6RJ9


Conserved Protein Domain Family
Cas9

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COG3513: Cas9 
CRISPR-Cas system type-II protein Cas9 [Defense mechanisms]
CRISPR-Cas system type-II protein Cas9 is part of the Pathway/BioSystem: CRISPR-Cas system
Statistics
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PSSM-Id: 442735
Aligned: 51 rows
Threshold Bit Score: 412.434
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6RJ9_C          1 Ms--------DLVLGLDIGIGSVGVGILNKVT--------GEIIHKNSRIFPAAq-------aENNLVRRTNRQGRRLTR 57  
YP_002344900    1 M---------ARILAFDIGISSIGWAFSEND----------ELKDCGVRIFTKVenpk--tgeSLALPRRLARSARKRLA 59  
WP_081436766    1 MtffggklymKYTLGLDVGIASVGWAVIDKDNn--------KIIDLGVRCFDKAeesk--tgeSLATARRIARGMRRRIS 70  
WP_012859073    1 M---------KYILGLDLGVASIGWAVTEINEkg----epVGLIDANSVIFKPLdnd---kgkLYNVERRDKRGSRRILR 64  
WP_015423233    1 Mk--------KRILGLDIGIASVGWALVEFDDefqdnkkkGTIIKSGVRIFTRAetpk--ereSLAKPRREARSQRRRIR 70  
WP_011139289    1 Mi--------ERILGVDLGISSLGWAIVEYDKdde---aaNRIIDCGVRLFTAAetpk--kkeSPNKARREARGIRRVLN 67  
WP_014621379    1 Ms--------DLVLGLDIGIGSVGVGILNKVTg--------EIIHKNSRIFPAAqa-------eNNLVRRTNRQGRRLTR 57  
WP_014748117    1 Min------eRLTFGIDLGIGSCGWAVLRHADaag---epGVIEGLGSWCFDVPetsk--eriPTNQVRRSNRLLRRVIR 69  
WP_077276356    1 Mik-----diSVNLGFDIGIASVGWAVLNNANg--------KILESGVSIFPSAsa-------eRNAERRSFRQSRRLVR 60  
WP_003611034    1 M----------RVLGLDAGIASLGWALIEIEEsnrgelsqGTIIGAGTWMFDAPeektqagakLKSEQRRTFRGQRRVVR 70  
6RJ9_C         58 RKKHRRVRLNRLFEESGLI-TDFT---KIS--------INLNPYQLRVKGLTDELSNEELFIALKNMVKHRGISYlDDAS 125 
YP_002344900   60 RRKARLNHLKHLIANEFKL-NYEDyqsFDEslakaykgSLISPYELRFRALNELLSKQDFARVILHIAKRRGYDD-IKNS 137 
WP_081436766   71 RRSQRLRLVKKLFVQYEII-KDSSefnRIFdts---rdGWKDPWELRYNALSRILKPYELVQVLTHITKRRGFKS-NRKE 145 
WP_012859073   65 RKKHRVERTKMLLVNSSFL-TNEEidnLYVg-------KLDNIYEVRLKGLKEQLSKNEIARLMIYYCKNRGFKS-NRKT 135 
WP_015423233   71 RRVERLNSIRELFVKNGVV-EEWSvskKNPnniyitlnQIKTPWQLRMESLDRKLTNEQFAVVLTHLAKHRGYKS-LRKD 148 
WP_011139289   68 RRRVRMNMIKKLFLRAGLI-QDVDldgEGgmfy--skaNRADVWELRHDGLYRLLKGDELARVLIHIAKHRGYKF-IGDD 143 
WP_014621379   58 RKKHRIVRLNRLFEESGLI-TDFTki-----------sINLNPYQLRVKGLTDELSNEELFIALKNMVKHRGISY-LDDA 124 
WP_014748117   70 RRRNRMAEIRRLFHAQGLL-PSADedaLKR--------PRLDPWELRARGLDQCLSAEEFAVALGHIARHRGFRS-SAKR 139 
WP_077276356   61 RRNVRLHDMKDLLEKAGFPyPTKQh-------------IYPNPYELRVKGLTEQLTKEELALALYHLVKRRGISY-DLKD 126 
