Conserved Protein Domain Family
PEP_mutase

?
pfam13714: PEP_mutase 
Phosphoenolpyruvate phosphomutase
This domain includes the enzyme Phosphoenolpyruvate phosphomutase (EC:5.4.2.9). This protein Swiss:O86937 has been characterized as catalysing the formation of a carbon-phosphorus bond by converting phosphoenolpyruvate (PEP) to phosphonopyruvate (P-Pyr). This enzyme has a TIM barrel fold.
Statistics
?
PSSM-Id: 433424
Aligned: 69 rows
Threshold Bit Score: 159.29
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EED17633          5 IKSvLKKN-QdRV----------------------------------------RLLEAHDHATKEAVRLTFsdn-----g 38 
EEU42669        391 IRAaFKAR-Q-LIhpcphlyqhqpqsssiniamsatqskvdilrerlntakpaIAMAAHSPLGAKLVEEAG--------- 459
Q12Q29           14 LKDiLLSP-T-TE----------------------------------------YLMEAHNAISAKIIEEVG--------- 42  Shewanella d...
Q4DNR3           14 LKSmLRSK-E-LS----------------------------------------FLMEAHNGLSARIVEETG--------- 42  Trypanosoma ...
ADD78458          2 iKK-LIAEkG-TL----------------------------------------IFIEAHNPLSALIASKAEqtnse-gri 38 
Q5E5F2           18 LINvIKSH-G-CI----------------------------------------RILETHNPISALIAEKASandidseen 55  Aliivibrio f...
Q63MP0           20 FKEkLATG-R-AL----------------------------------------RFIESHSPISAMISEKVYvahga--sq 55  Burkholderia...
Q893V9          153 LRQlLKLR-P-IV----------------------------------------KAIEVHNGITGLIAEKTvvern--gel 188 Clostridium ...
jgi:DaAHT2_1860 153 LRRlIDAK-P-MV----------------------------------------RLMEAHNGLTGLIVENLFeqqeg--rr 188
vbi:Arad_7864    15 LRAlLEKR-T-FL----------------------------------------RFLDIHNALSALIVEHTIveten--gs 50 
EED17633         39 esFDGIWLSGLTQTTYLGIPDTELISPLQRatyMSSSNNNIEQHgSRPLcaAFDADSG-GDVNDIPQLVALLLSLGVSMV 117
EEU42669        460 --FGAVWVSGFELSASYAVPDASILPMSTI---LEMTRAMGEVQ-NLPL--IVDLDTGfGNAVNVAYAVPRFAAAGATAV 531
Q12Q29           43 --FSGIWASGLTISSSLGVRDRNEISWTQV---IDAVEYMTDVV-DCPI--LLDVDTGyGDYNSFRRVVKKLCQRNISGC 114 Shewanella d...
Q4DNR3           43 --FKAIWASGLSISAQMGFRDNNEASWTQV---CDVAEQMSDAT-SIPI--LLDADTGyGNFNNARLLVRKLEKNGVAGA 114 Trypanosoma ...
ADD78458         39 vkFDGIWSSSLTDSASRGIPDNETLALSSR---LENIADIRNVT-DMPI--IMDADTG-GKPEHFSYYVKRMINNGVNGV 111
Q5E5F2           56 veYQGFWSSSLTDSVSQGKPDIELLDIKNR---ISNISDIFEVT-SKPL--IIDGDTG-GKIEHLSFNIRSLERLGVSAI 128 Aliivibrio f...
Q63MP0           56 seFDGFWSSSLTDSTLRGRPDIEILDIASR---LANVQHIFDVT-TKPL--IIDGDTG-GKPEHFALNVQSLERSGVSAV 128 Burkholderia...
Q893V9          189 dqFDAMWISSLCDSTAKGKPDIELVDMSSR---LDTVNDVMEVT-TKPI--ILDGDTG-GLVEHFVYNVRTLERMGVSAV 261 Clostridium ...
jgi:DaAHT2_1860 189 leFDGMWLSSLTDSTAKGKPDIEAVDVTSR---MRTLSDIVEVT-TKPI--LYDADTG-GRPEQFAFTVRTLERFGVSGA 261
vbi:Arad_7864    51 qsFDGMWASSLTDATARGMPDIEVVDVASR---LGSLGEVMQVT-SKPV--IYDADTG-GKAEHFAYTVRKLEWLGVSAA 123
EED17633        118 IIEDKsvtapgkEVNslagashsqgqadMYEFAKVLRAFRAAAGDSEIMITARIESFTtrmvgkneakelasVRLAVDNA 197
EEU42669        532 VIEDKaf----pKDSslragg-rhalvsIPEFQGKIAAA----KVSPVLVIARTEALI--------------AGLGEEKA 588
Q12Q29          115 CIEDKif----pKQNsfiger--qelasIAEFTGKIKAGIDHRENEDFVIIARTEALI--------------SGYGIDEA 174 Shewanella d...
