Conserved Protein Domain Family
TcpQ
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pfam10671: TcpQ 
Toxin co-regulated pilus biosynthesis protein Q
The toxin-coregulated pilus (TCP) of Vibrio cholerae and the soluble TcpF protein that is secreted via the TCP biogenesis apparatus are essential for intestinal colonization in the disease of cholera. TcpQ is part of an outer membrane complex of the TCP biogenesis apparatus, comprised of TcpC and TcpQ, and the TcpQ is required for proper localization of TcpC to the outer membrane. The domain is found in other Proteobacterial species apart from Vibrio.
Links
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Statistics
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PSSM-Id: 431425
Aligned: 30 rows
Threshold Bit Score: 72.6996
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6D9T2             348 VWKAEPGITLREFLTRQASTVecpyggKWTVVWPVNVDYPISARLVIHGSFDA---------LLERIFFLygPGKVDTPL 418 Pectobact...
BAM06297            62 TFVLVPGESLKENFEAWGKAS------GWKVLWHSEYSFPVKARYTAGRSFLG---------AVRRSIKIf-NAGSGGWL 125
Q3IFA7              97 RFE--NGSTLKKALSQYASNE------GIELYWYLSKDYVVKDHFRVDSNFTS---------TLYQVGRAi-NDDFENEV 158 Pseudoalt...
CASKLGSI:C427_4465  98 IFK--AGSTLRSAITEYAQSE------GMQVIWELDQDFIVKHPFQLDDSLLA---------SLKIIGNAi-DANFDGEV 159
WP_014109547       112 SFA--QGTTIRTEAMKYAEQE------GMQLIWDLNQDFIIRQRFLSENSLVA---------TLDEIAGAi-DANFIPQV 173 Glaciecol...
WP_014102511       356 RWAAVKGQDLRSTIESWGAQQ------GLQVIWMADSPYTVQRSVSFQGPLTG---------ALSRLLEQf-NDETERPV 419 Micavibri...
Q5DZ53              89 vLTAQEGESLKNRLLDFLSNN------GYKMIWNSQYDVLFDNDIIYEGDEALd--------VVKNISDD--LSVMGIDI 152 Aliivibri...
Q7WWZ0              85 AFRLVKGEALQQQLQNWANRA------GWTVAWNVPDGWIVPGDKDYGSDFES---------AVKRVVEE--LANNGADV 147 Cupriavid...
CAS:Atc_1166       180 VFVLTKGRLILTELQKWAAQS------GWTVVWQVPEDWMVPNTTTFSGGFRK---------AVSQVIQA--LSANGANV 242
Q5HXR5             222 VWTLIEGQPIRDQMIAWGDRA------GWRVIWPEGMNWMVPVTTGFTGPFRHddghggddgVMSQVIHA--LSAQGKTI 293 Gluconoba...

Q6D9T2             419 YGRANRSQC--VVAVSD 433 Pectobacterium atrosepticum
BAM06297           126 KVHAYLSNH--VLLVED 140
Q3IFA7             159 YTYLCHKQR--AAVITE 173 Pseudoalteromonas haloplanktis TAC125
CASKLGSI:C427_4465 160 KAYMCPLQR--SLVITS 174
WP_014109547       174 NVYFCNKKR--AIVIAE 188 Glaciecola nitratireducens
WP_014102511       420 GRIYNDPTLngQVLVVe 436 Micavibrio aeruginosavorus
Q5DZ53             153 HMNVYIKNN--VVLVYS 167 Aliivibrio fischeri ES114
Q7WWZ0             148 VGDSWRGNR--TVIISQ 162 Cupriavidus necator
CAS:Atc_1166       243 HAVFHTANN--TVVMSg 257
Q5HXR5             294 SLQLFTVNH--VALVTN 308 Gluconobacter oxydans
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