Conserved Protein Domain Family
zf-C2H2_12
?
pfam18658: zf-C2H2_12 
Spin-doc zinc-finger
This is a zinc finger domain C2H2 type which can be found in SPIN1 docking protein (SPIN-DOC) and Epm2a-interacting protein 1 (Epm2aip1). SPIN-DOC is a Spindlin1 (SPIN1) regulator that directly binds and strongly disrupts its histone methylation reading ability, causing it to disassociate from chromatin. Epm2aip1 is a glycogen synthase (GS)-associated protein. In the absence of Epm2aip1, the sensitivity of the liver to insulin, in which GS is a principal actor, is impaired.
Links
?
Statistics
?
PSSM-Id: 465831
Aligned: 31 rows
Threshold Bit Score: 78.8549
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
RXN06067      394 PWRLRLDYLVAYGPPeNPLCYCMVCSEHLPVP---RVSNFRKHIQECHPETCSLSRGERDAVVSAWIK 458 
ROT77287      133 KEEWRRQLLVDYDTR-TNMSICMLCFTTFKSYdgpRKNTYVKHAKRFHPSLEEYSEEERDLIISMYEK 199 
KDR19425       16 SDEWEEKYFFIVQ---NTKLLCLICREVVAVF---KEYNVKRHYETKHKDYLKFDKEVKQSKLKEFKS 77  
XP_031797434  108 LQSWEQEYLVGNSPGgSGRALCMVCGQELPTP---SARSARRHILRQHPHTLGLSPGEKSNILEAWSE 172 
XP_003798630   70 QLSWEQEFLVGNSPGgSGRALCMVCGAEIRSP---SADTARAHILEQHPHTLDLSPSEKSNILEAWGE 134 
GCF46038       68 CASWKQEYLIGKSSG-HDRLVCMVCGGALSAS---GPAAAREHILQHHAHSLDFSLEEKQNILEAWSE 131 
XP_013887771  890 EAAWRSRFLMDYNPL-NQLLVCMVCGELQYSH---SMDGVRAHIDEVHPHTLTLEPRERQRILEAWDE 953 
XP_009301278  993 QAQWRNVYLMDLDPV-IPLLVCMVCGEQQYSV---SVEGVKAHIEEVHPHTLSLGELEHRGILNAWDK 1056
CDQ77387     1467 DVVWRNRYLMDYDPL-NQLLVCMVCGELQYSH---SLEGVRAHIDEAHPDTLSLESPEHLRILEAWDE 1530
XP_030426649   66 GRAWQQEYLVGDCPG-RGGTVCMVCGTFLGTC---GPSAAREHVLQHHAHSLGLSPEEKHNILEAWSQ 129  Goodes thornscrub tortoise
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap