4ATV


Conserved Protein Domain Family
Na_H_antiport_1

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pfam06965: Na_H_antiport_1 
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Na+/H+ antiporter 1
This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyze the exchange of H+ for Na+ in a manner that is highly dependent on the pH.
Statistics
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PSSM-Id: 429217
Aligned: 337 rows
Threshold Bit Score: 245.39
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4ATV_D                     5 HRFFSSDASGGIILIIAAILAXIXANS-GaTSGWYHDFL--ETP--VQLRVGS----LEi------nKNXLLWINDALXA 69  Esc...
CAQ02540                  24 TSLIRSERVAAGLLLLAAVVGLVVANT-P-AGPGLIAWA--DGH--LAVPa-----iGVd-------LSLRHWVSDGLLV 85 
Q83MP1                     1 msIIRSERYSAIFLLCSAALAIIFANVlD--PDTWHA---------VHSAVSEyhifGL--------ITPHDIVADFLLA 61  Tro...
BAR05106                  30 arlsySDRASGLIMLAFALAGLLCANL-PlTRGFYHGLS--E----WTIGLPGt--nLM--------LGIGHWAQDGLLT 92 
kribb:BBB_1161            12 RRIAASDRISGLIMLAFAFAGLVLANL-PwTSHMFEAVA--E----TQLGIPGt--nII--------LPIGHWAQDGLLT 74 
A1A0Y8                    14 RRIAASDRISGLIMLGFALAGLLLANL-PfTAHAFEQLE--N----FHIAIPHt--nID--------MGLGHWVQDGLLT 76  Bif...
bcmhgsc:HMPREF0573_10928  51 ARFVSDDIVGGLILIIAAVLALVFANT-P-FREGYQAVAqfVPDpgLAQAAATd--tLSvlqklhlsMPIEEWARDGILA 126
Q2IE76                   205 ldFARWAPSTGLLLVVATAIAVAIANS-S-AGAAFTAAW--QAP--LGLSLGGrg-fA---------LPLVQWVNDGLLT 268 Ana...
Q2Y8T1                   189 ldFAKWAPSTGIMLLLATALAVVLSNS-A-LGPDFNEMW--EQR--LGITFQHsa-fE---------LSLRHWINDGLLV 252 Nit...
jgi:Fraau_1717            15 dhpvhagRRSGLLLVLAALAGLCLANVlP--AGRVTDFW--DQPwrLASSWQL--------------PSLANMFDEGLMA 76 
4ATV_D                    70 VFFLLVGLEVKRELXQGSLASLRQAAFPVIAAIGGXIVPTLLYL----AF-N------YADPIt--------------RE 124 Esc...
CAQ02540                  86 VFFFIVAVELKHEFLAGGLDSVSAALVPAIAAVGGVAVPAGVYL----AI-T------AGSGL---------------ER 139
Q83MP1                    62 VFFFAVAIELKHELVKGELSSFSKAIIPGVCAAGGILVPISIYLsvasVL----------------------------PN 113 Tro...
BAR05106                  93 IFFLVVGLELKQELTTGSLANPRAAAVPMIAALGGVLLPPAVFL----VV--------AGIGSrldlmhg--lafslvAH 158
kribb:BBB_1161            75 IFFLTVGLDLKQELTTGSLADPKAAAVPMLCAVGGMLMPPVLFI----TViSlfsrfaPPAPGivtiptgadvpfaeaAQ 150
A1A0Y8                    77 VFFLTVGLELKQELTTGSLSNPKAAAVPMLCAVGGMLAPPVLFI----GViSlf---aAAGSGqlviasgtsfsfaqmSN 149 Bif...
bcmhgsc:HMPREF0573_10928 127 IFFFTVGLELKEEFTHGALHDPRTAAMPIIAAVFGMAGPALVFV----VVtAi-----TGSGA---------------WH 182
Q2IE76                   269 LFFLVVGLEIKRELTVGRLASWRAAALPMAAAIGGMVAPAALYL----LViP-------AGPL---------------AG 322 Ana...
Q2Y8T1                   253 IFFLVVGLEIKREFTVGHLAERQSAMLPIAAAIGGMAVPALLYL----ILvP------PGPPMapgsdg----tdgawSY 318 Nit...
jgi:Fraau_1717            77 LFFLAAGLEIKLELCCGSLRGFRRAALPVAAACGGVLVPALIYL-----IcN------AGLPQ---------------VS 130
4ATV_D                   125 GWAIPAATDIAFALGVLALLGSRVPLALKIFLXALAIIDDLGAIIIIALFYTNDLSXASL--GVAAVA-IAVLAVLNL-C 200 Esc...
CAQ02540                 140 GWPVPTATDIAFALGVLAVFGRGLPAAVRVFLLALAVLDDLIAIVIIAVFFTTDLDVGAL--GLAVAG-VVLFAVVGR-L 215
Q83MP1                   114 GWPVPTATDVAFSLGILAIFGSSLPSKVRIFLLALAVLDDLAGIVIIATAFSVSISYWWI--IVACIT-VGLFGFCSYrL 190 Tro...
BAR05106                 159 GWAVPTATDIAFSLAILAIFAKSLPGSIRAFLMTLATVDDLLGIIIIALFYSS-LNAWYW--FLAVIIlAACWAFLVRrR 235
kribb:BBB_1161           151 GWAIPTATDIAFSLAVLALFAKALPGSIRAFLMTLATVDDLLAIILIAVFFSS-LNAWYW--FIGIAIcAAIWAFLVRlR 227
A1A0Y8                   150 GWAVPTATDIAFSLAVLALFAKALPGSIRAFLMTLATVDDLLAIILIAVFFSS-VNAWYW--FLGIAVcAVVWYFLVRmR 226 Bif...
bcmhgsc:HMPREF0573_10928 183 GWAIPTATDIAFAVAILQIFGRGLPNGARTFLLTLAVADDLGGIIVIAVFYGSNLNLVFLlpMAACAA-LFGFLCHKRkG 261
Q2IE76                   323 GWGTTISTDTAFAVAILVLLGDRVPVDLRVFLTAAVIVDDLVAIAVVALFYSGAISLPWL--LAAAAV-TALLAGLNR-A 398 Ana...
Q2Y8T1                   319 GWGVPMATDTAFAIALIAMMGKRVPVELRVFLTAAAIVDDIGAIIVVAIFYSGELHIAYL--GSAVAI-AGLLALLNK-G 394 Nit...
jgi:Fraau_1717           131 GWAVPTATDIAFATGMLGLLPQSLGRSLRPLLLALAMIDDVIAVLVVMLFYSQALAPGGAiwLLAAAT-LYLLLRCRDqA 209
4ATV_D                   201 -GAR--------RTGVYILV------GVVLWTAVLKSGVHATLAGVIVGFFIPLkek---hgR----------------- 245 Esc...
CAQ02540                 216 -GVGrtgaariaVVALLVLI------ALVTWWATLSSGIHATIAGVALGFALPR-------------------------- 262
Q83MP1                   191 aRCK--------TSKTFLIIpamllcALAAWVSVYQSGIHATIAGVMLGIMLNR-------------------------- 236 Tro...
BAR05106                 236 -RVP------------WVLVal---vGICAWAAMYEAGIHPTLAGVLVGLLTPSrpl---feEe---------------- 280
kribb:BBB_1161           228 -RVP------------WLLVav---iGVLAWVMMFEAGVHPTLAGVLVGLLTPSrem---hsEk---------------- 272
A1A0Y8                   227 -KVP------------WLAVai---vGVLAWVMMFEAGVHPTLAGVLVGLLTPAher---fgEk---------------- 271 Bif...
bcmhgsc:HMPREF0573_10928 262 ------------HWYFLLPL------GVLTWYFMLVSGIHATIAGVVLGMVVPAdkrdwevhNm---------------- 307
Q2IE76                   399 -AIS--------AAPPYVAL------GALLWACLHAAGLHPTLAGVILAVVTPT--------Rpppdlraltgqaqavle 455 Ana...
Q2Y8T1                   395 -GVY--------RASPYVIL------GIVLWVFVYASGIHATLAGIILALFIPT--------Rpppnlralmlqadailt 451 Nit...
jgi:Fraau_1717           210 aTVM------------LLSV------GVLIWIGLWRCGLHPALAGMVLGLLWPAgr------------------------ 247
4ATV_D                   246 -------------------------------SP---AKRLEHVLHPWVAYLILPLFAFANAGVSLg-------gV----- 279 Esc...
CAQ02540                 263 -------------------------------LS---GLRAAHALEPASNGIVLPLFAFSAALVAI---------P----- 294
Q83MP1                   237 -------------------------------KQ---GAAIEHALEPYINGIILPAFAFLAAMVRV---------P----- 268 Tro...
