5FMN


Conserved Protein Domain Family
Trns_repr_metal

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pfam02583: Trns_repr_metal 
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Metal-sensitive transcriptional repressor
This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression.
Statistics
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PSSM-Id: 426851
Aligned: 575 rows
Threshold Bit Score: 49.749
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5FMN_B          25 SLQKLVNRLSRIEGHIRGV-KTMVQ-----E-Nr-pCPEVLIQVAAVRGALDRVARLILDDHMNECIT---------RAA 87  Synechocystis...
jgi:Dacet_2336   7 AKKKLYNRISRISGQVNTIkEHLGNadyefR-D---PYELVHMLASVKGAVHSMMSEYLEIYAKGHLIedmrskekeEAD 82 
jgi:Acry_3563   87 EKRKLVNRLSRIRGQVEAM-QAALD-----A-Da-rCTALLQQATACRGALDGFIGTVIEHHIRQHIVd-------pKQQ 151
Q0BPT4          35 EKIRLLKRLKRIRGQVDALhRAVLE-----Q-Ga-aSTRLIQQATACRGAMDGFIAEIIEDHIREQIId-------aRNA 100 Granulibacter...
CAL62184         7 EKKQALTRIRRIKGQVATL-EQALD-----A-Ga-eCPAILQQLAAVRGAVNGLMATVLESYLREEFPs-------sEIR 71 
EEB87933        18 DKKQSLIRIKRVKKQVAIL-EKTLN-----E-Gn-sGDELLKQLTAVRGTINGLMAMVLNSYLREEFPe-------nEAL 82 
AER54828         7 dvARLTPRIRRLKGQVAAL-EKALA-----G-Qp-eCIAVLTQIAAIRGAAQGLLLEVLEGHMQAHVAg--------EKN 70 
Q8P3U6           7 DKSKLLARVRKIRGQVEAL-EKALA-----Q-Dv-eCTALLTQVAAFRGAAQGLMVELLTEHLQHHVAa-------pDAR 71  Xanthomonas c...
WP_004510401     8 ERKKLQNRISRIHGQIHSLkNKFDDekfklEeD---PYETIRQLTAIKGAVTGMITSYVEHFAKGHMIenikngtqaDAE 84  Arcobacteraceae
WP_014802305     9 SREKLGHRLNRVIGQLQSLqKRVVA-------GgsdCVADIQQIKAANNALWKVAEAYLEIHLSECMR------------ 69  Turneriella p...
5FMN_B          88 aegnieQELA------ELKEALDR 105 Synechocystis sp. PCC 6803
jgi:Dacet_2336  83 ------VQLS------KFLEILKv 94 
jgi:Acry_3563  152 etd-raQAAE------ELIGVVHS 168
Q0BPT4         101 rd--ssQAAE------ELIRLVHS 116 Granulibacter bethesdensis CGDNIH1
CAL62184        72 sds-qnKSID------ETISIVRS 88 
EEB87933        83 tes-qkKSIE------ETIAVIKS 99 
AER54828        71 par-rsAEVA------AIHKVLRS 87 
Q8P3U6          72 gt--reQAVE------EVAAILKT 87  Xanthomonas campestris pv. campestris
WP_004510401    85 ------AQID------NLLEIIKV 96  Arcobacteraceae
WP_014802305    70 ------QKKPaaeiekNLQSVIRa 87  Turneriella parva
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