Q4DNR3          115 CVEDKlf----pKTNslldergaqpladVKEFALKIRAMKDTQTDENFCVVARVESFI--------------AGWPLEEA 176 Trypanosoma ...
ADD78458        112 IIEDKtg----lKKNslfgteveqtladINDFSEKIKRGKSAVYIDDFMIIARLESLI--------------AGFDVEHA 173
Q5E5F2          129 IIEDKtg----lKKNsllgneveqkqdtIESFCTKIKKGKESQLTEEFMIIARVESLI--------------LDAGMEDA 190 Aliivibrio f...
Q63MP0          129 IIEDKtg----lKKNsllgndviqhqesIEDFCEKIRVGKAAQITDDFQIIARVESLI--------------LDKGMPDA 190 Burkholderia...
Q893V9          262 IIEDKtg----lKKNslfgtevqqtqdtVENFCYKISEAKEVLRTDEFMIIARIESLI--------------LEQGMEDA 323 Clostridium ...
jgi:DaAHT2_1860 262 VIEDKig----aKRNslfgagvgqvqasLEEMADKIQVGNRAKITSTFMIIARIESLI--------------LEQGQEDA 323
vbi:Arad_7864   124 IVEDKtg----vKRNslygtdvvqsqdtPDNFARKIAIAKKAQISQDFMLIARIESFI--------------LGKGLDDA 185
EED17633        198 LARAEVYKKGGADAIMIRSKEKDPSeVLSFLAQFrSqd-vkTPLVVVP----TtygsITDEELHQAG-ANVIIYANHLMR 271
EEU42669        589 IKRAMAYAEAGADTVLVHSKQKTPDeILSFCKAWtGt----VPLVIVP----TsypqLSFAEVAALDkVGLIICGNHAVR 660
Q12Q29          175 LRRAEAYYEAGADAILIHSKSSNADeVLEFCNLFtAp----CPIVIVP----TkyynTPTNVFEEAG-VSTVIWANHSLR 245 Shewanella d...
Q4DNR3          177 LKRATAYAEAGADAVLIHSKKKDSSeIDAFMAHWdNk----TPVVIVP----TsyasVPCAHFREIG-ISTVIWANHNLR 247 Trypanosoma ...
ADD78458        174 LERADAYVEAGADGIMIHSCKKTPDeVFLFSTKFrKky-psVPLICVPttysA----TSNRELSEAG-FNVIIYANHMLR 247
Q5E5F2          191 LERAFAYSESGADGIMIHSRHQDGKeIFDFAKQYrSky-pdKILVCVP----TsyneIKFDELKQAG-FNIVIYANHMLR 264 Aliivibrio f...
Q63MP0          191 LARAAAYCEAGADGVMIHSRKKDADeVIEFAQRF-RacrrdAYLVCVPtsfnA----ISFSELARH--FSVVIYANHLLR 263 Burkholderia...
Q893V9          324 LNRAYAYVNAGADGIMIHSRKKDPTeIFKFCDEFrKtd-knIPIVVVP----TsfntVTEEEFIAHG-VNVVIYANQLTR 397 Clostridium ...
jgi:DaAHT2_1860 324 LRRAHAYIDAGADGIMIHSRQKTVDeIAAFCAEYrKfk-krVPLVAVP----SsynsVYDHELQEMG-VDVVIYANHLLR 397
vbi:Arad_7864   186 LMRAEAYLAAGADGIMIHSREKLPDeVFSFCRKYnRfv-drKPLIVVP----SsfnmTTEQALADEG-VNICIYANQLIR 259
EED17633        272 AKITAGDAISsfFL 285
EEU42669        661 AAVASMRRTFkhIL 674
Q12Q29          246 ASVKAIRETAeiVF 259 Shewanella denitrificans OS217
Q4DNR3          248 ACIAAMQASTrmIF 261 Trypanosoma cruzi
ADD78458        248 AAYKAMENVSkeIL 261
Q5E5F2          265 AAYKAMEYTSeqIL 278 Aliivibrio fischeri ES114
Q63MP0          264 AAYPAMLAVAegIL 277 Burkholderia pseudomallei
Q893V9          398 SAFPAMQQTAtkIL 411 Clostridium tetani
jgi:DaAHT2_1860 398 SAYPAMLDTArsIL 411
vbi:Arad_7864   260 SAYPSMVETArsIL 273
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap