Conserved Protein Domain Family
PHTB1_N

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pfam14727: PHTB1_N 
PTHB1 N-terminus
This family includes the N-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis.
Statistics
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PSSM-Id: 464284
Aligned: 32 rows
Threshold Bit Score: 297.275
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001710020       1 MSLFSTVPCWSHa---LEErVDARAVAVLNLMRAKNNSAQIVVG--SLAGRLTVLRTESNE----SETLTNTVFSSETEN 71  
Q381Z0             2 GSLFKLRDHWYTry-gGEEfSHTQPLAVGNIDNHASGENKIIIG--SFSGLLRIMQPMKKG----AALPEDTLLEKDLGE 74   Trypanosom...
Q4CTU0             2 GSLFKLRDHWYSsy-rGEEfSHFSALTLGNADNNPDAEDKIIFG--SFSGTLRVLRPTKKG----AAQPDDTLIEKDFGA 74   Trypanosom...
XP_004990230       1 MSLFQAKEFWTTkacePGT-TDIGSLVVGNIDNNKDGIERIVVG--SLTGDLSIYTVAEME-----YRSEDLLFHTKLA- 71  
XP_001747349       1 MTLFQAREWWSTvvaePES-LSQACMVVDNLDNAADRADKIAVA--SYAGTLHVYAPSGQGadpeH----DKRLERDLGI 73  
EEH59516           1 MSVFKTCDFWSStckgDEK-FGVGSLAVGSYD------DKLILAtcSLFGVLRLYTPSESD-----FADGGHALELNLKL 68  
jgi:MICPUN_55060   1 MSVFKARELWCStc-dAREiFKGGCLAIGPPDAFNQRGVTIFVA--SISGILRVFLLHGEG-----HAVNNLILETDLKL 72  
EGR30350           1 MSLFQTKEWWSTripdEED-FDENHLCVSNIDNNKQNSDRIIVG--SYKGYLRIYAPKRRE-----YKIEDLIFEQNFNE 72  
XP_001015287       1 MSLFQTKEWWNTrisgNEE-FDDKHLLVANIDNNPQHQDRVVVG--SFQGFLRIYAPKKRD-----FQIDDMIFEQNFNE 72  
O01514             1 MSLFRLVEWVSQti------pNTSTILNASFFQDR---EQLVIG--GENGQITISDPGFR------DTNAHVLCTTETKY 63   Caenorhabd...
XP_001710020      72 PILGLELGFFTGPSplideaaSkpeNLELAVVHPHSIGIYTP-KRLQDGD---------------IGLELVSTVHF---- 131 
Q381Z0            75 PILQLACRPLELNS-------KgvaANLLAVLFPKRLALFRV-RCGKTRSgekens---gafnasCSIHLCYKTSL---- 139  Trypanosom...
Q4CTU0            75 PILQVACRPLEPVS-------GgqpKNLIVILFPKRLVLARL---LREREkekenentddflsalYRFTIHYEACL---- 140  Trypanosom...
XP_004990230      72 PVLQLEMGAFSSPD-----------ARELAILHPREIAVYTV-KGIVGQG---------------VELSKIFGAKL---- 120 
XP_001747349      74 PILQLQVADVSGDN-----------LNNLVVLHPREVVVYQV-QSDSSGG---------------LQLEQVYRHHL---- 122 
EEH59516          69 PILKIEFGRFELGK-------G---NISVVVLHPRKLMVYTLwqrmp--------------lskqYELHLNFEAVL---- 120 
jgi:MICPUN_55060  73 PVIQIEFGLFGEGG-------D---EASIVILHPHKLVICTL-QVDEAAArd-----------nlLHLLPLKIHRFketg 130 
EGR30350          73 PIIQILCGYFGQNP-------N---QIQLAILFFKKILIFEC-ETINQQD---------------IKLKKISQCNL---- 122 
XP_001015287      73 PIIQVGCGYYSPNA-------G---LLLLSVLFFKKLCIFEC-ETTADQR---------------INLKKTYVCNL---- 122 
O01514            64 AILQMASDNFLPSM-----------NNILAVLSPTKLTYYKVhFASPDETl--------------ASLDEIFSHSF---- 114  Caenorhabd...
XP_001710020     132 -SRYIISTCVITLPSpsteagaalYHSRLAVRTDDGILHICARRVMATH-RLGlM-YSFPTPMAFCPGTNSLVIATFDYT 208 
Q381Z0           140 -EGHAYNFTCGAFGGa--------KHEMVCVQSMDGQLTIVDRNLVLLRfLLPeKeFLLPGCLTYCRNRDCFLTCNSSMK 210  Trypanosom...
Q4CTU0           141 -ASTSYNFTCGNFGRa--------SHEMVCVQSMDGQITVVNHNTVVLQcFLPrSqFLLPGCFLYCSQRDYFLTNNSAMN 211  Trypanosom...
XP_004990230     121 -ERTAANFVPGRFGGa--------VKDVICVQSMDGALSFYNHGRLGLVrFVP-D-FLVPGPLCYLQHADAIITSSATWA 189 
XP_001747349     123 -KRTAANMVIGHFGQs--------EIAMICIQSMDGALTFFKKNREMLVrYLP-D-FLLPGPLDYVAEDDLLVTANSSWH 191 
EEH59516         121 -DQGALNMVIGQFGGs--------HKDVIGVQYSSGQLSVYAKGVTVMNcLLT-D-FTVSSPILYLHETDSFVTVSATTE 189 
jgi:MICPUN_55060 131 gQISAYNMVIGRFGGa--------ATNRICVQSFDGKLSFYDGEVLTLVfRLE-N-VLLPGPLAYAQQDDVLLIASSSFE 200 
EGR30350         123 -PRNSYNMCQGQFGGq--------TRYQICIQSCDGMLIIINQDQIQSQvQLS-D-FLLPSSLSYNQMTDQIILQNSSYE 191 
XP_001015287     123 -PRNAYNMCQGNFGGs--------QKDQICVQSCDGLLMIIESDQVTAGvQLQ-E-FLLPSPISYNSATDQIVLQNSSYE 191 
O01514           115 -STSAWNMCVIPIEE---------STPQILVQSIDCKLSLFQGDQCVFS-MVPlR-ALQPGPIGYCQTTQTLFVANNGF- 181  Caenorhabd...
XP_001710020     209 IVSFScadvmndtgGEAWNSSTEHDAtgPASTFNdegnpllrgvpqssKDVrSSPLKPQWTYVIGERIQQL--------- 279 
Q381Z0           211 VLCYK---------FSALTNDQPQTEtqGGALKSi------------kSEEhKETLTPLWAFPLGEDAIAIevcrfsr-- 267  Trypanosom...
Q4CTU0           212 LMCYS---------FATLVNNRIKPEvyMETNENg------------vSKTcGETISPSWTFLLGEDAVGIevcrhtr-- 268  Trypanosom...
XP_004990230     190 VCSYK---------FLVLASAGEAAAqrSGDSSQr------------sTKEgGKRVTSDWECNIGEEVLQLrvcg----- 243 
XP_001747349     192 IKAYK---------FRSMAAVSEESSsqQQQASNqvsa-------eqsTKT-GKKITEEFSFNLGEETMAIshvk----- 249 
EEH59516         190 LKCYK---------YGALVTESETISq-------------------------ARDMPAEWSVCLGEPALKIvgmdhlcny 235 
jgi:MICPUN_55060 201 LRCYQ---------FTDVASRLSRDScqAGFDTT--------------RG--EFVVRQHWRLCIGEPVLQIlpvsnns-- 253 
EGR30350         192 IQAYK---------ISNIGAVSNSDN--------------------------QKKLLPDWTLNIGDQCLKIltiere--- 233 
XP_001015287     192 IEAYK---------ISNIGAASNSNG--------------------------TKKLLPDWTLNIGEQCLKLecvcrd--- 233 
O01514           182 LAAIK---------FSLMSSGS------------------------------QKKINYDWSFNLGDTAIQMkvte----- 217  Caenorhabd...
XP_001710020     280 ----------------SygrcfgvdsgleGeVIALHTHGITLVNAStGLLSVENQLpDGLLFSMALFRApvkeKESTSqp 343 
Q381Z0           268 ----------glaendA------------D-IVILCQYALFVLKLN-GQMRYSKRL-DVAGLCLTSYDV----PAAGA-- 316  Trypanosom...
Q4CTU0           269 ----------glsaedA------------D-IVVLCHYSLFVLRLG-GELRFSKRL-DVESLCLTSYLVpntnA------ 317  Trypanosom...
XP_004990230     244 --------------------------tktPcILALGRTSLFWIADD-GSLLRSNRI-ESPLSCCLPFRCvg--------- 286 
XP_001747349     250 -------------------------vqdqSrLVVLGATSMYYLNMA-GELLSCKRF-EANCNCLATYRVvd--------- 293 
EEH59516         236 kkldtngnivfnseenM------------TnILVLTECSIFGISLS-GTICFQKKI-DFLPMTCAALPVlgssSSEKG-- 299 
jgi:MICPUN_55060 254 ----------adtresArgkqsfdinpcnD-VIVLAEKSIFVVSIS-GALKTQRRL-DFVPTACRVLSLslggSIGH--- 317 
EGR30350         234 --------------------------nrihdIAILTEESLYILNQQ-GAIRSQKYF-DYPAANIIIQPYqqkyIKTSSes 285 
XP_001015287     234 --------------------------hkvfdFIALTEEALFVITQT-GQIRTQKRF-DYPAANFYINEIpekhAKAVLdp 285 
O01514           218 --------------------------gskPtTIVLCRRHVSAFNAT-GSVVWQIRL-EAVGMAMCLYRSllinNTQF--- 266  Caenorhabd...
