Conserved Protein Domain Family
PRK03739

?
PRK03739: PRK03739 
2-isopropylmalate synthase; Validated
Links
?
Statistics
?
PSSM-Id: 235154
Aligned: 261 rows
Threshold Bit Score: 873.718
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
172041580  33 NSQMPNRRYLPFfeevDHITLPDRTWPDKVIDRAPQWCAVDLRDGNQALIDPMSPERKRRMFDMLVEMGYKEIEVGFPSA 112
145219021   1 MKTMNFRKYSAY----PAVPIEGRTWPDNRIEAAPVWCSVDLRDGNQALPVPMSVEEKVAMFKLLVSVGFKEIEVGFPSA 76 
119358246   1 MKTMNYHKYTAY----PAVGIANRSWPDQTITKAPIWSSVDLRDGNQALPVPMNVDEKVAMFQLLVSVGFKEIEVGFPSA 76 
189499177   1 MATMNYAKYEAY----PAVDIEGRTWPDKRITKAPHWCSIDLRDGNQALPVPMSVEEKVEMFRLLVDIGFKEIEVGFPSA 76 
78189630    1 --MMNYRKYVPY----PPVDLPNRSWPSKQITKAPIWCSVDLRDGNQALPVPMSVDEKVAMFQLLVSIGFKEIEVGFPSA 74 
78186028    1 MKTMNFNKYSAY----PAVGLTDRTWPDRTINEAPVWCSVDLRDGNQALPVPMSVDEKIAMFRLLVSVGFKEIEVGFPSA 76 
194335364   1 MKKMKYRKYAAY----PSVAITARSWPDKSITKAPIWCSVDLRDGNQALPVPMSVEEKVTMFQLLVSIGFKEIEVGFPSA 76 
194333029   1 MAMMQSSKYAAY----PVVDISDRTWPDKRITRAPVWCSIDLRDGNQALPVPMSVQEKIEMFKLLIGIGFKEIEVGFPSA 76 
21674916    1 MSTMNYKKYAPY----PTVGLKDRTWPDKTITKAPIWCSVDLRDGNQALPIPMSVDEKVEFFRLLVSVGFKEIEVGFPSA 76 
193211812   1 MSTMNYRKYASY----TPVGLKDRTWPDKIITKAPIWCSVDLRDGNQALPIPMSVEEKVEFFKLLVSVGFKEIEVGFPSA 76 
172041580 113 SQTDYDFVREIIEENKIPDDVTIQVLVQAREHLIRRTFEACAGAKNVIVHFYNSTSELQRRVVFRKDKEGIKKLATDAAH 192
145219021  77 SATEFAFVRRLVEEQLIPDDVTIQVLTQAREHLIRRSFEAISGAANAIVHMYNSTSTLQRDVVFRKSREEIKAIAVEGTH 156
119358246  77 SATEFAFVRRLIENGLIPDDVTIQVLTQAREHLIRKTFEAIKGARHAIVHLYNSTSRQQREQVFRMNKEEIKEIAVTGTA 156
189499177  77 AAVEFQFVRRLIEENLIPEDVTIQVLTQAREHLIRKTFDALEGVGNAIVHLYNSTSTVQRDVVFRMGRDEIKRIAMDGTR 156
78189630   75 SATEFAFARRLIESNLIPDDVTIQVLTQAREHLIRKTFEAISGAKHAIVHLYNSTSTLQREVVFRKNREEIKAIAIEGTR 154
78186028   77 SATEFAFVRRLIEGGLIPDDVTIQVLTQAREHLIRKSFDAISGARSAIVHLYNSTSTLQREVVFRKNMEEVKAIAIEGTR 156
194335364  77 SATEFAFARRLIEERLIPDDVTIQVLTQAREHLIRKTFDAISGAKHAIVHLYNSTSTLQRDVVFRKNREEIKAIAVEGTA 156
194333029  77 SAVEFQFVRTLIEENLIPDDVTIQVLTQAREHLIRRTFESLEGANRAIVHLYNSTSTVQRDVVFRKNRQEIKEIAIRGTA 156
21674916   77 SATEFAFVRKLIENNLIPDDVSIQVLTQSREHLIRRTFEAIKGAKNAIVHLYNSTSRQQRDIVFRMSREEIITIAVAGTR 156
193211812  77 SATEFAFVRRLIEENIIPDDVSIQVLTQSREHLIRRTFEAIKGAKNAIVHLYNSTSRQQRDVVFRMSREEIISIAVAGTR 156
172041580 193 LIKEIAQDY--PDTN-WRWEYSPESFTGTEIEYAKEVCDAVVEVIDPTPENPIIINLPSTVEMITPNVYADSIEWMHRNL 269
145219021 157 LCRQLKDES--GSAG-IRFEYSPESFTGTELDYALEVCHAVMEAWGASADNPVILNLPSTVEMSLPNMYADRIEWFCRNI 233
119358246 157 LVRRLKEES--GSAG-IRFEYSPESFTGTELEYALEVCHAVMDAWGASAQDKIILNLPSTVEMSRPNIYADRIEWFCRNI 233
189499177 157 LVRELKEAS--GNEG-IRFQYSPESFTGTEVDYALEVTHAVMDEWGASENDPIIINLPSTVEMSTPNIFADRIEWFCRNI 233
