Conserved Protein Domain Family
PRK12862

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PRK12862: PRK12862 
malic enzyme; Reviewed
Statistics
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PSSM-Id: 183799
Aligned: 97 rows
Threshold Bit Score: 1119.97
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
33595833   28 TYVIAIMDANFRKAALEYHEHGRPGKISVTATKPLVTQRDLSLAYSPGVAAACEEIVEDPANVFRYTGRGKLVGVITNGT 107
76800721    1 --------MGLEEDALEYHRTDPPGKLEISTTKPTNTQRDLSLAYSPGVAAPCSEIADDPEAAYTYTTKGNMVGVVSNGT 72 
148265506   1 --------MSKKMDALDYHSIGRKGKIEVISTKPCQTAADLSLAYSPGVAEPCLAIQQNPEDAYKYTAKGNLVAVVSNGT 72 
167648923   1 -MSDAEKKTFTDEEALNFHRYPTPGKIAIVPTKPMATQRDLSLAYSPGVAVPVHAIAADPDMAYEYTSKGNLVAVISNGT 79 
197106879   1 -MSDAEKRTFTDEEALSFHRLPRPGKIAIAATKPMATQRDLSLAYSPGVAVPVLKIADDPEAAYDYTSKGNLVAVISNGT 79 
197118271   1 --------MSKKLGALDYHSSGRKGKIEVIATKPCQTAADLSLAYSPGVAEPCLAIQENPDDAYKYTAKGNLVAVVSNGT 72 
221236599   5 DMSDAERKTFTDAEALAFHRYPTPGKIAIVPTKPMATQRDLSLAYSPGVAVPVHAIAADPDMAYEYTSKGNLVAVISNGT 84 
295687582   1 -MSDAERKTFTDAEALAFHRYPTPGKIAIVPTKPMATQRDLSLAYSPGVAVPVHAIAADPDMAYEYTSKGNLVAVISNGT 79 
302381626   1 MPDQTDKQTFSDQEALDFHRLPLPGKISMAPIKPMATQRDLSLAYSPGVAIPVLAIAADVDKAYDYTSKGNLVAVISNGT 80 
114569883   2 AESTYRADTQLDADALAFHMKPTPGKLSVASTKPMATQRDLALAYSPGVAAPVRAIAADPDTVYDYTSKGNMVAVVSNGT 81 
33595833  108 AVLGLGNIGALASKPVMEGKAVLFKKFAGLDVFDIEINETDPDKLVEIIAGLEATFGGINLEDIKAPECFTVERKLRERM 187
76800721   73 AVLGLGDIGAQASKPVMEGKGVLFKRFADIDVFDIELDEDDPAAFAESVARMEPTFGGINLEDISGPECFEIESYLREQM 152
148265506  73 AVLGLGNLGALAGKPVMEGKGILFKRFADIDVFDIELDTENPDEIIKACQLLEPTFGGINLEDIKAPECFYIEETLKKTM 152
167648923  80 AILGLGDLGALASKPVMEGKSVLFKRFGDVDSIDIEISSKDADEIITVVKNIGITFGGINLEDIKSPECFRIETELQELL 159
197106879  80 AILGLGDLGALASKPVMEGKGVLFKRFADVDAIDVEVASKDADEIITVVKNIGLTYGGINLEDIKSPECFRIETELQELL 159
197118271  73 AVLGLGNLGALAGKPVMEGKGVLFKRFADIDVFDIELNTENPDEIIKACQLLEPTFGGINLEDIKAPECFYIEEQLKKTM 152
221236599  85 AILGLGDLGALASKPVMEGKSVLFKRFGDVDSIDIEVTTKDPDEIITVVKNIGVTFGGINLEDIKSPECFRIETELQELL 164
