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Sublancin This family represents sublancin, a small bacteriocin active against Gram-positive bacteria. This family appears to be restricted to Bacilli. Sublancin was thought to be a lantibiotic but was later shown to be an S-linked glycopeptide. Glycosylation is essential for its antimicrobial activity. Sublancin is biosynthesized as a precursor peptide bearing an N-terminal leader peptide, and a C-terminal core peptide that is converted into the mature peptide. Sublancin comprises two alpha helices and a well-defined inter-helical loop. Sublancin inhibits B.cereus spore outgrowth, after the germination stage, approximately 1000-fold better than it inhibits exponential growth of the same cells and inhibits B.subtilis strain ATCC6633 and B. megaterium strain 14581. |
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PubMed References
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Jiyao W et al.(2023). "The conserved domain database in 2023.",