BAR05106                 281 -------------------------------SPr--AERYHDKLQPFSALLALPIFAFFATGISFtgseagiaaAagsaa 327
kribb:BBB_1161           273 -------------------------------SPr--AQRYASKLQPFSSLLALPIFALFATGVHF---------A----- 305
A1A0Y8                   272 -------------------------------TPr--AERYADKLQPFSALLALPIFALFATGVHF---------E----- 304 Bif...
bcmhgsc:HMPREF0573_10928 308 ------------------------------------VEQIAMKVNPVSAAFAVPFFAFFAAGVDIvdt------------ 339
Q2IE76                   456 aelrraregvlrhgpsepalraldaihdrieSP---ASKLLRTLDPWASYAVLPVFALANAGVAWv-------pG----- 520 Ana...
Q2Y8T1                   452 aetrrgr-evmhygpsepalealdaihdrleSP---AARMLRHLAPRSSFLVLPVFALANAGVVVe-------tS----- 515 Nit...
jgi:Fraau_1717           248 ------------------------------tRPwhgARRLKAALDPWVAYVVMPGFALIHASIDLh-------gL----- 285
4ATV_D                   280 -----TLD-Gl-TSILPLGIIAGXLIGKPLGI----SLFCWLALRLKLAHLPEGTTYQQIXVVGILCGIGFTXSIFIASL 348 Esc...
CAQ02540                 295 -----AVG-LaeLAPAFWGIALALPLGKLVGItaggLLGAWVARRRGA---PSGLAGRDLVTVSLLGGIGFTVSLLMSEL 365
Q83MP1                   269 -----HLP-LdeISPALWGILLGLLFGKLLGI----SVFGIIALKFFRK---KSISFFNLLVVSALGGIGFTVSLLMNEL 335 Tro...
BAR05106                 328 gtaagSVS-AftLSPIVWGIVAALVIGKPVGV----VAATWISTHLFRLKLAPGLKVRALIPMATACGIGFTVAFLMASL 402
kribb:BBB_1161           306 -----ELSpAlmLSPVVIGIIVALVIGKPLGI----MITAWLSTHVAGLTMAKGLRVRDMFPAACACGIGFTVSFLIASL 376
A1A0Y8                   305 -----SLTlAlfVSPVVVAVMVALVVGKPLGI----MTTAWLSTHVGGLKMAKGLRVRDMFPAACACGIGFTVSFLIASL 375 Bif...
bcmhgsc:HMPREF0573_10928 340 --pggAL--QmlANPVAIAVMLALPFGKLLGI----SGSVFVMEKFTPLHLEKGVTMGDMVPISLVAGIGFTVALLISHL 411
Q2IE76                   521 -----ALD-G--RGRLVAAIVLGLVAGKPLGM----FLAARLAVRAGLAVKPAAYAWRQLAGAGALAGIGFTMSLFIAGQ 588 Ana...
Q2Y8T1                   516 -----VFG-E--HIPLMLGTATALVIGKPLGF----ITATVTAVRLGFATKPDAYSWRQLGGAGALAGIGFTMSLFIASQ 583 Nit...
jgi:Fraau_1717           286 -----VLT-StaALRLGVGVVAGLVLGKPIGI----VLAAWAAIRLGLARRPAGMSWPQLALIGMLAGIGLTMAMFITTL 355
4ATV_D                   349 AFGSvdpelINWAKLGILVGSISSAVIGYSW 379 Escherichia coli
CAQ02540                 366 AFAGld-evRDEGTLAVLLGSGVSIVAAAVT 395
Q83MP1                   336 AFLGtp--vHEQGVIAVLIGSLLSAILAIIL 364 Tropheryma whipplei str. Twist
BAR05106                 403 AYHhe--llQNEARFGVLIGSLLSAALAAIL 431
kribb:BBB_1161           377 AYTnt--elSAEGRFGVLMASLIAALISGIL 405
A1A0Y8                   376 AYQda--elSAEARFGVLVGSMVAAVISGIL 404 Bifidobacterium adolescentis ATCC 15703
bcmhgsc:HMPREF0573_10928 412 SFRGdd-llTQAGSIGVVMGTALSIILGAVA 441
Q2IE76                   589 AFPdp--adFRAAKIAIFAASLLAGVLGALV 617 Anaeromyxobacter dehalogenans 2CP-C
Q2Y8T1                   584 AFPev--sdYAAAKIAIFGGSILSAIIGVAI 612 Nitrosospira multiformis ATCC 25196
jgi:Fraau_1717           356 ALTdv--haQRLARCAVLLGSLLSTLLAlgf 384
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