Conserved Protein Domain Family
SpoIIP

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pfam07454: SpoIIP 
Stage II sporulation protein P (SpoIIP)
This family contains the bacterial stage II sporulation protein P (SpoIIP) (approximately 350 residues long). It has been shown that a block in polar cytokinesis in Bacillus subtilis is mediated partly by transcription of spoIID, spoIIM and spoIIP. This inhibition of polar division is involved in the locking in of asymmetry after the formation of a polar septum during sporulation. Engulfment in Bacillus subtilis is mediated by two complementary systems: the first includes the proteins SpoIID, SpoIIM and SpoIIP (DMP) which carry out the engulfment, and the second includes the SpoIIQ-SpoIIIAGH (Q-AH) zipper, that recruits other proteins to the septum in a second-phase of the engulfment. The course of events follows as the incorporation firstly of SpoIIB into the septum during division to serve directly or indirectly as a landmark for localising SpoIIM and then SpoIIP and SpoIID to the septum. SpoIIP and SpoIID interact together to form part of the DMP complex. SpoIIP itself has been identified as an autolysin with peptidoglycan hydrolase activity.
Statistics
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PSSM-Id: 462168
Aligned: 58 rows
Threshold Bit Score: 211.424
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8RB76        91 KDPLNLIKFQIPVF------------------------AQVDYKKYQKVTQVTKGEEEKVIIPPPKVAEERkeekkepsg 146 Caldanaerobacte...
WP_013277587 112 DNPASILQAELPNLsvvnr---------------nmaeREERKTEADQKETFNQKRQAQDEVQETELNFTQtepsqkte- 175 Acetohalobium a...
Q0AWL6        51 fKKIELDKKQAASLfrevnvvfagektsfpmtrhyfkeKMPEELMISSIQALAYGRSEEDLRENEGENEVQlpevepepl 130 Syntrophomonas ...
CDC12637      85 kDILDIIKKYTELY-----------------------------------ADDKRDADIRATTYGKTGATHIfenvkvknt 129
CCY66546     102 dDILKLMEEEEKVI---------------------------------GSQKKKGSTSEESYTGGGTIVTYNnvqvqnkip 148
CDA13182      99 QDIAELMRQEEAVI---------------------------------DSQTVKGKTSEESYTGGGTVVTHKnvqvqskip 145
WP_013657132  81 GEPLSLLANAIPYIeen-------------------egFKASYNEIVGYFTPDDLKNQKISQTNEQVKETQndrtsqvqe 141 Cellulosilyticu...
WP_024727239  19 mgirffsghpdmvstavqnyylkavnelipsyhsggqpiygsvlnkiittyrndivpsicysenysevkssdlvknqfyd 98  Anaerostipes
CDA63573      77 weskesyflseepqltvreeteknpesektqetqksseVQNTQDQMPQKAEAESMEETEKTVIQKAVKKKKrkknkkaqt 156
CDE52835      81 tssvysfvenndskknliqytpdstkkdmmlaqeqtpaGNADGTDTAQNTMQEQEQTESPTDQQQDTQQNQqengqtvee 160
Q8RB76       147 e----------------------------------------------------------ekkgdnskpyLLIYHTHTMEA 168 Caldanaerobacte...
WP_013277587 176 --------------------------------------------------------------kfddnnlVGIYYTHTSES 193 Acetohalobium a...
Q0AWL6       131 eesr-----------------------------------------------------didyssffkdckVVFYCTHSAES 157 Syntrophomonas ...
CDC12637     130 tdtkpldie-------------------------------------------kvlaeplelsidrskpaILIFHSHTSEG 166
CCY66546     149 sdfyslnik------------------------------------------ellnqkadlkisdpskptVLIYHSHSTEC 186
CDA13182     146 edfysldie------------------------------------------rllqekadlkigdpseptVLIYHSHSTES 183
WP_013657132 142 kvsiealkdpqyvfnrymtasae---------------mefgvdmikewdfsklaqqpirlnesikgpqVLIFHTHSRED 206 Cellulosilyticu...
WP_024727239  99 ledneqsgvrvdevpakktvfnskkwndpnylrkyiyqvdsttmvtnseingkvllnkdlslkkskqpqILIFHTHGSEA 178 Anaerostipes
CDA63573     157 eetkeqqetvnmeelqdfqtlvgny----------ytvdasttadpeqinaeklagqdlrikkdasvpqILIYHTHSQEA 226
CDE52835     161 qtsagggqpsgvqetfspafsldqlknydflrsnlyivperasvlpqdldgetllsmdmsiakdpsvpqILIYHTHGSET 240
Q8RB76       169 FAATEenryvarYGYDRTDDLNY------TVAEVGEYLAEYL-IKEGIPVLHDKTIH--DYN-----YDKSYVNSLVTLK 234 Caldanaerobacte...
WP_013277587 194 Y-------------EESVSNFHSkpgtrgDVVEVGRKLIERLeSKHGINALHSTRVN--DSV-----YRESYMESRETAR 253 Acetohalobium a...
Q0AWL6       158 YIPD--------SGKARCDGQRG------LVNEVARSISKSL-SKRGLPAEFEDRIH--DFPe----YNKSYTNSRETVQ 216 Syntrophomonas ...
