Conserved Protein Domain Family
BCAS3

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pfam12490: BCAS3 
Breast carcinoma amplified sequence 3
This domain family is found in eukaryotes, and is typically between 229 and 245 amino acids in length. The proteins in this family have been shown to be proto-oncogenes implicated in the development of breast cancer.
Statistics
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PSSM-Id: 463605
Aligned: 28 rows
Threshold Bit Score: 182.521
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002407994 263 PSPTVVVPLSQIKQ----GVGFSVPS---IGNPSVPRSppargRRVSGSassageafsIAAAFAPPr-----aWLVGSPS 330
ERM99845     449 gSPITLSAVSRIRNgn-nGWRATVNG---AAAAATGRVn----NALSGA---------IASSFHDCn-----sGS--YLD 504
EEF39532     521 GPPVTLSVVSRIRNgn-nGWKGSVTG---AAAAATGRL-----SSLSGA---------IASSFHNCk-----gNNDLYLD 577
KRH22234     546 GPPITLSVVSRIRNga-nGWRGTVSG---AAAAATGRK-----NALSGA---------IASSFCNYk-----gN-----E 597
KRH25883     531 GPPITLSVVSRIRNgs-nGWRSTVTG---AAAAATNRM-----SSLSGA---------IASSFRNFe-----gNSTLFVN 587
CAN75263     520 GPPVTLSVVSRIRSgn-nGWRGTVTGaaaAAAAATGRM-----SSLSGA---------IASSFHNCk------ANDLFSN 578
XP_006363523 517 GPPVTLSAVGRIRSgg-nGWRNTVTG---AAAAATGRT-----ISFSGS---------IASAFHHCn-----sTR-QCAD 572
Q9FH32       440 dAPVPMSAISRIRSgnssGWIGTVSG---AASAAAGMVa----GSVPGT---------VTSTFCYCdeksnnnY-YGSVA 502 thale cress
XP_009132428 442 nAPVPLSAVNRIRSgnisGWMGTMSG---AAAAAAGMVg----GSLPGA---------TASAFCYSveqdknnHLYGSSA 505
XP_009127070 452 hiPVTLSPVIRIRSrdisGWMGTVSG---AAAAAAGMVgggggGSLQGS---------TTSTFSYCveqqnknTHYGSTA 519
XP_002407994 331 TARDKkeknPVDSLFIMNCNGILTEYIIDPRPCTA-------------GNKVSEDSPIELDVTAYAQWNLLRPPSSPDTK 397
ERM99845     505 S---R----IKHHLLVFSPCGFVIEYGLRLTPGEErlktvsdasgpgnIYESGQDQDMRLVIETLWKWNVSHRQNRAAEE 577
EEF39532     578 GTILK----SKYHLLVFSPSGCMIQYVLRISAGIDsmavv---pglgtAFESVPESDGRLVVEAIQKWNICQKLNRRERE 650
KRH22234     598 GNFSK----AKYQLLVFSPTGSMVQYALRTITGQDsavvs----glspAYESIPQADTRLVVEAIHKWNICHIR--RERE 667
KRH25883     588 GNYSK----EKCHLLVFSPTGSMIQYALQTINSQDsgvvs----gvtpAYESAPATDVRVVVEPIKKWNISQRQSWREGE 659
CAN75263     579 SSSLK----EKYHLLVFSPSGCVIQYALRISTGIDsttvv---sglstGYESTPDGDGRLVVEAVQKWNVCQKQHRRERE 651
XP_006363523 573 SGLLK----ANHRLLVFSSPGCMTQYALRMCSELDsvatv---pamgsTYEADLE--TKLVVEAIQKWNIFQKQNYKERD 643
Q9FH32       503 --DMC----SKTNLLVFAPSGCMTQYALREHQVGvgheta---amtgfDSESGLETEGKLAVDPIRRWSMIQNQSRRETH 573 thale cress
XP_009132428 506 ASDNS----LKRNLLVFAPSGCMTQYALKANQVGDgghe-----magfDFESGSETEGKVGVEPIRRWSMIQNQSRREMQ 576
XP_009127070 520 SDNSS----VTRNLLVFAPSGCMTQYALKAGEGGEalvm------tgiDSESGAETEGPVV--RIRRWYMVQNRSRREMQ 587
XP_002407994 398 QPlgsSNPLMttQQAPSAPVTkrsfkd--------vngmnRMDGSGGDYRHQTnDDSWLSQVE-IITHVGpHRRLWMGPQ 468
ERM99845     578 E----NVDIY--GESG--DSYkllpkgykn-satvyptnsGMPKRERLTSEEK-HHLYISNAE-LQMHHA-QTPIWVRPE 645
EEF39532     651 D----NVDIY--GENGISDSNkiypegkkk-gnsvhpegmGATIKEKINPEEK-HHLYISEAE-LQMHQP-HTALWAKPE 720
KRH22234     668 D----NVDIY--GENGISDVNkiypeevrekidtispkikNGVMKVNPCLEEE-HHLYISEAE-LQMHQA-QTPLWAKPE 738
KRH25883     660 D----NIDIY--GENVVSDSNklyseevkk-dniispkmkNVAVKWNSCSEKE-HQLYISEAE-LQMHQA-KTPLWGKTG 729
CAN75263     652 D----NTDIY--GENGNTDSSkifpegikk-enafhpetrSGVSKSKISPEER-HHLYISEAE-LQMHQA-QNPLWAKPE 721
XP_006363523 644 D----NADIY--GEFGCSDSSkvfpegitk-gnslssetrNTFTKEKIRSEIG-HHIYISEAE-LQMHRP-HNQVWAKPE 713
Q9FH32       574 DP---HSDIYg-GGTSVDSKSkvfpevvrk-qsveeawkvSKKGTTR--VVDK-RHLYIYEAEqQQTHLPtQLPLWARRK 645 thale cress
XP_009132428 577 DQ---HSDVYg-GGASSDSKSkvfpeivrk-qsadeswkvTKKGKAR--VEDK-HQMYMSEAE-LQMYEPtQLPLWGRRN 647
XP_009127070 588 DQ---QRDVYggGGATSGSGSnvfpeivrkesaeeepwkaNKKGKARRVVDNN-HQLYVSQTE-LRMYQPsHLPLWEWDN 662
XP_002407994 469 FSFKIINVPTNTT--TPNMSVpmsqSpekyamlssDMYGEDSDVQSPGF 515
ERM99845     646 MYFQVFLMDNVRMenLNDL-Y----E---------EIEIERVPTRTIEA 680
EEF39532     721 IYFQPMMTEGIKMdgENAM-L----G---------EIEVERLPTRTIEA 755
KRH22234     739 IYFHSMLQESTIMdeEAAASG----G---------EFEIERIPTCMIEA 774
KRH25883     730 IYFHSVGKEAILMmdEEAASG----G---------EFEIDKIPTRVIQA 765
CAN75263     722 IYFQTMMVDGLE---ENVL-G----G---------EIEVERFPTRMIEA 753
XP_006363523 714 VFFRSFVMDRIHLd--dEG-G----G---------EAEIEVIPTHIVEA 746
Q9FH32       646 FRFQELVLNRGEEisGGG--G----R---------EMEIEGIQTRTIEA 679 thale cress
XP_009132428 648 FRFQEWVLDVDEEsnGGG--G--------------EMELEGIQTRTVEA 680
XP_009127070 663 CRFEKLVLDVDEEs----------nG---------EMEIEKIKGQTIEA 692
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