4LGQ,2GEX,3EHC,2F98


Conserved Protein Domain Family
SnoaL

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pfam07366: SnoaL 
SnoaL-like polyketide cyclase
This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalyzing intramolecular aldol condensation.
Statistics
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PSSM-Id: 399975
Aligned: 29 rows
Threshold Bit Score: 96.215
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4LGQ_D        11 AVIQRFNREVI----ENGDXAAFAELVAPDFVNHSAPP----GVSPGPDGFAGFFTGXLHpALSDIRV---HIHEQIEEN 79  Chromobacterium...
Q8TQG8        22 LQLMTTLDDAW----NSQDWDTFEKRHTEKVEVYWPGQp---EPTRGRKSHHEEAVQFFK-TFPDNHVenrPYKVLFGQG 93  Methanosarcina ...
Q82M76        10 ALLRTAYQRL-----QSGDLDACVELLTENFIANVPGTp---DPLHGREIWRLGAQAMLE-GFPDLQV---DVEDMFSVH 77  Streptomyces av...
2GEX_B         8 ERCLEX-VAAW----NRWDVSGVVAHWAPDVVHYDDE-----DKPVSAEEVVRRXNSAVE-AFPDLRL---DVRSIVGEG 73  Streptomyces no...
Q8YQT8         6 TELLLQWANLW----SSGNVESFLSLFAEDCYYEDVAFs---MVSKGKEQLRDFFSATRT-ALPDLKI---NVQSCFASE 74  Nostoc sp. PCC ...
1_pfamImport   1 HLMDEMLATLA----DE---NPVRDEVAG-------------RVYRGKDQVAARYAELWQ-AFPDFNVr--PVRYTEQEG 57 
2F98_C        14 IAAVRRMVEAY----NTGKTDDVADYIHPEYMNPGTLEf---TSLRGPELFAINVAWVKK-TFSEEAR---LEEVGIEER 82  Streptomyces ga...
Q82DI4       115 GTVRRFLLEVA----TEGELPPLNDVMAENYHDHDPANe---QDAIGLDAMRREIEMWRR-GF-DFAF---TVEDQLAEG 182 Streptomyces av...
Q7NYY8         8 RVVQGFLDEVR----SGRDPDAAGRYLAASVAAHQLESenprTLTRSPANYAEHVREFQR-LFGDFTL---RVDELLVDG 79  Chromobacterium...
Q6LKM5         2 SLTITKYEQIWvdglNRGDVSGADEAFATNCVIHMAGAp---DPNLSVSDFKDLVSGLLT-AFPDLHT---SVNDQMVSG 74  Photobacterium ...
4LGQ_D        80 -GKVVTRKTIEATHTGAFFG-----QPASGKRIAIHAXDIVVVRD-GKYAEHWSCADLYGALAQI 137 Chromobacterium violaceum ATCC...
Q8TQG8        94 -DWTCSVATFTGTMKGPMIGadgkeIPPTNRKFKVEFCTVAHWKN-GEIVEERLFYDLVGLMKQI 156 Methanosarcina acetivorans
Q82M76        78 -DKVAVRVHFRGTHQGTFQG-----VAATHRPVGFRSIELYRIEG-DRIAEEWVAPDLMSLMQQI 135 Streptomyces avermitilis
2GEX_B        74 -DRVXLRITCSATHQGVFXG-----IAPTGRKVRWTYLEELRFSEaGKVVEHWDVFNFSPLFRDL 132 Streptomyces nogalater
Q8YQT8        75 -ANGALEWVMQGTHKEAFHN-----VPASHQMIEVRGVTFINLEN-GKIKTNKDYYNLATLLQQI 132 Nostoc sp. PCC 7120
1_pfamImport  58 --IVVMEAIYTGTHRGAYLG-----LPGSGKSFNVRLVNVFGFDD-ERIESETIYIDLAGQLRQL 114
2F98_C        83 aDWVRARLVLYGRHVGEMVG-----MAPTGRLFSGEQIHLLHFVD-GKIHHHRDWPDYQGTYRQL 141 Streptomyces galilaeus
Q82DI4       183 -DRVCTRWSWKGDHKGDFMG-----ILATGKQVTMTGTTVFRCGEdGKIVEGWWQYDRLGLLAQL 241 Streptomyces avermitilis
Q7NYY8        80 -DRAYARWTQFGRHLAEMDG-----YPPSGAPVALIDSACYRVEN-GKIVEYWIQADRMGLAPQL 137 Chromobacterium violaceum
Q6LKM5        75 -DKVATRWTAIGTHTGPLGG-----SPPSGNKAKFEGLILDRVVE-GQVVERWEQWDQMGMLQQI 132 Photobacterium profundum
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