Conserved Protein Domain Family
SP

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TIGR00879: SP 
MFS transporter, sugar porter (SP) family
This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Statistics
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PSSM-Id: 273317
Aligned: 20 rows
Threshold Bit Score: 367.435
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P11636     1 MTLLALKED-----RPTPKAVYNWRVYTCAAIASFASCMIGYDSAFIGTTLALPSFTKEFDFa----------------- 58  Neurospora crassa O...
P15685    74 MQDAKEADEsergmPLMTALKTYPKAAAWSLLVSTTLIQEGYDTAILGAFYALPVFQKKYGSl----------------- 136 baker's yeast
CAA98827  72 TEDAKEADEsergmPLATALNTYPKAAAWSLLVSTTLIMEGYDTAILGAFYALPIFQRKFGSq----------------- 134 baker's yeast
P13181    46 GESGSEGSQsvpieIPKKPMSEYVTVSLLCLCVAFGGFMFGWDTGTISGFVVQTDFLRRFGMk----------------- 108 Saccharomyces cerev...
Q12300    75 AGDGAIETTsillsQPLPLRSN-VMSVLVGIFVAVGGFLFGYDTGLINSITDMPYVKTYIAPnh---------------- 137 Saccharomyces cerev...
Q07647     1 MGTAKVTPSlvfavTVATIGSFQFGYNTGVINAPET-IIKDFLNYTLEERLEDLPREGLLT------------------- 60  Norway rat
AAB60641   1 MEQQDQS-------MKEGMG------TTWLLSTPQHWLMQQFYNETYYGRTGEFMEDFPLT------------------- 48  human
P07921    47 INGVPIEDAreevlLPGYLSKQYYKLYGLCFITYLCATMQGYDGALMGSIYTEDAYLKYYHLdi---------------- 110 Kluyveromyces lacti...
Q01441    34 FSMKNLIVAtpiilTPLLYGYNLGFVGPYSTMYGYASNCQLYSAKKSCETLTAAKCRWFNAStyvsnttygevcgwadrt 113 Leishmania donovani
Q06222    32 FSFENLGVAqvqvvGGTLNGFSIGFVAVYILLYEVATNCSLFKTTEACKAVGSYGCEWKDTevcsw-------------- 97  Trypanosoma brucei ...
P11636    59 -----------sYTPg----------------ALALLQSNIVSVYQAGAFFGCLFAYATSYFLGRRKSLIAFSVVFIIGA 111 Neurospora crassa O...
P15685   137 ------------NSNtg-------------dyEISVSWQIGLCLCYMAGEIVGLQVTGPSVDYMGNRYTLIMALFFLAAF 191 baker's yeast
CAA98827 135 ------------NDKtg-------------ewEISASWQIGLTLCYMAGEIVGLQLTGPSVDLVGNRYTLIIALFFLAAF 189 baker's yeast
P13181   109 ------------HKDgt-------------hyLSNVRTGLIVAIFNIGCAFGGIILSKGGDMYGRKKGLSIVVSVYIVGI 163 Saccharomyces cerev...
Q12300   138 ------------------------------syFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAVIFSIG 187 Saccharomyces cerev...
Q07647    61 -----------------------------------TLWSLCVAIFSVGGMIGSFSVGLFVNRFGRRNSMLLVNLIAILGG 105 Norway rat
AAB60641  49 -----------------------------------LLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPA 93  human
P07921   111 --------------------------------nSSSGTGLVFSIFNVGQICGAFFVP-LMDWKGRKPAILIGCLGVVIGA 157 Kluyveromyces lacti...
Q01441   114 tcflkysdeagcLSDsackwsysantcgnqvgYSSIQSGVFAGSLVIGSTMGALMGGYLTKRLDYCKSFLFIGLLSVIGN 193 Leishmania donovani
Q06222    98 --------kkecDSDsdgvnp-----cesligYSSLYSGIFASAMIVGSMVGSIIAGKCITMFGLKKSFIIVGVMSVVAS 164 Trypanosoma brucei ...
P11636   112 AIMLAADGQGRgidPIIAGRVLAGIGVGGASNMVPIYISELAPPAVRGRLVGIYELGWQIGGLVGFWINygVNTTMAPTR 191 Neurospora crassa O...
P15685   192 IFILYFCKSLG---MIAVGQALCGMPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWTFGQLFAAGIMknSQNKYANSE 268 baker's yeast
CAA98827 190 TFILYFCNSLG---MIAVGQALCGMPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWLFGQLFAAGIMknSQKKYADSE 266 baker's yeast
P13181   164 IIQIASINKWY---QYFIGRIISGLGVGGIAVLCPMLISEIAPKHLRGTLVSCYQLMITAGIFLGYCTN--YGTKSYSNS 238 Saccharomyces cerev...
Q12300   188 NSLQVASGGLV---LLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVS--QGTHSKNGP 262 Saccharomyces cerev...
Q07647   106 CLMGFAKIAESv-eMLILGRLIIGIFCGLCTGFVPMYIGEVSPTALRGAFGTLNQLGIVVGILVAQVFG---LDFILGSE 181 Norway rat
AAB60641  94 ILMGCSRVATSf-eLIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFG---LRNLLANV 169 human
P07921   158 IISSLTTTKS----ALIGGRWFVAFFATIANAAAPTYCAEVAPAHLRGKVAGLYNTLWSVGSIVAAFSTygTNKNFPNSS 233 Kluyveromyces lacti...
Q01441   194 VLT-HVATGLFhywVLFVARIVLGFPLGWQSITSSHYTDKFAPANHAKTLGTLFQVSVSTGIFVTSFFG-----LVLGNT 267 Leishmania donovani
Q06222   165 ALN-HISVATNefwVLCAGRVLMGIGLGVVCVICPMYVNENAHPKLSKVDGVLFQVFITFGIMLAAMLG-----LILDKT 238 Trypanosoma brucei ...
P11636   192 SQWLIPFAVQLIPAGLLFLGSFWIPESPRWLYANGKREE-AMKVLCWIRNLEPTDRYIVQEVSFIDADLERYTRQVGNGf 270 Neurospora crassa O...
P15685   269 LGYKLPFALQWIWPLPLAVGIFLAPESPWWLVKKGRIDQ-ARRSLERILSGKGPEKELLVSMELDKIKTTIEKEQKMSD- 346 baker's yeast
CAA98827 267 LGYKLPFALQWILPVPLALGIFFAPESPWWLVKKGRFDE-ARRSLRRTLSGKGPEKEILVTLEVDKIKVTIDKEKRLTSk 345 baker's yeast
P13181   239 VQWRVPLGLCFAWSLFMIGALTLVPESPRYLCEVNKVED-AKRSIAKSNKVSPEDPAVQAELDLIMAGIEAEKLAGNAS- 316 Saccharomyces cerev...
Q12300   263 SSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKDELNK-AAKSLSFLRGLPIEDPRLLEELVEIKATYDYEASFGPSTl 341 Saccharomyces cerev...
Q07647   182 ELWPGLLGLTIIPAILQSAALPFCPESPRFLLINRKEEDqATEILQRLWGTPDVIQEIQEMKDE-SIRMSQEK---QVT- 256 Norway rat
AAB60641 170 DGWPILLGLTGVGAALQLLLLPFFPESPRYLLIQKKDEAaAKKALQTLRGWDSVDREVAEIRQE-DEAEKAAG---FIS- 244 human
P07921   234 KAFKIPLYLQMMFPGLVCIFGWLIPESPRWLVGVGREEE-AREFIIKYHLNGDRTHPLLDMEMAEIIESFHGTDLSNPLe 312 Kluyveromyces lacti...
Q01441   268 IQYDAASNANTMGRMQGLVSVSTLLSIFVVFLPLITKDGySKSRRGDYEGENSEDASRKA-------------------- 327 Leishmania donovani
Q06222   239 VNYD--NDPDMAGRFHGFCAVSSVLSVAMFLVGMFLREStATFSQDD----DGKADGGMD-------------------- 292 Trypanosoma brucei ...
P11636   271 WKPFLSLKQRkV-QWRFFLGGMLFFWQNGSGINAINYYSPTVFRSIGITGtDTGFLTTGIFGVVKMVLTIIWlLWLVDLV 349 Neurospora crassa O...
P15685   347 EGTYWDCVKDgI-NRRRTRIACLCWIGQCSCGASLIGYSTYFYEKAGVST-DTAFTFSIIQYCLGIAATFVS-WWASKYC 423 baker's yeast
CAA98827 346 EGSYSDCFEDkI-NRRRTRITCLCWAGQATCGSILIGYSTYFYEKAGVST-EMSFTFSIIQYCLGICATFLS-WWASKYF 422 baker's yeast
P13181   317 WGELFSTKTK-V-FQRLLMGVFVQMFQQLTGNNYFFYYGTVIFKSVG--L-DDSFETSIVIGVVNFASTFFS-LWTVENL 390 Saccharomyces cerev...
Q12300   342 LDCFKTSENRpKqILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDN---SYLVSFISYAVNVAFSIPG-MYLVDRI 417 Saccharomyces cerev...
Q07647   257 VLELFKS-PS-Y-FQPLLISVVLQLSQQFSGINAVFYYSTGIFQDAGVQE-P--IYATIGAGVVNTIFTVVS-LFLVERA 329 Norway rat
AAB60641 245 VLKLFRM-RS-L-RWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPE-EHVQYVTAGTGAVNVVMTFCA-VFVVELL 319 human
P07921   313 MLDVRSLFRTrSdRYRAMLVILMAWFGQFSGNNVCSYYLPTMLRNVGMKSvSLNVLMNGVYSIVTWISSICG-AFFIDKI 391 Kluyveromyces lacti...
Q01441   328 -AEEYTMTQ--M-IGPILNGVAMGCVTQLTGINANMNFAPTIMSNLGLQP----LVGNIIVMAWNMLATFCV-IPLSRRF 398 Leishmania donovani
Q06222   293 -PNEYGWGQ--M-LWPLFMGAVTAGTLQLTGINAVMNYAPKITENLGMDP----SLGNFLVMAWNFVTSLVA-IPLASRF 363 Trypanosoma brucei ...
P11636   350 GRRRILFIG-AAGGSLCMWFIGAYIKIADPGsnkaedakltSgGIAAIFFFYLWTAFYTPSWNGTPWVINSEMFDQNTRS 428 Neurospora crassa O...
P15685   424 GRFDLYAFG-LAFQAIMFFIIGGLGCSDTHG----------A-KMGSGALLMVVAFFYNLGIAPVVFCLVSEMPSSRLRT 491 baker's yeast
CAA98827 423 GRYDLYAFG-LAFQTIVFFIIGGLGCSSTHG----------S-KMGSGSLLMAVAFFYNLGIAPVVFCLVSEMPSSRLRT 490 baker's yeast
P13181   391 GHRKCLLLG-AATMMACMVIYASVGVTRLYPhgksqpsskgA-GNCMIVFTCFYIFCYATTWAPVAWVITAESFPLRVKS 468 Saccharomyces cerev...
Q12300   418 GRRPVLLAG-GVIMAIANLVIAIVGVSEGKt---------vVaSKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRS 487 Saccharomyces cerev...
Q07647   330 GRRTLHMIG-LGGMAVCSVFMT---ISLLLKdey-----eaM-SFVCIVAILVYVAFFEIGPGPIPWFIVAELFSQGPRP 399 Norway rat
AAB60641 320 GRRLLLLLG-FSICLIACCVLT---AALALQdtv-----swM-PYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRP 389 human
P07921   392 GRREGFLGS-ISGAALALTGLSICTARYEKTkk-------kSaSNGALVFIYLFGGIFSFAFTPMQSMYSTEVSTNLTRS 463 Kluyveromyces lacti...
Q01441   399 SMRTLFLFCgFVGSLCCVFLGGIPVYPGVTKsd------kaI-SGIAITGIAIFIALYEMGVGPCFYVLAVDVFPESFRP 471 Leishmania donovani
Q06222   364 TMRQMFITCsFVASCMCLFLCGIPVFPGVAee-------kvK-NGVATTGIALFIAAFEFGVGSCFFVLAQDLFPPSFRP 435 Trypanosoma brucei ...
P11636   429 LGQASAAANNWFWNFIISRFTPQMFIK----------MEYGv-yFFFASLMLLSIVFIYFFLPETKSIPLEAM 490 Neurospora crassa OR74A
P15685   492 KTIILARNAYNVIQVVVTVLIMYQLNSekw----nwgAKSG---FFWGGFCLATLAWAVVDLPETAGRTFIEI 557 baker's yeast
CAA98827 491 KTIILARNTYNVVSIICSVLILYQLNSkkw----nwgAKSG---FFWGVLCFCTLIWAVVDLPETAGKTFVEI 556 baker's yeast
P13181   469 KCMALASASNWVWGFLIAFFTPFITSa----------INFYygyVFMGCL-VAMFFYVFFFVPETKGLSLEEI 530 Saccharomyces cerevisiae S...
Q12300   488 KCTAICAAANWLVNFTCALITPYIVDVgsh-----tsSMGPkifFIWGGLNVVAVIVVYFAVYETRGLTLEEI 555 Saccharomyces cerevisiae S...
Q07647   400 AAMAVAGCSNWTSNFLVGMFFPSAAAy----------LGAYv-fIIFAAFLVFFLIFTSFKVPETKGRTFEDI 461 Norway rat
AAB60641 390 SAFMVGGSVHWLSNFTVGLIFPFIQEg----------LGPYs-fIVFAVICLLTTIYIFLIVPETKAKTFIEI 451 human
P07921   464 KAQLLNFVVSGVAQFVNQFATPKAMKN-----------IKYwfyVFYVFFDIFEFIVIYFFFVETKGRSLEEL 525 Kluyveromyces lactis NRRL ...
Q01441   472 IGSSITVGVMFIFNLIINICYPIATEGisggpsgnpnKGQAvafIFFGCIGVVACVIEYFFLQPWVEPEAKMT 544 Leishmania donovani
Q06222   436 KGSSFVVMMQFIFNILINLLYPITTEAisggatgdqdKGQAvvfILFGLIGLICFVLQFFYLYPYDANQDHEN 508 Trypanosoma brucei brucei
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