Conserved Protein Domain Family
HAD-SF-IB-hyp1

?
TIGR01490: HAD-SF-IB-hyp1 
HAD-superfamily subfamily IB hydrolase, TIGR01490
This hypothetical equivalog is a member of the IB subfamily (TIGR01488) of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The sequences modelled here are all bacterial. The IB subfamily includes the enzyme phosphoserine phosphatase (TIGR00338). Due to this relationship, several of these sequences have been annotated as "phosphoserine phosphatase related proteins," or "Phosphoserine phosphatase-family enzymes." There is presently no evidence that any of the enzymes in this model possess PSPase activity. OMNI|NTL01ML1250 is annotated as a "possible transferase," however this is due to the C-terminal domain found on this sequence which is homologous to a group of glycerol-phosphate acyltransferases (between trusted and noise to TIGR00530). A subset of these sequences including OMNI|CC1962, the Caulobacter crescentus CicA protein cluster together and may represent a separate equivalog. [Unknown function, Enzymes of unknown specificity]
Statistics
?
PSSM-Id: 273654
Aligned: 10 rows
Threshold Bit Score: 197.178
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
CAC25181     105 AAFFDVDNTLIQGSSLIVFAQGLFRKKFFTIKEILPVVWKQVKFKLTg-sENADDVSRGREQALEFIKGRPVQELVDLCE 183 Corynebacterium...
CAA09091      21 LVAFDFDGTLTVKDSFNAFLKWRAGPRWSFGVLRLTPALIAYVFDRN---RGKLKAAAVRQFLKGATVAQIENDARAFAE 97  Caulobacter cre...
AAK80184       4 LAIFDVDYTLTKKETLFEFYKFMISKNPKI-IAKLPKILVAGILFFA---KILDAGKAKEMFIS-FIDGIKEEDMKEYVK 78  Clostridium ace...
O69629        27 AAFFDLDKTIIAKSSTLAFSKPFFAQGLLNRRAVLKSSYAQFIFLLSg--ADHDQMDRMRTHLTNMCAGWDVAQVRSIVN 104 Mycobacterium t...
CAB82873       8 AAFFDIDGTLTATTTMFDFLAHHLSLHGRPSEYAALHGRLRAMTEAGa-gRADRCRAYYRVYAGVEERGLLAEGERWFLD 86  Streptomyces co...
AAK78244       5 AAFFDIDGTLYREGLISEVFKKLIKYEIIDEEKWYKEVRPEFEKWDNrkgDYDDYLLKMTEIYVDALNGLSKSQVEFIAS 84  Clostridium ace...
WP_000042815   5 LYVFDLDDTLIDGDCAMIWNAFLAEKGIATERNFVEEDRRRMALYAQ----GKMDMAEYIAFAMQPLAQVPSTTVQDWVE 80  Vibrio cholerae
WP_005875092   6 IAIFDFDGTLTRCDSLLPFLR-QAQPVILF-WLRLPFYLAMWMCYKL---RLAPADRTKAAILSTVLKGKREVECRAMGQ 80  Porphyromonas g...
WP_031682951  20 GAFFDLDGTLVAGFTAVILTQERLRRRDMGVGELLGMVQAGLNHTLG---RI--EFEDLIGKAAAALAGRLLTDLEEIGE 94  Mycobacterium t...
WP_002857947   6 LALFDFCETLTNFQTLDRYLPLAGSKNINYTQS---KNLARRERFQR---ENLPYPRYEWLIDLDVDLAEEIAQEFVYTD 79  Campylobacter j...
CAC25181     184 EIVDqrmaDKMWPGTKQLADMHIAAGHQVWLVSATPVQLAQILAQRLGFTGAIGT-VAEAKDGVFTGRLVGDILHGPGKR 262 Corynebacterium...
CAA09091      98 AFAP----SLLRPDAVAVWRGWRAKGAKMVIVTASPDLIVAPFARGLGADLLIGTrLRCSDDGRILGGLDGNNCRAKEKV 173 Caulobacter cre...
AAK80184      79 EFYDlklsKILYVDAINTMKKLKSEGYDIFLISASAEFYLNELYNIKEVDRVIGTrFTN-ENGIFRRKIIGENCKGEEKV 157 Clostridium ace...
O69629       105 ETLHdivtPLVFAEAADLIAAHKLCGRDVVVVSASGEEIVGPIARALGATHAMATrMIV-EDGKYTGEVA-FYCYGEGKA 182 Mycobacterium t...
CAB82873      87 RVRTp---GFFHEPARAAFDAHAAAGDLTVLVSGSFDACLEPLAEHLGADVLLCS-RPEVHDGRYTGALT-TPMIGAAKA 161 Streptomyces co...
AAK78244      85 QVVNqk-gERVYTYTRDRIKWHKERGHKIITISGSPIELVRNMAEKYGFDDYRGAeYLLDENDVYTGEVI-PMWDSKSKE 162 Clostridium ace...
WP_000042815  81 ECVSrwivPKQFAQARELIAQLKQQGNTCLIISASVSFLVKTVAQRFGIEHALGIdLV-SQNGCYSGNIEGVASYREGKV 159 Vibrio cholerae
WP_005875092  81 RFVPai-eSILRPEALRCLEWHRSEGHRLVLLTASLLPCVEPWAEKTGFHTVIAT-LPEIKSGILTGRFEGNNCKGKEKI 158 Porphyromonas g...
WP_031682951  95 RLFAqrieSRIYPEMRELVRAHVARGHTVVLSSSALTIQVGPVARFLGINNMLTNkFETNEDGILTGGVLKPILWCPGKA 174 Mycobacterium t...
WP_002857947  80 VMAN------LNQNVMDRLFWHQDEGHTIVIVSGGLTIYIKEFARIYNIENIVAVdLEIYKN-KLTGNIDGIHTMQERKL 152 Campylobacter j...
CAC25181     263 HAVAALASIEQLdl--tRCTAYSDSINDLPMLSMVGTAVAVNPdSKL 307 Corynebacterium glutamicum
CAA09091     174 IRLREVFGPDVR-----LTAAYGDTSGDTEMLAIADEKGYRIF-RGK 214 Caulobacter crescentus CB15
AAK80184     158 KRLKEVLEEEKIevdfkESYMFSDSLSDMPLFKLVGHPYLVNP-KKR 203 Clostridium acetobutylicum ATCC 824
O69629       183 QAIRELAASEGYpl--eHCYAYSDSITDLPMLEAVGHASVVNPdRGL 227 Mycobacterium tuberculosis
CAB82873     162 AAVSALVAERSLsl--kDSHAYGDHVSDVPFMELVGHPVVVGRdPRM 206 Streptomyces coelicolor A3(2)
AAK78244     163 RAVHELEAKYNIdl--gESYAYGDTSGDLTMLKMVGNPVCINPtKEL 207 Clostridium acetobutylicum ATCC 824
WP_000042815 160 LRLQQWLAEQNEty--hDVHFYTDSINDLPLCQHADFAYVVNPcPRL 204 Vibrio cholerae
WP_005875092 159 HRLDRALPHWRDs----ISYGYGDSPSDRPLLSLCTHSYYRRFpal- 200 Porphyromonas gingivalis
WP_031682951 175 TAVQRFAAEHDIdl--kDSYFYADGDEDVALMYLVGNPRPTNPeGKM 219 Mycobacterium tuberculosis
WP_002857947 153 YKLAQKFNLKQFdl--kNSYAYSDCVSDIPLLSLVGNPNVIECgKDL 197 Campylobacter jejuni
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap