2P06


Conserved Protein Domain Family
NTP-PPase_Af0060_like
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cd11533: NTP-PPase_Af0060_like 
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Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs
This family includes an uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its homologs from bacteria. Although its biological role remains unclear, Af0060 shows high sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, members in this family consist of a single MazG-like domain that contains a well conserved divalent ion-binding motif EXX[E/D].
Links
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Statistics
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PSSM-Id: 212140
Aligned: 38 rows
Threshold Bit Score: 47.342
Created: 5-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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metal bindinghomodimer
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:E E E DClick to see conserved feature residue pattern help
Evidence:
  • Structure:2P06; Archaeoglobus fulgidus Af_0060 binds Mg2+, contacts at 4.0A
  • Comment:Most members of the NTP-PPase superfamily contain the well-conserved divalent ion-binding motif, EEED.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                          #  #                             #  #         
2P06_A        35 XHAKYXKRVsrpgntpr-pwfdfseeRLLSRLFEEXDELREAVeked--------------wenLRDELLDVANFCXYLW 99  Archaeoglobus f...
NP_623771      6 KEISLPKLNnltp----------sleSTALKLMEEAGELAQAIgkfrglngenvtlsereimekISEELLDVAQVAVSMM 75  Thermoanaerobac...
ZP_03494632    4 KTLSLPKLErltp----------tleSTMLKITEEVGELAQAIgkfrglsgeetrmpdeevvraIVTELLDVAQTATSMM 73  Alicyclobacillu...
YP_002472210   7 KLMVLRKLIdrkgnkid--hrtmtwqDWKKKVLEEAGELCEALssgd--------------kkkIMEEVLDVIQVGIGIL 70  Clostridium klu...
YP_001392505   2 HLMILDKEEtl--------------pEELLKLQEEFKEVRQAIlnkd--------------kenTTEEILDIMQVCIGML 53  Clostridium bot...
ZP_01810806    9 KLDTLVALNgvvkalelrfpdhngpfEYCTRLAEETGELIEVIyeskdgit------seeqknhLIKEQQDVLRVVLGIV 82  candidate divis...
YP_001320213   5 VKMPVLAKDhs-------------wvRHRLKLHEEHDELQQAIfgvkd------------nighVAAEALDTIQVCIGIL 59  Alkaliphilus me...
YP_001391666   3 LLMQVLRKNdklkidn----ttitskELITKITEEYKEVIEAIqkyennk-------rlinlkdIIRETYDLIQMCILVL 71  Clostridium bot...
ZP_02994762    2 QLMILKNSSklginn-----elltleNLIDKLQEEVKELKDAAedkn-------------nidhIAEEAWDSLQMCIEVL 63  Clostridium spo...
YP_001319179   8 KTISLPQLNglcp----------tleSTALKIAEENGELCRAIgkfrglsgerdtletqeafkeVAKELLDVAQTSFTMM 77  Alkaliphilus me...

Feature 1           
2P06_A       100 GKL 102 Archaeoglobus fulgidus
NP_623771     76 FVL 78  Thermoanaerobacter tengcongensis MB4
ZP_03494632   74 FVI 76  Alicyclobacillus acidocaldarius LAA1
YP_002472210  71 AKL 73  Clostridium kluyveri NBRC 12016
YP_001392505  54 DTQ 56  Clostridium botulinum F str. Langeland
ZP_01810806   83 GIY 85  candidate division TM7 genomosp. GTL1
YP_001320213  60 DKV 62  Alkaliphilus metalliredigens QYMF
YP_001391666  72 WKC 74  Clostridium botulinum F str. Langeland
ZP_02994762   64 DKL 66  Clostridium sporogenes ATCC 15579
YP_001319179  78 FLL 80  Alkaliphilus metalliredigens QYMF

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