Conserved Protein Domain Family
PHA03132

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PHA03132: PHA03132 
thymidine kinase; Provisional
Statistics
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PSSM-Id: 222997
Aligned: 13 rows
Threshold Bit Score: 598.285
Created: 9-Dec-2010
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
24943104    1 MSKV---PRGTRSKSVTSWYDESPegamaghfyeeiddfcvdskqltgdrcgKEESDADDEDCLYKQPTSrpspvpwdtd 77 
139472869  15 GEKA---SVTRGGRWDLGSSDDES----------------------------STSTTSTDMDDLPEERKP---------- 53 
139424532   4 FPGK---EAGPPGGWRKCQEDESPenerhenfyaeid---dfapsvltptgsDSGAGEEDDDGLYQVPTHwpplmaptgl 77 
18653827   12 LVRQ---MRDRKPRWDESSDDTDDv---------------------------dTESTDLEYDDVFPVVDThgl------- 54 
13095598    6 IPGK---CEDCFTCESYSFNFESDsgfscedvaqyrdlsqyrdlpqlntcheRHQQDIYERDNVY--------------- 67 
10140943    4 NSHN---NYNTPRRQNYDVPKAWEedslyeni-------------dfltqpaVSSDTSEDEEPLPLGRET---------- 57 
9625976     1 -----mtGRGQPPKKNDTYDYPRKqppkngsyd----------nydyptstkTRSTNKQRKDSNYPPRET---------- 55 
9628023    15 SEEAvpwSTQQPMGWEELESLGDGgg-------------------------sTSADEEFQWEAMFVKSRA---------- 59 
9631211     1 --mtekgLPPAPTNNNYDYPRPKPtgnnfnky-------------nihtstkTEKEGKQHQELKYPPRET---------- 55 
9629566     5 GKNN---PGFQPDSDSDEHVYAEPeevydnpfdamrr---qgvysllrppynRQEAVDSDDDATYATPSFdriitrrpst 78 
51518070    4 YPGK---GAGAPGGWRKCQEDESPeeqrqenfyaeid---dfapaeltspgsDSGPGEEDDEGLYQVPAHwpplmapigl 77 
82503257    4 FPGK---EAGPPGGWRKCQEDESPenerhenfyaeid---dfapsvltptgsDSGAGEEDDDGLYQVPTHwpplmaptgl 77 
83642858   14 PRYG---DYDVPKSWEEDNSDYEDidlw--------------------klaaEGQNESSDDEDEVPPAAHlpyvpppn-- 68 
24943104   78 qhydvpk----crlvkstnepanvydvPKFWGVPDKGIYDVPRprlsigapciasddhnetethskneannndggflept 153
139472869  54 ---------------------------LTGKSVKTSYIYDVPT------------------------------------- 69 
139424532  78 sger---------vpcrtqaavtsntgNSPGSRHTSCPFTLPRga----------------------------------- 113
18653827   55 -------------------------------mspGSQNYDVPT------------------------------------- 66 
13095598   68 ----------------------------------EATFFTPPRek----------------------------------- 78 
10140943   58 -----------------------------GRGSRGSTRPKTPR------------------------------------- 71 
9625976    56 ---------------------------IFEPDLAADPIYSVPR------------------------------------- 71 
9628023    60 ---------------------------GSPTAEDKSRTFTLPRgrpk--------------------------------- 79 
