2LC0


Conserved Protein Domain Family
FhaA_N

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pfam12401: FhaA_N 
FhaA, N-terminal domain
This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide- specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the major substrates of Ser/Thr protein kinases (STPK) and plays a role in the regulation of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis.
Statistics
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PSSM-Id: 463562
Aligned: 97 rows
Threshold Bit Score: 85.649
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2LC0_A            8 VQRVERKLEQTVGDAFARIFG--GSIVPQEVEALLRREAADGIQSLQGNRL--LAPNEYIITLGVHDFEKLGADPELKST 83 
jgi:Selsp_1109    3 FTKWETFLENHIEGFFNKKFG--SALEPIEVEKKLEKEIANAKRRAKKGKKewILPNAYTILMNEEDCHHLSS--QRFLD 78 
jgi:Olsu_1754     4 LRTFESRVSDAF-GGAPQGYT--APFSFRKLAKKAARELEAETYEIDGIDT---APALYTILVSSADDVAMRPLYAQLTQ 77 
WP_012809421      4 LSDFENRIGSVF-GAAPQGYA--EPFSFKKLAKRAAKEMERETYEIDGVDT---APALYTVLVAPQDDSLMRPLYADLTA 77  Lancefieldel...
jgi:TherJR_1792   4 wtKVEQWSEKHIEGFFKQKFT--GSIQPAEIAKMIAREMRDK-KTVSVSKI--YIPNEYTVFVGDKDWEQISSMVGSLAR 78 
BAF59967          4 FSDLEGSLEKYIEGFFKDKFG--GRIQPVEIAKKLAREMRDA-RRVSISNI--YVPNRYNVHLHPSDWENISQFASLLSG 78 
WP_013842310      4 fSGLEDSLEKYIEGFFKDKVSsdAKVQPTDIAKKLARAMRDK-RRVSVSNI--YVPNRYTVSLHPSDYKIIVPMAPLLAS 80  Desulfotomac...
jgi:Desca_1289    4 fSGLEDSLEKYIEGFFKDKFSsdARVQPTDIAKKLARAMKDN-RRVSVSNV--YVPNQYIVLLHPEDYLPIKPMAALISK 80 
jgi:Dred_1709     8 FSALESSLEKYIEGFFKEKFSsdALVQPTDIAKKLARAMRDK-RRISVTNV--YVPNEYDIILHTSDYSYIQPMVPLLTK 84 
jgi:Dtox_2309     7 FDSLETSLEKYIEGLFKEKQC--GKIQPVDIAKKLFREMRGG-KRISVNSV--FVPNNYIIYLNSDDLEAIRPYISSLTF 81 
2LC0_A           84 GFARDLADYIQEQGWQTYGDVVVRFEQSSNLHTGQFRAR 122
jgi:Selsp_1109   79 DLHILAEKKVILLDAFMDGKLAINIQKDAELSLGLCRVK 117
jgi:Olsu_1754    78 EITAFVEAQAQSRSYVFVGKPLARFMVDPSLRSGKFAVF 116
WP_012809421     78 EISNFVATQAQQKDYVFVGQPLVRFMVDPSLKPGKFAVF 116 Lancefieldella parvula
jgi:TherJR_1792  79 ELQDFVAAKAKQRNYAMVGPPQIKFEKDERVMPGFVEVK 117
BAF59967         79 ELQEYIRQKAEEKKYTLAGPPDVKFSRDETVPSGGMKVE 117
WP_013842310     81 EMSDYLVQKAEEKKFTPVGRPQIHFAEGEGLEPGDISIE 119 Desulfotomaculum ruminis
jgi:Desca_1289   81 EMADYLVQKATEKKFTLVGQPQIMFTQENSLQPGEIKID 119
jgi:Dred_1709    85 ELVDFLVENATEKKFTLVSVPILRFLENEDLKPGDIIIE 123
jgi:Dtox_2309    82 EMLEYVKKKARERKYTLVGSPSVDFQSGEHINIGDIKVS 120
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