1CW0


Conserved Protein Domain Family
Vsr
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cd00221: Vsr 
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Very short patch repair endonuclease
Very short patch repair (Vsr) is an endonuclease functioning in DNA repair that recognizes damaged DNA and cleaves the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches. It belongs to a superfamily of nucleases including archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411702
Aligned: 98 rows
Threshold Bit Score: 122.731
Created: 4-Sep-2001
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1CW0: Escherichia coli Vsr endonuclease active site binds divalent cations and DNA
  • Comment:essential for endonuclease activity
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                            #                         #                 #               
1CW0_A         4 HDKATRSKNMRAIAtrdTAIEKRLASLLTGqGLAFRVQDASLPGRPDFVVDeYRCVIFTHGCFWHH-------------- 69  Escherichia coli
WP_145362988   4 LSSNQRRRCMSQNRgknTSIELAVRSHLHRrGMRFRKNVKALPGCPDIVFSrAKLAIFLDGDFWHG-------------- 69  Planctomycetes ...
OGF74359       5 FTKKKRSEIMSKIHarnTKAEVLVFRGLRKkGVYFQKHYKKAKGSPDVALPhKKRAVFIDGDFWHG-------------- 70  Candidatus Giov...
PYP84628       5 MTPEQRSHAMRRVKlkdGPLELAIQRELRRlGLCFQCNYKRLQGSPDIVFVkKKVAIFIDGDFWHGwr------------ 72  Acidobacteriia ...
WP_133882383   5 LTPERRSRLMSRVRsadTDIETSLRSELHRrGLRFRKHVKSLPGRPDIVFGpARVAVFVDGDFWHGw------------- 71  Panacagrimonas ...
RRF95332       5 VSPEVRSKIMSKIHgkdTKPEVLLRKELWHrGYRYRKNFRKLPGSPDIVMTkYRLCIFVDSEFFHGkgfyggleskkyes 84  Coriobacteriace...
WP_013556002   5 HTSERRSYNMSKIRskdTKPELRFRRALHArGLRYRTHVKELPGKPDVVFPrIKVVIFVDGDYWHG-------------- 70  Deinococcus mar...
WP_110887586   8 MTREQIAARMANVRradTGIEVTLRSALHRrGLRFRKNVKGLPGSPDIVFPrRKVAVFVDGDFWHGw------------- 74  Deinococcus yav...
PIZ00438       5 FSKEKRSEIMSKIRskdSIAELIVFRFLRKeGIYFQKHYGKVIGKPDIALPsKKKAVFIDGEFWHG-------------- 70  bacterium (Cand...
KUK64788      15 KANRDISAIMRKVRssdTKLEVMFRKSLWNrGFRYRVCPVNLPGKPDVVLSsKRLAIFIDGDFWHGg------------- 81  Desulfotomaculu...

Feature 1                                                    #                                   
1CW0_A        70 --Hh----C----YLFKVPAt--------rTEFWLEKIGKNVERDRRDISRLQELGWRVLIVWECALrgrekltdEALTE 131 Escherichia coli
WP_145362988  70 --YrfpswH----HKLSKPW----------REKIEETRKRDRRIHRRLRRHGWCVARFWEHEIRSDL--------TAVVD 125 Planctomycetes ...
OGF74359      71 --Ykf--lK----QKQRLPK----------KYWIAKIEGNMKRDRIATAKLKKEGWKILRVWEHEVIkk-----pTITVE 127 Candidatus Giov...
PYP84628      73 lpSw----E----HKLSEFW----------KLKLHANRKRDQRNFRCLRAADWTVIRLWEHEIRSSK--------TRCID 126 Acidobacteriia ...
WP_133882383  72 -rFr----Ek--aQKLPPYW----------REKIRANRVRDLRNFRLLRRQGWKVVRIWGHSIKADP--------SAAAD 126 Panacagrimonas ...
RRF95332      85 leEq----Lk--hSNHPDYW----------LPKIKRNMERDQEVDAELTESGWHIIHFWSKDVMKHT--------DECIR 140 Coriobacteriace...
WP_013556002  71 --Ye----LprrrHKLDPKW----------VAKITGNMARDRRHSAALRAAGWSVIRVWEHQVMKDL--------DRTVD 126 Deinococcus mar...
WP_110887586  75 --Rf----Eer-gHKLKPFW----------REKVERNMERDRCNVADLQALGWRVLRVWEHEVEERL--------DDVVE 129 Deinococcus yav...
PIZ00438      71 --Rdf--eKrk-nKLPKIYW----------RDKIAGNIKKDRAVNRELKKLGWQILRIWERKIKTKK--------TREQT 127 bacterium (Cand...
KUK64788      82 --Q-----W----QKRKLSAleeqfqgtssKEYWLRKIRGNMKRDCAATTSLLSKGWTVLRFWESEVqk----nlEKCIE 146 Desulfotomaculu...

Feature 1                 
1CW0_A       132 RLEEWICGE 140 Escherichia coli
WP_145362988 126 EISRLLKSS 134 Planctomycetes bacterium Pan189
OGF74359     128 KISNFLLKK 136 Candidatus Giovannonibacteria bacterium RIFCSPHIGHO2_02_43_16
PYP84628     127 RILRALKHE 135 Acidobacteriia bacterium AA117
WP_133882383 127 RVQRTIAWR 135 Panacagrimonas perspica
RRF95332     141 TVEETLATL 149 Coriobacteriaceae bacterium
WP_013556002 127 RIAKLIRCR 135 Deinococcus maricopensis
WP_110887586 130 RVLRLLDDE 138 Deinococcus yavapaiensis
PIZ00438     128 LERIKNFLL 136 bacterium (Candidatus Howlettbacteria) CG_4_10_14_0_8_um_filter_40_9
KUK64788     147 LTLEVVKKE 155 Desulfotomaculum sp. 46_80

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