9631211    56 ---------------------------IFEPGLPPSPIYSVPR------------------------------------- 71 
9629566    79 gevermpgtpsrrppeqsdsesdyediGAYGQPARQSIYQTPRrstirckvssvgenydiprdtq--------------- 143
51518070   78 sger---------vpcraqggaasntgTSVGGRRPSCPFTLPKga----------------------------------- 113
82503257   78 sger---------vpcrtqaavtsntgNSPGSRHTSCPFTLPRga----------------------------------- 113
83642858      --------------------------------------------------------------------------------    
24943104  154 ptkvnndvghriveqgagetpkpftWLQKSELTGLQDIRQMEGRETPPARHTERVCSKAGKISGYLGPDHTSDSFLFQAA 233
139472869  70 -------------------------VPTSKPWHLMHDNSLYATPRFPPRPLIRHPSEKGSIFASRLSATDDDSGDYAPMD 124
139424532 114 ------------------------qPPAPAHQKPTAPTPKPRSRECGPSKTPDPFSWFRKTSCTEGGADSTSRSFMYQKG 169
18653827   67 -------------------------SPSGTPWELLHPDALYAHPRCPPKRAVVPGGGARPKVSAFSARLQYVGRQSFGDR 121
13095598      --------------------------------------------------------------------------------    
10140943   72 -------------------------GLVRPRQDADNPSSDEGFDWEPLESFTSQPGAFSFLEPPRLSSSNTASGLRSSCS 126
9625976    72 -------------------------------------------------------------------PPSRVPHKLVKVN 84 
9628023    80 ---------------------neprPERGKGKTPKKPKKPDQGATLLVGEEPRPRLGSRTRSKSRSRDKHQLPDDIYDVP 138
9631211    72 -------------------------------------------------------------------QPSRVIQKLVKVN 84 
9629566   144 ---antvtvqtthggarprsraprvLVRHPEAGGNKPDFLPVDKPLPSVPQHVPQGYEEMAGSPPPERDVRSPRPQRRPN 220
51518070  114 ------------------------qSLPAQQQKPTAPTPKPRSRECGPSKTPDPFSWLRKTSCADGGADSTSRSFVYQKA 169
82503257  114 ------------------------qPPAPAHQKPTAPTPKPRSRECGPSKTPDPFSWFRKTSCTEGGADSTSRSFMYQKG 169
83642858   69 -----------------ppnprrsrAPRVLVPALDVPSLSTSSWVLSPGSDLPNPLVSVGAEGGEANSNSIGSLSSSHSD 131
24943104  234 HQASLDLGSECYAGEGSEDQSP---------------------PHSRPLTSKN----------GYKVKPSFLTHLPIPRG 282
139472869 125 RFAFQSPRVCGRPPLPPPNHPP---------------------PATRPADASMgdvgwadlqgLKRTPKGFLKTSTKGGS 183
139424532 170 FEEGLAGLGLDDKSDCESEDES---------------------NFRRPSSHSAlkq----kngGKGKPSGLFEHLAAHGR 224
18653827  122 ETRQLTGAQFSSESEHEYAEIP---------------------ERTTTRPVESgdk----rnfTSGRRGAISGPSSTKPS 176
13095598      --------------------------------------------------------------------------------    
10140943  127 DFTILGSSGENPTSHANLSEEE---------------------MYEEIPPLAS-----------------NPSDERHPRQ 168
9625976    85 YKSNLVPITASNSVSELLSLHD---------------------ETQVTECVEAplia--kspdITVYEKMFSVRPKHTLT 141
