Conserved Protein Domain Family
SLC-NCS1sbd_u1
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cd11555: SLC-NCS1sbd_u1 
uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain
NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).
Links
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Statistics
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PSSM-Id: 271404
Aligned: 38 rows
Threshold Bit Score: 487.455
Created: 9-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Na binding siteputative
Feature 1:Na binding site [ion binding site]
Evidence:
  • Comment:based on the structures of Vibrio parahaemolyticus vSGLT (SLC5), Aquifex aeolicus LeuT (SLC6), and the NCS1, Microbacterium liquefaciens Mhp1, bound with Na+, functional studies of Escherichia coli PutP (SLC5) and mammalian NIS (SLC5), and mutational analysis of vSGLT
  • Comment:one of two Na+ binding sites in Aquifex aeolicus LeuT, where it is referred to as the Na binding site 2
  • Comment:Mhp1 may have a flexible cation specificity
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                  #  #                                               
CAJ97263   45 DERLTNEDLAPLRKQ--TWGTYNIFAFWMSDVHSVGGYITAGSLFALGL-TSWQVLVSLLVGILIVQYFCNLVAKPSQVT 121 Ralstonia eutropha...
BAL25627   25 DPRLYNHDLAPVPQDkrTWNGYSIFAMWMSDVHSVGGYTFAASLFLLGL-SGWQVLAALTIGIVLVNILMNWVGKPSLVH 103 Azoarcus sp. KH32C
EFL21003   12 DPRLYNEDLAPAAER--KWGTYSIFALWMSDTHAISNYAFAASLFVLGL-PTWQVFLSLLAGITIVHWFMNRMGHAGHRT 88  Streptomyces hygro...
ABE75695   31 NSRLYNEDLAPLQPEqrNWGWFAIFNVWSNDIQSLFGYTLAASLFLSYGlNGWWVMAAIICSGFIVMLMVNLTGKPSVKY 110 Psychrobacter cryo...
EAV42683   12 DGGLYNEDLAPIPASerKWGAFEIFNVWNNDIQSLFGYTLAASLFITYGlNGWMVFAAIVLAGFFVMVLVNLTGRPSVKH 91  Labrenzia aggregat...
EBA17478   22 DPSLYNEDLAPVPADkrDWGWFELFNVWANDVQSLFGYTLAASLFLAYGlNGWAVFAGIVLAGFIVMGLVNLIGKPSVQY 101 Roseobacter sp. SK...
EFL20761   30 DPTLYNDDLAPLPYEkrKWGAFEIFNVWSSDLHSLFGYTLAATLFTTSGlSGWWTFAGVILAGLIVMLLVNLTGKASVKY 109 Streptomyces hygro...
ADX74437   19 DPSLYNEDLAPLPASrrTWGWFAIFNVWSNDIQSLAGYTLAASLFITAGiNGWFVFAAIILSGFIIKFLVDLSGRPSVKY 98  Arthrobacter phena...
EAQ25029   14 TMDPEGNTLNPVGANekTWGWFAIFNVWANDVQSLFGYSLVASLFISYGvSGWTAFAALIAAGLFTMWMVNLSGAAGERY 93  Roseovarius sp. 217
EAS85369    4 SSKLYNSDLAPTPSSkkNWGWFEIFNVWANDVQSLFGYTLAASLFLASGlNGWAVFAALILAGFFIMWLVNLSGKPSVKH 83  Candidatus Pelagib...

Feature 1                                                                                     
CAJ97263  122 GTPYPVICRASFGVLGANIPAVIRGLIAVAWYGIQTYLASSAFLVLALHFFPALapyadvklhGFAGLSTLGWAAFMVLW 201 Ralstonia eutropha...
BAL25627  104 GIPFPVMARVSMGVMGANLAATIRGIVGIVWYGVQTYFASKAVATLVLLFVPAAvvl---retSFLRLDFLGWGCFLFMW 180 Azoarcus sp. KH32C
EFL21003   89 GVPFPVLARASWGVYGANIPALIRAVMAVAWYGIQTWLASEAVVLLGVQVAPGLaay---dhnSFLGLSTLGWIAFLLMW 165 Streptomyces hygro...
ABE75695  111 GIPFPVLIRASMGINGANLPAILRAIIGIFWYGVQTYFASTAVAILLTIVIGSPd-------tTFLGLNSTAWIAFVIVW 183 Psychrobacter cryo...
EAV42683   92 GVPYPVIARASMGVYGARFPALVRGIVAIFWYGVQTYFASTAVALLFNTLIGSEgg------aEFLGMTAVGWISYLIVC 165 Labrenzia aggregat...
EBA17478  102 GIPFPVMARASMGVRGANFPAVIRAVVAIFWYGVQTYFASTALALAIVALTGAStd------pVFLGLALVDWVAFLFVW 175 Roseobacter sp. SK...
EFL20761  110 GIPYPVMARVSMGVRGAQFPALVRAVVAIFWYGVQTYFASTAITLLIIALTGYSepe----ggDFLGLSSVAWISYFIVV 185 Streptomyces hygro...
ADX74437   99 GFPFPVLARASMGVRGAQFPAIVRAVVAVFWYGAQTYFASTAISLALNAVLGRPgg------aEFLGMDWVSWASYVLAS 172 Arthrobacter phena...
EAQ25029   94 GIPYPVLARASLGTSGAKLPAILRATVAVFWYGVQVYFASTAVALLIRSITGASgg------aEILGLTGIDWLSFFIVW 167 Roseovarius sp. 217
EAS85369   84 GIPYPVFARVSMGVFGANFPAMARGLVAMFWYGAQTYAASTAVALLITGITGMEge------vMLLGMTGVMWVSFIFVS 157 Candidatus Pelagib...

Feature 1                                                                                     
CAJ97263  202 VLQALVFWTGMETIRKFIDWAGPAVYVVMIALAIWLVNKagWENVNFTLSFvk--------yTGWEAVPVMLSAIALVVS 273 Ralstonia eutropha...
BAL25627  181 FFQLVIFQRGMEAIRKFIDFCGPAVYVVMFALMAWILSKagLGALDLTLGDkv--------lTGAESVGAMGSAILLVVS 252 Azoarcus sp. KH32C
EFL21003  166 ALQAVLLTRGMEFIRKVQDFATGPVVWLVMLVLAIWLVVkaGGDISLTASLtg--------lGGGEQLHQSLIAVSLTVA 237 Streptomyces hygro...
ABE75695  184 VFQILLFWAGIEPIKHFLNWAGPLVYVVMVILMAVIWYQs-GSELLPAINSifas----gsdYSGNAIQAFTAIVGTMVA 258 Psychrobacter cryo...
EAV42683  166 VFQVALFMKGIDWVGKFLNWAGPFVYIVMIALCLVIWWKa-GNGIFAALGTifeg---seasDPRGPVAAFVAVVGTMIA 241 Labrenzia aggregat...
EBA17478  176 GFQIALFWNGIDLIVGFLNFAGPFVYAVMLTLAVVIWIEa-GNDLWSEVGTifrg----tggYEGSQLGAFAAVVGTMIA 250 Roseobacter sp. SK...
EFL20761  186 VFQLGLFLRGIDWVTRYLNWAAPAVYLVMVALVAVIWIHa-GNRLLPELGNviag----dgdDGGAPVSAFVSVVGTMVA 260 Streptomyces hygro...
ADX74437  173 ALQVVLFLGGIERIARFLNFAGPAVYAVMIALLAAIWIQv-GPQLPQAVGTvfsr----eavTGWAAFSAFAAVTGTMVA 247 Arthrobacter phena...
EAQ25029  168 AFHIVIFWRGMNWVETFLNIAGPFVYLVMIGLVIVLWQRs-DGQLLSAAGTifan----pdaTFASEFNGFVAIVGTMVA 242 Roseovarius sp. 217
EAS85369  158 AFQVYLFWQGVDLIKKFLNFAGPAVYAVMIVLMLVIWAKa-GGGLFSEVGTifsggertggfEGLGSFGAFIAVFGIMVG 236 Candidatus Pelagib...

Feature 1                                                                                     
CAJ97263  274 YFSGPMLNFGDFSRYAKDfKSVKRGNFWGLPVNFLGFSLLTVITTSATLPVFGKl----ITDPVETVSHIDStfAMLLGA 349 Ralstonia eutropha...
BAL25627  253 YFAALLLNFGDFSRFGKSeRQMRIGNFLGLPVNFIVFSIITVIVTAGSTTVFGAm----IMDPVEIVARIDNkfAVVLGS 328 Azoarcus sp. KH32C
EFL21003  238 TFLTLVLNYADFARFTPDhRSYRRGNLLGLPVNFTAFALVSVLMTAGTISVFGQa----ISDPVQVIAKIDNpvVTIVGA 313 Streptomyces hygro...
ABE75695  259 YFAAVVINFGDFSRFLRSeRDMRLGNLLGLPINMVFFSFIALVITAGTLVIFGEa----LTNPSDIVDRVDSlpLTIIAA 334 Psychrobacter cryo...
EAV42683  242 YFAAVVINFGDFSRFVSDeRAMKRGNFWGLPVSMAFFSFIALFVTAGTVVLFGEk----LVNPADIVDRVDNvlLTLIAA 317 Labrenzia aggregat...
EBA17478  251 YFSAVVINFGDFSRFVRSeDEMRKGNLLGLPINIAFFSLIALIVTAGTVAIWGEa----LTNPTEIIARVDSlpLTILAS 326 Roseobacter sp. SK...
EFL20761  261 YFAAVIINYGDFSRFVKTeRQMKRGNLWGLPVSLAFFSFLTLVITAGTGVLYGKp----LTDPTDILKQVDNtwLTVVAA 336 Streptomyces hygro...
ADX74437  248 YFAAVVINFGDFARNVRTeKAMRLGNLTGLPLSLALFTFLSVFITAGAYLLYQDgqgepLTNPADIVGLVDSvpLTVLAA 327 Arthrobacter phena...
EAQ25029  243 YFAAVMINFSDFSRYAKDkPTMLLGNLTGLPFNMILFSALALLTTAGAAVVFGEe----ITNPSEIVERTDSvlLGIIAA 318 Roseovarius sp. 217
EAS85369  237 YFAAVVINFGDFARFVKNeDEMRKGNLWGLVGNVILFSFITLMITGGTIAIFGEy----VASPTEMVAKVDNlgLTIIAA 312 Candidatus Pelagib...

Feature 1          #  ##                                                                      
CAJ97263  350 FTFMTATIGINIVANFVSPAFDFSNVSPKHISWRTGGMIAAVASIFI-TPWNLYNNPaVIHYTLDVLGAFIGPLFGILIA 428 Ralstonia eutropha...
BAL25627  329 LTFVIATMGINIVANFVSPAYDIANLFPKHVDFKRGGLIASILAVLV-CPWIFVDSPkAITVFVSVFGAILAPLYGVMMG 407 Azoarcus sp. KH32C
EFL21003  314 ISFVIATVGINVVANFVSPAYDFANLAPKYLNFKRGGMLTAVLAVVV-MPWKLYSNPvVIQYFLGALGAFLGPLVAILLV 392 Streptomyces hygro...
ABE75695  335 LTFFAATVGINMVANFIPPAYDLANLFPKHINFRMGGLITAVIAFFVgALWLSFISKiGIVGFVNTIGAVIAPFFGILVI 414 Psychrobacter cryo...
EAV42683  318 ITFFAATVGINLVANFIPPAYDIANLNPEKISAKTGGIITAVIAFFIgALWVSVISNiGIAAFVDTLGAFLAPLYGILVA 397 Labrenzia aggregat...
EBA17478  327 VMFLMATVGINLVANFIPPAYDLANLLPSKINFRVAGIITSAYALVIgGLWVSTISHiGILGFVNTLGAVLAPVYGIMIA 406 Roseobacter sp. SK...
EFL20761  337 LTFFAATVGVNLVANFIPPAYDLSNTNPDIITARAGGVITATAAFVVgALWVPVISHlGIARFVETLSALLAPFYGILVI 416 Streptomyces hygro...
ADX74437  328 ITFLVATLGINVVANFIPPSYSLSNISPARISFRKAGMITAVAGFIIgALWVAVISSiGLPKFVDTLGAVLAPLYGIIIA 407 Arthrobacter phena...
EAQ25029  319 ITFFAATVGINLVANFIPAVNGIANLAPGKISFRQAGLITSFFALIIgGLWTSFISEfGISGFVNTLGATLAPIFGIMIV 398 Roseovarius sp. 217
EAS85369  313 FAFFAATVGINMVANFIPPAYDLANLMPDKINFKTGGLITAGFGFIIgGMWVAVITQmGLFPFVNTLGAILAPVFGIMMV 392 Candidatus Pelagib...

Feature 1                                                                                     
CAJ97263  429 DYYLVRRQHVDVDDLYTlnprGRYWYrNGFNPAAVATMIPAAIIPILCVVVPAWq-----------sAANYSWFIGMGIA 497 Ralstonia eutropha...
BAL25627  408 DFYLVKKQVVKPAELYTmspdGRYHYdGGWNKVGLAALALSGAISIGWELATQFfhl--------lpENNFGWVIGAVAG 479 Azoarcus sp. KH32C
EFL21003  393 DYYFVRRGRIDIDALFSadeaGEYYYrKGFNPEAIIAFVPAAAVAAVLALAKAFk-----------dVAPFSWVFGLAVA 461 Streptomyces hygro...
ABE75695  415 DYYLIKRQHIDMNDLFSaqptGAYYYyKGWNIRALIAFAIGALFSIATVLIPALt-----------kLEGYGFLLGAAIG 483 Psychrobacter cryo...
EAV42683  398 DYYLVRKQNIDVEALFSsdpeARYHYnNGWNMKAIFAFAIAALFSVATVWVPALs-----------eLSGYGWVIGAVLG 466 Labrenzia aggregat...
EBA17478  407 DYYLVKSGKLEVGQLFSasrdGPYYYsKGWNPAAIVSFILPAGFSILTVWVPMLs-----------aLAGFAWVIGAGFG 475 Roseobacter sp. SK...
EFL20761  417 DYFLIRKRQLNVEHLFSaepgTAYYYsKGWNLRALAAFGLAAIFSVSTVWAPELk-----------gLTGYAWIFGAALG 485 Streptomyces hygro...
ADX74437  408 DYYIIRKQRLNLQDLYStdpnGAYYFaHGWNRRALVAFGLAAVFSVLAVWLPQVa-----------qLSGFAWILGASLG 476 Arthrobacter phena...
EAQ25029  399 DYYVHRKGHLDLDDLYDmq-gGRYHYqNGWNRTAVTAFGLAAVFSVSTVWVPWFg-----------fLSGYNWIIGAVLG 466 Roseovarius sp. 217
EAS85369  393 DYYIIKDEKLDVDALFDdspkAKYHYsGGFNTKGMLAWVLSGYIAVGTVWPNILilglgdffanlggGGGYAWIIGASLG 472 Candidatus Pelagib...

Feature 1               
CAJ97263  498 LVLYRQLAPR 507 Ralstonia eutropha H16
BAL25627  480 ASIYLAFMRA 489 Azoarcus sp. KH32C
EFL21003  462 GAIYYLRTAK 471 Streptomyces hygroscopicus ATCC 53653
ABE75695  484 GIVYWVLMRP 493 Psychrobacter cryohalolentis K5
EAV42683  467 GVLHLGLMRL 476 Labrenzia aggregata IAM 12614
EBA17478  476 GVFYWAIAKR 485 Roseobacter sp. SK209-2-6
EFL20761  486 AALHYLLMRG 495 Streptomyces hygroscopicus ATCC 53653
ADX74437  477 GIFHWVAMQK 486 Arthrobacter phenanthrenivorans Sphe3
EAQ25029  467 GMLYVFLKKG 476 Roseovarius sp. 217
EAS85369  473 AVVHLAISKR 482 Candidatus Pelagibacter ubique HTCC1002

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