6R3W,3WJB


Conserved Protein Domain Family
THAP4_heme-bd
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pfam08768: THAP4_heme-bd 
THAP4-like, heme-binding beta-barrel domain
This domain can be found in THAP4 from mammals and At1g79260 from Arabidopsis. THAP4 catalyzes the heme-based conversion of peroxynitrite into nitrate-NO3- in vitro. At1g79260 is a nitrophorin-like heme-binding protein that may reversibly bind nitric oxide (NO) and be involved in NO transport. This entry also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-beta-barrel structural organization. Proteins containing this domain are putatively related to fatty acid-binding proteins (FABPs).
Links
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Statistics
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PSSM-Id: 462593
Aligned: 146 rows
Threshold Bit Score: 59.8964
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6R3W_A         8 ALQALSPLLGSWAGR--GAGKYPTI-RPFEYLEEVVFAH-VGKPFLTYTQQTRA-VAD-GkPLHSETGYLR--VCRPGCV 79  Mycobacterium t...
3WJB_B        27 fVAPLSYLLGTWRGQ--GEGEYPTI-PSFRYGEEIRFSH-SGKPVIAYTQKTWK-LESgA-PLLAESGYFRprPDGS--I 98  thale cress
CBI24126      17 AIQPLSYLLGTWRGQ--GEGGFPTI-NSFSYGEELLFSH-SGKPVIAYSQRTWK-LSSgE-PMHAESGYWRpkPDGT--I 88 
XP_015166417   5 AVKPLSDLLGTWKGE--GEGFFPTI-SSFNYSEELQFTHsPNKPVIAYSQKTWN-LKSgQ-PMHSESGYWRpkPDGT--I 77 
Q5QM86        15 AVAPLAFLLGKWRGE--GEGSFPTI-SPFRYGEELLFSHhPSKPVISYTQRTWK-AASgE-PMHAESGYWRprPDGS--V 87  Japanese rice
XP_001774489  12 VLQPLSFLLGTWRGQ--GEGGFPTI-QSFKYGEEIKLWH-SGKPVIAYSQKTWK-AASgE-PMHAESGYWRpkPDGS--I 83 
ERM97473      14 AVAPLSFLLGTWKGQ--GEGSFPTIsSSFHYGEELTFSHsGGKPVIAYAQKTWK-LASqE-NMHAESGYWRpkVDGS--I 87 
EDV29273      40 SLQDVSWLLGTWSGQ--GDGIYPNI-KSFSYKEEIKFSH-VGQPNLQFQSSSWH-LTN-NtPMHFESGFWF---FDRNHV 110
EGI70277       9 ALESLAWLEGTWRTEnqGSGKYPTI-KDFSYYDEISFMS-LGQPMFNYTAQSFSnSDL-KkPMHRETGFLKv-NPGTNQV 84 
EFN74959       9 VLEPLAWLEGTWRTd-cGSGNYPTI-KEFKYYEEISFTY-IGQPMFNYTARSYSiSEP-KkPMAQSTGFLKv-DPKTNKI 83 

6R3W_A        80 ELVLAHPSGITEIEVGTYSvtgdVieLELSTradGSIGLAPTAKE--VTALDRSYRI--DGDeLSYSLQMRAVGQP-LQD 154 Mycobacterium t...
3WJB_B        99 EVVIACSTGLVEVQKGTYNv--dEqsIKLKS---DLV---GNASK--VKEISREFELv-DGK-LSYVVRLSTTTNP-LQP 165 thale cress
CBI24126      89 EVVIAQSTGLVEVQKGTYNa--eEklVKLQS---ELV---GNASK--VTEISRVFELv-NGE-LSYVVQMATNLNS-LQP 155
XP_015166417  78 EVVIAQSTGLVEVQKGTYDm--kEgvVKLKS---ELV---GNASK--VKEITRVFKVe-NCE-LSYVVEMATSLTD-LQP 144
Q5QM86        88 EVVISQSTGLAEVQKGSFDa--eKktVTLQS---ELV---GNASK--VKQITRAFQLv-DGE-LSYVVQMATITTS-LQP 154 Japanese rice
XP_001774489  84 EVIIAQSTGLAEVQKGIYDa--eRkmVQLQS---DAV---CNASK--VLSIGRVFEVk-GDE-LMYTVEMGIHGHD-QQP 150
ERM97473      88 EAVIAQSTGLVEVQKGTYDa--eKkmVQLQS---ELI---GNATK--VREITRTFEFi-SGE-LVYVVQMATNSTT-LQP 154
EDV29273     111 KAAIAHNLGVCDIMEGEMT----NnqITVTT---TDITRKSDSKPpkVTKVQKIYKLleDGD-LEYIMLMETEQYP-LQE 181
EGI70277      85 TLISAHNFGLTTIECGEIT----DktINLNS---TDITRIKEAKIphVTQVRREFKLh-DNC-LEYIFYMATSNTPvLTE 155
EFN74959      84 FLILAHNFGLTSIEEGEII----NnvVCLDS---IDILRMKGAKPpqVTQMRRIFKLd-DNN-LEHVFYMATSNTPeLTE 154

6R3W_A       155 HLAAVLHR 162 Mycobacterium tuberculosis
3WJB_B       166 LLKAILDK 173 thale cress
CBI24126     156 HLKALLKK 163
XP_015166417 145 HLRASLKK 152
Q5QM86       155 HLKALLKK 162 Japanese rice
XP_001774489 151 HLRAVLKK 158
ERM97473     155 HLRGLLKK 162
EDV29273     182 HLRSRFKK 189
EGI70277     156 HLQAKYTK 163
EFN74959     155 HLRAKYVK 162
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