9628023   139 NPPMLAPVDSYGNPVEQVSSSEsdfedianirpilrrqqpvtvKHRREPSPEPlgh----ptfVHRYDKPSYDEEVCQKK 214
9631211    85 YVTSPATITASKSVTELLSLHD---------------------TISVSGPSEPslva--kspdLAVYEQMFSVRPKHTLT 141
9629566   221 PPVIIFSDSETESDAEAVGERQ---------------------RGSKVDVPTSwkrlmmtketGTKSKTAFDKLKGSFEK 279
51518070  170 FEEGLAGLGLDDRSDCESEDDA---------------------NFRVPSSSPAlkq----kngSKGKPAGLFEHLASHRR 224
82503257  170 FEEGLAGLGLDDKSDCESEDES---------------------NFRRPSSHSAlkq----kngGKGKPSGLFEHLAAHGR 224
83642858  132 FTVLHFPEGHPNPISQSADLYE---------------------EPPYANMSSSlnm----ytsGRVTGNKLASGKTPKRS 186
24943104  283 EFTKLSRSAA------------QLKK-LSGSVLNILHLDDEQET--SKARA-------WDPSRRVPIVTQFKNHTPvykp 340
139472869 184 LKARGRDVGDrlrdggfafsprGVKSaIGQNIKSWLGIGESSATavPVTTQ-------LMVPVHLIRTPVTVDYRN---- 252
139424532 225 EFSKLSKHAA------------QLKR-LSGSVMNVLNLDDAQDTr-QAKAQ-------RKESTRVPIVTHLTNHVPvikp 283
18653827  177 HGAGLTRKTK--------------TS-LSVSLKNLLRIKDDDAKv-DVPRP-------VTVPVHLMQPHPMTEYRN---- 229
13095598   79 --------------------lpSITA-LSESFTNLSFTDGTTTS--PDWPA-------KPAPAHLLYPRPPTGYTD---- 124
10140943  169 LSGAVAQGAIrksprklkfkpaKFKG-LSSSLLNPFTASDSGRR---ARRQ-------TPTCQPGFTPIFQDLGEPhyvk 237
9625976   142 KLEGKQKMFTrkkkgsfvkigsNMLE-FGESLKSKLHNDSKKSPd-EPDGL-------VHVPVHLLYPPKHQDPVP---- 208
9628023   215 DKGGRTKSKNwlrqpgvkskltSMKD-LSGSFKSLMHIRSDGEKhkQQQRPggsgapgGATPRDVFNTFLGSGTCPsfkn 293
9631211   142 RTEEKQKMFTrkkkgsfvkigsNVLE-FGGSIKSKLHNSCKKSVd-SPDGL-------VHVPVHVLYPPLHQEPIP---- 208
9629566   280 FMSGNTKNEGteehrsvvrrrgDGTG-FRYSYMSKMSTDFPAGPtr---------------------------------c 325
51518070  225 EFSKLSKHAA------------QLKR-LSGSVMNILNLDDAPEAr-QTKTQ-------RKECLRVPIVTHLTNHVPvikp 283
82503257  225 EFSKLSKHAA------------QLKR-LSGSVMNVLNLDDAQDTr-QAKAQ-------RKESMRVPIVTHLTNHVPvikp 283
83642858  187 QGEKLSSKAA------------RIKE-LSSSLLNALSLSDGAQAtrPKTRR-------RPPPPNTSMIDLLSE--Psytr 244
24943104  341 ACSLYFEGVPGVGKTTMLKHLKSVF-GDLTVVFNEPMAFWTGVYENTLKRTSKLL-KGRGGQTSGSADLLSCQMKFATPF 418
139472869 253 VYLLYLEGVMGVGKSTLVNAVCGILpQERVTSFPEPMVYWTRAFTDCYKEISHLMkSGKAGDPLTSAKIYSCQNKFSLPF 332
139424532 284 ACSLFLEGAPGVGKTTMLNHLKAVF-GDLTIVVPEPMRYWTHVYENAIKAMHKNVtRARHGREDTSAEVLACQMKFTTPF 362
18653827  230 AFLIYLEGVMGVGKTTLLNSMTGMVpQENVLSCPEPMKFWTCVYSNCLKEQRSIVkQGTHGKLITSARVYACQSKFALPF 309
13095598  125 AYFIFFEGVMGVGKTTLLKTLARND-MNNVIIFEEAMNYWKTVFSDCHKLIYDVMkMGKHGSFSVSSKLLACQMKFLTPL 203
10140943  238 ACTVFFEGCMAAGKTTLLNFARQTLsDDEALTIPEPMRFWTEVYTNVLSQIVKINkECKPGKTSTTAELVSCQLKFATPL 317