295687582  80 AILGLGDLGALASKPVMEGKSVLFKRFGDVDSIDIEVTSKDPDEIITVVKNIGVTFGGINLEDIKSPECFRIETELQELL 159
302381626  81 AILGLGNLGHMASKPVMEGKAVLFKRFADVDSFDVEVKTTDPDEFITVVKNIGDTWGGINLEDIKSPECFVIESELQDLL 160
114569883  82 AILGLGNLGPAASKPVMEGKAVLFKRFADIDAVDIEVDYTDPEKFIACVRGFGDTFGGINLEDIKSPECFEIETRLREEL 161
33595833  188 KIPVFHDDQHGTAITVCAAVVNGLAVAGKRIEDVKLVTSGAGAAALACLDLLVDLGLPLEHIWVTDIEGAVYQGRTALMD 267
76800721  153 DIPVFHDDQHGTAIISGAALLNACEIADKSISDLNITFSGAGAAATATAEFYVSLGVAPENITMCDIDGIITEDRVANDD 232
148265506 153 NIPVFHDDQHGTAIISSAALLNALHLVDKKIEDIRIVVNGAGAAANSCAKLAIALGVKPNNMIMCDTKGVIYKGRVEGMN 232
167648923 160 DIPVFHDDQHGTAIICAAGLINACHITGKKLEDVRVVLNGPGAAGIASLELIKAMGVRPENCIAVDSKGVLYQGRTEGMN 239
197106879 160 DIPVFHDDQHGTAIITAAGLINACEITGRKLSDIKVVLNGPGAAGIATLELIKAMGVPHDNVLAVDRKGVLWRGRPEDMN 239
197118271 153 NIPVFHDDQHGTAIICSAALLNALMLVQKKIEDIRIVVNGAGASANSCAKLAIALGVKPNNMIMCDTKGVIYKGRVEGMN 232
221236599 165 DIPVFHDDQHGTAIICAAGLINACHITGKKIEDVKVVLNGPGAAGIASLELIKAMGVRAENCIAVDSKGVLYRGRTEGMN 244
295687582 160 DIPVFHDDQHGTAIICAAGLINACHITGKKLEDVKVVLNGPGAAGIASLELIKAMGVHPANVIAVDSKGVLYEGRTEGMN 239
302381626 161 DIPVFHDDQHGTAIISTAGLINACHITGRRFEDVKMVLVGAGAAGLSSLSLMKSLGVRPENATVVDLHGVIYRGRTEGMD 240
114569883 162 DIPVFHDDQHGTAIIAAAGLINACDLTGRRMEDLKVVLCGAGAAGLTVLELIESMGVKSANTIVVDIDGVVYEGRPGGHE 241
33595833  268 PDK--ARYAQPTEARTLAEVIEGADVFLGLSAGNVLKPEMVATMAANPLILALANPNPEILPEAAHAVRDD-IIMATGRS 344
76800721  233 PHSyvEPFAEPAGG-DLADAIAGADVFVGLSVGGIVSPEMVQSMAEDPIIFAMANPEPEIGYEAAKQARDDtVIMATGRS 311
148265506 233 PYK--ELFAADTHFRTLEEAADGADVLFGLSVKGAFTPEMVASMAPNPVIFAMANPDPEITPEAALAVRSD-VMIATGRS 309
167648923 240 QWK--SAHAVDTPLRTLAEAAKGADVLLGLSAKGAFTPEIIASMAPNPVIFAMANPDPEITPEEVHAVRKD-AIMGTGRS 316
197106879 240 QWK--SAHAVDTDKRTLAEALEGADVFIGLSAKGALNGELVRAMAPKPIIFAMANPDPEITPEEVYKVRPD-AIVATGRS 316
197118271 233 PYK--ELFAAETHFRTLEEAAVGADVLFGLSAKGAFTPEMVRSMAPNPIIFAMANPDPEITPEEAHGVRGD-VIIATGRS 309
221236599 245 QWK--SAHAVETDKRTLAEAVVGADVLLGLSAKGAFTPEMIASMAPNPVIFAMANPDPEITPEEVKRVRKD-AIMGTGRS 321
295687582 240 QWK--SAHAVKTDKRTLAEAVAGADVLLGLSAKGAFTPEMIASMAPNPVIFAMANPDPEITPEEVHAVRPD-AIMGTGRS 316
302381626 241 QWK--SVHAIDTDKRTLAEAMVGADVVLGLSAKGAITPAMVATMAPRPIIFAMANPDPEITPEEVLAVRKD-AIIATGRS 317
114569883 242 RLN---RHAIKTDKRTLADAAEGADVLLGLSAAGVFTKDIVASLAPNPIIFAMANPTPEITPEEVKEVRND-VIMATGRS 317
33595833  345 DYPNQVNNVLCFPYIFRGALDVGATTITREMEKAAVLAIASLAREEQNEVVAAAYGTYDISFGRDYLIPKPFDPRLIVRI 424
76800721  312 DYPNQVNNVLGFPFIFRGALDVRATEINQEMKVAAAEALANLAKQDVPDAVVKAYGDQPLQFGPEYIIPKPLDPRVLFEV 391
148265506 310 DYPNQVNNVLGFPFIFRGALDVRATCINEEMKLAAVKALAKLAREECPDSVCKAYGNQKFVFGPNYIIPKPFDPRVLLHV 389
167648923 317 DYPNQVNNVLGFPYIFRGALDVRARRVNHEMKIACANALAMLAREDVPDEVAAAYHGRQLKFGPQYIIPSAFDPRLIWYV 396
197106879 317 DYPNQVNNVLGFPYIFRGALDVRARRVNMEMKIACARALAQLAREDVPDEVAAAYHGTQLKFGPEYIIPTPFDPRLIWYI 396
197118271 310 DYANQVNNVLGFPFIFRGALDVRATAINEEMKLAAVHALAKLAREEVPDSVSKAYGNEKFSFGPTYIIPKPFDPRVLLHV 389
221236599 322 DYPNQVNNVLGFPYIFRGALDVRARRVNHEMKIACAQALAMLAREDVPDEVAAAYHGRQLKFGPDYIIPSAFDPRLIWYV 401
295687582 317 DYPNQVNNVLGFPYIFRGALDVRARRVNHEMKIACAQALAMLAREDVPDEVAAAYHGRQLKFGPQYIIPSAFDPRLIWYV 396
302381626 318 DYVNQVNNVLAFPYLFRGALDVRARRINHEMKIACAHALAQLAREDVPDEVAVAYRGRKLRFGPDYIIPTPFDPRLIWYI 397
114569883 318 DYPNQVNNVLGFPYIFRGALDVRARTINEEMKIAAAQALAALAREDVPDEVAQAYKVDRLQYGPDYIIPTPFDPRLISWV 397
33595833  425 APAVAKAAMEGGVATRPIADLDAYAEQLQQFVYHSGAFMKPLFSQAKQIvrdggRARIVFTEGEDERVLRAVQVIVDEKV 504
76800721  392 SGAVAEAAMESGVARDDL-DLDTYREELEARLGKSREMMRVVLNKAKSE-----PKRLVLAEGDDPKMIRAAYQLVEQGI 465
148265506 390 APAIAQAAMDSGVARQPIEDMAKYIEHLEKTQGKSKEIMRMIINKAKSD-----PKKIVFPEGENEKILRAAKELVEEGI 464
167648923 397 PPFVAQAAMDTGVARKPIADMDAYRASLAQRLDPTAGFLQKISGAVLAN-----PKRIVFAEGEDPTVIRAAYAYQTGGF 471
197106879 397 PPFVAQAAMDTGVARKPIEDMDAYRAALAQRLDPTAAFLQKLQGAVLSGp----RKKVVFAEGEEPSVIRAAYAFQSAGL 472
197118271 390 APAIAQAAMDTGVARLPIADMGKYIEQLESSQGKSKEIMRMIINKAKSD-----PKKVVFSEGEDDKILRAAQVLVEEGI 464
221236599 402 PPFVAQAAMDTGVARKPIADMDAYRAGLAQRLDPTAGFLQKISGSVLAN-----PKRIVFAEGEDPSVIRAAYAYQSGGF 476
295687582 397 PPFVAQAAMDTGVARKPIADMDAYRAGLAQRLDPTAGFLQKISGAVLAN-----PKRIVFAEGEDPSVIRAAYAFQTGGY 471
302381626 398 PPFVAQAAMDTGVSRVTIDDMDAYRARLRERVDPSAALMQKISSAVRAAp----NRRVVFAEGEESTVIRAAWAFKQAEL 473
114569883 398 PPFVAQAAIESGVARRPLEDSEAYKQVLARRLDPTAAVQQRITASIRAA-----QKTIVFAEGEEQAVIRAAHAFQVQGL 472
33595833  505 AKPILVGRPQVLLSRIEKFGLRLRLGQDVEVCNPEYDERFHQYWTTYWELMCRNGITKEMARVEMRRRL-TLIGAMMVHL 583
76800721  466 AHPILVGDKRAIWEQAAELGLDFDP----EIVDPA-TDELDPYAERLYELRKRNGVTRREADGRVRDGN--YLASVMVEM 538
148265506 465 ARPVLIGDRTKILQKMAELAIEL----DVPIIDPADSELTEKYAAELYQVRQRKGLTLSESQRILRRKSrTHFGSMMVRM 540
167648923 472 GKAILCGRENLVHENMRVVGLD-PETAGLEIVNARLSDRNPDYVDALYARLQRQGYLKRDVQRLINQDR-NSFAASMVTL 549
197106879 473 GEAILVGREELVHENMLLAGLS-PAEAKLQVINARLSPWNEVFVDNLYARLQREGYLRRDVQRLINQDR-NAFAASMVAL 550
197118271 465 AKPILIGDQKKIKQKMDDLNLDL----DVPIMDPSDSEFTEEYAAELYRLRQRKGLTISECRRIMRRKSrAHFGNMMVHM 540
221236599 477 GKAILCGRENLVHENMKLVGLD-PDTAGLEIINARLSDRNPDYVDALYARLQRQGYLKRDVQRLINQDR-NSFAASMVTL 554
295687582 472 GKAILCGRENLVHENMKLVGLD-PETAGLEIVNARLSDRNPDYVDALYARLQRQGYLKRDVQRLINQDR-NSFAASMVTL 549
302381626 474 GTPILLGREDLIRKNAAEAGLS-FDEMGIEIVNARVSEMNDAYTDWLYEKLQRRGYLRRDVQRMINQDR-NYFAAAMVAR 551
114569883 473 GKAILVAREDVVAANMKELGI---PAGSLEVCNARLSEHNSEYADYLYERLQRKGYLRRDVQRRVNNDR-NVFSACMLKM 548
33595833  584 GDADGMICGAVSGFHDHLRFIDQVIGRKPGATTYAAMNILLLDERTVALVDTHVNEDPSAEQIAEYTVAAAEEMQRLGLA 663
76800721  539 GDADAMLTGLTNHYPTALRPPLQVVGTADDADYAAGVYMLTFKNRVVFVADATVNQSPDEEVLAEVAQHTAELARQFNVD 618
148265506 541 GDADALLGGIDTHYPETIRPALEVVGKQQGLSSVHGLYMMVSRKDVYFLADTTVTIDPTAEELAETAILAAEKVRMLDLE 620
167648923 550 GEADGMVTGVTRSFDQALEEVLRVVDPAPGGR-IMGMSVVLAKGRTIFVADTNVTELPEAEELVEIACEAARAVTRLGFK 628
197106879 551 GHADGMVTGVTRAYDQVLEEVLRVIDPAPDGR-VMGMSVVLAKGRTLFIADTNVTEMPEAQDLVEIAIEAARAVKTLGYR 629
197118271 541 GHADALLGGIDTHYPETIRPALQVLGKQGGLSSVHGLYMMVSKQNVYFLADTTVTIDPTAEELAETAILAAEMVTKLDIE 620
221236599 555 GEADGMVTGVTRSFDQALEEVLRVVDPAPGGR-IMGMSVVLAKGRTIFVADTNVTELPEAEELVEIACEAARAVRRLGFK 633
295687582 550 GEADGMVTGVTRSFDQALEEVLRVVDPAPGGR-IMGMSVVLAKGRTIFVADTNVTELPEAEELVEIACEAARAVRRLGFK 628
302381626 552 GQADAVVTGTTRNFNMVLKEIRRVLDVKDS---LIGLSIVLAKGRTIFVADTSIHELPDAQELADIAIQAAATVRKLGRT 628
114569883 549 GHADGMVTGVTRHSNVVMKDVELVLDPIEGSR-PVGVTIAITRGRSLVIGDTSVTEFPDAQALAEIAEVTANAARRFGIT 627
33595833  664 PKVALLSRSNFGSGSSASGAKMRHALELVNRQA-PGLEIDGEMHGDCALDESLRLRLLPDSPLKGSANLLVCPNVDSGNI 742
76800721  619 PRVALLSYSDFGTVDNEGTRKPRQAAEMLRDDDaVDFPVDGEMQADTAVVEEMLTGDYSFADLDEPANVLVFPNLEAGNI 698
148265506 621 PRVAMLSFSNFGSVKHPQALKVRRAVEIVKERA-PELIVEGEMQADTAVVPELLEG-FTFSKLKTNANILIFPDLNSGNI 698
167648923 629 PRVAFMSYSTFGNPMGLRSEKVREAVAMLDEMD-VDFEYEGEMPPELALDPERRAN-YPFMRLTDSANILIMPAIHAASI 706
197106879 630 PRVAFLSYSAFGNPMGERSEKLREAVAMLDEMDgVDFEYEGEMPPEIALEPERRGN-YPFMRLTGPANVLIMPAIHSAAI 708
197118271 621 PRVAMLSFSNFGSVDHPQTRKVKRAVEIVKERA-PNLIVEGEMQADTAVVPDLLDG-FTFSKLKTPANILIFPDLNSGNI 698
221236599 634 PRVAFMSYSTFGNPMGLRSEKVREAVAMLDEME-VDFEYEGEMPPELALDPEKRAN-YPFMRLTDSANILIMPAIHAASI 711
295687582 629 PRVAFMSYSTFGNPMGLRSEKVREAVAMLDEMD-VDFEYEGEMPPELALDPERRAN-YPFMRLTDSANILVMPAIHAASI 706
302381626 629 PRVAFLSYSTFGNPPGERGDNVRAAIRILDAKG-VDFEYEGEMPPELALDPGQRAN-YPFMRLSRDANVLVMPALHSAAI 706
114569883 628 PHLAFLSYSSFGNPPGERTAKIQQAVEILDAQG-ADFEYEGELAADVALDPD-HHKLYPFSRLTQPANVLIMPAIHSASI 705
33595833  743 AYNLLKTVAGKNVAVGPILLGANAPVHIVTSSATVRRIVNMAAMAVVNADAVR 795
76800721  699 AYKLLQRLG-GAEAIGPMLVGMDKPVHVLQRGDEVKDIVNLASVAVVDAQNDA 750
148265506 699 CYKLLHHLG-GAEAIGPILMGMNKPVHVLQRGDSVDDIVKMAAIAVVDVQNI- 749
167648923 707 STKLVQSLGGATV-IGPVLLGLSKPIQIAPLSASVSKILNMAMMAAYEGAGDL 758
197106879 709 STALLKSMGGATV-IGPILLGLSKSVQICPLSASVSRILQQATLCAYDRPLAE 760
197118271 699 CYKLLHHLG-GAEAIGPILMGMNKPVHVLQRGDDVNDIVNMAAIAVVDVQNL- 749
221236599 712 STKLVQSLGGATV-IGPVLLGLSKSVQIAPLSASVSKILNMAMMAAYDQPVDD 763
295687582 707 STKLVQSLGGATV-IGPVLLGLSKSIQIAPLSASVSKILNMAMMAAYDQPVGD 758
302381626 707 STQLVQALG-GATVIGPLLVGLEKSVQIVSLGASVSEIITAATFAAYEEGGSV 758
114569883 706 AVRLLKAAGGATV-IGPMLVGLEKPVQIARLGANVTDIVNLAGIAAFDLNKVP 757
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