Conserved Protein Domain Family
GlxB

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cd01907: GlxB 
Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases including glucosamine-fructose 6-phosphate synthase (GLMS or GFAT), glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase), asparagine synthetase B (AsnB), beta lactam synthetase (beta-LS) and glutamate synthase (GltS). The GlxB fold is also somewhat similar to the Ntn (N-terminal nucleophile) hydrolase fold of the proteasomal alpha and beta subunits.
Statistics
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PSSM-Id: 238888
Aligned: 27 rows
Threshold Bit Score: 250.648
Created: 21-Jun-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative active
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       #                                                                               
O87390        2 CGIVGLFLkdsrlepQLGQLLSDMLITMTDRGP---------DSAGLAIYGSategkakvtiqsakpeidfadlerdlae 72  Sinorhizobium me...
O26293        2 CGIAGVVYkdg-klhSVGADMTRMLHALQHRGP---------DSAGFAIYGGlgleendyllnievkdkpglldmvketv 71  Methanothermobac...
NP_275334     2 CGIAGVVYkdg-klhSVGADMTRMLHALQHRGP---------DSAGFAIYGGlgleendyllnievkdkpglldmvketv 71  Methanothermobac...
NP_614346     3 CGIAGIVLpe---pgPVGAILTEMLDALQHRGP---------DSAGYGLYRDvdtavfvlelpaedgemellseverale 70  Methanopyrus kan...
YP_118313     2 CGIVGLHLrdatlypRLGALLTGMLDQLCDRGP---------DSAGMAVYGDptwsppgestvslldaglpaadlaarlt 72  Nocardia farcinica
ZP_01264900   2 CGIVGIYLktkkyekDLGKFLSGMLDGMATRGP---------DSAGFAIYTKqnknkfkysiclnkltdkefkkkiskfl 72  Candidatus Pelag...
YP_544568     2 CGIVGLLVknqnmraNIGELMLPMLIGMTERGP---------DSAGLAIFGApvdngerkfslycadpdfdwarlsvdln 72  Methylobacillus ...
AAZ22110      2 CGIAGLIHrgk--ssNVGSELQGMLQALKHRGE---------DSTGYALYGDtdgknfimrfkvgenvgegsssimedvs 70  Candidatus Pelag...
ZP_00678508   2 CRIGAIKSl-----nYVHPSRALQLMNSQQKGHdnsgfamvmQDLGGIFADYkdlptlslactdeglkiaegilgaagfk 76  Pelobacter propi...
YP_358006     2 CRIGAIKSr-----hYVHPSQALLLMQSQQKGH---------DNSGFAMVMQdlggifenykhlptlslactdeglqiak 67  Pelobacter carbi...
Feature 1                                                                                       
O87390       73 agv-----------------------------------parvavksthavvaiaaarladvravlaairPDVRIMGAGDS 117 Sinorhizobium me...
O26293       72 elvspigs--------------------------devipsvenhiiyrcritlesfsqlkplimdidsiDDVIVLNGSHS 125 Methanothermobac...
NP_275334    72 elvspigs--------------------------devipsvenhiiyrcritlesfsqlkplimdidsiDDVIVLNGSHS 125 Methanothermobac...
NP_614346    71 grqlkrver------------------------iaedagtrvyrlfvegfstgrqgqrelaevvekienSDITVLSAGHG 126 Methanopyrus kan...
YP_118313    73 aalg----------------------------------vpvtgldlapttvlhapldaaalsaavpdiaPHARVIGFGTD 118 Nocardia farcinica
ZP_01264900  73 kk--------------------------------------itlktfsdhvileteekpekvleildsklKEVSLVGYGKS 114 Candidatus Pelag...
YP_544568    73 nglq----------------------------------aeatvevkvnhavvttsvspdtvkawlkehyPQLHLLSVGQL 118 Methylobacillus ...
AAZ22110     71 vydkrkkivdqy-----------------lselgakivkeerilpyslryeldydvkdllefsqkiesiPGVEILSMGKS 133 Candidatus Pelag...
ZP_00678508  77 qvfewipetnrmpgld---------ikampnyvfrtfdypetyakspakekeelltatrlklraamergETGFAYSFWPD 147 Pelobacter propi...
YP_358006    68 aimdargfrmvhewepqtnrqpgldiqamphyvfqtfdypetyadasqkdkeellldtrlelragmeedCKGFAYSFWPD 147 Pelobacter carbi...
Feature 1                                          ##                          ##               
O87390      118 VEIYKEVGLPKDVVARFdv----rSMGGSHGIGHTRMATESAVTTlGAHPFSTGs--DQCLVHNGSLSNHNNLRREL-IR 190 Sinorhizobium me...
O26293      126 FEMIKDVGSVLEIADRYdt----wSKKGTHAIGHTRFSTESIVDRyHAHPFQSYiipDITVVHNGQITNYWKIREPL-ER 200 Methanothermobac...
NP_275334   126 FEMIKDVGSVLEIADRYdt----wSKKGTHAIGHTRFSTESIVDRyHAHPFQSYiipDITVVHNGQITNYWKIREPL-ER 200 Methanothermobac...
NP_614346   127 FEILKDVGTAAEVSEQYgv----eAIEGTHGIGHVRFSTESEVDRyHAHPFQSYmipNMAVVHNGQITNYYTIRERL-EI 201 Methanopyrus kan...
YP_118313   119 LTVLKGVGHPTALAHRFgl----pAAAGWQGVAHTRMATESAVTAaGSHPFSVGp--DQCLVHNGSFSNHRSVQHEL-RR 191 Nocardia farcinica
ZP_01264900 115 INIFKQTGNPKDVVRKFkl----sSFSGTHAIGHTRMATESAITTqGSHPYSTSe--DECLVHNGSLSNHNNVRRSL-KK 187 Candidatus Pelag...
YP_544568   119 MDIYKDTGTPAQVASRYdf----sKLSGSHLVGHTRMATESAITPsHAHPFTAGe--DWCLVHNGSLSNAHSIRRKL-EH 191 Methylobacillus ...
AAZ22110    134 LEVIKDLGNAQMVLDRYdl----gKVVGTHAIGHARMATESGVDIkSAHPFWGYpfsDVSVVHNGQLTNYWNNRRML-EN 208 Candidatus Pelag...
ZP_00678508 148 VITLKEIGDPRDIGTFFglwdendRFTAKVITAQCRQNTNYAIVRyAAHPFFLQ---GYTTLANGENTFYQKNKEFQaSL 224 Pelobacter propi...
YP_358006   148 VVTLKEIGDPRDIGTFFniweaddKFTAKVITAQCRQNTNYAIVRyAAHPFFIQ---GYTALANGENTFYQKNKEFQqNL 224 Pelobacter carbi...
Feature 1                #                                                                      
O87390      191 EGIAFETQNDTEVAAAYLTAEMakgkd--------------------------lgqaLTGALDDLDGFFTFVVGTKSGF- 243 Sinorhizobium me...
O26293      201 KGHIFETNNDTECIVHYVADKLasgys--------------------------leeaLEQSVKDMDGPFSYIVGTPQGV- 253 Methanothermobac...
NP_275334   201 KGHIFETNNDTECIVHYVADKLasgys--------------------------leeaLEQSVKDMDGPFSYIVGTPQGV- 253 Methanothermobac...
NP_614346   202 KGYQFKTNNDSECIVVYVADKLrdgys--------------------------leeaMEEAIRDLDGPFCFIISTPDAI- 254 Methanopyrus kan...
YP_118313   192 AGVVFDSDNDTEVGARFIAAQLaqgvd--------------------------lekaLTLLNERFDGFYTLLVADSESF- 244 Nocardia farcinica
ZP_01264900 188 EGQKFNSENDTEVAAGYISNQIskgen--------------------------leetLKNSLKDLDGFYTFIAGTKDGF- 240 Candidatus Pelag...
YP_544568   192 EGISFETDNDTEAACRFLQWRMregdd--------------------------lktaLEHGFDELDGFYTLLMGTKDQL- 244 Methylobacillus ...
AAZ22110    209 KGMRFMSECDSELIAVYIAQKMkegas--------------------------leegMKASLTGLDGVFTYFVATKDSL- 261 Candidatus Pelag...
ZP_00678508 225 NPAYIGFESDSQCFLYTLHYMHrelgwplsyykhiitplpfeevqkredreqlsairQSLAHLEINGPNTIIGALPDHTl 304 Pelobacter propi...
YP_358006   225 HRGYIGFESDSQCFLYTLHHVHhelgwplpyykhvitplpfedvvkredqqqllalrQSLAHLEINGPNTIIGVLPDNTm 304 Pelobacter carbi...
Feature 1                                                             
O87390      244 GVVRDPIACKPAVMAET-DRYVAFGSEYRALVnlp-dieSARIWEPEPATVYFW 295 Sinorhizobium meliloti
O26293      254 GIAKDQLGLRPGVMAEN-DEVFAVASEEVSLRev---mdTSEVEQISPGEVRVY 303 Methanothermobacter thermautotrophicus
NP_275334   254 GIAKDQLGLRPGVMAEN-DEVFAVASEEVSLRev---mdTSEVEQISPGEVRVY 303 Methanothermobacter thermautotrophicus str...
NP_614346   255 AVARDPLGLRPGVIGFGkDGAVAVASEEVALRrif-gdeLEGIEQIEPGEYEVF 307 Methanopyrus kandleri AV19
YP_118313   245 AVVRDPIACKPAVVAET-DRWVAMASEYRALAdlp-gvaDAHIFEPEPEEVYLW 296 Nocardia farcinica
ZP_01264900 241 ALLRDEIACKPAVVAET-KDYVAVASEFQCMAhlp-nvnTAKIFEPKPGIVYHW 292 Candidatus Pelagibacter ubique HTCC1002
YP_544568   245 ALVRDPFACKPAIVAEH-DDYVAIASEFRSLAhlp-dikNAKVFEPAPKEMYVW 296 Methylobacillus flagellatus KT
AAZ22110    262 GMAKDTMAAKPLVLYES-DDLVAMGSEEIAIRsvl--pqEIDTYDPFDGEVKVW 312 Candidatus Pelagibacter ubique HTCC1062
ZP_00678508 305 FVCCDAKKLRPIVVGHT-KEMVAFSSEVCGINeimpdrdWETDIYPNEREIVVI 357 Pelobacter propionicus DSM 2379
YP_358006   305 FTCCDAKKLRPVVVGRD-EDTVVLSSEVCGINeilpnrnWETDIYPNEREIVVI 357 Pelobacter carbinolicus DSM 2380

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