9625976   209 AFFIFLEGSIGVGKTTLLKSMNGILgGKNVLAFHEPIAYWTDVFSNSLEEVYKLTlPAKVGRTSNSAKLLACQLKFASPL 288
9628023   294 AFFLYLEGSMGVGKTTLIRHMREIN-GDNVISFVEPMFYWREVYSDCVKLIYSACkPFNLGKMSTSKKVLSAQMKFMTPM 372
9631211   209 AFFIFLEGSIGVGKTTLLKSMRGILpGKNVLTFHEPMAFWKNVFSNSLDEVYKLTlPAKVGSMTNSSKLLACQLKFAAPL 288
9629566   326 ATVLYFDGGIAVGKTTALEAAAEFL--HNILVISEPIPYWTSTFDKNVCQQIYDVvKTKEKGKKHSKKVLQCQMAFAQPF 403
51518070  284 ACSLFLEGAPGVGKTTMLNHLKAVF-GDLTIVVPEPMRYWTHVYENAIKAMHKNVtRARQGREDTSAEVLACQMKFTTPF 362
82503257  284 ACSLFLEGAPGVGKTTMLNHLKAVF-GDLTIVVPEPMRYWTHVYENAIKAMHKNVtRARHGREDTSAEVLACQMKFTTPF 362
83642858  245 ACTVFLEGCMAVGKTTLLNYIRRSSpPDEVMTIPEPVQYWTQVYQNVLEEIVRIHkQWKPGKLSSSAALVACQLKFATPL 324
24943104  419 RVAAARKRTFYSSENGPRP-VAPLDCWILHDRHLIAATVVFPLLHLKNKLLSFSDFIQLLSTFNAEDGETIVWLKLNMAE 497
139472869 333 RTNATAILRMMQPWNVGGG-SGRGTHWCVFDRHLLSPAVVFPLMHLKHGRLSFDHFFQLLSIFRATEGDVVAILTLSSAE 411
139424532 363 RVLASRKRSLLVTESGARS-VAPLDCWILHDRHLLSASVVFPLMLLRSQLLSYSDFIQVLATFTADPGDTIVWMKLNVEE 441
18653827  310 RATAAGIGRNLQPWLVGNG-STKPANWIVFDRHLLSATVVFPLVHVKYNRLTPDHLFQILSLFSAHDGDVVVLLTLNSSE 388
13095598  204 KSLGRVTAMFSGKEMQRSPgRSDVSHWVMFDRHALSACLVFPLVMLKSGMLSFEHFISLVSTFRANEGDIIVLIALDHGE 283
10140943  318 KTQSLFLQRSVKKDSEMQP-VGPLDKWVIVDRHQLSALVVFPLVLMRRGMLSFSDFFNLLGMFEAHPGEVIALMSVNVEE 396
9625976   289 LALKTATDRLSSPKNS----LLSSDMWVMFDRHPLSATVVFPYMHFQNGFLSFSHLIQLWSSFKASRGDNIILLNLNSQE 364
9628023   373 KCLQTSVRRYVKANEPLQE-KTAMDNWLLFDRHPLSATLVFPYLSLKNGYLAFEHFLALAANFTAHEGDIIALLCMGEED 451
9631211   289 LALKTSTDRLSISNRS----NLSSNMWVMFDRHPLSATVVFPYMHYQNGFLSFSHLVHLWGSFRASHGDNIILLNLNSQE 364
9629566   404 HATQHLLRRTCLGTKVSDG---TCNNYVLIDRHMVSPTVIFPCLFFRLGVLRFCDLLSLLSVFSAQKFDNVVLFKLHPKV 480
51518070  363 RVLASRKRSLLSTESGARP-VAPLDCWILHDRHLLSASVVFPLMLLRGQLLSYSDFIQILATFTADPGDTIVWMKLNGEE 441
82503257  363 RVLASRKRSLLVTESGARS-VAPLDCWILHDRHLLSASVVFPLMLLRSQLLSYSDFIQVLATFTADPGDTIVWMKLNVEE 441
83642858  325 KSQCCYVKHCVQEDAGRRA-VAPLDRWVVCDRHPLSALVVFPLVWLRRGMLSFGDFLDLLAMFEANVGEVIVLISIPTDE 403
24943104  498 NLRRIKKRGRRYEAS-NEEYLKRVNWAYHAVYCAWLLTQYFTPEDIVRVCAGITTISTVCHHSPTPIIRSSVAEKLYKSS 576
139472869 412 SLRRVRARGRKNDGTvEQNYIRELAWAYHAVYCSWIMLQYITVEQMVQLCVQTTNIPEICFRSVRLAHKEETLKNLHEQS 491
139424532 442 NMRRLKKRGRKHESGlDAGYLKSVNDAYHAVYCAWLLTQYFAPEDIVKVCAGLTTITTVCHQSHTPIIRSGVAEKLYKNS 521
18653827  389 AHRRIQSRGRKEEKGiTQNYLRQVAWAYHAVFCTWVMMQYLTPEQMVQLCVQTVSIEDICNMNSRLTHRFLTLTKLHEQS 468
13095598  284 AIRRIKTRKRPEEETiSLTYVIRLHWCFVAVYNTWRLLQYFTAREATEVCLDIKTINGLCLSKDICYQKCLEFQTLWNES 363
10140943  397 NFTRLKKRGRVCERHiDRDYIKEIKGSFNAAYCAWLFLQYFSIQTTMQICMGLSSLDEACATEGVC---HTTASRIWNNS 473
9625976   365 NLKRVKKRNRKEEKSvSIEHIRLLNNCYHAVYCAWLLVQNFTPEEIVEVCFNAKHITDLSSSKPSFLAKHVSTEDMLKSS 444
9628023   452 NLKMVKLRNRKGESGvTSAHLKDLGQAFHACYCTWLLLKYLSPEDMVSVCCCDVTLNDICIMRSMSSSKVTMAKSLFNKS 531
9631211   365 NLERVKRRNRKEEKCvSLEHIRMLNSCYHAVYCAWLLVQNFTPEEIVEVCFNTKQITDLRSSKPSFLEKHVSIEDVLKSS 444
9629566   481 AATRVKERGRNPEGViNHTYLQLLNEVLDAIFCAWELLAIVPPEVIVDAMLSQTSVKTVFQKAGFVAPRARLMEQMFRDS 560
51518070  442 NLRRLKKRGRKHESGpDAGYLKSVNDAYHAVYCAWLLTQYFAPEDIVKVCAGLTTITTVCHQSHTPIIRSGVAEKLYKNS 521
82503257  442 NMRRLKKRGRKHESGlDAGYLKSVNDAYHAVYCAWLLTQYFAPEDIVKVCAGLTTITTVCHQSHTPIIRSGVAEKLYKNS 521
83642858  404 NMIRLQKRGRACEQHiNLPYLKEIRGSFHAAYCAWLFLQYFPVEVTMKLCLQQMTMENACAISKKVSLD--TAQKIWGNS 481
24943104  577 IFNVLKDVIHPFR-ADTVLLEVCLTFAKTLARLQFIIVDLSEFQDDLPGCWTEIYMQALKNPQIKSHFFDWNGLSKFQTD 655
139472869 492 MLPMITGVLDPVR-HHPVVIELCFCFFTELRKLQFIVADADKFHDDVCGLWTEIYRQILSNPAIKPRAINWPALESQSKA 570
139424532 522 IFSVLKEVIQPFR-ADAVLLEVCLAFTRTLAYLQFVLVDLSEFQDDLPGCWTEIYMQALKNPAIRSQFFDWAGLSKVISD 600
18653827  469 MIPMVAEMLVSVK-EHVTLMEVCLGLFKELRKLQILIVDAGEHLDDACGLWGNIYGQVMSNEAIKPRAVNWPALESYIQT 547
13095598  364 LLAILRDIIFPYK-SDCTILELCLNVCTQIQKLKFVVSDATKYIGDVRGLWEDISTQILQSRVIKTRPVDWANLKSLAKE 442
10140943  474 MLVTLSDIISQFS-NDYTVQNVCYNFFSQLSTLKFVVIDLSAFRHDVPGAWGEFYMQVMKNGDIKTRVMDFTAIKALADT 552
9625976   445 IFNTWIEMTKAHR-DSCTLMECLLTFCKELEKVQLIHVNVSPFTDDIPGLWASIYTSIRRNSAIKPNRVNWLALEDLART 523
9628023   532 MFPTLMDVIQPFR-SNCTIIEICLTLFMELKKVEFIVVNASEFIGDIPGVWTSIYTQSLRTQAIKTQSIDWSGLRAFSLT 610
9631211   445 IFNAWMDMTKAYR-DNCTLMECLLTLCKELEKVQLLHINASSFTDDIPGLWVSISTNIKRNSAVKPRRVNWLALEDLAHT 523
9629566   561 IFNDLRENVRQLPlHGSSIPTLLHKFCYELSKPHMVKLDAGQFPNDVPGLWTHIYTQILTDPAIKTCDLKWNILEKGISG 640
51518070  522 IFSVLKEVIQPFR-ADAVLLEVCLAFTRTLAYLQFVLVDLSEFQDDLPGCWTEIYMQALKNPAIRSQFIDWAGFSKFISD 600
82503257  522 IFSVLKEVIQPFR-ADAVLLEVCLAFTRTLAYLQFVLVDLSEFQDDLPGCWTEIYMQALKNPAIRSQFFDWAGLSKVISD 600
83642858  482 LFTTLSDVIGPFT-YDPTILQVCLHFCYQLIKLQFLVIDLSPFQDDLTGAWSEIYMQVMKNSDIKTRMLNLAAIKALSDE 560
24943104  656 FDRDNKA 662
139472869 571 VNHLEET 577
139424532 601 FERGNRD 607
18653827  548 LTKLEGN 554
13095598  443 FCG---- 445
10140943  553 AHNTHAS 559
9625976   524 FNSQ--- 527
9628023   611 YNS---- 613
9631211   524 FNSQ--- 527
9629566   641 GDPQ--- 644
51518070  601 FERGSRD 607
82503257  601 FERGNRD 607
83642858  561 AHNCSVS 567
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