Conserved Protein Domain Family
UPF0552

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pfam10574: UPF0552 
Arp2/3-interacting proteins Arpin
This family includes proteins such as Arp2/3-interacting proteins (Arpin). Arpin regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex. It induces cell turning by pausing cell migration.
Statistics
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PSSM-Id: 463152
Aligned: 12 rows
Threshold Bit Score: 335.146
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6DJ71         1 MSRIYHNTSLRNKPVHDERIAGSWEPTAFQRGAGVLLEGTLLDFSRHSLTDSKGKK------ERWYILYLMPSKIHRRHF 74  tropical clawed...
EKC28598       1 MSRIYDNKPLHNLPVINVDIPSIWDPNQYSSGDGVILEGNIKGRSRFSLTDKSHSKvpndyfFRYYILHTEVQRAHRRKF 80 
XP_009023782   1 MSRIYSNDPLTALPVKNIFYDQVWNESDWHQGSGVILEASVKSRLRFSLIDKNQQK------IRYCAFVLLVRRAHRRVF 74 
EEN66649       1 MSRLYNNQPLLSIPVQTHQLTTAWQPEKHQKGSGVILEGVIEGRSRHVIIDTSQAK------FRYIVLHVRPSRAHRRKF 74 
KJE95198       4 EHMLYDDRALQSTPSTASNYAGSL--SIGGSGVGVLFEGRFAERTRHTITDASGAK------HRFIILHCDYVSAFRRQY 75 
XP_007256299   1 MSRIYDNTALQNKPVHNEKLSTVWDPAFYQRGAGVILEGTFIDVSRHAITDTNNRK------ERYYILYVKPSRIHCRKY 74 
Q1LWJ6         1 MSRIYDNTALLNKPVHNEKLSFTWDPIVHQSGHGVILEGTVVDFSRHAITDVKNRK------ERYNVLYIKPSRVHRRKY 74  zebrafish
XP_006629060   1 MSRIYHNTALQNKPVNNEKLTSVWQPSTYQRGAGVILEGKLVDVSRHVISDAGGRK------DRYYVLYIQPSQAHRRKF 74 
XP_013120719   1 MSRIYHNTSLQNKPVHSEKFDRAWCPSAFESGPGVLLEGKLLDVSRHAITDSNNQK------VRFYVLYIQPSRIHQRKF 74 
Q17QU3         1 MSRIYQDSALRNKAVRSARLPGAWDPAAHQRGDGVLLEGELLDVSRHSILDAHGRK------ERYYVLYIRPSRIHRRKF 74  cattle
XP_007479387   1 MSRIYHDSALRNKAVHSIRLPGSWDPAAYQRGNGILLEGELVDVSRHNISDANGKK------ERYYVLYLSASGVHRGEF 74  gray short-tail...
CAF91422       1 MSRIYHNTSLQNKSVHNEKFDGVWSPSVYESGEGVLLEGRLEDVSRHTISDDKNQK------NRFYVLYVRPSRIHQRKF 74  spotted green p...
Q6DJ71        75 DSKGNEIEPNFSDT---KKVNTGFLMSSY----------------------------K--VEAKGESDKISVEELIQLVN 121 tropical clawed...
EKC28598      81 ESNGREIEPNFSET---HKVRTGYLNSSY----------------------------K--VEPKGQTDKLSSDQVKDIVC 127
XP_009023782  75 DGK-KEIEPNFSAT---EKVRTGFLHSSY----------------------------K--VVPKGQSDFLTYDELVKIIQ 120
EEN66649      75 DSEGREVEPNFSDT---WKVNTGYLHSSY----------------------------K--VEARGQTDRLSAAELEAAVT 121
KJE95198      76 DEKGKEIEANQGKT---TKVNTGYLNSSY----------------------------K--LK-DSDADAVSVDQLHRMVA 121
XP_007256299  75 DAKGNEIEPNFSET---KKVNTGYLMSSY----------------------------K--QEAKGESDRLTEDQLKDIVN 121
Q1LWJ6        75 DSKGNEIEPNFSDT---KKVNTGFLMSSY----------------------------K--VEAKGETDCLDERQLREIVN 121 zebrafish
XP_006629060  75 DAKGNEIEPNFSES---QKVNTGYLMSSY----------------------------K--VEAKGVTDRLSDEELRALIN 121
XP_013120719  75 DANGKEVEPNFSDT---KKVNTGFLMSSY----------------------------K--VEAKGESDRLSEEQLSAAVN 121
Q17QU3        75 DPKGNEIEPNFSAT---RKVNTGFLMSSY----------------------------K--VEAKGDSDRLTPEALKGLVN 121 cattle
XP_007479387  75 FCRRKEFESEFSSAvrvN-----CLFLLS----------------------------RffVEAKGDTDRLLPMELKGLVE 121 gray short-tail...
