1URO,2EJA


Conserved Protein Domain Family
hemE

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TIGR01464: hemE 
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uroporphyrinogen decarboxylase
This model represents uroporphyrinogen decarboxylase (HemE), which converts uroporphyrinogen III to coproporphyrinogen III. This step takes the pathway toward protoporphyrin IX, a common precursor of both heme and chlorophyll, rather than toward precorrin 2 and its products. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Statistics
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PSSM-Id: 273640
Aligned: 19 rows
Threshold Bit Score: 425.155
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1URO_A        18 TFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRA-AqDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGM 96  human
AAL51183       4 KVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKkAgSFLDLCYSPDLAVEVTLQPIRRFGFDAAILFSDILVVPHALGR 83  Brucella melite...
P42503         5 TILRALKGEVLPTPPVWLMRQAGRYLPEYRATRAqAgDFLSLCYTPDLAAEVTLQPIRRYGFDAAILFADILLLPQALGL 84  Rhodobacter cap...
Q9ZC83         3 QILNPLKNS--NKIPIWFMRQAGRYLPEYKKVREtTkNFLDFCYDVNKATEVTLQPIRRYGLDAAIIFSDILVLPNALGW 80  Rickettsia prow...
CAD00290       8 LFLKAARKEQVDRIPVWYMRQAGRSQPEYRKLKEkYs-LFEITHQPEICAYVTKLPVDQYGVDAAILYKDIMTPLPGMGV 86  Listeria monocy...
O66667         6 LLLRSLRGEPIGRFPVWLMRQAGRYMPEYRKIRNrVkNFLELCKNVDLATEISLLPLKILGVDAIIIFSDILVPLEPLGV 85  Aquifex aeolicu...
2EJA_A         6 LLLRSLRGEPIGRFPVWLMRQAGRYMPEYRKIRNrVkNFLELCKNVDLATEISLLPLKILGVDAIIIFSDILVPLEPLGV 85  Aquifex aeolicus
WP_010921590  13 KFLSALEGQSHANPPVWFMRQAGRYLPEYRAVRAtApDFISFCFDPEKAAEVTLQPMRRFPFDASIVFADILLIPGALGQ 92  Caulobacter vib...
WP_010900739   3 PFRKAIKGYDHDRIPVWFMRQAGRYLPSYMKYRQrMg-IEEMMSSPDVIVDVTHDPVDRIGVDAAIIFADITTPLSGMGL 81  Thermoplasma ac...
WP_027479618   5 AFLKTARGEQAPYTPVWFMRQAGRYMPEYRALRAgKt-MLECIRTPDLAAEITLQPIKAMPLDAAILFNDILTPLPTMGL 83  Deinococcus rad...
1URO_A        97 EVTMVPGKGPSFPEPLREEQDLERLRdP-EVVASELGYVFQAITLTRQRLAG-RVPLIGFAGAPWTLMTYMVEGGGSSTM 174 human
AAL51183      84 DLRFEEGKGPLMTPID--ADEIFWLE-T-EGVAKRLEPVYETVRLVREQLPD-ETTLLGFCGAPWTVATYMIAGHGTPDQ 158 Brucella melite...
P42503        85 DLWFETGEGPRMSTVTS-MEGVKGLK-GkDDIHDKLAPVYETCKILSRELPK-ETTFIGFAGMPWTVATYMIAGRGSKDQ 161 Rhodobacter cap...
Q9ZC83        81 EVDFKENIGPVLKQFKS-QKDFQYLQ-R--DSNNKLEKVYKIIKKVKEKLPS-NTSLIGFAGSPWTVMSYMLEGKGKRDF 155 Rickettsia prow...
CAD00290      87 DVEIKSGIGPVIHNPIRSFQDVEKLT-I-FKPEIEVPYVLDTIKLLADDMLD--VPLIGFAGAPFTLASYMIEGGPSKNY 162 Listeria monocy...
O66667        86 KVEFVEGEGPKLS----WSGKVSDLK-K-YDP-SQNAYVYEIIKRVKEAQDEv--PVIGFAGAPFTLLSYLIEGGASKDF 156 Aquifex aeolicu...
2EJA_A        86 KVEFVEGEGPKLS----WSGKVSDLK-K-YDP-SQNAYVYEIIKRVKEA-QD-EVPVIGFAGAPFTLLSYLIEGGASKDF 156 Aquifex aeolicus
WP_010921590  93 KVWFEAGEGPKLGDMPSV-ESMAEKA-G-E-AGKALSLVGETLTRVRSALDP-DKALIGFAGAPWTVATYMIE-KGSSDR 166 Caulobacter vib...
WP_010900739  82 RVRFLDSVGPVVENNI-EKSGISAVE-E-FDPSSFSHPVLKAISKYRERYAD---PLIGFAGGPVTLLSYIISDGVDRDL 155 Thermoplasma ac...
WP_027479618  84 SLDFVGGVGPVIHNPINTPKDVDVLG-V-PATAETMPYTAESIRLLMPELNSrGIPLIGFVGAPFTLASYAIEGKGSRNY 161 Deinococcus rad...
1URO_A       175 AQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARlreaglA 254 human
AAL51183     159 APARLFAYRFPEAFEKLLNDLADVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVy------ 232 Brucella melite...
P42503       162 AAAHKFKDTDRAAFSALIDAVTVATIEYLSKQVEAGCEVVKLFDSWAGSLKGQDFEDFAVEPARVITAEMKRRf------ 235 Rhodobacter cap...
