3O4X


Conserved Protein Domain Family
FH2

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smart00498: FH2 
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Formin Homology 2 Domain
FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.
Statistics
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PSSM-Id: 214697
Aligned: 27 rows
Threshold Bit Score: 211.44
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3O4X_E      22 VYKPEVQLRRPNWSKFVAed----------lSq------D-----CFWT---------K-------VKEdrfE---N-NE 60   house mouse
AAH01710     3 PIQTKFRMPLLNWVALKPsq----------iT-------G-----TVFT---------E-------LND---EkvlQ-EL 40   human
AAC34395   586 PIKTKFRLPVFNWTALKPnq----------iN-------G-----TVFN---------E-------IDD---E---R-EL 620  torafugu
AAD39906   619 alPTKRKTVKLFWRDVKLagghgvsasrfgpC-------A-----TLWA---------S-------LDP---V---S--V 662  human
NP_592869  983 TRRPTRRLKQMHWEKLNsg-----------lE-------F-----TFWTgpsd--eanK-------ILE---Tl-hT-SG 1025 Schizosaccharomy...
NP_012107  871 PPPTEKRLKQIHWDKVEd------------iK-------D-----TLWE---------DtfqrqetIKE---L---QtDG 911  Saccharomyces ce...
AAA34455  1351 YPRPHKKLKQLHWEKLDCtd----------nSiwgtgkaE-----KFAD---------D-------LYE---------KG 1390 baker's yeast
NP_594737  871 LCNPSKRLKQLHWKRLEVp-----------fE-------K-----TLWNivvadpyllT-------LKL---T---A-EG 913  Schizosaccharomy...
NP_588046  848 LHKPTRPLKRVHWQRVDPlp----------gP-------NvftkfCLNF---------D-------ITA---KvfiD-NG 890  Schizosaccharomy...
NP_499047  372 ENAQPKYMKSLDWTILNDlq----------mK-------G-----TVFA---------D-------CRS---N---M-EL 406  nematode
3O4X_E      61 LFAKLTLAFsaqTKTSKAKKdQEggEEK----K-SVQkKKVKELKVLDSKT--AQN--L--SIFLGSF---R--MPYQE- 123  house mouse
AAH01710    41 DMSDFEEQFk--TKSQGPSLdLS--ALK----S-KAAqKAPSKATLIEANR--AKN--L--AITLRKG---N--LGAER- 99   human
AAC34395   621 ELERFEElf--kTRAQGPIMdLS--CTK----S-KVAqKAVNKVTILDANR--SKN--L--AITLRK------------- 672  torafugu
AAD39906   663 DTARLEHLFesrAKEVLPSKkAG--EGR------------RTMTTVLDPKR--TNA--I--NIGLTTL------PPVHV- 715  human
NP_592869 1026 VLDELDESFamkEAKTLVKKtCA--RTD------YMSsELQKLFGIHFHKL--SHK--NpnEIIRMIL---HcdDSMNE- 1089 Schizosaccharomy...
NP_012107  912 IFSQIEDIFkmkSPTKIANKrNA--ESSialsS-NNGkSSNELKKISFLSRdlAQQ--F--GINLHMFs--Q--LSDME- 979  Saccharomyces ce...
AAA34455  1391 VLADLEKAFaarEIKSLASKrKE--DLQk--iT-FLSrDISQQFCINLHMY--SSLs-V--ADLVKKIlncD--RDFLQt 1458 baker's yeast
NP_594737  914 IFKQLEDCYplrEVTVSNKK-VK--EYT----G-FMPvDLQQMVSIRLHRF--NSLtpI--EIAKKFF---HcdHDIME- 977  Schizosaccharomy...
NP_588046  891 LLDFLDEKFdntPREDFVAVeIS--DQR----SsLLPdTVEQNMAIILRSV--SNMp-V--EDLVQKF---L--VEPDF- 953  Schizosaccharomy...
NP_499047  407 YAENIARK--------------------------IENtKAFQSFVLSDDMR--TVV--E--EVRSRVS------IQLFE- 447  nematode
3O4X_E     124 -IKNVILEVNEA---V-LTESMIQNli-kQMP-EPEQLKMLSELK--EE-----Y-DDLAES-EQ-F-GVVMGT-VP-RL 183  house mouse
AAH01710   100 -ICQAIEAYDLQ---A-LGLDFLELlm-rFLP-TEYERSLITRFE--REqr--pM-EELSEE-DR-F-MLCFSR-IP-RL 162  human
AAC34395   673 ----ANKTFDLK---T-LPVDFVEClm-rFLP-TEMEVKALRQYE--RErr--pL-DQLAEE-DR-F-MLLFSK-IE-RL 732  torafugu
AAD39906   716 -IKAALLNFDEF---A-VSKDGIEKll-tMMP-TEEERQKIEGAQ--LAn----PdIPLGPA-EN-F-LMTLAS-IG-GL 777  human
NP_592869 1090 --CVEFLSSD-K---V-LNQPKLKAdlepYRI-DWANGGDLVN-S--EKd----A-SELSRW-DYlY-VRLIVDlGG-YW 1150 Schizosaccharomy...
NP_012107  980 -FVMKVLNCDNDivqN-VNILKFFCke-eLVNiPKSMLNKYEPYS--QGkdgkaV-SDLQRA-DRiF-LELCINlRF-YW 1050 Saccharomyces ce...
AAA34455  1459 pSVVEFLSKSEI---IeVSVNLARNya-pYST-DWEGVRNLEDAKppEKd----P-NDLQRA-DQiY-LQLMVNlES-YW 1525 baker's yeast
NP_594737  978 -L-VDFFNDRKF---F-RQEGLKKQlk-pYMS-SRNE--EVMEVS--EK-----L-LELSRF-DQiY-TLIVVD-IDtYY 1036 Schizosaccharomy...
NP_588046  954 -LPASILYFDRA---S-L-ASTNAYtd-pFIPySTDYTKKNPKEP--TAd----V-NSLSYF-EK-FfVLFVVNlRH-YF 1016 Schizosaccharomy...
NP_499047  448 -VMFAIHRMDIK---V-LNQNLVDSll-qIAP-TNSDAQLLRKM------------ENLSDPnEE-F-LLGLTK-ID-HI 504  nematode
3O4X_E     184 RPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSENFSSLLELTLLVGNYMNagSRNa-GAFGFNISFLCKLRDTKS 262  house mouse
AAH01710   163 PERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNs-SKRg-AAYGFRLQSLDALLEMKS 240  human
AAC34395   733 TQRMNIITFIGNFSDNVAMLTPQLNAIIAASASVKSSPKLKRMLEIILALGNYMNs-SKRg-CVYGFKLQSLDLLLDTKS 810  torafugu
AAD39906   778 AARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNg-----sQSSGFELSYLEKVSDVKD 852  human
NP_592869 1151 NQRMNALKVKNIIETNYENLVRQTKLIGRAALELRDSKVFKGLLYLILYLGNYMNdyVR---QAKGFAIGSLQRLPLIKN 1227 Schizosaccharomy...
NP_012107 1051 NARSKSLLTLSTYERDYYDLIFKLQKIDDAISHLNRSPKFKSLMFIITEIGNHMN----Kr-IVKGIKLKSLTKLAFVRS 1125 Saccharomyces ce...
AAA34455  1526 GSRMRALTVVTSYEREYNELLAKLRKVDKAVSALQESDNLRNVFNVILAVGNFMNdtSK---QAQGFKLSTLQRLTFIKD 1602 baker's yeast
NP_594737 1037 EKRMAALKIKSFLANNFRDFRRQIRKLHCASLELKSSLHFKYFLNLVLHIGNFMNdaPRR---AKGYRLESLLRASMIKN 1113 Schizosaccharomy...
NP_588046 1017 QERMKALKFRSTLFGDLEILEVRMKEVIDTSDSIMEDKNFAEFFQVLLIIGNYFNepYDR---ASAFSLYMIYRLETLRD 1093 Schizosaccharomy...
NP_499047  505 EEKLETMKHMYRFPEQVELLKENIIKYEIAVKVLSESRALRNVMQLVLAILNIGFfdDRQclSINGFSVSDISSILSTNT 584  nematode
3O4X_E     263 A-DQKMTLLHFLAELCENDHPEVLKFPDelahvekasrvsaenlqksldqmkKQIADV--E--R--D---V--QNFPAAT 330  house mouse
AAH01710   241 T-DRKQTLLHYLVKVIAEKYPQLTGFHSdlhfldkagsvsldsvladvrslqR---GL--E--L--T---Q--REFVRQD 305  human
AAC34395   811 T-DRKMTLLHYIALIVKEKYPELANFYNelhfvdkaaavs---lenvlldvrelgKGM--D--L--I---R--RECSLHD 875  torafugu
AAD39906   853 T-VRRQSLLHHLCSLVLQTRPESSDLYSeipaltrcakvdfeqltenlgqleRRSRAA--E--E--S---L--RSLAKHE 920  human
NP_592869 1228 A-NNTKSLLHILDITIRKHFPQFDNFSPelstvteaaklnieaieqecseliRGCQNL--QidC--D---S--GALSDPT 1297 Schizosaccharomy...
NP_012107 1126 SiDQNVSFLHFIEKVIRIKYPDIYGFVDdlkniedlgkislehvesechefhKKIEDLvtQ--F--Q---V--GKLSKEE 1196 Saccharomyces ce...
AAA34455  1603 T-TNSMTFLNYVEKIVRLNYPSFNDFLSelepvldvvkvsieqlvndckdfsQSIVNV--E--RsvE---I--GNLSDSS 1672 baker's yeast
NP_594737 1114 D-KTGLTLLHTIEKIVRTHFPQLEAFLVdlkaipeisrfnleqleqdcndicERMKNV--E--K--DfsnE--GIFSNHK 1184 Schizosaccharomy...
NP_588046 1094 S-SSALTLMHYFDEIIRTRFPELLQAEStfkkiqsvsgynidamvagvdgayDEFCDF--Q--T--S---LkdGALSKCD 1163 Schizosaccharomy...
