Conserved Protein Domain Family
SLATT_6

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pfam18169: SLATT_6 
SMODS and SLOG-associating 2TM effector domain 6
The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family associates with a SMODS nucleotide synthetase domain fused to the predicted AGS-C sensor domain. It is sometimes further coupled to R-M systems.
Statistics
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PSSM-Id: 408000
Aligned: 11 rows
Threshold Bit Score: 216.783
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012585348   2 MNKENLLKVIADSGYNIGFGAKKNFATFDIVEKAPGWLGFLSLIVGIYALF--VPELA---TNHISAAMVVFGITTLYIS 76  Thauera sp. MZ1T
WP_056453466   1 MTKDGLLKSIAETGYNVGFGAKKHFATYDIVEKAPGWIGFISLAVGILSLV--FEGLS---AKLPSACLTIAGVVALYIA 75  Brevundimonas s...
EDM25467       1 MDRNDLLKHIAETGYNVGFGAKKHFATFDIVNKAPGVISFLSMAVGILALV--CKNFS---TNWVSAALIILGIIGLYIS 75 
WP_036275054   1 MDKNDLLKHIAETGYNVGFGAKKHFATYDIVDKLPGLIGFVSTAVGIFSLF--IDVLT---DNYLSATFIVLGICGLYIS 75  Methylomonas
Q6ARQ5        15 MNKEDLLKHIAETGYNVGFGAKKHFATYDIVEKTPGFISFFSMAFGIYALA--FEGLS---TKFLSASFVVLGIVGLYIS 89  Desulfotalea ps...
CBG91687       1 MTQSEMLKLIARHGYNVGFGAKKNFATYDLICKASGWISFISLAVGVFALF--IPELA---TNVISAILIIFGVATMYIQ 75 
Q62NB9         1 MERNLFLRQLAENGYNVIYGAKKHFSTYDTVVKMPGRIAFITLAIGIWQIY--KPSFPy--NSEISLLLIIASIIALTIS 76  Bacillus lichen...
WP_009600069   1 MSEQTTKKQIAREYYNVIYGAKLNLASLDICEKLPSIISLLSLSLGILGLS--FETFN---NKSLASFLLIAGLIGLMLK 75  Vibrio caribbea...
WP_005299114   1 MTEQTIKKQVAREYYNVLYSAKLHFASFDICEKLPTMISVISLSFGVLGLA--FAEFN---SKALAALLLIIGIIGITLK 75  Photobacterium ...
KHJ37051       1 MDKTNFLKTLAQKGYDIGFGAKKNFASFDIINKLPTWVGFISLAIGIIQIA--YENMPf--NKELSILLILVGIAIIYID 76 
WP_008409467   1 MDKYSLLKSLAEKGYNIGFGARKTFLSYGIYSKIPRFLSLCTVFVGVYQMTtrYKNLNpgtQEIVSVIIICIGILALILD 80  Peptococcaceae
WP_012585348  77 FYLPDKERYEKAGIELTGGFHRLRALYYEVRSlpdGADFTKQVA---EHDAIVRASLNSTVSKQIFLSDWYAHFKFFWQQ 153 Thauera sp. MZ1T
WP_056453466  76 FYDRDKGKYERAGKEMTQLFNQLRDLYRQVQA---DADLKVSAG---SLGLIEGRFYEVAISKQILFSDWYAHYKFFAQH 149 Brevundimonas s...
EDM25467      76 MRSRDNNKYEATGNKLIKMFNELKTLYFKVKEa-sPESLENHNV---TLNSIEAKYCDSCISDQVLFSGWWAHYKFFWEH 151
WP_036275054  76 FYDATKIDYETSAKEITKIFNDLKRLYYKAKSa-kPDDLAAIET---ELMALENKYYQVAISKQILFSDWYAHYKFFWQH 151 Methylomonas
Q6ARQ5        90 LYDHKKTAYESYGIKLTQLYNDLAKLYRKTKNs-dGSDIEILEN---QLSQLQGEYYSSCQSKQILFSDWYAHYKFFWQH 165 Desulfotalea ps...
CBG91687      76 FYDSEKQSYESAGIEQTKIFNELEVIYRNVKSd-aNFDYQRTQQ---SIDAIMSRFYGTVISKQIFGSNWYAHYKFYCEF 151
Q62NB9        77 QYNSEKDRYREVGNRLIQIHNELREIYYQAKSs-eQENFSNESNeaiRMNELLNEFYQISISKQIFLSDWVAHYKLFFQS 155 Bacillus lichen...
WP_009600069  76 PREIQKDKYCKAGGELTDISKRLELLHSEIEPs-ePESEASGRV---ELRKLQTEHKEVYQPSPVFLASWYAHYKLFSEH 151 Vibrio caribbea...
WP_005299114  76 PRELQKGQYEATGVSLTDISKKLEHIYCEIDVq-dTESVAKARA---DLAQAQADHRAVGTMPPVLMSSWYAHYKVFSEH 151 Photobacterium ...
KHJ37051      77 VFKNSAQLYEKEGVRLTKLFNKMRDLYYSVQSd-nNYSYSKYES---EYLNILSDFYSTTISKQVFMSQWFAHFKFFYEM 152
WP_008409467  81 AGSKDKEHYNQVGKQLASLYNELQTMYNTVKNmddHADFSPFEK---RMKEIEAEVHRIAISTKCHLPIFLPTFT-FSMV 156 Peptococcaceae
WP_012585348 154 QTDWLDEQKHFKLlRDKLPLSFSLTV 179 Thauera sp. MZ1T
WP_056453466 150 QIEWIDEQKHFTW-RDQVPLSFRACL 174 Brevundimonas sp. Root1279
EDM25467     152 QIGWIEEQKKFKFfRDKVPLTLTVTM 177
WP_036275054 152 QIGWIEEQKTFSFlRDKIPLSFSFFV 177 Methylomonas
Q6ARQ5       166 QIDWVDEQKHFSFlRDKIPLTFSLFV 191 Desulfotalea psychrophila
CBG91687     152 EKAWVEEELNLTL-KDKIPLSLCFLA 176
Q62NB9       156 QYEWIDEQKKFTW-KDKIPISFRIAV 180 Bacillus licheniformis DSM 13 = ATCC 14580
WP_009600069 152 NNKWFCIELGLTW-KDKIPLSLRSTV 176 Vibrio caribbeanicus
WP_005299114 152 NSDWMSKELELGF-NDKVPLSLRAVI 176 Photobacterium damselae
KHJ37051     153 QIDWINIELKFNFfRDKIPNSLKTTF 178
WP_008409467 157 APKLIGLMSSYTS-PSRINFHFYTTK 181 Peptococcaceae
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