78189630  155 LVRHLKEES--PNSAgIRFEYSPESFTGTELDYALEVCHAVMEEWGASATNKVILNLPSTVEMSTPNIYADRIEWFCRHL 232
78186028  157 LVRQLKDES--RNSG-IRFEYSPESFTGTELEYALEVCHAVMDTWGASKDEKIILNLPSTVEMSRPNLYADRIEWFCRNI 233
194335364 157 LVRRLKDES--GNAG-IRFEYSPESFTGTELDYALDVCHAVMDTWGASADEKIILNLPSTVEMSQPNIYADRIEWFCRNI 233
194333029 157 LVRELREAF--GNKG-IRFQYSPESFTGTELEYALEVCQAVMETWGASADEKVIVNLPSTVEMSTPNIFADRIEWFCRNL 233
21674916  157 LVRELKEASgnPG---IRFEYSPESFTGTELEYALDVCHAVMDEWGASATNKVILNLPSTVELSTPNVYADRIEWFCRHI 233
193211812 157 LVRELKEESgnPG---IRFEYSPESFTGTELDYALDVCHAVMDEWGASAENKVILNLPSTVELSTPNVYADRIEWFCRNI 233
172041580 270 NRRDSIILSLHPHNDRGEGVAAAELGYMAGADRIEGCLFGNGERTGNVCLVTLGLNMLTQGVDPQIDFSDIDQIRRTVEY 349
145219021 234 MDRGAAIISVHAHNDRGTAVATAELALLAGADRIEGALFGNGERCGNMDIVTMALNLFTQGVDSGLDFSDLPYIREVYRR 313
119358246 234 KERDAVLISVHAHNDRGTAVATAEFAVMAGADRVEGALFGNGERCGNMDIVVMALNLFSQGVDPELDFSDLPRIREVYRK 313
189499177 234 RERKAVIISVHTHNDRGTAVAAAELAVMAGADRVEGALFGNGERCGNLDIVTMALNLCTQGVDPELDFTNLAHISDVYRK 313
78189630  233 TNRDAALLSVHAHNDRGTAVATAELALLAGADRVEGALFGNGERCGNMDVVTIALNLLTQGVNPELNFSDLPRIREVYQR 312
78186028  234 KDRDAVLISVHAHNDRGTAVATAEFAVMAGADRVEGALFGNGERCGNMDIVTMGLNLLTQGVNPGLDFSDLPRIREVYSR 313
194335364 234 KARDAVLISVHAHNDRGTAVATAELAVMAGADRVEGALFGNGERCGNMDVVIMALNLFSQGVDPELDFSDLPRIREVYRR 313
194333029 234 SDRDAAIISVHTHNDRGTAVASAELAMMAGADRVEGALFGNGERCGNLDIITMALNMYTQGVDSRLDFSNLTHLTEVYRE 313
21674916  234 KNRDAVLLSVHAHNDRGTAVATSELAVMAGADRIEGALFGNGERCGNMDIIIMALNLMTQGVDPELDFSNLPHIKQVYSR 313
193211812 234 KDRDAVLFSVHAHNDRGTAVATSELAVMAGADRIEGALFGNGERCGNMDIIIMALNLMTQGVDPELDFSNLPHIKQVYSR 313
172041580 350 CNQLRVPERHPYGGELVFTAFSGSHQDAINKGLAamaerdaaedtpedpasadsetlteaVRNv----TWEVPYLPIDPK 425
145219021 314 CTRMDVHPRHPYAGDLVYTAFSGSHQDAISKGMK--------------------------AHGshgdgLWDVPYLPIDPG 367
119358246 314 CTRMDIHARQPYAGELVYTAFSGSHQDAISKGMK--------------------------AHKmssdgIWDVPYLPIDPG 367
189499177 314 NTRMSIHPRQPYSGELVYTAFSGSHQDAINKGMK--------------------------AIRasgnnCWNVPYLPIDPR 367
78189630  313 CTRMEIHPRHPYAGELVYTAFSGSHQDAISKGMK--------------------------AQCacsqgIWAVPYLPIDPQ 366
78186028  314 CTRMDVHPRHPYAGELVYTAFSGSHQDAISKGMK--------------------------ARGqkgdgLWAVPYLPIDPE 367
194335364 314 CTRMDIHPRNPYSGELVYTAFSGSHQDAISKGMK--------------------------AQPlspggLWAVPYLPIDPQ 367
194333029 314 CTRMPVHPRHPYAGELVHTAFSGSHQDAINKGMK--------------------------ARTeseneVWCVPYLPIDPK 367
21674916  314 CTRMTVHPRHPYSGDLVYTAFSGSHQDAISKGMK--------------------------AHQraadgVWDVPYLPIDPE 367
193211812 314 CTRMTVHPRHPYSGDLVYTAFSGSHQDAISKGMK--------------------------MHKrapegIWDVPYLPIDPQ 367
