2WNB,2WML,2WNF


Conserved Protein Domain Family
GT29_ST3GAL1

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cd23980: GT29_ST3GAL1 
beta-galactoside alpha-2,3-sialyltransferase 1
ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).
Statistics
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PSSM-Id: 467708
Aligned: 6 rows
Threshold Bit Score: 552.95
Created: 29-Nov-2018
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2WNB: Sus scrofa sialyltransferase binds CMP and disaccharide, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                      #                                 
2WNB_A        17 CTCTRCIEEqrvsAWFDERFNrsxqplltaknahleEDTYKWWLRLQrekqpnnlNDTIRELFQVVPGNVDpllekrlvS 96  pig
2WML_A        17 CTCTRCIEEqrvsAWFDERFNrsxqplltaknahleEDTYKWWLRLQrekkpnnlNDTIRELFQVVPGNVDpllekrlvS 96  pig
Q11200        61 CSCSTCISElghsLWFDQRFNstmqpfltsqnalipEDSYRWWLKLQgekspkniNDTLKELFGIIPGDRDplqergtfS 140 chicken
XP_018123765  55 CGCDTCVAEpegsTWFDERLNlsisplltkqnnvipESVYKWWLTLQgekkpkdiYEVMEELFKVIPGDFDlmdq-spyR 133 African clawed ...
2WNF_A        17 CTCTRCIEEqrvsAWFDERFNrsxqplltaknahleEDTYKWWLRLQrekqpnnlNDTIRELFQVVPGNVDpllekrlvS 96 
KFO30978      59 CTCTHCISQrkvsAWFDERFNqtlqplltahnavleENTYQWWLRLQrekkpsnlSDAVKELFSVVPGNVDpmlhkrsvG 138 Damara mole-rat
Feature 1               ###                    ##                    # #               #         
2WNB_A        97 CRRCAVVGNSGNlkesyyGPQIDSHDFVLRXNkAPTEGfeaDVGsKTTHHFVYPESFRELaqeVSXILVPFKttDLEWVI 176 pig
2WML_A        97 CRRCAVVGNSGNlkesyyGPQIDSHDFVLRXNkAPTEGfeaDVGsKTTHHFVYPESFRELaqeVSXILVPFKttDLEWVI 176 pig
Q11200       141 CRRCAVVGNSGNlrqsqyGQDIDSHDFVLRMNrAPTIGyesDVGsKTTHHFVYPESYKELaenVSMIVIPFKtlDLRWIV 220 chicken
XP_018123765 134 CRTCAVVGNSGNlkssyyGPEIDEHDFVLRMNhAPTARfeqDVGsKTTHHFVYPESVRDLqanVSMILIPFKtlDLQWII 213 African clawed ...
2WNF_A        97 CRRCAVVGNSGNlkesyyGPQIDSHDFVLRXNkAPTEGfeaDVGsKTTHHFVYPESFRELaqeVSXILVPFKttDLEWVI 176
KFO30978     139 CRRCAVVGNSGNlreslyGADIDSHDFVLRMNkAPTAGfeaDVGsKTTHHLVYPESFRELgenVSMVLVPFKtiDLQWVV 218 Damara mole-rat
Feature 1                   ##                                                                   
2WNB_A       177 SAttTGRISHTYVPVPAKIKVKk--------------------------------------------------------- 199 pig
2WML_A       177 SAttTGRISHTYVPVPAKIKVKk--------------------------------------------------------- 199 pig
Q11200       221 TAltTGTINFTYVPVPRKIKVRk--------------------------------------------------------- 243 chicken
XP_018123765 214 SAltHGTINRTYIPVPRKVRVSk--------------------------------------------------------- 236 African clawed ...
2WNF_A       177 SAttTGRISHTYVPVPAKIKVKk--------------------------------------------------------- 199
KFO30978     219 SAttTGTISHTYVPVPTKIRVKqdkqpdfpepcgdrgegshecpaiwgteviptsnqsraeqmalfvraalkptaqgwfs 298 Damara mole-rat
Feature 1                                                       # ###                 ###      ##
2WNB_A       200 -----------------------EKILIYHPAFIKYVFDRWlqghgRYPSTGILSVIFSLHiCDEVDLYGFGadskgNWH 256 pig
2WML_A       200 -----------------------EKILIYHPAFIKYVFDRWlqghgRYPSTGILSVIFSLHiCDEVDLYGFGadskgNWH 256 pig
Q11200       244 -----------------------EKVLIYNPSFIKYVYENWlqnhgRYPSTGLLSVIFALHvCDEVNVYGFGadskgHWH 300 chicken
XP_018123765 237 -----------------------EKVLVYSPELMKYVYDKWllnhgRYPSTGLLAVIFALHvCDKVDIYGFGadskgNWH 293 African clawed ...
2WNF_A       200 -----------------------EKILIYHPAFIKYVFDRWlqghgRYPSTGILSVIFSLHiCDEVDLYGFGadskgNWH 256
KFO30978     299 glsrcvpvatslasqaqpeptffPQILIYHPAFIKYVFDNWlqghgRYPSTGILSVIFSMHvCDEVDLYGFGadskgNWH 378 Damara mole-rat
Feature 1        #               ##                      
2WNB_A       257 HYWENNpsagafrktgVHDGDFESNVTTILasiNKIRIFK 296 pig
2WML_A       257 HYWENNpsagafrktgVHDGDFESNVTTILasiNKIRIFK 296 pig
Q11200       301 HYWENNasagafrqtgVHDGDFEFNVTLTLasiEKIKFFK 340 chicken
XP_018123765 294 HYWENNasagafrvtgVHDGDFEASILANLtsiNKVLMFR 333 African clawed frog
2WNF_A       257 HYWENNpsagafrktgVHDGDFESNVTTILasiNKIRIFK 296
KFO30978     379 HYWENNpsagafrktgVHDADFESNVTATLaaiHKIRIFQ 418 Damara mole-rat

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