Conserved Protein Domain Family
XynE_like

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cd01830: XynE_like 
SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.
Statistics
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PSSM-Id: 238868
Aligned: 30 rows
Threshold Bit Score: 226.74
Created: 16-Aug-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this super-family
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Citation:PMID 7773790

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #                                        #                               
CAD21013  194 AIAILGNSITDGRGtttnaqnrwpd-----rmaealngetgVLNLGIGGNCVVeygi--sepaLKRFDRDILSqqGISSV 266 Prevotella bryantii
BAC75025  242 TVVVFGDSLVDGTGatpgadnrftdkl--aerlvadrrpldVVNAGIGGNRILndspcygdkaEDRFRRDVLDrpGLRTV 319 Streptomyces averm...
EAA66354  222 GLVILGDSITDGRGsddnknnrrwpdalaerlqrsnlghiaVNNEAAGGNAILaggl--gpplLDRYHRDALGqkGVKYV 299 Aspergillus nidula...
AAK24123  199 AIVAFGDSITDGYGvqpntnlrwtdg----lierlkgkniaVLNLGIGGNRVLadgl--gpsgVSRFDRDVLSqsGVSHL 272 Caulobacter cresce...
AAU34219  211 SLMVFGDSLMDGVGtspdtdnrfsdkl--aerliaagrpqgMTNAGLAGDPLLhdspcfgekgTARFAKELRDraALRTV 288 Streptomyces hygro...
EAL87181  225 SFAIIGDSITDGRGsdtngnnrwpdlllarmqkyrptssiaLLNQAAGGNRILadgl--gpnvLSRLDRDVLAhsGVRYA 302 Aspergillus fumiga...
EAA69045  223 AVVLLGDSITDGRGstddtndrwsdal-aahlqasgmknvaVNNMAAGGNAILqggl--gpplLQRYKRDALEqpGAKFV 299 Gibberella zeae PH-1
BAC71044  213 AVALLGDSVTDGFGstpgadrrws-------dalagrtgrpVLNAGIGGNLLLndsawygekgVHRLRRDVLGheGVDTL 285 Streptomyces averm...
EAQ86429  258 AFVILGDSITDGRGstddgndrwpdlllarlqkagnlshvgVNNQAAGGNAVLnggl--gptlLTRYERDALRvaGVKWV 335 Chaetomium globosu...
YP_590041 199 AIAILGDSITDGRGsttngndrwpdrlaerlaadpktagigVLNLGIGGNRLLldgt--gpraLDRLQRDIFAqsNVRWL 276 Acidobacteria bact...
Feature 1           #                                                                         
CAD21013  267 VIFEGTNDIgisnkn--------yehvadTLIASYRVLASRAKaKGLKVYGATITPtkg-------ngwYSLWHEAIRQT 331 Prevotella bryantii
BAC75025  320 IIHLGANDIgapemgdpcm-gsaprvtarQLIEGHKKLIRAAHaRGVKAVGATILPmkga-----lfpvYSERGEKVRAA 393 Streptomyces averm...
EAA66354  300 MIFEGVNDIgvsdpdte-----mqnqlfnSLVDAYLRIIRDCKnAGLTTIGATITPfgg-------sqyADPSRERTRLR 367 Aspergillus nidula...
AAK24123  273 IILEGVNDLgalnretaqd-aptnarmaqDLIGAFAGMVAKARaRGIKAIGATILPysgs-----ayyhPPAEAEAARQA 346 Caulobacter cresce...
AAU34219  289 FIHLGANDLaqsqqddpct-rnrppvtaqQLIDGHRALVRAAHaRGIKAIGVTILPlrsa-----vfpfTTPAGDKIRRQ 362 Streptomyces hygro...
EAL87181  303 MIFEGVNDIgvasadpa-----aqqrigdELLVAFRQIATRVQaAGIPIFGATITPfgtpvgsnytqpySSDEREKTRQR 377 Aspergillus fumiga...
EAA69045  300 VIFEGVNDIgpsatdaa-----tqkkikdGLIAAYQQIAGDIKkAGMTSIGATITQmlg-------nqyYAPEREVTRVA 367 Gibberella zeae PH-1
BAC71044  286 VVLLGLNDIgfsetdeqptykpapvveadELIAGHRELIRRSR-GRLRVVGATLLPfgg-------sdhWGEHAAKVSHE 357 Streptomyces averm...
EAQ86429  336 MVFEGVNDIggggtdsg-----tqngigsRLQQAFEKIARDCKaAGIKTIGGTITPfggn-----gqsySNPTREQTRVK 405 Chaetomium globosu...
YP_590041 277 IVLEGVNDLgtrpkekga---adagataaDILSAYQQIIREAHsHNIRVYGATILPfdg-------aayATSENVADQQK 346 Acidobacteria bact...
Feature 1                                          #  #                 
CAD21013  332 VNEWIRqTDVFDGVIDFDKAVRDPkdeqql-lpaysEDGLHLNPEGYRVMGEFAASFF 388 Prevotella bryantii
BAC75025  394 VNHWIRtSGAYDSVLDVDRALASPadpalprpgyvvEDGLHPNEAGSHAIASAVDLNA 451 Streptomyces avermitilis MA-4680
EAA66354  368 INEWILkHSPFDHTVDFSSFIGDGdqlra---efdsGDHLHPNVAAYKELARRLDLKI 422 Aspergillus nidulans FGSC A4
AAK24123  347 VNAWIRaPGNFDAVIDWDAALRDPvrpthl-lpaydNDGLHPNMAGYKAMADAIPLSL 403 Caulobacter crescentus CB15
AAU34219  363 LNHWIRtSHTYDAVLDADRVLTDPanpnrprpgyisQDGLHPSDAGYLALASAVDLNA 420 Streptomyces hygroscopicus
EAL87181  378 VNDFIRsSGVFDAVLDFDKVLRDPrapgvlaeefdsGDHLHPNVRGYQALADHFPLEV 435 Aspergillus fumigatus Af293
EAA69045  368 INEWILnNGTFDHTVDFASLIGKGdkllp---qydsGDGLHPNPVAYKEMGTKFPIKF 422 Gibberella zeae PH-1
BAC71044  358 VNEWIRrSGEYDAVVDLNRALADPadpgrlhpaydfGDHLHPNDAGYEVMAEAVAGVL 415 Streptomyces avermitilis MA-4680
EAQ86429  406 VNDWILkSGTFDATVDFGALIGDPsvksqlarqydgGDHLHPNVAGYQAMANGFPLDF 463 Chaetomium globosum CBS 148.51
YP_590041 347 INDWMRtSRAYDAVIDFAKLLADPshpdrllpafdtGDHLHPSAPGYKAMGDAIPLSL 404 Acidobacteria bacterium Ellin345

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