2XWX,5FJQ,5L2V,5AA7,6RW7,5OPF,4OY6,4OY7,4OW5,6IF7,5FTZ,2BEN,5WSZ,4A02,2YOW,3UAM,4GBO


Conserved Protein Domain Family
LPMO_AA10
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cd21177: LPMO_AA10 
lytic polysaccharide monooxygenase (LPMO) auxiliary activity family 10 (AA10)
AA10 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs), which may act on chitin or cellulose. The family used to be called CBM33. Activities in this family include lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54), lytic cellulose monooxygenase (C4-dehydrogenating) (EC 1.14.99.56), lytic chitin monooxygenase (EC 1.14.99.53), and lytic xylan monooxygenase/xylan oxidase (glycosidic bond-cleaving) (EC 1.14.99.-). Also included are viral chitin-binding glycoproteins such as fusolin and spheroidin-like proteins.
Links
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Statistics
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PSSM-Id: 410624
Aligned: 345 rows
Threshold Bit Score: 100.459
Created: 22-Jan-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Cu binding site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H H x [FY]Click to see conserved feature residue pattern help
Evidence:
  • Structure:5OPF: Micromonospora aurantiaca lytic polysaccharide monooxygenase binds copper
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #                                                                               
2XWX_A         1 HGYVSAVengvaegrVTLCKFaangt------geknTHCGAIqyepqsvegp---------------------------d 47  Vibrio cholerae
6RW7_A         1 HGYIESPps-----rQQHCGAeqkpd------npssAKCDEAfanyraaggqnshwynf--------------msvvahh 55  Teredinibacter ...
5OPF_A         1 HGSVVDPas-----rSYSCWQrwggdfqnpamatqdPMCWQAwqadpnamwnwnglf------------------regva 57  Micromonospora ...
AIF91543      25 HGFVDSPga-----rNYFCGAvtkpdei-eagtaeyPACGDAfvndwngayqfmsv-------------------lnhhe 79  Cellvibrionacea...
TXI91590      25 HGYIEQPps-----rNYFCGAvtkpdqi-lygtpqyKECAAVfimpdgsinndgynym---------------silshtk 83  Neisseriales ba...
WP_071904958  25 HGLIQDPps-----rNWYCGAftkpdet--grpgeyAECADAfrddfsggyqfmsv-------------------lthaq 78  Cystobacter fer...
PTT90914      54 HGLIQDPps-----rNWFCGAitkpdqt-gngtaqyPECETAfatnrtgsynfmsv-------------------lthdl 108 Pelomonas sp. H...
WP_142905513  29 HGLIESPsa-----rNHFCGVitkpnea-gtpqaqyPVCAQAfenlgtqgynfmsvlthhrgrlrplpplsppqtppane 102 Cellvibrionacea...
WP_111642934  22 HGLINEPas-----rNWICGAvtkpd-----qaepgSICAEAfegdfnggyqfmsv-------------------lthsl 72  Marinimicrobium...
WP_143732512  24 HGLIQEPks-----rNQLCGVeikpd------qasgTICEEAfasdhlggyqfmsv-------------------lthtq 73  Microbulbifer s...

Feature 1                                                                   #                    
2XWX_A        48 gfpvtgprdGKIASAe--------sALAAALDeqtadrWVKRPIQagPQTFEWTFTa-nHv--TKDWKYYITkpnwnpnq 116 Vibrio cholerae
6RW7_A        56 egrkvvkgtEHVCGFdg------etWNPAPYDtp--anWPVTSFNsgQQTFVWDISygpHfsdTEELVFYITkpgfsfdp 127 Teredinibacter ...
5OPF_A        58 gnhqgaipdGQLCSGgrt-----qsGRYNALDtv--gaWKTVPVTn-NFRVKFFDQa-sHg--ADYIRVYVTkqgynalt 126 Micromonospora ...
AIF91543      80 grkvegpvtTNVCSFdse----nwdGARTPWDep--idWPTNDISagPMEFAWDISygpHfddTADFRYWITkpgfqyqv 153 Cellvibrionacea...
TXI91590      84 gakevrplpKNVCGFdse----afgHGKTLWDep--inWPTSNMKsgSNQFVWNISfgpHfsdTDQFRYWITkpdfkyqv 157 Neisseriales ba...
WP_071904958  79 gravvsplpQNVCGFnse----twrGGATPWDks--inWPTSTISpgPRTITWNISwgpHyddTEEFRYWITkpgfvyev 152 Cystobacter fer...
PTT90914     109 graavtplpENVCGFnsetfgkgatPWDTPMN------WPTNPVSpgRKKISWNISwgpHfsdTAEFRYWITkpgfqfsp 182 Pelomonas sp. H...
WP_142905513 103 aggvtpplaQHVCSYdse----sfdGNPTVWDqp--idWPTNNLQagRNRFTWNISwgpHfsdTQEFHYWITkpgfqftv 176 Cellvibrionacea...
WP_111642934  73 grkgvsplpDNVCGFdsstwdggptPWDKPLD------WPTHSVSagPLTISWDIAwgpHfddTEEFVYYITredfeyqv 146 Marinimicrobium...
WP_143732512  74 grsvvkqlpERVCGFdsetwnggptPWDSAID------WPIVNISagNRKFTWNISwgsHfedTEEFRYWITkpdfhfqv 147 Microbulbifer s...

Feature 1                                                                          # #       
2XWX_A       117 p--lsrdafdlNPFCVVEGnm------------vQPPKRVSHECIVPerEGYQVILAVWDv-gDTAASFYNVIDVK 177 Vibrio cholerae
6RW7_A       128 treltwadfedQPFCDESIvpgdfst-nsaveadMANSHINVTCNVPsrSGRHVIFAEWGrneHTYERFFSCVDVD 202 Teredinibacter turn...
5OPF_A       127 ---splrwsdlELVGQIGNtpasq------wtreVDGVSIQIPANAPgrTGRHVVYTIWQa-sHLDQSYYLCSDVD 192 Micromonospora aura...
AIF91543     154 gedlawsdfedQPFCDLDYdhanqsa-ypnvradTSTIHFYTTCNVPsrAGRHVIYAEWGrneHTYERFHGCIDVS 228 Cellvibrionaceae ba...
TXI91590     158 gkplswndfesTPFCEIKWtgqsts----tlqadYAANKFKMLCNVPvrKGRHVIYGEWGrtpSTYERFHSCMDVI 229 Neisseriales bacterium
WP_071904958 153 gkpltwddfetEAFCVLKYndknptg-npavvadKANSLFHTTCNVPqrEGRHVIYAEWGrnhYTYERFHGCVDVV 227 Cystobacter ferrugi...
PTT90914     183 tkalswadfeeQPFCTLKYddtqpsa-npdvvadKGATAFHTYCTLPqrGGRHVVYGEWGrnyFTYERFHSCMDVV 257 Pelomonas sp. HMWF004
WP_142905513 177 gtplawsdfeaQPFCQLAFdrenpga-npdivarVDDAKFDTFCDVPqrSGRHVIYAEWGrnyFTWERFHGCVDVV 251 Cellvibrionaceae ba...
WP_111642934 147 geplrwsdfeeEPFCDLTGyddtnpgatpniiprRDLVWFDTVCELPerSGRHVIYGEWGrnyFTFERFHGCIDVE 222 Marinimicrobium sp....
WP_143732512 148 gvplrwsdfesEAFCKLDYddtnptg-nlkiipdKDNSLFHTYCDVPerSGRHVIYAEWGrnqWTYERFHGCVDVM 222 Microbulbifer sp. GL-2

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