XP_001710020     344 irqrrinlpeiSSIVVLDSNRTLHFFRGGELRWTSRLSDsidEPVGVHTPQYMaqlfvprsppkmcSQDGLFVVQSRSGS 423 
Q381Z0           317 -----------SNVLVGTATGSVLVFSDTSLEWSAKMTEg--VPLCMEVTQLM-------------EMQGLVVSLNTEGT 370  Trypanosom...
Q4CTU0           318 -----------CNLLIGTVNGSVNVYSDASLDWSAKMATd--APLCLAVGEFF-------------KTRGMIVSLSTEGT 371  Trypanosom...
XP_004990230     287 ---------esAHVVVCGTDGIVRVMHDKKVAWAAGGAG---SPVAVATTTQC-------------GVKGLLTLLDENGT 341 
XP_001747349     294 ---------qqINLLLGCDDGILRVLRDKTVIWAAGGVS---QPLALSTFDSP-------------SLPGLIAIVSAEGH 348 
EEH59516         300 -----------RAFLVTGSTGNVQLYSGMNLLWAARHSF---SFIALSIAPIG-------------DTGNCMVGLGDDGY 352 
jgi:MICPUN_55060 318 -----------FGVVVADSTGSIMVFRDSQLLWTSKLPV---KPVDLIVSYFP-------------DTFGHIIALGRDAV 370 
EGR30350         286 ekt------kalqiIVSSFTNHLMIYEEFQLIWATRTDF---VCFGVSLGCFE-------------DQKGLIVGLNDQGD 343 
XP_001015287     286 lsq---qplrvISLIITSFTHHLMIYEDFQLLWATKTDH---VCHGVGVGTFD-------------GQRGLLVGLNDEGW 346 
O01514           267 -----------NRLIVSTSDDTLLIFQDNKLVWNCNAQM---SPVALLVCSYNk------------SYENTITMMAPDGK 320  Caenorhabd...
XP_001710020     424 IQVHLLGTNPldvdgrpssllpsllSPIAIPKQA-------VTKTLMEEAQKRVSALKAQHASMRT-----GLDELITVN 491 
Q381Z0           371 VAVNYLGTDP---------------EEEPIQPLQsk---evDYAEAVDELRRVQQAIKRITNAEDGtsktrEAEKVLEVT 432  Trypanosom...
Q4CTU0           372 VSVNYLGTDP---------------EEKPIQPLEsk---etDYVEMERELRQTLHAIKQAGGSEKS-----SAKENVTVE 428  Trypanosom...
XP_004990230     342 LSVVYLGTDP---------------RLPVLKSQNe-----hNYEAMDSELKRLQKIMSAAKDGKL------KTVPDAQLQ 395 
XP_001747349     349 LTLYYLGTDP---------------SLPQLTQPsr----pmNHEALDAEMTELQSVIRAAAAGA-------LSKDTAQEH 402 
EEH59516         353 LSMSYFGTEL---------------PADVVAPGKdi---gnDFEKKCSEQLRRIREISVSNCEAQRylp-----eaLQIR 409 
jgi:MICPUN_55060 371 LSISCLGTLP---------------HDTSIRGHErn---evSYQMIDKEYGELCSDPFKRSSDAFA-----TRAQQVEIS 427 
EGR30350         344 LQVFYLGTEQ---------------PQSQIFK-EknegyqqTYAQIEQKYNQVFKEINNKQSSGIQektqiNDNEQMNVV 407 
XP_001015287     347 LNVSYLGTEP---------------PLNQMDSFAplpgqnlTINQISDMYEVAFQKINQLESKQPVkk--aDANETMNIN 409 
O01514           321 VVVGYLGTEP---------------NLYRLPEdkv----ivNYAERMEEYKRMEQKIKESDAAGGAi----KRKEGIQMK 377  Caenorhabd...
XP_001710020     492 CGIS 495 
Q381Z0           433 WDVI 436  Trypanosoma brucei
Q4CTU0           429 GILR 432  Trypanosoma cruzi
XP_004990230     396 VEIS 399 
XP_001747349     403 IHLS 406 
EEH59516         410 AKVL 413 
jgi:MICPUN_55060 428 VRFQ 431 
EGR30350         408 CKIQ 411 
XP_001015287     410 IQVS 413 
O01514           378 LSIG 381  Caenorhabditis elegans
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