4PEV


Conserved Protein Domain Family
PBP1_BMP-like

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cd19964: PBP1_BMP-like 
Click on image for an interactive view with Cn3D
periplasmic binding component of a basic membrane lipoprotein (BMP) from Aeropyrum pernix K1 and its close homologs in other bacteria
Periplasmic binding component of a family of basic membrane lipoproteins from Aeropyrum pernix K1 and various putative lipoproteins from other bacteria. These outer membrane proteins include Med, a cell-surface localized protein regulating the competence transcription factor gene comK in Bacillus subtilis, and PnrA, a periplasmic purine nucleoside binding protein of an ATP-binding cassette (ABC) transport system in Treponema pallidum. All contain the type 1 periplasmic sugar-binding protein-like fold.
Statistics
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PSSM-Id: 380619
Aligned: 34 rows
Threshold Bit Score: 270.621
Created: 21-Dec-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:4PEV; Aeropyrum pernix ABC transporter system solute-binding protein binds adenosine, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ##      ###                                                               
4PEV_A     54 SVLVLFDVggrgDLSFNDXAALGADRAAeELGVDVVFQTPqslAVXESVLDAASRsgEYDLIVLVgfl----wqePLEKV 129 Aeropyrum pernix K1
EEG51300   71 KAAMITAQpl-gDKGVTDNTYEGFKRGCeEFGYEPTVVEVq-aGEYEETLRALCQe-GYDIIMPCwsa----ledACAKV 143 [Clostridium] aspa...
BAS27897   30 RAVMISPYg--kGVPFDSLAYQGLEDAAeKHGLQVKLVEArdqSEYESQIQAMAEl-GYDIVFALhdy----faePMKAV 102 bacterium HC45
OFR31941   41 GTVLIMNQp--aGNPFADLVFAGMEKAAqEKGLKAQQIPGvqaGAYEQQLRSAAQa-GNNPIAVLwdd----lgnAVARV 113 Actinomyces sp. HM...
SKC47026   44 KAAVLTIRk--lTTPADLNTLDGINKLKdELGIDIKIVECieiSEYKEQVQALSEe-GYDVIYFIydn----fleAVEEI 116 Clostridium haloph...
CUO46626   43 KVALVVNQkf-gDKASMDDLAKGADQAAeDFGVEIKKLESaeaSKFEEDVRAMSKa-GYDLIVTTygy----mtdATKLV 116 Eubacterium contortum
SHI88812   45 KAVYITTSp--lGNDFTDLIWSGFKELE-KEGWEVKCIEVkeaSEYPEQIRAMAAq-GYTAMFTMfdelsnvaldLADEL 120 Lutispora thermoph...
SNR57599   41 SVALVTPQka-gDGGPTDNLIAGLNTLK-AAGYTTRHVAApdpSSHESTLRSLAQs-GTPVIVVSfsd----ftqVLKTV 113 Actinomadura mexicana
EEG52848   54 MTAMIIIIp--qGDPFLTLAYNGVKQYAqEYGKEAKIIEAldkSEYTEQVRAMAEa-GANPIYVVwdd----ladVAFNL 126 [Clostridium] aspa...
SEK14733   43 LIALVHTQaa-gDASAVDAMIARLKLLGkETGMQTRAIYAkdpSTYETIFRTLADa-GAAVIVSTfne----vsePFKAL 116 Variovorax sp. OK202
Feature 1                 #                                                          #  #     
4PEV_A    130 APRyPEQKYALIDAatre---rydNVASYLFREQEVASLVGIIAAdianniskatgeeAKAGAVAGXDippLWRFHIGYL 206 Aeropyrum pernix K1
EEG51300  144 SAEyPDSEFIMVFSeie-----lpNVKSLISKQEDGSYLAGVAAAmtt--------knDHIAFMGGSDnpqINKFLAGYD 210 [Clostridium] aspa...
BAS27897  103 APLyPGTTFILIDSqvdg---glpNMLSVAMEPQEGCYLAGIAAAhat--------qsKKVGFIGGLDhpiIIQFLAGFE 171 bacterium HC45
OFR31941  114 APEfPDTKFLVIDSavdp---kldNVQTVLIDSSQSSYLAGVVAAslt--------hsKKIGFVGGQDmgvVNEWACGFE 182 Actinomyces sp. HM...
SKC47026  117 APNyPDTKYIGLWIdkpd--hnlaNFKPLFFRPEQGAFLSGVVAAltt--------etNQVGFIGGGInpgILTFLAGYE 186 Clostridium haloph...
CUO46626  117 SKEyPDTKYAAIFQtindgsekyeNVWDTEFHGEGAFYLGGYIAGklt--------kaNHVGFVVGAEeptPNAEGNGFM 188 Eubacterium contortum
SHI88812  121 AEQyPDLHIFLLDTymeh---dkaNVTSVTVDPFESSFVAGYVAAhmt--------dkKDIGWIGHKDilkVHRFRDGFI 189 Lutispora thermoph...
SNR57599  114 APDfPKTRFVHIYSdpyk--pempNVQTVSFDTQGPSYLAGVLAAtvs--------ktGVVGFIGGTAipsLNADYHAFE 183 Actinomadura mexicana
EEG52848  127 APDfPDTQFILVDTyats---dlpNVKTIVVEPQESAFIAGVVAAktt--------ktKQVAWIGNMDlptVNRWRAGFE 195 [Clostridium] aspa...
SEK14733  117 APKyPKTQWLQLFGdemk--pampNVTTVSYDYYLGTYLAGIFAGrms--------ttGKIGFIGGMSippLNADYNAFK 186 Variovorax sp. OK202
Feature 1                            #                        #    #                     ##   
4PEV_A    207 YGVQYYNqaxgtdveXVWTYTGRFdDPTLGKTTAEQXLQQGV-RVFYGVagltHVGXFNAVKEAaargviAFSIGQDASQ 285 Aeropyrum pernix K1
EEG51300  211 AGAKAVNpd----ikIDVTWVGSFdDPAKGKELALMLYDQGA-DIIYVAaaasSTGVFDAAKETg-----GMVVGCDVDQ 280 [Clostridium] aspa...
BAS27897  172 AGLHSVDpe----idISVAFSGVFdDPVKGREMALAMIDRGA-DVIMHAadftGVGVLKAAAERg-----VWGVGVDLDQ 241 bacterium HC45
OFR31941  183 AGLKSVDpa----vdFIVNYAGTFtDPQKGQQIANSMAGEGI-DVIFQAanqtGLGVINGAADRg-----IKAIGSDTWQ 252 Actinomyces sp. HM...
SKC47026  187 AGIKYIDpd----veLAVSWAGTFeDPLKGKELGTSLYGRGV-DVIFQVanqtGLGVIHSAKEQn-----KYAIGVDVDQ 256 Clostridium haloph...
CUO46626  189 MGVKAANpd----atVEFSYVGSYeDPAKAKEVTSAMISKGC-DVIQTDsgasNAGVVEACKEAg-----ILCAGEISDY 258 Eubacterium contortum
SHI88812  190 AGVQYADlg----knVITAFTGDPfDPVKGQETAKTMIKNNDiDIIYQSaylgGPGVISACAEAg-----IKCIGVDNWQ 260 Lutispora thermoph...
SNR57599  184 AGAKATRad----iaVKSAFVGSFgDPVKGQQIAQTMFNNKV-DVVLAYaggsSVGVVKAADQAk-----TFVIYDNVES 253 Actinomadura mexicana
EEG52848  196 AGVKYGDpd----vaCESIYIGSSdDPNKGGELAKQLIGKGA-DIVMHSanqaGLGVIRACEEMg-----VLSIGSDEWQ 265 [Clostridium] aspa...
SEK14733  187 AGVLSVRkn----atVTVAFAGSFqDPVKGREIATQMFNGGI-DFIQTDaaatDAGIIAAANDKp----gRLVSCLDPAQ 257 Variovorax sp. OK202
Feature 1                  #                                     
4PEV_A    286 EWYDpqTIIISGLKRVDVAVYTAIKDVVegr-frgGIVSLGLkEGGLGLSD 335 Aeropyrum pernix K1
EEG51300  281 NGIVpgQVIGSMVINYGNWVYQAFQEREdgg-lkfGAYKYGLeNDGLDLLL 330 [Clostridium] asparagiforme DSM 15981
BAS27897  242 SDVApgHVLASALKDARGAVRAAVQMVVegt-fepGVMIYGLeQGADLVAI 291 bacterium HC45
OFR31941  253 GDVAegSVPWSALKDAGAATYTSTINVLedk-fvsGLFVYDStEGAPLYDQ 302 Actinomyces sp. HMSC065F11
SKC47026  257 SDLApgNVVASCLLDHGYATYDSIKQAYegn-fntEQVYYGLkEGMNVVAI 306 Clostridium halophilum
CUO46626  259 YDTYd-GFYGIEGIGFGDTVYKAIEMLEngeypggEHGIRDLtNGGYFMDW 308 Eubacterium contortum
SHI88812  261 GYIDp-CVFWSAVKSMDVAVKTLAEGHVsgk-qyaTSINFDIaSGGAVYDQ 309 Lutispora thermophila DSM 19022
SNR57599  254 AQTAt-SVIAVASQHYGATMAKRVLTIAdgt-wkpGGSEAGLaDDGTFLER 302 Actinomadura mexicana
EEG52848  266 GAINedIVFWSALKDTTGATYAAGKSVSegq-fkpGMEIFGLdSGAKLYDD 315 [Clostridium] asparagiforme DSM 15981
SEK14733  258 YPQGpkSLISIVSLHFGKSLYDEASKILktg-kggAHLNTGLgTGVVGLEL 307 Variovorax sp. OK202

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