172041580 426 DIGRSYEAVIRVNSQSGKGGVAYIMKTDHNLDLPRPMQVEFSGIVQAVTDAEGGEVNPKAMWDIFATEYLDrt----apV 501
145219021 368 DVGCSYEAIVRINSQSGKGGVAFVLEKDYGIQIPKWMQPDFAWEVQALADRTGEELSPQRIHELFLDGIVRlrqpsvslK 447
119358246 368 DVGCSYEAIVRINSQSGKGGVAYVLEKDYGIQIPKWMQPDFAEAVQAVADRTGEELSPEEIHSLFHKEYVTlkep-falK 446
189499177 368 DVGCSYKAIVRINSQSGKGGVAYIMENDFGYEIPKWMQPHFGSAVQSKVDTTGRELLPEEIRELFHEEYIRmhd--pylM 445
78189630  367 DVGCNYEAIVRINSQSGKGGVAFVLEKEYGIQIPKWMQPDFAEVVQAMADRTGIELTPEQIHDLFQKEYVQahep-vvlK 445
78186028  368 DVGCTYEAIVRINSQSGKGGVAYVLEKEYGIQIPKWMQPDFAEAVQAVADRTGEELSATQIHDLFHSEYVRlqga-lalK 446
194335364 368 DVGCNYEAIVRINSQSGKGGVAYVLEKEYGIQIPKWMQPDFAEVVQAVADTTGVELSVEQIHDLFHAEYVKlrqp-itlK 446
194333029 368 DVGFSYKAIVRINSQSGKGGVAYVMEKEFGYSLPKWLQPDFGLVVQAIVDREGRELSPEEIRDLFSREYVRler--pylL 445
21674916  368 DVGCNYEAIVRINSQSGKGGIAYVLEKEYGIQIPKWMQPDFGAVVQEVTDRTGEELSAEQIHELFQKEYIGate--pylM 445
193211812 368 DVGCNYEAIVRINSQSGKGGIAYLLEKQYGIQIPKWMQPDFGTAVQEVTDRTGEELSAEQIHELFQKEYIGate--pylM 445
172041580 502 DVIST-TVDGGQNEGEESAVTSQ-Ief--nGEAKTLKGRGNGPIAAYCDALE-SLGVDVEVQEYNQHARTSGDDAEAAAY 576
145219021 448 KCTISwADSVQLESGEAATLIRAeVevdg--slinFDATGNGPLDAFVKGFGeKSSISFRVDEYAEHAIGHGSGAEAIAY 525
119358246 447 KCHISwDDEEPDRNDEEATIIACvVqmke--qefrLDAVGNGPVDAFVKGFVaESGIEFSVEDYIEHAIGRSAGALAVAY 524
189499177 446 KKCTIkWEDQDPERDDEVSTTLS-CilqhnDTERSFTANGNGPVDAFVRGMMqQTGLVFSVDEYAEHSIGHTADAKALAY 524
78189630  446 KCHIRwDEAAAPKQAEDDTTITCvVqake--relrFEAQGNGPLDAFVRGFMrESGMEFSVEEYAEHAIGRSSGAQAIAY 523
78186028  447 KCNISwAEGDGESSGAATTLISSvVaygd--relsFKAEGNGPLDAFVKGFIrEGGLEFTVEEYAEHAIGHSAGASAIAY 524
194335364 447 KCQISwDDEEPRRQDEEDTTISCiVqtre--kefnFTAQGNGPLDAFVKGFVrESGVDFSVDEYAEHAIGRSAGALAIAY 524
194333029 446 KKCHIsWEDEDPDRNDEVATTIT-SalqegEREFGFTARGNGPVDAFVTGFIhDSGIDFIVSEYSEHAIGHGADTQAIAY 524
21674916  446 KKCTIsWSDEDPDRNDEVATIVS-AsmvgpQGEFSFRAKGNGPLDAFVRGMVsHTGIDFHVDEYAEHAIGHSSDAMAIAY 524
193211812 446 KKCTIsWSDEDPDRNDEVATIVS-AsmvgpKGEFTFKAKGNGPLDAFVRGMVsHTGIDFHVDEYTEHAIGHSSDAMAIAY 524
172041580 577 VLAEVNG-QRVWGVGIAGSITYASLKAVTSAVNRALN 612
145219021 526 VRIVCDDgRSACGAGVDSNISLASIRATLSALNRLS- 561
119358246 525 VRIGCPDgRVSYGAGIDSNISLASIKAIVSALNRLP- 560
189499177 525 IRIKEEGgRESIGAGIDSNISLASIKAVLSAVNRL-- 559
78189630  524 IKIVDNEgKVAFGAGVDSNISLASIKATVSALNRLP- 559
78186028  525 VRICCPDgRISFGAGIDSNISLASIRATQSALNRLH- 560
194335364 525 IKIGCTDgRVSFGAGIDSNISLASIKATVSALNRLP- 560
194333029 525 VKITLPDgTVSYGAGIDSNISLASIKAVMSAVNRLDT 561
21674916  525 IRLSFDDvALVCGSGIDSNISLASIKAIVSALNRYKK 561
193211812 525 IRLSFDDvALVCGSGIDSNISLASIKAIVSALNRYKK 561
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap