Conserved Protein Domain Family
LarC

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COG1641: LarC 
CTP-dependent cyclometallase, nickel-pincer nucleotide (NPN) cofactor biosynthesis [Coenzyme transport and metabolism]
Statistics
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PSSM-Id: 441248
Aligned: 225 rows
Threshold Bit Score: 236.952
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_070395674   2 TkLAYLDCPTGIAGDMCLGALVSAGVPWEYLLEKLAALGIeQ-EYHLRLSQVHHNGQLATKVDVDLPdqdhqhhhhqqeh 80 
WP_011460167   1 MkAAYLDCFSGISGDMLLGALVDAGLDFNLLQRDLAGLDL-D-EYELYEQKVLKQGIRGTQIHVHALe------------ 66 
WP_011344193   1 MkIAYFHCFAGISGDMILGALIDAGLDFEQLKADLAKLSL-D-GYELQVKKVKKQGISATKVDVIIEe------------ 66 
WP_012680494   1 MkVGYLECFAGLSGDMMLGALIDAGVPAALLSETAAALGI---GASLKMHAVDRSGIRAAKVDVYAGeelaehaphahsh 77 
WP_013580428   1 MrIAYLDCFAGISGDMFLGALIGTGVPLEVLQDAATAMNL---NVTLKQETVDRSGISSIKIHVLEGdkpaegqapdtft 77 
WP_014183141   1 MrIAYFHCFAGISGDMTLGALVDAGLDWELLQADLAKLPL-S-GYQLQREKVIKKGISGTKVQVLTEe------------ 66 
WP_014812233   1 MrIAYFECFSGASGDMILGALLDAGLPLSVLVSELEKLNL-G-HFELRAEKTTRKGLSGTKAHVLIDqh----------- 67 
WP_014425339   1 MkAIYLDCFAGISGNMFLGAMLQAGVPQAYLEKELQKLPMaD-EFALEVQEVWQKGIHAVYVDVKLTaadhah------- 72 
WP_089608791   1 MkTAYFDCFSGISGNMIIGAFLSAGMPLDYLKCELAKLPL-DnEYQLITKNVTKQGIGACYFDVKPChdq---------- 69 
WP_125669455   1 MkAIYIEAFAGISGNMLLGALIDAGVPFDHLASEMKKLHL-G-EYELINERVNKCGIDANYFNVLLPdehqhdvtighrh 78 
WP_070395674  81 hhehghehhhehghehhhehghehhhehrsgiteistpeqnhhHHp-------tRHLPDIEKLITAAKLPSRVCQWSLAI 153
WP_011460167  67 -------------------------------------------GHv-------hRHLSDIQAIIGRSALPPQVKEKSLEI 96 
WP_011344193  67 -------------------------------------------EHa-------hRHLQDIKKIISESSLPEVVKEKSIQV 96 
WP_012680494  78 dhlhd---------------------hdhdhphshdhahphshSHah------gRTWKQIRALLEAAPLPEPARRLALDT 130
WP_013580428  78 hqaaphvh---------------thapktqhqhktghphtheePHthdhphvhgRSLSVIRTMIQAAPLAPAVKTLAIQT 142
WP_014183141  67 -------------------------------------------GHv-------hRHLRDVREIINSSTLPEVVKEKSIQV 96 
WP_014812233  68 -----------------------------------------hhGHh-------hRRLADITQIISRSGLSEAVKAKSLQV 99 
WP_014425339  73 -------------------------------------pehhehHHa-------hRTMKDIREILEQSALSMAVKQQAVAI 108
WP_089608791  70 -----------------------------------------dhQPh-------sRHLHHIRELIEQSSLAGRVKKLSLEI 101