WP_003611034   71 RRRQRMNEVRRILHSHGLL-PSSDrdaLKQ--------PGLDPWRIRAEALDRLLGPVELAVALGHIARHRGFKS-NSKG 140 
6RJ9_C        126 DD-----------GN-S-SIGDYAQIVKENSKQLETK---TPGQIQL--E--RY---Q---TYG------QL---RGdft 170 
YP_002344900  138 DDk---------------EKGAILKAIKQNEEKLAny--qSVGEYLY--K--EYf--QkfkENSke--ftNV---RN--- 186 
WP_081436766  146 D------------LStT-KEGVVITSIKNNSEMLRTKnyrTIGEMIF--M--ETp------ENS------NK---RN--- 190 
WP_012859073  136 EDleilkslgekiSEkDsDEKKLKPIIAKNTELIESKg-lTPIEVIYmiR-----------ENDn-----SIlgfKN--- 195 
WP_015423233  149 D-----------------KAGKVLEAISQNKKRLNDSdyrTLGEMFC--KneSY---Ke-----------HK---RN--- 189 
WP_011139289  144 E------------AD-E-ESGKVKKAGVVLRQNFEAAgcrTVGEWLW--R--ERg------ANG------KK---RN--- 187 
WP_014621379  125 S------------DDgNsSVGDYAQIVKENSKQLEt---kTPGQIQL--E--RY---Q---TYG------QL---RG--- 167 
WP_014748117  140 KA-----------ANtSgEDSKMLSALLVTRERTAry--rTVGEMFA--RdpEY---Sa-----------RR---RN--- 184 
WP_077276356  127 VE-----------DEtGkNSSAYQESLQKNQTLLKr---lTPGEIQL--N--RL---K---NEG------KV---RG--- 170 
WP_003611034  141 AKt----------NDpAdDTSKMKRAVNETREKLArf--gSAAKMLV--EdeSFvlrQtptKNGaseivrRF---RN--- 200 
6RJ9_C        171 vekdgK--------KHRLINVFPTSAYRSEALRILQTQQEFNPQ-ITDEfiNRYLEILTGKRKYYHgpgneksrtdygry 241 
YP_002344900  187 -----K--------KESYERCIAQSFLKDELKLIFKKQREFGFS-FSKKfeEEVLSVAFYKRALKDfs------------ 240 
WP_081436766  191 -----K--------VDEYIHTIAREDLLNEIKYIFSIQRKLGSPfVTEKleHDFLNIWEFQRPFASgdsi---------- 247 
WP_012859073  196 -----K--------EGNYKFGFKRNQVIDEVRKILGTQq-----iLSKEivDEYIDILSSQRDFSDgpggdsky------ 251 
WP_015423233  190 -----K--------GGEYINSVARELIEEEVEKIFVKQREKGNNfADVNteREYLKIAFSQKPAGSis------------ 244 
WP_011139289  188 -----K--------HGDYEISIHRDLLVEEVEAIFVAQQEMRSTiATDAlkAAYREIAFFVRPMQRie------------ 242 
WP_014621379  168 -----DftvekdgkKHRLINVFPTSAYRSEALRILQTQQEFNPQ-ITDEfiNRYLEILTGKRKYYHgpgneksrtdygry 241 
WP_014748117  185 -----R--------DGIFDRTVARDDLIHEVGKLFEAQRARGSAfASPDleADFNAIAFRQAEMQDse------------ 239 
WP_077276356  171 -----Qivt---edEGTLLNVFPTADYRDEAMTILSQQQAFYPN-ITDEfiKQVSEIITRKREYFKgpgslksptdygiy 241 
WP_003611034  201 -----R--------EGDYSRSLLRDDLAAEMRALFTAQARFQSAiATADlqTAFTKAAFFQRPLQDse------------ 255 
6RJ9_C        242 rtsgetldnifgilIGKCTFYPDEFRAAKASYTAQEFNLLNDLNNLTVPT-------ETKKLSKEQKNQIINYVKNE--K 312 
YP_002344900  241 ------------hlVGNCSFFTDEKRAPKNSPLAFMFVALTRIINLLNNLkn----tEGILYTKDDLNALLNEVLKN--G 302 
WP_081436766  248 -----------lskVGKCTLLKEELRAPTSCYTSEYFGLLQSINNLVLVEd-----nNTLTLNNDQRAKIIEYAHFK--N 309 
WP_012859073  252 -------kidytklAGKCKY-TGEVRAVKSAPSYEIFTMLQKLNDIRYVKftsedkiEKKKLSKEVIHKLYDLVVEK--N 321 
WP_015423233  245 ------------kmVGFCTFENGEKRAPRDSYSAELFKVLCTINNTTFTDmk---tgEIRSFSKEEIGKTLETVKNV--K 307 
WP_011139289  243 ------------kmVGHCTYFPEERRAPKSAPTAEKFIAISKFFSTVIIDne---gwEQKIIERKTLEELLDFAVSR--E 305 
WP_014621379  242 rtsgetldnifgilIGKCTFYPDEFRAAKASYTAQEFNLLNDLNNLTVPTe-------TKKLSKEQKNQIINYVKNE--K 312 
WP_014748117  240 ------------rlVGNCPFERDEKRAARWAPSFERFRLLTRLINLRIATa-----eGERRFTPEDLARVSAELGAT--A 300 
WP_077276356  242 kkdgtvldnlfeilIGKDKIFPDEYRAASNSYTAQLFNLLNDLNNLRIDTt------EDGKLTTEHKEEIIHYLKTTdkK 315 
WP_003611034  256 ------------klVGPCPFEVDEKRAPKRGYSFELFRFLSRLNHVTLRDg-----kQERTLTRDELALAAADFGAA--A 316 
6RJ9_C        313 A-MGPAKL-FKYIAk---------lLS----------------CDvad----ikGYRIDkSG------------------ 343 
YP_002344900  303 T-LTYKQT-KKLLG-----------LS----------------DDye-----fkG-----EK------------------ 325 
WP_081436766  310 E-IKYSEI-RKLLD-----------IE----------------PEil-----fkAHNLThKNpsg--------------- 340 
WP_012859073  322 KtLTYDLI-EKSIDeenikllnipkLSkskyvelrksyfkernDNenlteeeinAFNEKlNNer---------------- 384 
WP_015423233  308 D-VKYAKI-RKDLG-----------LE----------------DSvk-----fsGVDYReNAksk--------------- 338 
WP_011139289  306 K-VEFRHL-RKFLD-----------LS----------------DNei-----fkGLHYKgKPktakkreatlfdpnepte 351 
WP_014621379  313 A-MGPAKL-FKYIAk---------lLS----------------CDvad----ikEYRIDkSG------------------ 343 
WP_014748117  301 K-LPVSRV-RALIG-----------LL----------------PDer-----ftTIRVEdED------------------ 328 
WP_077276356  316 K-INMLALiSQVTG-----------------------------AEqth----ikGFRIDrDD------------------ 343 
WP_003611034  317 K-VSFTAL-RKKLK-----------LP----------------ETtv-----fvGVKADeES------------------ 344 
6RJ9_C        344 ---------KAEIht-----fEAYRKM-----KTLETldi------eqmDRETLDKLAYVLTLNTEREGIQEALEHe--- 395 
YP_002344900  326 ---------GTYFie-----fKKYKEFi----KALGEhn---------lSQDDLNEIAKDITLIKDEIKLKKALAK---- 374 
WP_081436766  341 ------nneSKKFye-----mKSYHKLk----STLPTdiwg----klhsNKESLDNLFYCLTVYKNDNEIKDYLQA---- 397 
WP_012859073  385 --------mKQELirn---nlKAYKELk----SKFKKnnidenrikelgGIYFLDLVAELLTYSKTDEKLEYFVENve-- 447 
WP_015423233  339 -------geGEIFvs-----mKTYHEIk----SKIEKlskekw-dnlkgNTELLDSIVNIIANLKDDESIKKEFQK---- 397 
WP_011139289  352 lefdkveaeKKAWis-----lRGAAKLr----EALGNefyg----rfvaLGKHADEATKILTYYKDEGQKRRELTK---- 414 
WP_014621379  344 ---------KAEIht-----fEAYRKMk-----TLETldi------eqmDRETLDKLAYVLTLNTEREGIQEALEHef-- 396 
