Conserved Protein Domain Family
TPR_hemY_coli

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TIGR00540: TPR_hemY_coli 
heme biosynthesis-associated TPR protein
Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. [Unknown function, General]
Statistics
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PSSM-Id: 273126
Aligned: 17 rows
Threshold Bit Score: 289.188
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012345802  20 TLGANDGVVSIYWSPWRVDLSLNFFVLLLLASGAAVYIAVGSINRLVGLPERARLWRLQRRERAAQMALRESLGLLFSGR 99  Leptothrix chol...
WP_000620221  20 QYAGQQGYVLISIANRTIEMSVTTLVIFIIGALAALFALEFLVKKILYTSFHTWNWFSVRKQRRSRRYTNEGIIKLLEGD 99  Vibrio cholerae
WP_005694537  20 YISGQQGYVRIETANRIIEMSITTLVIFFIISLAIIYAFEWGVTRFFRLSRSSYQWFSNRKRVKAQKQTLEGLVKMDEGD 99  Haemophilus inf...
WP_019080200  20 MLAGHQGYVLIQTDNYNVETSVTGLVIMLVLVLVAFLIVEWILRRIFRTGARTRGWFLGRKRTRARKQTKAALIKLAEGD 99  Yersinia entero...
WP_010945525  20 YLAGSQGYVRIETDSKVIEMSLVMLVVFFIMAMSMVYIIEWTIIRFFRLSKGSYSWFFHRKQKQAQQETLEGLMKFREGD 99  Haemophilus duc...
WP_005772915  20 eMTRDTGYLLIVYRHWSIETTLWAAILSLLILFILFYIIFRLLGRAARLSKNIHRWRKMKQYRRARQLTTAGLCELAEGR 99  Coxiella burnetii
WP_012488959  22 LAQGD-GYLLIAFGTKTIEMTLWMAAMLGVLLYGVIWLIRQLIQGSIHVTRRFREIFLFGSVERAQKRAASGMVDYLTGD 100 Cellvibrio japo...
WP_004526333  22 VGRFDTGQVLIVYPPYRIDVSLNFFVLAIIVAFIVLYALMRIVRNVWRMPQRVAAYRARMRNERAQAALRDALANLYAGR 101 Burkholderia ps...
WP_011002278  20 FTELNLSNVVLLYPPYRVDVSLNFVLASLVLVFVVLHLLLRLFHHVTGMPARAAAYRERTRILRASAALRDAMESLFAGR 99  Ralstonia solan...
WP_011040946  20 FLIDEKGYILIAMGNTTIELTVLSAGIMLTLLFIALVISLKLLRGGLNISFGTWNKLAFAGQRRGIANFNKGLAAYMLED 99  Colwellia psych...
WP_012345802 100 YSRAHKAAqraleiraltTELTADVEFGALAHLLAASSLHRLQDRTRRDEQLGRALGm---LGAPALPTpvaegaRLLAT 176 Leptothrix chol...
WP_000620221 100 WTQAEKKV----------TRWANHHDMPLLCYLVASEAANGMGDRAKRDRYLALAAQ----QNNSTLAV------ELTRA 159 Vibrio cholerae
WP_005694537 100 YAKAEKLI----------GKNAKHSAEPVLNLIKAAEAAQQRGDEFSANRYLIEATEl---AGSDNLLV------EIART 160 Haemophilus inf...
WP_019080200 100 FKQVEKLL----------TRNADHAEQPMVNYLLAAEAAQQRGDEFRTNQYLERAAEv---ADTDQLPV------DITRV 160 Yersinia entero...
WP_010945525 100 YSKAEKLF----------SKNAKHAGSPILNLIKAAEAAQQRGDEFNANKYLIEASQl---SPNS-VVV------ELTRA 159 Haemophilus duc...
WP_005772915 100 WPSAEQKL----------VKGAKITKNPLVNYLAAAQAANAQQSYERRDNYLRLAHTk---AKGSDIAV------DLTQA 160 Coxiella burnetii
WP_012488959 101 WVEARKKL----------VRTFEKIEFPLPNYLAAARSSFEMGDEEEAERLLELARQ----HPNSELPV------VLTRA 160 Cellvibrio japo...
