSFVGMPIVAF 167 Acidaminobacter...
WP_073051186  89 VVTAIAAVa-gVAIIFFGLGgplLGEKLMAITAIAPLaGGGMAGILTSQALTNAGyieLAVWPILLITLQGFIGMPIVAF 167 Dethiosulfatiba...
WP_109732958  90 VLVCLAVSl--SLILIVGFAlrpIIGRELAIMSPGPIaGGGAAAAMVAAAIGGIKp-qLASYPWLIFMLQGLIGFPLCGW 166 Clostridiales
WP_109732605  94 SLLCIIASl--VLVVIVGFGltpILGKGLAFLAPGSViGGGASCAIASRWVLDKNp-aISVFPWLVFMFQGLFSVPVVTW 170 Faecalicatena o...
WP_047915670  88 IRLSSISLl-sIILTALIIGg-iCYNMRVSLSTIPTLtGAGIGAMLMNAAALKANqpyYGAVAMTVFVSHTFISFPFASY 165 Lactococcus pis...
WP_087164400  93 TLLCLSAFlilIVLELLILTp--VLGKGLAFLAPGSVvGGGASCAIASRWVTDAHp-eLAVFPWLIFMAQGLFSVPVVTW 169 Lachnoclostridi...
WP_057911190 166 MLRQEGGRLVKEFKangskldpeaae----------------faagqqpsvfkSQNVFNLKPe-----------YETPAF 218 Lactobacillus p...
WP_087218291 169 FLRREGRTLIESFRrdkalraqss-------------------agesagtkaaRKTVNDLVPa----------kYKTYTY 219 Lachnoclostridi...
WP_006780616 167 MLRRAGRKLLTGYRsgaallqetke------------------eqkpekakksRRTLNDMVPe----------kYKVPSY 218 Hungatella hath...
WP_078710973 166 FLRKEGERLVEEIRnnpnlikess-------------------tksegeqatsKKKIYEYVPt----------kICTPTY 216 Anaerorhabdus f...
WP_092591315 168 FVRGEMRDLLSKVRsgelkhpne---------------------vqtesvasqNTKLIDKLPe----------lYKTPAF 216 Acidaminobacter...
WP_073051186 168 LLRGEARDIALKIRsgsfkkde-----------------------etdetsitEIKAIDKIPe----------kYKTPSF 214 Dethiosulfatiba...
WP_109732958 167 AMRKELQHKKMLIDkngyvkst-----------------------vqqtqenhKKKLCDKVPq----------sYKSTAY 213 Clostridiales
WP_109732605 171 ALKREGKALSQEFRarnsqggnqgapegagnippmigpgcpgngkspaagqagKVPFCERIPa----------kYKNTAY 240 Faecalicatena o...
WP_047915670 166 FLKKEAKAKLVTLR---------------------------------------ASKDITLTQpkarakqmtftpYRTPTF 206 Lactococcus pis...
WP_087164400 170 ALKKESRRLLSEQGdagagqkerasgt-------------engqgkarggvqkKPPLCMRIPd----------kYKTTPY 226 Lachnoclostridi...
WP_057911190 219 ILARVAMVALFSTWCAGLInn-------aINPNVVCLIFGVIahqFGFLEDNALNQAGVFNWLMYGLLAYVFAQLSVTTP 291 Lactobacillus p...
WP_087218291 220 YLTKLGILACIVYFINLYTgk-------yFSDTILQIAIGIIgvmCGFLEKEPLKKAESMGILQLCLTASFMRNFANSTP 292 Lachnoclostridi...
WP_006780616 219 YLAKLAILAIVAVLLESITg---------LNVSLTMIVVGVLaahFGILEKDPLKKANSFGILMLCLTASFMRYFADASP 289 Hungatella hath...
WP_078710973 217 YLTVMGVLGCLGLIIFKLLng-------aIDRSIVMIIVGVAasqFGLIPPNPMNKSDSAGILNLALFASFMSGFADTTP 289 Anaerorhabdus f...
WP_092591315 217 YFLVLAILGTLNLALYINVtskiqyisliMDKSIVALVIGIVlgnLGLLDKGVMSKTMSSGILDISFYAYIMTFLTGASV 296 Acidaminobacter...
WP_073051186 215 YFLALAIIGTLNLFVYTNFiknipfisllLDKSITALLIGMIlgnLGILDKGVMGKTESNGILDISFYAYIMTFLTGASL 294 Dethiosulfatiba...
WP_109732958 214 YWSTLLIFAVLNIAVNKAFlgq-----fkINTNVTAIILGIVlshFGILEKDPLSKSNSMGMLFLGLIASMANSFAMVGA 288 Clostridiales
WP_109732605 241 FLGIIMIVTVINNLLHGTVlag-----lnINPNITALLFGLIlgsLGFMDKAPLFKADAYGLLLLGLMGLMANTIANCPW 315 Faecalicatena o...
WP_047915670 207 YLATFFILAAAVEFIALKTh---------LNSAILQVLTGILarkIGLLQKNSLFKTSSSGLLMIALFASFMQSFSEISF 277 Lactococcus pis...
WP_087164400 227 FLGSIMIATVLNNILQNTLfsg-----lnINPNITALLLGILlgsLGLMDKAPLFRSDSYGLLILGLMGLMANTLANTPW 301 Lachnoclostridi...
WP_057911190 292 QIMGSIilQIIVLIALGLLGMFLa--SRILAKPFGMSwqMAYACSLTSLFGFPADYILTsEVAHTVAGTKDEERYLLhnM 369 Lactobacillus p...
WP_087218291 293 QQLFGLivPIFGFLVLGSIAIAIa--SILFGKLMKFSvnMSMAVGLNCFLGFPFNYIICnEAISATAETEEEREYLNgiL 370 Lachnoclostridi...
WP_006780616 290 QQVFSLilPVAAFLLFATAGIALf--SIPLGKKFGYPieLSVAIGLNCFLGFPYNFVITnEVIASLAENQGESDYLDgiL 367 Hungatella hath...
WP_078710973 290 ASIGQMviVVFGLLIIATVGILLf--SIPVGKKFGYStwMASAIGLNCFLGFPYNYNLTnEAVDVVAKTEEEKTYLTeqM 367 Anaerorhabdus f...
WP_092591315 297 ATIKAMmlPLVLTFVMATIGIGVf--SWIVGRGVGYTsrLSMAVGYNCYLGFPFNYMITkEAARAIAGNVEEEEILFdtM 374 Acidaminobacter...
WP_073051186 295 ATIKSLivPLLIAFIMASLAIAVf--SLLVGKRVGYSsrMSVAVGFNCFLGFPFNYMLTkEAAKAVAGTSEEEKLIFdtL 372 Dethiosulfatiba...
WP_109732958 289 PELLAMikPLVIVFAVSTLVMFIi--GIIGSKIFKMSkyRGIAIALNCYVGFPYNFMLCrEAVTSMTDDKEQQKLLEddL 366 Clostridiales
WP_109732605 316 QGLVAFipPLLIVFVISTIVLVLc--GIVGAKVCGFRaeRGIVLTMNCMMGFPVNDMLT-NNAAAAGESEAEKGYIKsqV 392 Faecalicatena o...
WP_047915670 278 ATLLKLl-AIAIPLNLSAIGVILvitKRLANQQFSWA--MSAAIAMNSFLGFPFNFSLTrEAIQAATAIAEEQEALSeqL 354 Lactococcus pis...
WP_087164400 302 QAVVAYipALLLVFTFSTAVLLLc--AAAGARILGLShyRAAALLMNCMMGFPVNDMLI-RQAAALGGTEERQAFLRreL 378 Lachnoclostridi...
WP_057911190 370 MPKMLVGGFATvsVASVIIASIFL 393 Lactobacillus parabuchneri
WP_087218291 371 MPKMIISGIVAvsIVSTIVAGMFV 394 Lachnoclostridium sp. An14
WP_006780616 368 MPKMIIGSIVAvsMVSAVIASVLV 391 Hungatella hathewayi
WP_078710973 368 LPKMIIGSVVAvtLVSCIVAGVLV 391 Anaerorhabdus furcosa
WP_092591315 375 LPTMLIAGFICvtIVSVLMAGVLS 398 Acidaminobacter hydrogenoformans
WP_073051186 373 LPTMLISGFVCvtIVSTLMAGALS 396 Dethiosulfatibacter aminovorans
WP_109732958 367 MPTMIVASLISvtLVSVIVAGLML 390 Clostridiales
WP_109732605 393 GPLLGIGTMLIsnAVSVLIVSIMV 416 Faecalicatena orotica
WP_047915670 355 LPHMILASTFSvsLMTPFIASICI 378 Lactococcus piscium
WP_087164400 379 GPVLGIGTMLIsnGLSILAVGILV 402 Lachnoclostridium sp. An131
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