1PYF


Conserved Protein Domain Family
AKR_AKR11A1_11D1
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cd19083: AKR_AKR11A1_11D1 
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AKR11A and AKR11D families of aldo-keto reductase (AKR)
Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Links
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Statistics
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PSSM-Id: 381309
Aligned: 7 rows
Threshold Bit Score: 481.534
Created: 2-Apr-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative activecatalytic
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     ###                               #    #                        
1PYF_A      3 KAKLGKSDLQVFPIGLGTNAVGGHNLYpnLNEETGKELVREAIRNGvTXLDTAYIYGiGRSEELIGEVLRef-nREDVVI 81  Bacillus subtilis
PMC27885    4 SVKIGRSDVVANPLGLGTNAVGGHNLFpdLKDEDGIKLVKAALDNGiNLLDTAYVYGlGHSEELVGQAIKdy-dRHKIVI 82  Gardnerella vaginalis
OUU81947    3 TRKLGKSGIDISCIGLGTNYVGGHNLYvgVDEAEGVRLVKQAIDSGvTHIDTADVYGtGRSXELVGQAIAg--rRDEVVL 80  Hyphomicrobiaceae ...
SCZ78180    3 KIKLKKTDIDISRIGLGTNAVGGHNLYsaLDEAEGRALVREALAQGiTFFDTADAYGlGRSEELLGEVLRg--kRNEVVI 80  Acidaminobacter hy...
PCQ21645    4 RVKLGKSNIEVNPIGLGTNAVGGHNLYpnLDEEQGKNVVRAALDNGvNLLDTAFIYGpGRSEELVGEVLKey-nREDVVI 82  Klebsiella pneumoniae
P46905      4 TRTLGKTKLKVKRIGFGANAVGGHNLFpnLNDETGKDLVRTALDGGvNFIDTAFIYGlGRSEELIGEVVQergvRNELII 83  Bacillus subtilis ...
ALM30350    4 KVQIGKSELYVNPIGLGTNAVGGHNLYpnLNEEVGKDLVHKALDNGiNLLDTAFIYGpKRSEELIGEVLKergnRAEAVI 83 

Feature 1       #                                         ##                            ##    
1PYF_A     82 ATKAAHRKQGNDFVf-dNSPDFLKKSVDESLKRLnTDYIDLFYIHFPDehTPKDEAVNALNEXKKAGKIRSIGVSNFsLE 160 Bacillus subtilis
PMC27885   83 ATKGAHDFSTGKEVi-nNDPKFLTDQVNKSLKRLgTDYIDIYYIHFPDhdTLKAEAVGALQKLREEGKIRAIGISNFsLD 161 Gardnerella vaginalis
OUU81947   81 ATKGGLLFGEHGSGv-nNEPAYLRGALERSLKRLnVDYVDLYYIHRHDgeTPTEDAFGALMDFKREGLIRSAGVSNFdLS 159 Hyphomicrobiaceae ...
SCZ78180   81 ATKGAIQNGADGSRrinNRPEYLRSALEASLKRLeTDYVDLYYIHYVDpeVPLAESVGALERLKEEGKIRAIGLSNAtAE 160 Acidaminobacter hy...
PCQ21645   83 ATKGAHYFDGDDTKl-sNAPEFLKEQVENSLKRLqTDYIDLYYIHFPDdeTPKDEAVAALQELKDSGKIKAIGVSNFtLE 161 Klebsiella pneumoniae
P46905     84 ATKGAHKEVDGSIEl-dNSREFLRSEVEKSLKRLkTDYIDLYYVHFPDgkTPLAEVAGTLKELKDEGKIKAIGASNLdYQ 162 Bacillus subtilis ...
ALM30350   84 ATKGAHKIVGDEVLl-dNSPAFLKQSVEDSLKRLqTDYIDLYYIHFPDknTPKDEAVGALKELKDEGKIRSIGVSNFsLD 162

Feature 1                   #                            #######                              
1PYF_A    161 QLKEANKdGLVDVLQGEYNLLNREae-kTFFPYTKEHNISFIPYFPLVSGLLAGKYtedttfpegdlrneqehFKGERFK 239 Bacillus subtilis
PMC27885  162 QIKEANAdGYVDVVEDEFSLLHQDhlteGMLDYLHDNQISFVPYFPLASGLLTGKYvkdvsfpeddirsqiadFKEPRYS 241 Gardnerella vaginalis
OUU81947  160 ALQAAAGaGQVXALQSCYNLLQRDve-sDVLPWCVQNNVSFIPWGGLAYGLLGGRYnrdfklhdndwrqrtglFDAASFS 238 Hyphomicrobiaceae ...
SCZ78180  161 ELKAANHsGALNAYQGPYNLLQREve-aAHLPYCVETGIAFVPYGPLAFGILGGKYgpdfklspedwrnkvalFHKEQFQ 239 Acidaminobacter hy...
PCQ21645  162 QLKEANKnGNVDVIQHEYNLLNREn--eHILEYTAEHDITFIPYFPLAAGLLAGKYdenttfdd--lraekpeFQGEAFK 237 Klebsiella pneumoniae
P46905    163 QLQDFNAdGYLEVFQAEYSLIQRDae-kELLPYCEKQGISFIPYFPLASGLLTGKFtqdtvfdd--frkdkpqFQGETFI 239 Bacillus subtilis ...
ALM30350  163 QLKEANKdGYVDVVQGQYNLIQREae-nDILPYTAANHISFIPYFPLAAGLLAGKYdkntkfnd--lredmphFIGEAFQ 239

Feature 1                         #                ######  #  ##                    
1PYF_A    240 ENIRKVNKLAPIAEKHNvdIPHIVLAWYLArpeIDILIPGAKRADQLIDNIKTADVTLsQEDISFIDKLF 309 Bacillus subtilis
PMC27885  242 SILDAVDKVRDIADAHHatVAQTILAWYLKnplISVVIPGAKKAKQVIANAKAMDITLtDDEYQTIELAF 311 Gardnerella vaginalis
OUU81947  239 RNMDTIDSLKSIADECGstPAXLAIKWLLSkdaVSSVIAGAKNSEQVRDNVNALRGEVsEENIAAVDALT 308 Hyphomicrobiaceae bacterium ...
SCZ78180  240 ANLHRVSRLKLIADGKNttLSNLALAWLLHqpgVDAVIPGGKRPEQVAENVKGALVTLtEEELALILNAV 309 Acidaminobacter hydrogenofor...
PCQ21645  238 ENLKKVDKLSEIAQEHGvdVAHIVLAYYLTkpsLDVIIPGAKRGEQVIDNLKALEVNLtEENIQLIESLF 307 Klebsiella pneumoniae
P46905    240 HNLKKVDKLKAVAEEKQadTAHVALAWLLTrpaIDAIIPGAKRPEQLQDNLKTLNIELtEDEVNFISDIF 309 Bacillus subtilis subsp. sub...
ALM30350  240 QNLEKVERLRQISSAKGveVAHLVLAWYLTrdsIDVLIPGAKRADQVLDNLKTLDVQLtSSEIKDIDHIF 309

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