Q9ZC83       156 RTSKKFIYENKILAKDLLNFITEKTSDYLINQVKSGVDLLKIFDSWSGVLAEDDFTEFVIEPTKKIILKVKEVf------ 229 Rickettsia prow...
CAD00290     163 HQTKSFMYREPEVWAILMEKLGRMTANYLIAQINAGASAVQLFDSWVGALSRADYAEYIRPVIEMIVREVKAVh-----P 237 Listeria monocy...
O66667       157 KSTKLFMWENPKEYKRLMDILTETVLAYLKEQIKAGADVVQIFDSWVNNLSLEDYGEYVYPYVNYLISELKDF------S 230 Aquifex aeolicu...
2EJA_A       157 KSTKLFMWENPKEYKRLMDILTETVLAYLKEQIKAGADVVQIFDSWVNNLSLEDYGEYVYPYVNYLISELKDF------S 230 Aquifex aeolicus
WP_010921590 167 SGARTFAYQNPETLDALIQVLVDATIDYLAMQVDAGAQALKLFESWAEGLSEPLFDRLVTQPHIRIIEGLRAR------G 240 Caulobacter vib...
WP_010900739 156 FRVKRMMITEEKAYQAVMTRLTDMIIEFARMQISAGVDAFQIFDSWAGYLSPGEYEHFVKPYVYDILQELSG-------- 227 Thermoplasma ac...
WP_027479618 162 EKTKRFMYAEPAAWARLMGKFESVLADYLTEQVKAGASAVQIFDSWVGALSVYDYQTFVKPATAGLIERVKKLg------ 235 Deinococcus rad...
1URO_A       255 -PVPMIIFAKDGHFALEELAQ-AG-YEVVGLDWTVAPKKARECVGKT-VTLQGNLDPCALYASEEEIGQLVKQMLDDFg- 329 human
AAL51183     233 pQARIIGFPKGAGMLYAGYRE-KTgVDMLGLDWSVPLSFAALLQEEG--AVQGNLDPLRVVAGGNALDEGVDAILERMgq 309 Brucella melite...
P42503       236 pGLPVIAFPREAGQGYIGFAE-KTgADCVAIDNSVSPDWAAENVQKGkTCVQGNLDPSYMVTGGQELVEATKKVVAAFkn 314 Rhodobacter cap...
Q9ZC83       230 vKTPIITFPKGAGLLYEKFIE-EVpIDILAVDQMVPLEKMKEWSNKV--IIQGNLDPVILLTNKEIIKEKTYKILQAMkg 306 Rickettsia prow...
CAD00290     238 -TTPIIMQAVGASHLLEEWET-MP-LDVVGVDWRETITSARKKV-PT-KAIQGNLDPSTLLAPEKCLKEAN-RILQegvl 311 Listeria monocy...
O66667       231 -DTPVIYFFRGSSSFIDLAVD-YR-ADALSVDWSVDIPELFK-IYD--KGFQGNLEPAVLYASEEVIEEKTLGLLRRIpv 304 Aquifex aeolicu...
2EJA_A       231 -DTPVIYFFRGSSSFIDLAVD-YR-ADALSVDWSVDIPELFKIY--D-KGFQGNLEPAVLYASEEVIEEKTLGLLRRIpv 304 Aquifex aeolicus
WP_010921590 241 vTVPIIGFPRGAGTLVEDYAArTP-VQGVALDTSASAKLGQT-IQKT-KTIQGALDPLLLRAGGDALLKRVDEMLEQWnq 317 Caulobacter vib...
WP_010900739 228 -SIPTIYFSTMTSSYVADM-D-LP-ADFYSIDWRIDMKRFSAEIPDE-KGIQGNLDPAIVNYDYALHEAS--KIVEAAsg 300 Thermoplasma ac...
WP_027479618 236 --VPVIYFGTGATHLMPDMAS-LG-SDVMGADWRTPLDKAWDLIQPG-QSIQGNLDPLLLQAPWRELKHQTDRILHeang 310 Deinococcus rad...
1URO_A       330 PHRYIANLGHGLYPDMDPEHVGAFVDAVHK 359 human
AAL51183     310 -gPLVFNLGHGITPQAPIENVQRMIDRVRG 338 Brucella melitensis bv. 1 str. 16M
P42503       315 -gPHIFNLGHGITPEANPDNVTLLMETIRK 343 Rhodobacter capsulatus
Q9ZC83       307 -kNFIFNLGHGILPETHPENVEFLTQYVRL 335 Rickettsia prowazekii str. Madrid E
CAD00290     312 EPGYIFNLGHGVFPEVPPEMLKQLTNYIHE 341 Listeria monocytogenes EGD-e
O66667       305 KTRYVFNLGHGLAPDMELEKVKYLVDLVKS 334 Aquifex aeolicus VF5
2EJA_A       305 KTRYVFNLGHGLAPDMELEKVKYLVDLVKS 334 Aquifex aeolicus
WP_010921590 318 -gPYIFNLGHGILPDTPIAHVEAVLERVTG 346 Caulobacter vibrioides
WP_010900739 301 RDRYIFNTGHGLLPSTDPEKLKRLVEYVHS 330 Thermoplasma acidophilum
WP_027479618 311 RPGHIFNVGHGLLPETPQDMVHRLTDYVHE 340 Deinococcus radiodurans
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