Conserved Protein Domain Family
Rv0340_fam
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NF038176: Rv0340_fam 
Rv0340 family protein
Homologs of Rv0340 from Mycobacterium tuberculosis H37Rv are regularly found encoded upstream of the genes for IniB, IniA, and IniC. As with those families, mutation in this family can contribute to resistance to isoniazid, a front-line treatment for Mycobacterium tuberculosis that works by inhibiting cell wall biosynthesis. Rv0340 and glycine-rich repetive protein IniB are homologous across the N-terminal 50 amino acids of each, but otherwise dissimilar.
Links
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Statistics
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PSSM-Id: 468397
Aligned: 55 rows
Threshold Bit Score: 105.427
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_065135069              1 MANSLLDFVISLVRDPEAAARYAANPAQAIADAHLTDVTSVDVNNLIPMVSDSLSMAGPT-GAVAGMPV--ADPGNVWAS 77  Myco...
PRJNA329584:BCA37_26585   1 MANELLDFVMDLVRDPDAAARYAADPSQAIADAHLTNVTSADVNNLIPMVSDSLSMAAPAfGADAGLDD--TLDGNVWTS 78 
WP_057170305              1 MANSLLDFVMSLVRDSDAAARYAADPAAAIADAHLSDVTSADVDQLIPVVAESLSSAVPGvDATSWAGTlpAVDSNVWTS 80  Myco...
WP_142552450              1 MANSLLDFVMSLVRDPDAAAQYAANPAQTIADANLTDVTHVDVDNLIPVVAESMSTPQPSgGIPASADTllDSAHNVWAS 80  Myco...
WP_163672764              1 MANPLLEFVLSLVRDPEAAARYAADPERAIADAHLTDVTRVDVNSLIPVVSESMSa-----G---------AMDDNVWTS 66  Myco...
TXI51793                  1 MANSLLDFVLSLVRDPDAAARYAADPAGAIADAHLTDVTSADVNNLIPMVTDSMSTAAPA--------L--GGDGNVWTS 70 
WP_167107204              1 MANSLLDFVMSLVRDPDAAARYAADPAGSIAAAHLTDVTSVDVNNLIPMVADSLSTAVPSfGADP------TADGNVWAS 74  Myco...
WP_094477804              1 MANSLLDFVMSLVRDPDAAARYAADPAGAIADAHLPDVTSADVNNLIPMVADSLSGPMSGsAFGPGAGA--GGDGNVWAS 78  Myco...
WP_135422634              1 MANSLLDFVMSLVRDPDAAARYAADPATAIADAHLTGVTSADVNNLIPMVADSLSGPLSG-AIPSFGAS--GGDANVWAS 77  Myco...
PRJNA374925:B1R94_02780   1 MANSLLDFVMSLVRDPDAAARYAADPAGAIADAHLTDVTSVDVNNLIPMVADSLSGPLSStGSGFGPDH--GGDGNVWAS 78 

WP_065135069             78 GAATAAFDAFTPHTPAASV---SQHGAIsglGGVINQP--AAHLP----VDTPAGPPPVQIG---HPEQSGLVTGGGMPE 145 Myco...
PRJNA329584:BCA37_26585  79 GAATAAFDAFAPLTTEHITd----------iPTVVDTA------------GPEVASVVPDFE---PLVDTVLADDPALGD 133
WP_057170305             81 GAATAAFDAFGIDDSVPVIadgLDNLPVhevPSITD----DGVGVv---QGLDDEYADVPVN---TVVEDLPLHDNILDH 150 Myco...
WP_142552450             81 GAATAAFDAFDAHLPIQGSdvvADHVPMv--ANVIELP---------------EDSTPTIVDhgfDDLSLPTVDAPVVDD 143 Myco...
WP_163672764             67 GQAVSAFDAFGDELPAQITgddLAPAg----REVIDTSdlSDTSDvpdrLGAFDDVLDAPDG---MPAPVGAMDDAVVGR 139 Myco...
TXI51793                 71 GAATAAFDAFDAHVSAPVE----HAAAHdalTSVIGRP--PGADQsvitEHAAGAPDPFEAP---AHAADTGLEHP-IDD 140
WP_167107204             75 GAATAAFDAFDAAAPAMTP---NSHPVD---TGVIQPPadDGPAVv---ADTGGDHSVVEPV---SVDPSTQFTDPAADQ 142 Myco...
WP_094477804             79 GAATAAFDAFDAHVPAAPA---PVDRPVitdVAQHTDP--AAGLI----SDPGTDHAAVGLS---LPDTSAQVSDAGFEH 146 Myco...
WP_135422634             78 GAATAAFDAFDAHLPGTSPs--DVHPVI---TDAAQHV----AGDttliTDPGADPSAAGLP---LPDASPQVIDAGFEH 145 Myco...
PRJNA374925:B1R94_02780  79 GAATAAFDAFDAHLPAAPLp-eTHPVITdlvQRVANEP--GLI------TDPGAESAGLQSA---LADASAQVSDTVADP 146

WP_065135069            146 -----IAFDHGG-FPASDPGLWDHSVIhpdaHPHDAPPDHHGFGMH 185 Mycobacterium gordonae
PRJNA329584:BCA37_26585 134 -----APADPAP-------ALWEGPAT----DPQPLDEGHHTFDLF 163
WP_057170305            151 --------------------EWSAA------------PDAAGFDLF 164 Mycobacterium sp. Root265
WP_142552450            144 -----LRVDDGAgSPDLGQHDVSDPLD-----GHLDHPHDPGFDIF 179 Mycolicibacterium hodleri
WP_163672764            140 -----DWFDDGLgAVSAPLDGLDGPVDa--gDLEDLPHQGSGFDAF 178 Mycolicibacterium poriferae
TXI51793                141 plgqqPLEHQPE---WGDHGGWEHTGL----DDGHPTPEHPGFDLF 179
WP_167107204            143 ------HLDPGHtPDWLADAGWDHSHI----DDSHPGPDHQGFDLF 178 Mycobacterium sp. DL592
WP_094477804            147 s----APADAGS--DWVDHAAWDHTHV----DDSHGTTDHPGFDLF 182 Mycolicibacterium sphagni
WP_135422634            146 d----QALDPAP--DWVDHTAWDHSHV----DDTHGAGDHQGFDLF 181 Mycolicibacterium sp. CH28
PRJNA374925:B1R94_02780 147 a----PAVDTAL--DWVDHAGWEHTHT----DDTHGTTDHPGFDLF 182
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