Conserved Protein Domain Family
FYVE_LST2
?
cd15731: FYVE_LST2 
FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins
Lst2, also termed zinc finger FYVE domain-containing protein 28, is a monoubiquitinylated phosphoprotein that functions as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Unlike other FYVE domain-containing proteins, Lst2 displays primarily non-endosomal localization. Its endosomal localization is regulated by monoubiquitinylation. Lst2 physically binds Trim3, also known as BERP or RNF22, which is a coordinator of endosomal trafficking and interacts with Hrs and a complex that biases cargo recycling.
Links
?
Statistics
?
PSSM-Id: 277270
Aligned: 15 rows
Threshold Bit Score: 114.364
Created: 1-May-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
putative Znputative
Feature 1: putative Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens EEA1 (1JOC) binds two Zn2+ ions through its FYVE domain.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #  #            #  #    #  #                  #  #  
Q9HCC9        810 DPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSShsaPLPRYGQVKPVRVCTHCYM 874  human
ELT87597      581 EPPEWLPDDECHQCMACEVPFTFVRRRHHCRNCGKIFCARCSAnsvCLPHFGHAKPVRVCNHCFL 645  Capitella sp. I Grassle & Gr...
XP_002407330  643 SPPVWLPDELTASCMDCSAHFTLLRRRHHCRKCGKIFCSRCSShsiSLPHYGHSKPVRVCNACFI 707  black-legged tick
EKC31928      747 EPPQWVPDDQMEKCMSCEIPFNFVRRRHHCRNCGKIYCGRCSAnfvPLPHFNYMTPVRVCNHCFL 811  Pacific oyster
XP_785516     925 DPPLWMPDETSDECLACRSSFTVLRRKHHCRNCGQIFCARCSAnsvPLPRYGQTKPVRVCNRCYM 989  purple urchin
EFX86696      560 TPPAWIPDESAPHCMSCQSVFTVVRRRHHCRNCGKVFCGKCSAnavPLPRYGHVKPVRVCNRCFM 624  common water flea
EFN88291     1201 RAPAWVPDNDAPRCMACQAGFTVVRRRHHCRNCGKVFCGRCSSnnvPLPRYGHTKPVRVCNRCFL 1265 Harpegnathos saltator
NP_001087164  456 VPPEWLPDNASSHCMSCYASFTLLRRRHHCRSCGKIFCSQCSAyssTLPYIISTHPVRVCSHCFH 520  African clawed frog
Q9TZD0        559 MGVRWVPDEDCEQCTACSMPFNFVRRRHHCRNCGRIFCHKCSCntiSIPEHGYDRKVRVCNLCYV 623  Caenorhabditis elegans
EFX75246     1012 PPILWVPDHLAPSCMRCSTPFWMARRRHHCRNCGKVFCSECADrdlPLPHQNLFQPVRVCNVCYD 1076 common water flea

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap