Conserved Protein Domain Family
trifunc_aldol

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NF041633: trifunc_aldol 
KHG/KDPG aldolase/sugar kinase fusion protein
The N-terminal region of this protein resembles the bifunctional KHG/KDPG aldolase (4.1.2.14 and 4.1.3.16), while the C-terminal region resembles 2-dehydro-3-deoxygluconokinase and 2-dehydro-3-deoxygalactonokinase.
Statistics
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PSSM-Id: 469516
Aligned: 31 rows
Threshold Bit Score: 850.355
Created: 25-Apr-2023
Updated: 4-May-2023
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
TEU03854                  6 KVFKNIQKSQLIVLLTPKSKNECVKAYELLRSSG-IVLEIALRSEHAVGGIKSIIKKYPGALVLAGTVMTQEQAEKAIQA 84 
16_ncbifamImport          1 ALWQTLKQNRLIALLAPPDAESCVRAYEALHPLG-VVLEVTLRTDAAHAGLAAVRARYPDALLLAGTVTTAAQVDRALAA 79 
26_ncbifamImport          1 SLWEKLRHYRLTALLAPQSPEACVAAYELFEPLG-IVLEIALRTSAALDGIAAVRGRHPDALLLAGTVLTASQAEQAIAA 79 
6_ncbifamImport           1 EITEKFKELKLIPVIKIEDVENAVPLAEALIKGGlPAAEITFRAAGADKAIAAISKAFPDMLVGAGTVLTTEQVDAAKAA 80 
4_ncbifamImport           1 TILEKIKNVKMVPVIALERVEDAVPLARALTEGGlPCAEVTFRFPDADKCIMEMKKACPEMFVGAGTVLTKEQVDAALAA 80 
24_ncbifamImport          1 NTYDRIKECRMIPVIALDNVSDAKPLAKALYEGGlPCAEVTFRREGADLCIKAMKEEYPDMLVGAGTVLSIKQVDAALNA 80 
5_ncbifamImport           1 EILSKISAMGVIPVVVIDDAKDALSLAKALIDGGlPCAELTFRTAACEEAIKLISKEYPEMLIGAGTVLTTEQADKAVAA 80 
PRJNA284866:E4N87_00995   3 KIFKQIEKIGIVPVIVLDNEKDALPLGKALSAAGlFCAEITFRTEAAEKAIKVFAKNFPDFLVGAGTVLSPEQADKAIAA 82 
13_ncbifamImport          1 DKLEQIAKAGILPVIAIPSLETAVPLARALVKGGiSAIEVTLRTPCALDAIAAIRKAFPAMAIGAGTILEEGQVVAARRV 80 
12_ncbifamImport          1 NLFEKVAATGILPVVAVPSRELAVPLARALQRGGaTAIEVTLRTPCALEAIADIRRDVPEMAVGAGTILTSGQVESARRA 80 
TEU03854                 85 GAAGVVSADYIPEVVDVCVHKDVMCVPGGLSDAGKQLVQKATGYGCSLEELRDKYPYQWVYKLFPAFSGKLSNIDLPLSW 164
16_ncbifamImport         80 GASGIVSADFFPEVVRACVLKDVMCIPGGLSDVGKQLVLKAELYGCTLAELREQHSHQWIYKLFPAVAGLPTMLEVVPAW 159
26_ncbifamImport         80 GAAGIVSPDYLPPVVQVCVARDVMCVPGGLGDVGKQLAQKAESYDCTLAELRKHHPYQWVHKLFPVTAGGALLVDVAAAW 159
6_ncbifamImport          81 GATFIVSPGFNPKVVAYCNEIGIPVFPGCTTPSEIEQAIELG---------------LDTVKFFPAEQS--GGIDKIKAM 143
4_ncbifamImport          81 GAEFIVSPGLNPEVVQYCLSKNVPILPGCATPSDIEKALSLG---------------LTCVKFFPAEAN--GGVKMLKAL 143