WP_014748117  329 ---------RDIVartg-eaaPGTWRLr----KTLGEalwa----emqaRPDQLDAIAHVLSFFEATAKIRSELDR---- 386 
WP_077276356  344 ---------KPEWhs-----lAIYRKIc----RNFAElgid----vatwPTTLLDDLGRILTLNTENGEIRRALTTekfk 401 
WP_003611034  345 ---------KLDVvarsgkaaEGTARLrsvivDALGElawg----allcSPEKLDKIAEVISFRSDIGRISEGLAQ---- 407 
6RJ9_C        396 --FadgS-F---SQKQVDELVQfrkanssiFGKGWHNFSVKLMMELIPELYETSEEQMTILTRlgkqktt---------- 459 
YP_002344900  375 --Y---D-L---NQNQIDSLSKl------eF-KDHLNISFKALKLVTPLMLEGKKYDEACNELnlkvain---------e 429 
WP_081436766  398 --N---N-L----DYLIEYIAKlp-----tF-NKFKHLSLVAMKRIIPFMEKGYKYSDACNMAeldftgssk-------- 453 
WP_012859073  448 -rY---S-LfkeQRDIVEIIKTf------pNYTKNGNLSLSLVRELNKLLMEGHDYESSLSSLnyyidtd---------- 506 
WP_015423233  398 --L---K-I---DEDIIDVLLNf------eF-KKFINLSFKALRKIIPFQFQGQKYITASTSAgyslkqe---------g 452 
WP_011139289  415 --L---P-L---EAEMVERLVKi------gF-SDFLKLSLKAIRDILPAMESGARYDEAVLMLgvphke----------- 467 
WP_014621379  397 adG---S-F---SQKQVDELVQfrkanssiFGKGWHNFSVKLMMELIPELYETSEEQMTILTrlgkqkt----------t 459 
WP_014748117  387 --L---G-L---PAAVIEALDRgledgafaKFKGAGHISAKACRNLLPHLQQGHRYDQACRLAgydhaastlshta---- 453 
WP_077276356  402 ekY---PfL---TESLVDTMIQnkqwfhtsSNQKWHSFSLKTMSLLIPEMLVTSKEQMTLLYdlglikek---------d 466 
WP_003611034  408 --A---G-C---NAPLVDALTAaasdgrfdPFTGAGHISSKAARNILSGLRQGMTYDKACCAAdydhtasrergafdvgg 478 
6RJ9_C        460 sssnktKYIDE--KLLTEEIYNPVVAKSVRQAIKIVNAAIKEYGDFDNIVIEMARETNED-DEKKAIQKIQKANKDEKDA 536 
YP_002344900  430 dkkdflPAFNe--TYYKDEVTNPVVLRAIKEYRKVLNALLKKYGKVHKINIELAREVGKNhSQRAKIEKEQNENYKAKKD 507 
WP_081436766  454 ----lekcnkltvEPIIENVTNPVVIRALTQARKVINAIIQKYGLPYMVNIELAREAGMTrQDRDNLKKEHENNRKAREK 529 
WP_012859073  507 vdwekfPTISEieDSLSTKITNPNVKHILVILRKLYNTLLFKYGRPEKVHLELSRDFSNDfSTRNKIQKEQLENKVRREV 586 
WP_015423233  453 iknklvP-------PAKENINVAVVARAFAQTRKVINAVIRKYGQFDQINIELATELKNSkFDRSKIEEGQKKFQSQKDK 525 
WP_011139289  468 -ksailPPLN----KTDIDILNPTVIRAFAQFRKVANALVRKYGAFDRVHFELAREIN-TkGEIEDIKESQRKNEKERKE 541 
WP_014621379  460 sssnktKYIDe--KLLTEEIYNPVVAKSVRQAIKIVNAAIKEYGDFDNIVIEMARETN-EdDEKKAIQKIQKANKDEKDA 536 
WP_014748117  454 -qvvskagfnalvTELGESIANPIARKALTEGLKQIRAMCARWGLPGAIHIELAREVGNSiEKRRELESQRETTTKRRQT 532 
WP_077276356  467 niyeteTQINl--PHILADLYNPVVRKSVKQTMKIFNALYQKYPNIQYIAIEMPRDTN-EeDEKKQIKEFQKKNEQEKDK 543 
WP_003611034  479 hgrealKRILqeeRISRELVGSPTARKALIESIKQVKAIVERYGVPDRIHVELARDVGKSiEEREEITRGIEKRNRQKDK 558 
6RJ9_C        537 AMLKAANq---------YNGKAelphsvfhgHKQLATKIRLWHQQGERCLYTGKTISIHDLInnsnqFEVDHILPLSITF 607 
YP_002344900  508 AELECEK----------LGLKI---------NSKNILKLRLFKEQKEFCAYSGEKIKISDLQde-kmLEIDHIYPYSRSF 567 
WP_081436766  530 ISDLIRQ----------NGRVA---------SGLDILKWRLWEDQGGRCAYSGKPIPVCDLLnd-slTQIDHIYPYSRSM 589 
WP_012859073  587 AAFEMYGankd---ivaGKDRL---------SNDDFVRIKLWEEQNKVCMYSGRTIEKYQLTsa--eVQIDHILPYSKSF 652 
WP_015423233  526 IFKEVQEl--------rGGMTP---------SSSLLLKYRLWREQDERCVYSGRKISFEDLLdt-gfLDIDHIIPYSKSM 587 
WP_011139289  542 AADWIAEt--------sFQVPL---------TRKNILKKRLYIQQDGRCAYTGDVIELERLFde-gyCEIDHILPRSRSA 603 
WP_014621379  537 AMLKAANqyngkaelphSVFHG---------HKQLATKIRLWHQQGERCLYTGKTISIHDLInnsnqFEVDHILPLSITF 607 
WP_014748117  533 ERDEIRGl--------lALEDV---------DDDTLLRYRLWKEQGGKCLYTGKDIHVRQLIatdnsVQVDHILPWSRFG 595 
WP_077276356  544 AYLEFLSlsgvsetelnNKIYK---------NKKLRTIMRLWYQQQGICPYSGKPMPAEDILstpnnYEIDHIIPISVSF 614 
WP_003611034  559 LRGLFEKevg----rppQDGAR---------GKEELLRFELWSEQMGRCLYTDDYISPSQLVatddaVQVDHILPWSRFA 625 
6RJ9_C        608 DDSLANKVLVYATANQEKGQRTPYQALDSmDda-wsFRELKAFVRESkt---lSNKKKEYLLTEEDisKF--DVRKKFIE 681 
YP_002344900  568 DDSYMNKVLVFTKQNQEKLNQTPFEAFGN-Dsa--kWQKIEVLAKNL------PTKKQKRILDKNY--KD--KEQKNFKD 634 
WP_081436766  590 DDSYMNKVLVLTDENQNKRSYTPYEVWGS-Te---kWEDFEARIYSMh----lPQSKEKRLLNRNF--IT--KDLDSFIS 657 
WP_012859073  653 DNSYSNKVLVFSNENQDKKERTPYQWLKG-Te---kWNEFKQRVRLNln---iSNKKKENLLFEDE--VV----NNEFLE 719 
WP_015423233  588 DDSFNNKVLCLAEENRNKKNDIPFNYYQR-Idr--dWNLLISIITSMkn---mKIAKKSRLLKQEL--SD----IEGFIE 655 
WP_011139289  604 DDSFANKVLCLARANQQKTDRTPYEWFGH-Daa--rWNAFETRTSAPsnrvrtGKGKIDRLLKKNF--DE--NSEMAFKD 676 
WP_014621379  608 DDSLANKVLVYATANQEKGQRTPYQALDS-MddawsFRELKAFVRESkt---lSNKKKEYLLTEED--ISkfDVRKKFIE 681 
WP_014748117  596 DDSFNNKTLCLASANQRKRGQTPWEWFSL-TgtpeaWEVFASRVETSkd---lRGFKKRNLLLKNA--DEv---AQRFRS 666 
WP_077276356  615 DDSMNNKVLCFANMNQEKGKSTPYEMMQN-Ghg-qsFASLKAMVAKNkr---mDNTKKKNLLFTEK--LSdiDVRKRFIA 687 
WP_003611034  626 DDSYANKTLCMAKANQDKKGRTPYEWFKA-EktdteWDAFIVRVEALad---mKGFKKRNYKLRNA--EEa---AAKFRN 696 
6RJ9_C        682 RNLVDTRYASRVVLNALQEHFRahk---------------idtKVSVVRGQFTSQLRRHWGIe----------------- 729 
YP_002344900  635 RNLNDTRYIARLVLNYTKDYLDflplsddentklndtqkgskvHVEAKSGMLTSALRHTWGFsa---------------- 698 
WP_081436766  658 RNLNDTRYISRFLKNYIESYLQfsnd-------------spksCVVCVNGQCTAQLRSRWGLnk---------------- 708 
WP_012859073  720 RELHATSYSSRLALNIFQRLIPvsdedkydehgnekvkylynrNVIAFQGKMTSMLRNLYSLnkythsfesdtldidnka 799 
WP_015423233  656 RNINDTRYATRYIKDFLENNLEfkene------------fikvKVQARSGGLTSVLSYNWGMsk---------------- 707 
WP_011139289  677 RNLNDTRYMARAIKTYCEQYWVfkns-------------htkaPVQVRSGKLTSVLRYQWGLes---------------- 727 
WP_014621379  682 RNLVDTRYASRVVLNALQEHFRahk---------------idtKVSVVRGQFTSQLRRHWGIe----------------- 729 
WP_014748117  667 RNLNDTRYAARLLAEAAKLFYPagdrqe----------kdgrrRVLTRPGPLTAALRHAWGLeslkk------------- 723 
WP_077276356  688 RNLVDTRYASRVVLNELQQFVKgnq---------------ldtKVTVVRGKFTSVLRKRWSIn----------------- 735 
WP_003611034  697 RNLNDTRWACRLLAEALKQLYPkgekdk---------dgkerrRVFSRPGALTDRLRRAWGLqwmkk------------- 754 
6RJ9_C            --------------------------------------------------------------------------------     
YP_002344900      --------------------------------------------------------------------------------     
WP_081436766      --------------------------------------------------------------------------------     
WP_012859073  800 filkefeinkdnlkmtaynvntgleitsetkveknksgefktikdellkkeldkkenlieisdyfkdkvlfdlkivdfee 879 
WP_015423233      --------------------------------------------------------------------------------     
WP_011139289      --------------------------------------------------------------------------------     
WP_014621379      --------------------------------------------------------------------------------     
WP_014748117      --------------------------------------------------------------------------------     
WP_077276356      --------------------------------------------------------------------------------     
WP_003611034      --------------------------------------------------------------------------------     
6RJ9_C        730 -------------------------kTRDTYHHHAVDALIIAASSQLNLWKKQK 758 
YP_002344900  699 -------------------------kDRNNHLHHAIDAVIIAYANNSIVKAFSD 727 
WP_081436766  709 -------------------------nREESDLHHALDAAVIACADRKIIKEITN 737 
WP_012859073  880 idtvepeiisilykmitalkeevyskNRENHLHHSLDAFLLTIMNRSMQMKLik 933 
WP_015423233  708 -------------------------dREESYFHHAKDAIIVACSTQGMVQYISK 736 
WP_011139289  728 -------------------------kDRESHTHHAVDAIIIAFSTQGMVQKLSE 756 
WP_014621379  730 -------------------------kTRDTYHHHAVDALIIAASIQLNLWKKQK 758 
WP_014748117  724 ----------------------adgkRVSDDRHHALDALAVAAISEREVQRLTR 755 
WP_077276356  736 -------------------------kTRDTHHHHAIDAAVIAVTPTLRIWKKEN 764 
WP_003611034  755 ---------------------stkgdRIPDDRHHALDAIVIAATTESLLQRATR 787 
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