WP_004526333 102 FSRAEKAA----------RDALAVDANQSAASLVAAAATHRMHEYARRDEWLAKVSG-----QEWQDAR------LLATA 160 Burkholderia ps...
WP_011002278 100 FGRAERLA----------REAQAWEPQRETAALIGARAAHRMQETDRRDAWMAEVT-----SPDREQAK------LVSMA 158 Ralstonia solan...
WP_011040946 100 YSQAEALF----------AKSAIPSKRKQSAYLLAASASAKLDLNSNTNHYLALLEKetvkLKDVGLES------VIVNI 163 Colwellia psych...
WP_012345802 177 EWAIDDRD---PDRAFEQLAQLPAGVARRTQALRLRLQAARLSRQPLEALKTARLLAKHQGFAPVAAHGILRSLAIEVLD 253 Leptothrix chol...
WP_000620221 160 KQQLGDGD---NQAALETLTQLQRNHPHNTVVLNLLKQCYQALGEWQPLLALLPKLVKAKRLSNEEAQQLEITAQRGILQ 236 Vibrio cholerae
WP_005694537 161 RILLQQNK---LPAARSSVDSLLEMARRNKEVLKLAVEIYLRSKAYQALDKILDNVANSGLFNDEEFKDLRSKTENGLLD 237 Haemophilus inf...
WP_019080200 161 RIQLAQGH---VHAARHGVDRLLDQAPRHPEVLRLAEQAYLRSGAYSSLLEILPAMSKVQVHTAEEIAALEQQAYIGMMN 237 Yersinia entero...
WP_010945525 160 KILVQQNK---LPAARSAIDSLIELAPRNTEVLRLAIDIYKQSKAFNVLDAVLENVGQNSFLSTEEYIALEHFVNDGLLD 236 Haemophilus duc...
WP_005772915 161 RLQISKNQ---WEQALATLERVNRANPNHACTLQLLKQVYVHLQDWEKLRHLLPRLRKQKVESAEALDAFEKIIYVNLLS 237 Coxiella burnetii
WP_012488959 161 RLQIQAGR---YEQALAIIKPIELEQPRLPAVLDLLHQIYLAQNNWRALQEMFPAMRKAKVLSAPELQELETRLAVEQLG 237 Cellvibrio japo...
WP_004526333 161 DMRADGRD---AEGALAALAEMQASGGKRIHAQQIALRAQQQNKNWAEVLKIAKALEKREALHPAAAVRLRQQAAEHLLR 237 Burkholderia ps...
WP_011002278 159 ELLVDARD---ADGALEKIAQLQAQGARQIQAQRIALRAHQHLKNWNEVLRLTRALEKRNAIHSVLAARLKQMACETLLQ 235 Ralstonia solan...
WP_011040946 164 KLLMNQDKtetYAKARALIDENHKQIGHDARLLALEIDLCIIEQRFAQAVQYIAAARKEKTILDETVQTWEQLAYYGSFN 243 Colwellia psych...
WP_012345802 254 t---ARDADQLR--------RIWLQLDPADRRDPVVTARAASLAAELDAVTDGRGWLRPHWEHihqlGER---ERaaVLR 319 Leptothrix chol...
WP_000620221 237 diasPKGSEGLM--------QHWAQLSRKLKAEPELLMCFITQLIQRKADYEAFSMIKESLKK----QAT---PE--LYA 299 Vibrio cholerae
WP_005694537 238 ekmnEEGIDGLL--------TWWNQQPRHRRNNIELKISLIQRLIDCNDHESATELTFEILKKlgdnTAI---SLp-LCT 305 Haemophilus inf...
WP_019080200 238 qcmaEEGSDGLK--------RWWKDQSRKVRNEIPLQVALAEHLIECDDSDVAQQIILDGLKR----QYD---ER--LVL 300 Yersinia entero...
WP_010945525 237 ekmnEEGQDGLL--------TWWENQPSRIRKSIYVRTGLIQRLIDTEDHESAEQIALETFKK----YEDkqlLS--LLK 302 Haemophilus duc...
WP_005772915 238 aa-dRKGKQALI--------AMWNSFPRRSTQEIELIDVYTHSLIKYDEGDKAIPLIESALKK----EWN---SN--LVS 299 Coxiella burnetii
WP_012488959 238 da-gKAAQQKLIaerlpflqQQWKDLARAQQKTPEVVLAYSQALVDNYHDQEAESLVRKMLNS----EWY---PP--LVN 307 Cellvibrio japo...
WP_004526333 238 d--rRHDADALL--------EVWQSLSAAERQSPRLADLAAELLIALERRQEARRIVEDALAH----NWN---AR--LLR 298 Burkholderia ps...
WP_011002278 236 e--rRHDTDALN--------DFWRELTTEERRSPRIASQAALYFAQLGRTDEAKRIVEDALRA----HWD---GR--LIR 296 Ralstonia solan...
WP_011040946 244 esikQHDSEVLH--------DNWNGLSRKVKQREAVLFAYCKVLTENEITEPLNKLLVPLFKK----SPS---GD--FLK 306 Colwellia psych...
WP_012345802 320 AFVDVL-PGLPAD----WLPLLEDAVAA--QPQDAPLAYAAGRAMAERQLWGRARRLLEVAASNASA-------ELglr- 384 Leptothrix chol...
WP_000620221 300 LLPELN-ISDRHP----LIALLQEALRR--DGNNAEAHSALGQLYLREKHWADAQKHLEKALSLRSS-------VS---- 361 Vibrio cholerae
WP_005694537 306 QITRLQ-PEDNSK----LLKLIEKRAKRvdEKQKCCINRALGYLYVRNNEFIKAADVFKNVIACPEQ-------LEq--- 370 Haemophilus inf...
WP_019080200 301 LIPRLK-SGNPEP----IEKSLRQHIKQ--HGATPLLNSTLGQLMLKHGEWEKASEAFKAALAQRPD-------GY---- 362 Yersinia entero...
WP_010945525 303 QLTRIQ-VAEDSKlvktLIKRADKAEEC--YRDD--YARALGYIYARLSLFDEARSYFVMLLEHQEC-------TAn--- 367 Haemophilus duc...
WP_005772915 300 TYGLAR-GEKKTD----QLTTAETWLKK--YPKEPELFLCLGRLSRREKFLGKARDYLQTSIKLMPS-------SA---- 361 Coxiella burnetii
WP_012488959 308 LYGRLQ-LKEIRA----QLRMAEGWLKQ--HGDDPHLLLTLGRLMVRLEQWDAARDYFQRSFKLSAK-------VE---- 369 Cellvibrio japo...
WP_004526333 299 RYPDTA-GADALP----LIQKAEGWRRE--RPDDADLLFALGRLCQQQQLWGKAQSFLESALKLADD-------EPlr-- 362 Burkholderia ps...
WP_011002278 297 RYADCAvPGKALP----LIQQAEKWLAQ--HPVDADLFYTLGMLCFKEQLWGKAQSSLESALKYADAdhhgnlrAH---- 366 Ralstonia solan...
WP_011040946 307 QIRNLP-IKRADE----LIAIVQKQLHK--NIHSGKWLSCLGHLAMKSEQYSMAEKAFGSLLKLEDT-------EYgtqy 372 Colwellia psych...
WP_012345802 385 -qdAWRWLGQIADQEGDEDQAQRCYRKA 411 Leptothrix cholodnii
WP_000620221 362 ---DYAYLADALEKQNFTRAAHDVSRKA 386 Vibrio cholerae
WP_005694537 371 --nDLMMASYVFEQAGDKALAEQVRQES 396 Haemophilus influenzae
WP_019080200 363 ---DYAWLADALDKLHRPEDAAQARREG 387 Yersinia enterocolitica
WP_010945525 368 ---DRIMALHVAEQTNDTALIAKIRTLN 392 Haemophilus ducreyi
WP_005772915 362 ---AYRELGQVYEEQNQKDSALDCYRKA 386 Coxiella burnetii
WP_012488959 370 ---TAMELAALMDKLGDHKASADYYRQS 394 Cellvibrio japonicus
WP_004526333 363 -irAHRALARLFEHLGETDKAAQHYRES 389 Burkholderia pseudomallei
WP_011002278 367 ---AHLALAQLYEQTDRQEEAQRHFRQS 391 Ralstonia solanacearum
WP_011040946 373 drqDLQAFAQVHSKQGQFQAADALWSKA 400 Colwellia psychrerythraea
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