24_ncbifamImport         81 GAQFIVSPGLDEDIVSYCLEKNVCVIPGVSTASDVAKAHALG---------------LRVVKFFPAEAA--GGVKMLKAL 143
5_ncbifamImport          81 GADFIVSPGFNPEVVSYCIEKGITIIPGVATPSEIEQALTFS---------------LEVLKFFPAEAN--GGIDAINAI 143
PRJNA284866:E4N87_00995  83 GAKFIVSPGLNPKVVEHCVNLGYPVIPGVSTAGEIEQAMSFG---------------LETVKFFPAEAA--GGLKFIKAI 145
13_ncbifamImport         81 GADFLVSPGLDPVIVRAAQAAGMPIVPGVTNPSEITAAVKMG---------------LCLLKFFPSEAN--GGISALTLM 143
12_ncbifamImport         81 GAQFLVSPGFDPEIAQAAKSAGLPYVPGVTNPTEVTAAVKFG---------------LKTLKFFPAEAS--GGIAALKLL 143
TEU03854                165 KGPFRNLTVIYTGGITLDTLKEAIRK----APEGIFCASALTKNMEKPALMKEEIHQWREILRPH-------------LL 227
16_ncbifamImport        160 KAVYPDLTIVYTGGVAAHHIPEITRR----DANSIICGSALTRACDDPEAMASEARRWLAAIHa--------------AQ 221
26_ncbifamImport        160 QAVYPELTVVYTGGVTFERLAEIVRR----DPRAIICGSALTRHIEDAQATAAEAQRWLDVIHGRas---------gtPQ 226
6_ncbifamImport         144 AAPYTKMTFIPTGGISPANIKKYLAFnkviACGGSFMVKEDLIKNKDWDKITELTKNAVDLVNg--------------KE 209
4_ncbifamImport         144 SAPYNKVTFMPTGGISDANMNDYYALknviACGGSFMVPGKAVKEGDWETITALTKKVVTKLSG--------------KA 209
24_ncbifamImport        144 SAPYNMMTFMPTGGISMDNMASYYALknviACGGSFMIDAKSIKEGDFDTIKNRTVEVVGAIDriin--------ggsDK 215
5_ncbifamImport         144 SAPYGSIKFMPTGGISEKNIAKYLTSkkiiACGGSWMVKKDLIAAGEFEKITAMTKSAVSLVDSIrn----------pKT 213
PRJNA284866:E4N87_00995 146 SAPYPNIKFMPTGGINAQNIAEYAAFskviACGGSWMVSKELISSKDFKKIEEESAIALQIVKEArnpkkspgaltalsS 225
13_ncbifamImport        144 HGPFPEVRFVPTGGMTMQNIGSYLAKefvaACGGSYMAKSADVKAGAWDKIAAACARCVDIARRAra-----------pA 212
12_ncbifamImport        144 HGPFPDVAFIPTGGMCRENIGRYLTEkfvaACGGSYMAKSADVLAGNWEKIAAETARCVAVAAKAra-----------gQ 212
TEU03854                228 KPKKIQKVKEPLERREP-----TVVTIGELMVRLSPPAGIRLQNARNFDVNFGGAEANVAVSLARFGMNAAFVTALPQND 302
16_ncbifamImport        222 PGPVSIDKTAAPTSGGr-----TVVTFGEIMLRLAPPAGRRLSQVANLDATFGGAEANVAVALVQCGSAARFCTAVPDNP 296
26_ncbifamImport        227 RAPRAITASRSAAHAGPaa--gAVVTFGEIMLRLTPPAGRRFSQSGSLDASFGGAEANVAVALAQWGVPSRFVTAVPDQA 304
6_ncbifamImport         210 EPVVKTEKKita---------gkVVTFGEIMLRLAPLDYLRFFQNDMLEATFGGGEANVAVSLANFGREAAFVTKLPDND 280
4_ncbifamImport         210 AEPVPNSK--SCLIGSPsladkrVITFGELMLRLAPEGYYRFLQADTFQATFGGGEANVAVSLANYGMDAAFVSKLPKHE 287
24_ncbifamImport        216 SKTVSIDTD-DKKIDMSnlsnskVITFGELMLRLAPQGYLRFVQADTFEATFGGGEANVSISLANYGMNTSFVTKLPNHE 294
5_ncbifamImport         214 EKEEQVEKSLP----TEgceidgFVSFGEIMLRLCPYDYLRFIQTDCFEATYGGGEANTAVSMAHYGFDSSFVTKLPKHE 289
PRJNA284866:E4N87_00995 226 DSKSST----------EtnqapkVITMGEIMLRLSPTGFNRFVQADALELVFGGAEANVAVSLANFGMRPSYITKLPAHE 295
13_ncbifamImport        213 RGGKTFPRQKRLt---------AFVGFGDFLLRLSPPGYRRFSQASTFETYYTGAEANVCASLAVMGARARFVTRVPDNP 283
12_ncbifamImport        213 TDAMPFPPQKRLs---------RMVGFGDFLLRLSPPGYRRFSQANAFESYYTGAEANVCASLAVMGAKASFVTRVPDNP 283
TEU03854                303 LGDHAFNTLRMHGVDARFILRQGKRIGVYYLEHGAGPRPSKVVYDRARSAFSELGSSDLDWGQILEDAQWFHWTGITPAL 382
16_ncbifamImport        297 LGQAVVNTLRGFGVDTTHVLRQGRRLGVYYLEHGVAQRPSQVIYDRAGSAVSELAPGQIDWDAVFADAGWFHWTGITPAL 376
26_ncbifamImport        305 LGQAAIEALRAHGVDTAHVLRHGTRLGLYYLEQGAAQRPSRVIYDRMNSAIAELAPGQIDWNAALQNAGWLHCTGITPAL 384
6_ncbifamImport         281 IGQGAINSMRYFGVDTSMITRGGERVGIYYLEKGASQRASKVVYDRAYSAISMATKKDFDWDKIFDGVSWFHFTGITPAL 360
4_ncbifamImport         288 IGQMAVNSLRKFGVDTSMITRGGDRVGIYYLEKGASQRPSKVIYDRAGSAIATASKTDFNWDAIFEGAGWFHFTGITPAL 367
24_ncbifamImport        295 IGQMSVNSLRKYGVDTSLIVRGGSRVGIYYLEKGASQRASKVIYDRAGSAIAEASKTDFDWDKIFDNAGWFHFTGITPAL 374
5_ncbifamImport         290 IGQAAVNSLRKYGVDTSKIVRGGDRVGIYYLEKGASQRPSKVIYDRAGSSIACASGSDFDWDKIFAGKKWFHFTGITPAL 369
PRJNA284866:E4N87_00995 296 IGQAAVNSLRRYGVDVSGIVRGGKRVGIYFLEKGASQRASKVIYDRANSAIAEASPSDFNWKEIFKGASWFHFTGITPAL 375
13_ncbifamImport        284 IAETGLGELRRLCVDVSHVVRGGERLGLYYVEKGASQRPSKVVYDRMHSGVTTASRRDFDWARIMKGASHFHFTGITPAL 363
12_ncbifamImport        284 IARVGLGELKRLDVDVSRVVFGGDRIGLYYLEKGASQRPSLVVYDRMHSGMTTARRTDFNWTEILRGASHFHFTGVTPAL 363
TEU03854                383 SDSLAASLREGLTLAKKKGITVSVDLNYRKKLWSEDKARKVMTELMPFVDILIGNEEDPHRVFGIQSKRTDVAAGKLDVE 462
16_ncbifamImport        377 SDSAAAVTREALEAARRAGLTVSVDLNYRATLWTPARAREVLTPLMEYVDIAIGNEEDAAQVFGIRAARTNVAAGQLDID 456
26_ncbifamImport        385 SASAAELTRQALESAKNADLTVSFDLNYRAKLWPPQRAREILTPLMQHVDVLICNEEDAAQVFGIHAGNSDVAAGKLDAE 464
6_ncbifamImport         361 GDNVAEICLEACKKANEKGITVSCDLNFRKKLWSSQKAGEVMGKLMPYVDVCIANEEDADKVFGIKAENTDVHGGKLNHE 440
4_ncbifamImport         368 SDELAAICEEACIAAKERGIVISCDLNYRNKLWSKEKAGEVMGRLCKYVDVCIANEEDASDVFGIKASNTDITGGTLSHE 447
24_ncbifamImport        375 SDELADITLEACKKAKEKGIIVSCDLNYRNKLWSKEKAGEVMEKLCRYVDVCISNEEDAYDVFKIKAPDTDVTAGEINSE 454