CAF91422      75 DVSGNEIEPNFSDT---KKVNTGFLMSSYsnsgsktsnssesakvqtqkpagvshhtE--VEATGKSDRLSEDQLSALIN 149 spotted green p...
Q6DJ71       122 KVELMKISEKYTPRE---TVAFWLPEVDVEKTELELGEQLRVKTMGDSPFVFSLAKVDSGTVTKCNFAGDAQAGASWTDN 198 tropical clawed...
EKC28598     128 HDDLTKITSPRLPKEctgCLSLWLQENEMEKMELEEGEMIRVKTSGNGPFICSITKMDAEAKTKGNYAGGENVGGSWTDK 207
XP_009023782 121 PTNVLTVFGLDTNEKd-sFINVFLEENDLEKLEISDKDEIRLKTKGNSPFLENLCKINALNSALSNYAGDDKIGASWTDK 199
EEN66649     122 SAELSGLTQQVLRDG---CLPFWVGEEELAGMELNSGDNVRLKTRGDGPFIYNIAQLDGATSQVSNFAGGDMVGSSWTEK 198
KJE95198     122 PTVSKLARPGHATSGk--TLEFWGEEDVLKKFEFYKGDGVRLKTRGESPFIETIARLDTATSQIANYSGDQPVGQSWTDK 199
XP_007256299 122 KKELITVTEKHCPKQ---AFAFWILETEMEKVELESGQEIRLKTKGDGPFIFSFAKVDAGTVTKCNFAGDEQTGASWTDK 198
Q1LWJ6       122 KEQLVKVTIKHCPRE---AFAFWISEAEMDKTELEPGQEVRLKTKGDGPFIFSFAKLDSGTVTKCNFAGDENAGASWTEK 198 zebrafish
XP_006629060 122 KAELVKVTEKHTPSQ---SLAFWIPEGEMEMIELEQGQEIRLKTEGDGPFIYSLAKLDGGSVTKCNFAGDGKTGASWTDK 198
XP_013120719 122 KAELMKITDKHRPAG---TWAFWYPEADMEKTELETGQDVRLKTRGNSPFVFSLAKIDGGTVTKCNFAGDDKAGASWTDK 198
Q17QU3       122 KPELLALTESLTPAE---TVAFWMPESEMEAMELELGAGVRLKTRGDGPFLDSLAKLEAGTVTKCNFAGDGKTGASWTDN 198 cattle
XP_007479387 122 KPELLVVTGSHTPDQ---TFAFWIPEAEIEKIELELGAEVRLKTQGDGPFIGSLAKLEAGTVTKCNFAGDGQTGASWTDN 198 gray short-tail...
CAF91422     150 KVELVKITDRYRPSG---TWAFWYPESEMDKTEMEAGQEVRLKTRGNSPFIFSLAKMDGSTVTKCNFAGDQKAGASWTDK 226 spotted green p...
Q6DJ71       199 IMAQKSQSTSACfe-prGQGDGAEDDEW 225 tropical clawed frog
EKC28598     208 IMGMKSSQPADT-----SQTEGVDEDEW 230
XP_009023782 200 IMAVKQNLELQEee---------pnDEW 218
EEN66649     199 VMAVKRDQEer----reEENQGVEEDEW 222
KJE95198     200 LMT-KGKQTEANlstkdKAGASADDSEW 226
XP_007256299 199 IMANKADTLSDSkp--aEQGQGADDEEW 224
Q1LWJ6       199 IMANKSNQENTGks--aAQGEGADDDEW 224 zebrafish
XP_006629060 199 IMSNKAGVGVAVkd--rGPGEGAEDDEW 224
XP_013120719 199 IMANKADTSSTQkp--gG-GEGAEEDEW 223
Q17QU3       199 IMAQKSSEGAASet--rEQGDGAADEEW 224 cattle
XP_007479387 199 IMAQKSLEGTASei--rGQGDGAEDDEW 224 gray short-tailed opossum
CAF91422     227 IMANKADAADSQrp--gGEGDGVGEDEW 252 spotted green pufferfish
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