1LW4


Conserved Protein Domain Family
TA_like
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cd06502: TA_like 
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Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.
Links
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Statistics
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PSSM-Id: 99748
Aligned: 17 rows
Threshold Bit Score: 320.434
Created: 18-Jul-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1LW4, Thermotoga TA with bound PLP
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1LW4_A      7 DLRSDTVTKPTEeXRKAXAQaevgdd-vygedpTINELERLAAETfg-keAALFVPsGTXGNQVSIXAHtqrgdEVILEA 84  Thermotoga maritima
NP_487336   7 QFASDNYAGICPeAMNYMIQanqgsapaygndeWTQKATDYFRELfeidcEVFFTFnGTAANSLSLAALcqsyhSVICHE 86  Nostoc sp. PCC 7120
Q9HTF1      7 QFASDNYSGICPeAWAAMAEanrgheraygddqWTARASDYFRQLfetdcEVFFAFnGTAANSLALAALcqsyhSVICSE 86  Pseudomonas aerugi...
NP_356838   2 FFASDNWAGAHPaVNERLSRestrfaaaygtseLDLSIEKRFNEIferevAVFFVAtGTAANSLSLASIarpggLTFCHS 81  Agrobacterium tume...
NP_522677  15 GFTSDNIEGASPeVLDAILAanagqaapygaddCTARVEQTLSELferevKVFLVPtGTAANALCLGAMtppwgNVYCHP 94  Ralstonia solanace...
AAD42401    5 RFFSDNAATVAApVMDAIIAanqsdm-aydsdkWSQKLDAIFSELfgtdvTAHWAVtGTAANALSLSAIcppfgGVLCSQ 83  Zymomonas mobilis
NP_625381  18 GFASDNYAGAHPeVLAALALangghqvaygeddYTENLQRVIRSHfgsgaEAFPVFnGTGANVVALQAVtdrwgAVICAE 97  Streptomyces coeli...
NP_421887   9 DFASDNVAGAMPeVMEALIAanagtasgygtdhVSRAAADRIRAAldadaQVRFTAsGTAANAFALTLLaqpheAVLAHE 88  Caulobacter cresce...
P75823      3 DLRSDTVTRPSRaMLEAMMAapvgdd-vygddpTVNALQDYAAELsg-keAAIFLPtGTQANLVALLSHcergeEYIVGQ 80  Escherichia coli
NP_281048  22 DLRSDTVATPTEaMREAAAQapvehg-ehgddpAVAAVEATAADAvg-maAAVFVPsRTMANQIGAQVHtargqSVLVER 99  Halobacterium sp. ...

Feature 1                                                                                     
1LW4_A     85 dSHIFWYEVGAXavl-sgvXPHPVpgkn-gaxDPDDVRKAirprn---ihfprTSLIAIENTHNrsggrvvplenIKEIC 159 Thermotoga maritima
NP_487336  87 tAHIETDECGAPefasngsKLLLAkgen-gklTPQEIESVitkrvd--ihypkPKVISITQATElgtly--sieeLLDIK 161 Nostoc sp. PCC 7120
Q9HTF1     87 tAHVETDECGAPeffsngsKLLLAqtev-gklTPASIRDIalkrqd--ihypkPRVVTLTQATEvgtvy--rpdeLKAIS 161 Pseudomonas aerugi...
NP_356838  82 eAHVIEDECGAPdff-sgmRMVAVegpd-gkmLPENLIERiarypqdavhhgrAAAITMTQATEagtvy--tldeIDAIS 157 Agrobacterium tume...
NP_522677  95 sSHINNDECGAPefytngaKLVAVdgps-akiDVEKLRAAtrvkvg-dvhstqPACVSLTQATEvgsly--tlneIEAIG 170 Ralstonia solanace...
AAD42401   84 dAHVQTDEGGAPefytggsKLLLVpgeg-akiTPEALKTRaeaiad-svhmvqPHAVTITNSTElgqvy--tpeeTAAIG 159 Zymomonas mobilis
NP_625381  98 sAHINVDEGGAPerm-gglKLLTVptpd-gklTPELIDRQaygwdd--ehramPQVVSITQSTElgtly--tpdeIRAVC 171 Streptomyces coeli...
NP_421887  89 hAHICTDETGAPgffgqgvGLIGLpgas-gkmELAALEAAlaqpdv--syrqpAAALSLTTATEygtvy--sedhLRALI 163 Caulobacter cresce...
P75823     81 aAHNYLFEAGGAavl-gsiQPQPIdaaadgtlPLDKVAMKikpdd---ihfarTKLLSLENTHNgkvl---preyLKEAW 153 Escherichia coli
NP_281048 100 aSHSYRRGSGGLaqh-agvQARAFdggetgcpTAEQVAAEitagg---ghrpeVGLACVEIAHGanggvvapvdaFAAAV 175 Halobacterium sp. ...

Feature 1                                                  #                                  
1LW4_A    160 TIAKehgINVHIDGARifnasiasgv--pvkeyagyaDSVXFCLSXGLCApVGSVVVGDrDFIERARKARKXlgggxrqa 237 Thermotoga maritima
NP_487336 162 KVAQkyqLKIHMDGARfanavaamnkspaemswksgvDVLCFCGTKNGMAlGEAIIFFNrALAEDFDYRCKQagqlaskm 241 Nostoc sp. PCC 7120
Q9HTF1    162 ATCKelgLHLHMDGARfsnacaflgcspaelswkagvDVLCFGGTKNGMAvGEAILFFNrDLAEDFDYRCKQagqlaskm 241 Pseudomonas aerugi...
NP_356838 158 KIAKengLPLHMDGARfanalaalgttpaemtwkrgvDVLSFGGTKNGCWcAEAIVFFDpSLARDFSFLRKRtaqlfsks 237 Agrobacterium tume...
NP_522677 171 QLCKdarIKLQMDGSRfanalvslgcspaamtwkagvDALSFGATKNGVVaAEAIVLFDlSLAAEMGYRRKRaghlfskm 250 Ralstonia solanace...
AAD42401  160 AVARekgLRFHLDGARfanavaalgcnpadltwkagvDLMSFGFTKNGAMaAEAIVFFDrELAAHNKRRRKRaghllskg 239 Zymomonas mobilis
NP_625381 172 EHAHahgMKVHLDGSRianaaasldvpmrtftnavgvDLLSLGGTKNGALfGEAVVVLNqDAVRHMKHLRKLsmqlaskm 251 Streptomyces coeli...
NP_421887 164 APVKakgYGVHLDGARlanavaggfd--lksiakmgvDILVMGGTKAGSTpTEAVVFLNpDHAKRLDARLKHagqliskg 241 Caulobacter cresce...
P75823    154 EFTRernLALHVDGARifnavvaygc--elkeitqycDSFTICLSKGLGTpVGSLLVGNrDYIKRAIRWRKMtgggmrqs 231 Escherichia coli
NP_281048 176 ETAHehdVPVHVDGTRvfsaatalgv--daatllspvDSVAVCLSTGLGApMGAVLAGSeSFVASARRVQEMygggmqqa 253 Halobacterium sp. ...

Feature 1                                                                                     
1LW4_A    238 GVLAAAGIIALTk------xVDRLKEDHENARFLAlklkeigysvnpedvktNXVILRtdnlkvnAHGFIEALRns---- 307 Thermotoga maritima
NP_487336 242 RFISAPWLGLLEtg----awLKNAQHANQCAAYLEnell----------kieGVEIMFpr---evNAVFVKLPEqvingl 304 Nostoc sp. PCC 7120
Q9HTF1    242 RFLAAPWVGVLQdd----awLRYADHANRCARLLAelva----------dvpGVSLMFpv---eaNGVFLQLSEpaieal 304 Pseudomonas aerugi...
NP_356838 238 RFIAAQFEAYLQdd----lwLGLAGHANAMANRLRagfg----------slnSARLAWpt---qaNEVFAILPKaaaeaa 300 Agrobacterium tume...
NP_522677 251 RFLSAQIEAYLAnd----lwLRNARQANDMALRLArgle----------gmhGASVLGat---eaNIVFCRLPStlienl 313 Ralstonia solanace...
AAD42401  240 RFIAAQIEAMLKnd----lwLDLARSSNTVAKRIAea-------------vdPKRHAYpv---kaNEVFLFISMeerael 299 Zymomonas mobilis
NP_625381 252 RFVSVQLEALLAkd----lwLRNARHSNEMAQRLAegvr----------avhGVEILYpv---qaNAVFARLPHevser- 313 Streptomyces coeli...
NP_421887 242 RFLAAPWLGLLGengqtapwAARAAHANAMAQKLAal--------------mPVPIKHpv---eaNGIFVEMDElalerl 304 Caulobacter cresce...
P75823    232 GILAAAGIYALKn------nVARLQEDHDNAAWMAeqlreaga--dvmrqdtNMLFVRvge--enAAALGEYMKar---- 297 Escherichia coli
NP_281048 254 GMVAAAGVCALEn-------RHRVHEDHENARRLAedldalpg-vtaaepdtNIVLADtr---daDVTAAAFLAgce--- 319 Halobacterium sp. ...

Feature 1                                                       
1LW4_A    308 ---gVLANAVsd------------tEIRLVTHkdvsrNDIEEALNIFEKL 342 Thermotoga maritima
NP_487336 305 kannWLFYTFig-----------vgGVRFMCSwnttkSRIDELVGDIKTG 343 Nostoc sp. PCC 7120
Q9HTF1    305 rargWRFYTFig-----------egGARFMCSwdtdiERVRELARDIRLV 343 Pseudomonas aeruginosa
NP_356838 301 tqkgAKFYDWleprdmpenvgkdevLIRMVTSfatteADVDEFLSICAAV 350 Agrobacterium tumefaciens str. C58 (Cereon)
NP_522677 314 lqagFRFYHNrwe----------pnVVRFVTSfattaDDVDNLLRHMKAA 353 Ralstonia solanacearum
AAD42401  300 rkqgFVFYDWgh------------dKIRLVASwdqpeHEVVALEKALKAL 337 Zymomonas mobilis
NP_625381 314 lqkrFRFYFWdea----------agDVRWMCAfdtteNDVDAFVSALKEE 353 Streptomyces coelicolor A3(2)
NP_421887 305 rgegWFVYRFld------------gTVRFMCSwattpEMVEDLGAALKRV 342 Caulobacter crescentus CB15
P75823    298 ---nVLINASp--------------IVRLVTHldvsrEQLAEVAAHWRAF 330 Escherichia coli
NP_281048 320 --eeGVLGTAdg-----------eyTVRFCTHrdiggADIAAVVSAAGEV 356 Halobacterium sp. NRC-1

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