CDC12637     167 YELIErdwy-aegSTSRSNDENL------NVVRVGTEIENYL-TGKGYTVIHDKIIHddD-------YTGSYPHSRKTLE 231
CCY66546     187 YTLLDagyy-tesTDSKTKDITR------NMVRVGDDICRIL-EARGIGVIHDREIH--DSS-----YNAAYDSSRKSVA 251
CDA13182     184 YTLLDagfy-teaADLKTKDTSR------NMIRVGDDICSVL-EARGIGVVHDREIH--DES-----YNAAYDSSRKTVS 248
WP_013657132 207 YMGGL------------------------TVIEVAEALKKELeDEYDISVLHIEDSFyeESNkgkfpTGGEYERMEAKIK 262 Cellulosilyticu...
WP_024727239 179 Y------------KDSRKGEKSD------TVIGAGDVLTKLLkEQYGINVIHDRGIY--DVKngkedRSKAYYYAAASVE 238 Anaerostipes
CDA63573     227 F------------ADSEEGNISD------TIVGMGNYLTELLeNKYGYNVIHNTSVF--DMIdgvldRNTAYNLAETEIS 286
CDE52835     241 F------------ADSTDDIKGT------GIIAAGAKLAEYLsSVYGYNVIHCTEIF--DNVngvfdRSKAYDYSRETVQ 300
Q8RB76       235 RILKEYPSIKAAIDLHRDGygavmkpgvesipalsslPNQEFRkkyTIEINGEKVARVSFIIG------------SRRtp 302 Caldanaerobacte...
WP_013277587 254 QLIEDNPNLQMVFDIHRDAla---------------kQDKELF---TTTIDGQKVAKVMIVVAk----------aNKNyg 305 Acetohalobium a...
Q0AWL6       217 KILQSNNRMLALFDIHRDSip---------------gLEKAE----TVEIDGKKSARILIIVG-------------TDer 264 Syntrophomonas ...
CDC12637     232 EILAENPQIQIVLDIHRDSit---------------lDDGTKMk-pIAEIGGRKAAQLMIITGaee------gkvKDF-- 287
CCY66546     252 QYLEKYPSIEITIDVHRDSit---------------yKNGTKVk-pTATVNGKKAAKMMIISGcey------gsvKNF-- 307
CDA13182     249 EYLEKYPTIEITIDVHRDSit---------------yKNLTKVk-pTQEVNGKKAAKMMIISGcey------grvKNF-- 304
WP_013657132 263 QVIEENLSISVAIDLHRDGv-----------------DDKVHL---VTDINGKQTAKVMLVAPlcrnrn-vsgqvVNKvd 321 Cellulosilyticu...
WP_024727239 239 RYLKKYPSIQVVIDLHRDGv-----------------KESTKL---VSKQNGVEMAQFMFFNGisrtakngdikyLKN-- 296 Anaerostipes
CDA63573     287 SILAANPTVEVVIDLHRDG------------------LDGEKL---VTQIDGKQVAKIMFFNGlsrtarngnvdyLPN-- 343
CDE52835     301 QILTDNPGIQVMIDLHRDGv-----------------RDDLHL---VTDVNGKPTAQIMFFNGvsrssakgdiayLYN-- 358
Q8RB76       303 emnEDWRKNYEFAKKISDKLNELYPGLSLGVQVKPYSEYNQHVLEKAILIELGSNYNTLEEAIATTKYLAKAIS 376 Caldanaerobacter subt...
WP_013277587 306 lshPEWRKNLRFAYRLADEINSMYPNLLRKVKVVDNRRYNQDLHPHSVLLEIGGVSNTSAEAKRSTRLMADVIA 379 Acetohalobium arabaticum
Q0AWL6       265 kshPEWRKNLEFAQEIYRQGEKKYPGLIKGIRT-KAGTYNQEFFPRALLLEFGGDLNSFVEARYAGMLFSDILI 337 Syntrophomonas wolfei...
CDC12637     288 ---PDWEYNLRFALRLQKRCEDMFPGLMRPVLF-SQRKYNMDITHFSLLIEMGSEANTLEEACYSGRLLACALA 357
CCY66546     308 ---PNWEYNLRFACSVTDKLNSLYPELMRPILF-SERKYNMDLTKNSFLLEIGTDANTLDEACYSGRLFANALA 377
CDA13182     305 ---PDWEDNLRFSCAVTNKLNSDYPGIMRPILF-SERKYNMDLTKNSFLLEIGTDGNTLDEACYSGRLFAAALA 374
WP_013657132 322 lpnPYLGDNLAFALQTLLTANEYYPGFSRKIFC-DEWRYSTHMKPQSLLMEWGAQTNTGEEALNAVEPMAQILA 394 Cellulosilyticum lent...
WP_024727239 297 ---PNKKTNLAFSLQLQAEAMKKYPGLTRKIYI-KGYRYNLHYRGRSLLIELGAQNNTVKQAKNAMKPLAEILN 366 Anaerostipes
CDA63573     344 ---PYIEENLAFSFQLQIKAQEYYPGFTRHIYL-QSLRYNLHLKPRALLIEAGSQLNTVEEEKNAMEPLADILD 413
CDE52835     359 ---RYRSQNLSFSLQAKLEALGKYPDFTRKNYI-DAYQYNLDLLPRAMLIEAGAQTNTVQEELNAMEPLADILD 428
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