5_ncbifamImport         370 GDNVAEITLEALKAAKKNGLTVSCDLNYRGKLWTREKAGKVMAKLCEYVDVLIANEEDAGDVFGIRSEGTDVTSGVVNHD 449
PRJNA284866:E4N87_00995 376 SKNAAEICLEACKTARSMGITVSCDLNYRKKLWTPDEAKETMSSICEFVDICISNEEDAEKVFGITSKNTDVSSGKLNEK 455
13_ncbifamImport        364 GGELPAIVADACRAAKKAGALVSCDLNYRKNLWSPQEARRTMTRLLPQVDYLIANEEDAEKVLGIKADDSDVTGGRLSRD 443
12_ncbifamImport        364 GGELPEIVADACRAAKETGCVVSCDLNYRKALWSTDQAAKTMIPLLGMIDYLIANEEDIEKVLGIRATESDVTGARLSRD 443
TEU03854                463 GYRGLAKELAKRFG-FKKVAISLRESLSASENIWSACLLSGNKFIKSPKHRVWIVDRVGTGDAFAAGLIFSLLKGKTDKE 541
16_ncbifamImport        457 AYRDVAEQLIARCG-LRLAAITLRESLSASDNRWSACLHDGQQFCHSKTYAIHVLDRVGSGDAFAAGLIHELNAGKAAPD 535
26_ncbifamImport        465 AYRNVAEQLLSRFG-FRAVAITLRENLSASDNRWSACLHDGKEFNISRCYPIHVVDRVGAGDAFAAGLIYAWRAGREPRQ 543
6_ncbifamImport         441 GYKYVADELVKRFG-CKYVAITLRTSISANDNKWAAMLYDGENSYFSKSYDVHIVDRVGGGDSFGAGLIYGISEGYAPQD 519
4_ncbifamImport         448 GYKDVARQLAARFG-FSYVAITLRESLSANDNNWAAMLYDTQEFYFSKKYPVHIVDRVGGGDSFGAGLIYAMAHAYAPAD 526
24_ncbifamImport        455 GYKYVAEELKKRFG-FSYVAITLRESISASDNRWGAMLYDGKDYYFSKKYNVHIVDRVGGGDSFGAGLVYSLTHNYTSAD 533
5_ncbifamImport         450 GYKSVARQLKERFG-FAAVAITLRESVSANDNNWSAMLCCNDEYYFSKKYAMHIVDRVGGGDSFAGGLICAMMKGFAPKQ 528
PRJNA284866:E4N87_00995 456 GYKEVAAKLCKKFG-FQKVGITLRESTSASKNNWSAMLYTKGKAYFSKKYTMQVIDRLGGGDSFAAALICAELKGFKPQK 534
13_ncbifamImport        444 GYVDVARRLVAAFPnLKAVAITLRRSISASDNVWGAMLYAGGRAFFSRDYNVHIVDRVGGGDSFAAGLVYALGSGYGPQE 523
12_ncbifamImport        444 GYADVAAQVVRSFPnIQAVAITLRRSLSASDNVWGAMLYAGGSAYFSRDYNVHIVDRVGGGDSFAAGLIYALGNGYGPQE 523
TEU03854                542 ALNFGVAAACLKHSICGDFNLVNVEEVERVAAGETAGRVQR 582
16_ncbifamImport        536 ALEFAVAAACLKHSLHGDFNLVSRAEIEAIAGGDVSGRVRR 576
26_ncbifamImport        544 TLEFAVAASCLKHTIAGDFNLVSVAEVEALAAGAAAGRIQR 584
6_ncbifamImport         520 ALEFAVAASCLKHSIQGDFNRVTVAEVKTLMGGDGSGRVSR 560
4_ncbifamImport         527 TIEFAVAASCLKHAVEGDYNMVSVDEVKKLAGGDASGRVQR 567
24_ncbifamImport        534 AIEFAVAASCLKHSIEGDYNFVSVDEVNKLAKGDASGRVQR 574
5_ncbifamImport         529 VIEFAVAASCLKHSVQGDFNMVSFDEVMKLAGGDGSGRVQR 569
PRJNA284866:E4N87_00995 535 QIDFASAASCLKHSINGDFNQVSFDEVLTLAQGDASGRVQR 575
13_ncbifamImport        524 VVEFAAAASCLKHSIELDVNLSTLDEIKRLASGDGSGRVQR 564
12_ncbifamImport        524 AVEFAAAASCLKHSIELDVNLSTVEEIRRLMEGDGSGRIQR 564
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