WP_125669455  79 ehphaghhhhehgd--tghnhehhsdcaqhchqvkvseepvhhHHe-------hRNLHDIAHIITHSDLHDKIKMQSLQV 149
WP_070395674 154 FRKLAEAEGAVHGispDKVHFHEVGATDAIIDIVGTCLGLDWLGIDQIYCSPLPTGGGTVWAAHGRLPVPVPAVLKLWEs 233
WP_011460167  97 FTRLGKAEAKIHGtdiEQIHFHEVGAVDAIVDIVGAVIGFWRLGIEKVFASPIHVGKGFVKAAHGLLPVPAPATLELLT- 175
WP_011344193  97 FTRLAEAEAKVHQttlEKVHFHEVGAKDAIVDIVGAVIGLWRLGIEEVYSSPIHTGMGFTQSAHGKIPVPAPATLELLK- 175
WP_012680494 131 FALLAGAEAKIHGmavEDVHFHEVGNVDTITDIVCAAVGLAWLDVNAWYAAPVNVGSGFVQCAHGQFPVPAPATAELLR- 209
WP_013580428 143 FELLGQSEAKIHNvpvDDIHFHEVGAVDAIIDIVAASAGIVHLNIGTWHASPVNVGGGMVVCAHGTFPVPAPATADLLR- 221
WP_014183141  97 FTRLAEAEAKIHQtsvDQIHFHEVGAMDAIIDIVGSVIGLWRLEIEEVYASPVHIGTGFTKCAHGTIPVPAPATLELLQ- 175
WP_014812233 100 FEVLAEAEASVHGttkDEVHFHEVGAMDSIIDIVGSVAGLAALGVESVFCSPLHVGCGTVQCAHGILPVPAPATAKLVL- 178
WP_014425339 109 FTEIAEAEGKVHGkpaDEVAFHEVGAVDSIVDIVGAAICLDYLEVERVFVSKLTTGSGFVQCAHGMMPVPAPAVAELLL- 187
WP_089608791 102 FQRLGDAEATVHRcslDEVHFHEVGGVDAIIDIVGAAICYHYLGIERVSASPLHVGHGMVKCAHGMMPVPAPATAQLLK- 180
WP_125669455 150 FTALAEAEAKVHGktvDEVHFHEVGAIDTIIDIAGCVLALEYLGIEKIFVSNIHTGSGFVNCAHGLMPVPAPATAELLQ- 228
WP_070395674 234 rQVPVysNGIERELVTPTGAAIAVTLATSFGSPPA-MTIQKIGNGGGSRQL-PIPNMLRLWIGESSeavklskskvkpsn 311
WP_011460167 176 -GVPIyaQDVEGELATPPGAAIVTAYCREFGPFPK-IRVERVGYGAGVKDL-TIPNLLRLTVGELAdedk---------- 242
WP_011344193 176 -GCPIysEGIEAELTTPTGAAILTSFCKEYGDMPL-MEVTQIGYGAGERDL-EIPNVLRLSIGIKReekgfck------- 245
WP_012680494 210 -GVPVysAGPAGEAITPTGAALLRALGCRFEGKPI-FAAQSVGYGAGTRNPkDFPNVVRLSIGEAGqat----------- 276
WP_013580428 222 -NIPTysAHIQKELVTPTGAAILRALSPTFGPQPP-MSIASIGYGAGTRNPeSFPNVLRLSIGESGapgpds-------- 291
WP_014183141 176 -GVPIysKDIEKELVTPTGAAIITTYCQDFGNMPP-MRADTTGYGAGEHDL-VIPNLLRVTIGGKLdqvgsdgh------ 246
WP_014812233 179 -GKPVysTGVPGELLTPTAAALLTVLASGFGPMPF-MVPYEVGHGAGSRDL-EIPNLLRVFIGDTEnqs----------- 244
WP_014425339 188 -GWQTetGTEKKELVTPTGAGIVKALGTYSEGLPKgFVSEKIGYGAGSHEL-SLPNVLRLYFGEyh-------------- 251
WP_089608791 181 -GIPIysTEVKGELVTPTGAAILTTLTDEFGPLPP-LTPEIIGYGAGTWEL-PIPNVLRLYLGEMKpp------------ 245
WP_125669455 229 -GLQHshGKIEKELTTPTGAALMKVLAVSTNDIPQgFSGSKIAYGAGTWDL-EIPNVLRISIGEwe-------------- 292
WP_070395674 312 lppqtlhqsplsansssanSSLETISVLETQIDDLNPQAIGYVFEELFNAGAVDVFTQAIGMKKSRPGILLSVICHPQDL 391
WP_011460167 243 ---------------gqegIREGEALTLEVNIDDMNPECYDYLFEKLFQAGAMDVYIQTIQMKKNRPAVLLTVQTPYHKL 307
WP_011344193 246 ------------hteqknsFHQGEAVKIEANIDDMNPEFYDYLITKFLKAGAMDVYLERVQMKKNRPAILLNLLVHAHQV 313
WP_012680494 277 -----------------asFATDTVTVLECAIDDASPQVLAHALELALEYGALDTLATPATMKKGRPGTLLTVLCRPEHA 339
WP_013580428 292 -------------rtwvstETTQEIRVIETNIDDATPQLLAHVADLALKQGALDVTLTPVIMKKGRPGTIVTVLCTPADQ 358
WP_014183141 247 -----------iryggkgdVRQGDALMMEANIDDMNPEFYDYLINKFLKAGAMDVFLRKIQMKKNRPAIVLSLLIHTHQL 315
WP_014812233 245 -----------------seLGSEIVAILETNIDDMNPQVYDHLVEKALGMGALDVFLLPIQMKKNRPATLVTIMCPIDLV 307
WP_014425339 252 ------------------gAAVSELAVLEANIDDMNPQIYGYLYERLLAAGALDVWTTPIFMKKNRPAQKLSVLVESGRQ 313
WP_089608791 246 ------------------sPAQETAAILEATIDDMNPEFYPFLMEKLFQAGAADVFLTPIQMKKNRPGILVTITSRLANH 307
WP_125669455 293 ------------------aEAGGELLVAECNIDDMNGELYPYVQERLLQAGALDCWLTPIIMKKGRPAQTLSVLLDPQNL 354
WP_070395674 392 EACQAVLFRETTTLGVRRLTQ-QRAILPREIQQVqtkyGQISVKVAWSDrsphkTIMNVHPEYQDCAKLAKDNNCSWLEV 470
WP_011460167 308 EEMRRILFQETTTIGLRVYPI-KKYMLPYELLTVetnyGSAKVKVAFMEg----RACTVSPEYEDCRRLARLTGEPLKQI 382
WP_011344193 314 EEFCRLIFAETTTIGVRTYPV-KKYMLPYEIISVetefGPVPVKVAKYQg----VVQNIAPEYEVCRKIADEQQKPLKEI 388
WP_012680494 340 DALAALLFRETTTLGMRRRHE-QRLILDRQMVTVetrfGRIRVKLASHAg----ERLNAMPEYEDCRRAAREHAAPIQQV 414
WP_013580428 359 STLTQLLLTELPTLGVRTRTE-TRTILDRTHRTAetpyGPIRIKSGSLSg----TLLNETPEYEDCRAAAAAHKVPLKTV 433
WP_014183141 316 ETFYQQIFSETTSIGVRVYPV-TKYMLPYEIKTLqtklGQAKVKVARYQd----SLRNVAPEYEDCRRLAEEQQIPLKEV 390
WP_014812233 308 KAFSDLLMRETTTIGVRWRVE-NRIKATRSIKEIrtkyGLIRFKIACAGd----EITNIHPEYEDCKRLAMEQDIPLKKV 382
WP_014425339 314 SDCAGIIFAETTSIGLRVMPVgERLEAARHMAKVetsyGVVNCKVSAWDg----RICSVSPEYEDCKALAMAQNVPLKLV 389
WP_089608791 308 QPLLDVLFAESTTIGIRTHPV-ARYTLDRALHTVetslGSVRIKIGKAGa----GILNISPEYEDCRLLAEKTGIPLKDI 382
WP_125669455 355 DQLTDILLTETTSLGVRYYAV-HRHINYRKVTIVslpeGEVRIKYAQMDg----KIVNIAPEFEDCKVLALKSGHSLKTI 429
WP_070395674 471 HHLALSTWYSQHGA 484
WP_011460167 383 YEEIKEKAKILLYS 396
WP_011344193 389 YDLVKFRAYQRLT- 401
WP_012680494 415 MQAALAALSEAAPV 428
WP_013580428 434 QQAALAAPSK---- 443
WP_014183141 391 YDMIKYEAYQRLEA 404
WP_014812233 383 LEEAHFAALNALRD 396
WP_014425339 390 QQEAIKSFNDIIG- 402
WP_089608791 383 YLEAQAKGYQLLKK 396
WP_125669455 430 MQAAAAAAEAQLEQ 443
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