Conserved Protein Domain Family
LC_FACS_bac

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cd05932: LC_FACS_bac 
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase
The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Statistics
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PSSM-Id: 341255
Aligned: 5 rows
Threshold Bit Score: 925.718
Created: 2-Nov-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
WP_011799700  33 GGVIQDYTWSQVADQVRRMAAHLKAQGwePGSNVAILSKNCAWWLMSDLAIWMAGHVSVPLYPTLaPDTIAHILTHSEAK 112 Polaromonas nap...
ABO21018      31 DGKVVEYTWGRAVDEARRMAAYLKSLNlpEKSRIGLISKNCAQWVMTDWAIWMAGHISVPLYPTLnADTVNYILNHAECD 110 Marinobacter hy...
NP_231971     41 NRQFVEFTYAEVADKALRLVSALRALGadPGDKVALISKNCAEWFICDLAMMLGDYISVPIFPTAgSETIDYCLEHSESK 120 Vibrio cholerae...
NP_715995     30 KGQYLDFTWNEVQEKVQQLAGALRHLGlePGDKIAVLSKNCAEWFITDLALMHGGYISVPIYPTAnPDTIRYVLQHSGAK 109 Shewanella onei...
NP_250308     31 GGRVEELSWGEVGDQARRAAAWLRTLDlpAGSRIAIISKNCAHWIVTDLAIWMAGHVSVPLYPNLtAESARQVLEHSESA 110 Pseudomonas aer...
Feature 1                                                                          #             
WP_011799700 113 ACFVGKLDawenmkpgvpgglpcisyplsppdvlnnHDGWDAICARQAPLqgelvrGAEELATLIYTSGTTGRPKGVMQS 192 Polaromonas nap...
ABO21018     111 VLFVGKLDdwdsmksgvpesv---rcisyplsppndFETWDDIVAKYPPLegktrrDPEELATIVYTSGSTGRPKGVMLS 187 Marinobacter hy...
NP_231971    121 ILIVGKLDdnkatahvlaerpnlisislpypsaakcQYEFQTLIKQHQPSeerpthFDEKLMSIVYTSGTSGQPKGAMLT 200 Vibrio cholerae...
NP_715995    110 AIFLGKLDhwadqeagvggel---lrlampydtmpaQYQWEQLLNMGNPLieaplpEPDQIMTLIYTSGSTGQPKGAIQT 186 Shewanella onei...
NP_250308    111 VVFVGKLDdwpamapgvpegi--ptvamplhpegrfDRQWSDLQACAPLEgdt-ptAAEQLATLIYTSGTTGVPKGVMHN 187 Pseudomonas aer...
Feature 1                                  ##                                            # ##  # 
WP_011799700 193 FGsFAWALDAGITRIDLtgQDRMLSYLPLAHVVERvLVEHGWLRTGMRLYFAeSIDTFPADLQRARPTIFFSVPRLWVKF 272 Polaromonas nap...
ABO21018     188 FNnMAFAAAGGIETLGVgpGERMLSYLPLAHVFERtFVELGSLYSGFQLYFAeSLDTFVQDLQRARPTLFLSVPRLWVKF 267 Marinobacter hy...
NP_231971    201 YGaFTWSAQQLINHIGIeeNDRLFSYLPLAHITERvYIFGSSIIGGVLTAFPeSLDTFIEDVKMHRPTLFISVPRLWTLF 280 Vibrio cholerae...
NP_715995    187 FAsYGWTCQAVVRDLRTngNDRLLSYLPLAHITERvAIEGSSFYSGSVVAFVeSLDSFVADVQRAKPTVFFSVPRLWSLF 266 Shewanella onei...
NP_250308    188 FSsFAFAASRGVELFGTreDDRMLSYLPLCHVAERmFVEMGSLYGGTTVFFAeSLDTFVEDMKRARPTLLFGVPRIWTKF 267 Pseudomonas aer...
Feature 1                          ##                                             ######         
WP_011799700 273 QQGVHHKIPPARLQLLLSIPVIGALVRRKvlkaLGLDQCRIAAGGAAPMPLALLSWYrKLGLPINEGYGLTENlAVSHLT 352 Polaromonas nap...
ABO21018     268 QHGVLQKVPKQKLDRLLKIPVVNKLIKKKvlkgLGLDKVKLAGSGSAPLSNDVLDWYrNLGLELLEGYGMSENfAYSHMN 347 Marinobacter hy...
NP_231971    281 QQRIQDKLPQKKLNILLKIPFVNSLIKRKladgLGLDQARVLGCGSAPVSPALLEWYrSVGLNITEAWGMTESfAYSTLN 360 Vibrio cholerae...
NP_715995    267 QKNIIDKIGVSKLNLLLKIPLISSLVKHKihkgLGLNHCRLLGSGSAPIPPSLIHWYhSIGLNICEAWGMTENcAYSIIN 346 Shewanella onei...
NP_250308    268 QMGVYSKMPAQKLDRLLKLPILGRIVGRKvlagLGLDAVRYALCGAAPVPEALLLWYrRLGLDVLEVYGMTENsGYSHVC 347 Pseudomonas aer...
Feature 1                                                                    #           #  #    
WP_011799700 353 VPGT-NQEGTVGPAYPGVEDRIDPeTGEIQMRSPALMMGYYKDPVQSRAAFTeDGWLRTGDKGQLDARGNLHITGRVKDL 431 Polaromonas nap...
ABO21018     348 KPGR-TRTGYVGEALPGVEVKISD-QGEVLVKSPATMMGYYKDEEKTAEAFTeDGFLRTGDKGEIDEMGRLKLTGRIKEI 425 Marinobacter hy...
NP_231971    361 YPFRaDKIGTVGNAGPGIELKIAE-DEEILVRSKGLFAGYYKNDTATAESFNdDGWLHTGDIGSLDSEGYLTIQGRKKDT 439 Vibrio cholerae...
NP_715995    347 YPFDvRKIGTVGKPVQDCQIRQGE-DGELLIKSPGLMTAYYLQPEATAAAFDaDGFFHTGDLCAIDADGCVTITGRVKDN 425 Shewanella onei...
NP_250308    348 RPGR-QKTGWIGQNSPGVEVRISD-EGEVQVRSGATMVGYYKEPEKTAEVLTaDGFLRTGDKGEQDADGNLRLTGRMKEI 425 Pseudomonas aer...
Feature 1            ####                                                                     #  
WP_011799700 432 FKTSKGKYIAPAPIEDKLVMHEAVEACVVTGANLGRPLGIVMLNAEavarsrdaaaRTELEASLSEHLKGVNATLDpHEQ 511 Polaromonas nap...
ABO21018     426 FKTSKGKYIAPAPIENRLMSHDAIEMVCVSGANQTQPHALVVLGEEirpkaadesfRKELEESFRQLIQDVNKTVDpHEQ 505 Marinobacter hy...
NP_231971    440 FKTAKGKFVAPVPIEKKLFEYSRVEMMCLIGSGLPAPILLAVPHNFph------fdRARYERTTQKVIARINSELEsHEQ 513 Vibrio cholerae...
NP_715995    426 FKTAKGKYVAPVPIERKLAQDPHVELICVIGSGLPHPVALVQLSEGanl-----qaREEVRASLKATLDSVNPHLEsHEH 500 Shewanella onei...
NP_250308    426 FKTSKGKYVAPAPIENRLAVHDRIEQVCVVGEGLSAPLGLCVLSEVgrrea-lngtRGALESSLRAHLEQVNGALDkHER 504 Pseudomonas aer...
Feature 1                                         
WP_011799700 512 LACLVIVTTaWTVDNDIITPTFKVKRNRIEDIY 544 Polaromonas naphthalenivorans
ABO21018     506 LAFITVVSDeWSIENSFLTPTLKLKRNVVEDAY 538 Marinobacter hydrocarbonoclasticus
NP_231971    514 IKGVLMIKDpWSIDNGILTPTLKIKRHVLEKKY 546 Vibrio cholerae O1 biovar eltor str. N16961
NP_715995    501 VDAIVVVNEpWSIENDVLTPTLKIKRHVLEKAF 533 Shewanella oneidensis MR-1
NP_250308    505 LVGLVLVQEtWAVDNGFLTPTLKIKRNMVEGAY 537 Pseudomonas aeruginosa

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