NP_499047  585 P-SGQ--SVQSILVTILKDEinld-------------------------------------------ldeL--FGLIDVL 616  nematode
3O4X_E     331 -DE--K--DKFVEKmtsfVKDAQEQYNKLRMMHSNMETLYKELGDYFVFDPK---K-L-SVEEFfMDLHNFRNMFLQAVK 400  house mouse
AAH01710   306 -D---------CMVlkefLRANSPTMDKLLADSKTAQEAFESVVEYFGENPK---T-T-SPGLFfSLFSRFIKAYKKAEQ 370  human
AAC34395   876 -HS----------VlkgfLQASDTQLDKVQRDAKTAEEAFNNVVNYFGESAK---T-A-PPSVFfPVFVRFLKAYKDAVE 939  torafugu
AAD39906   921 -LA--P---ALRARlthfLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQaarE-V-RIMQFcHTLREFALEYRTCRE 992  human
NP_592869 1298 vFH--Pd-DKILSVilpwLMEGTKKMDFLKEHLRTMNTTLNNAMRYFGEQPN---DpN-SKNLFfKRVDSFIIDYSKARS 1370 Schizosaccharomy...
NP_012107 1197 -NL--DprDQIIKKvkfkINRAKTKSELLIGQCKLTLIDLNKLMKYYGEDPK---D-KeSKNEFfQPFIEFLAMFKKCAK 1269 Saccharomyces ce...
AAA34455  1673 kFH--Pl-DKVLIKtlpvLPEARKKGDLLEDEVKLTIMEFESLMHTYGEDSG---DkF-AKISFfKKFADFINEYKKAQA 1745 baker's yeast
NP_594737 1185 -ALhpD--DHICEVmvpwIPSGKSMVDELNSDITELKTTLKTTLLMYGENPD---EpT-SSARFfNNLNEIILEYKKAST 1257 Schizosaccharomy...
NP_588046 1164 -QHhpD--DKAYDIlsewLPEAKERIRNIKKLKTDMLTKLENTVKYLCEYDSi--D-K-VRNSFfKNLNSFYEMYSIAKA 1236 Schizosaccharomy...
NP_499047  617 -E--------------------KIENDDVNSVAQDLMVLDDKTVRAEKEMEH---S-G-S-NIPlSEFVENAKTISKERW 669  nematode
3O4X_E     401 ---E-N-QKrretEEK------M--RRAKLAk-EKAEKERL-EKQQK--REQLIDMNAE-------G---DETGVMDS-L 452  house mouse
AAH01710   371 ---EvE-QWkk-eAAA------Q--EAGADTp-GKGEPPAPkSPPKA--RRPQMDLISE-------L---KRRQQKEP-L 423  human
AAC34395   940 ---E-NeLRkk-qEQA------M--REKLLAe-EAKQQDPKvQAQKK--RQQQHELIAE-------L---RKRQAKDH-R 992  torafugu
AAD39906   993 rvlQ-Q-QQkq-aTYR------E--RNKTRGr-MITETEKFsGVAGEapSNPSVPVAVSsgpgrgdA---DSHASMKS-L 1056 human
NP_592869 1371 ---D-N-LKse-eEEA------S--QHRRLNl-VNNHKEHVlERAMS--ENNKMDNEAM-------D---GFLDKLRN-V 1422 Schizosaccharomy...
NP_012107 1270 ---E-N--Iek-eEME------R--VYEQRk--SLLDMRTSsNKKSN--GSDENDGEKVn------R---DAVDLLIS-K 1320 Saccharomyces ce...
AAA34455  1746 ---Q-N-LAae-eEER------LyiKHKKIVe-EQQKRAQEkEKQKEnsNSPSSEGNEE-------DeaeDRRAVMDK-L 1804 baker's yeast
NP_594737 1258 ---V-N-QKme-kEEElaflrlQ--ALKASVk-SNNAENSGsSKNEE--VSATMENLIS-------Q---LQKGLCDDsL 1316 Schizosaccharomy...
NP_588046 1237 ---E-N-EErf-eKEK------R--RIMSEDrdKLIRGRQKtSIVAKy-RNKRELPEDS-------D---DKQDTASK-D 1290 Schizosaccharomy...
NP_499047  670 ---E-H-FKsl-kTSI------E--RLTIYLg-SPLPRHQNlDAHSP--FNNVLQMLRS-------L---KTAIELDD-A 721  nematode
3O4X_E     453 LEALQ 457  house mouse
AAH01710   424 IYESD 428  human
AAC34395   993 PVYEG 997  torafugu
AAD39906  1057 LTSRL 1061 human
NP_592869 1423 KLESH 1427 Schizosaccharomyces pombe 972h-
NP_012107 1321 LREVK 1325 Saccharomyces cerevisiae S288c
AAA34455  1805 LEQLk 1809 baker's yeast
NP_594737 1317 SNKTD 1321 Schizosaccharomyces pombe 972h-
NP_588046 1291 KNSLE 1295 Schizosaccharomyces pombe 972h-
NP_499047  722 SDDHH 726  nematode
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