Conserved Protein Domain Family
ku70

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TIGR00578: ku70 
ATP-dependent DNA helicase II, 70 kDa subunit (ku70)
Proteins in this family are involved in non-homologous end joining, a process used for the repair of double stranded DNA breaks. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). Cutoff does not detect the putative ku70 homologs in yeast. [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 273151
Aligned: 4 rows
Threshold Bit Score: 962.43
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAA32018  45 PEAVADYRFSGRDSLIFLVDASKAMFEpYENEEAATPFDMTMQCIRNVYTSKIISSDKDLLSVVFYGMENNKNSADFKHI 124 chicken
AAA36155  24 LEASGDYKYSGRDSLIFLVDASKAMFE-SQSEDELTPFDMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNI 102 human
AAA39396   9 PDTGGEYKYSGRDSLIFLVDASRAMFE-SQGEDELTPFDMSIQCIQSVYTSKIISSDRDLLAVVFYGTEKDKNSVNFKNI 87  house mouse
AAC41612  16 ESSTVDFG-QAVDGILFLIDATEGMFEeVDG---DTAFMQCIKAAKSTMLNKITSSPKDLVGIILFGTDKDNNPNRFKNV 91  Rhipicephalus appen...
BAA32018 125 YVLQELDNPGAKRILELDQYRGDEGRVLFRETFGHNADYSLGEALWACSNLFSDVRVRLSHKRIMLFTNEDNPHANDSAK 204 chicken
AAA36155 103 YVLQELDNPGAKRILELDQFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSAK 182 human
AAA39396  88 YVLQDLDNPGAKRVLELDQFKGQQGKKHFRDTVGHGSDYSLSEVLWVCANLFSDVQLKMSHKRIMLFTNEDDPHGRDSAK 167 house mouse
AAC41612  92 YVLQDLESPGAESVLKLEKLIAD-GPKKFKQEYGHGNVNM-ADVLWTCALMFSKS--RAGQRRVLVLTNQDDPHKGSGDL 167 Rhipicephalus appen...
BAA32018 205 AKLARTRAGDLRDTGIILDLMHLKKPGG--FDISLFYRDIINVAEDEDLGIQPDESGKLEHLMKKVRAKETRKRALSRLN 282 chicken
AAA36155 183 ASRARTKAGDLRDTGIFLDLMHLKKPGG--FDISLFYRDIISIAEDEDLRVHFEESSKLEDLLRKVRAKETRKRALSRLK 260 human
AAA39396 168 ASRARTKASDLRDTGIFLDLMHLKKPGG--FDVSVFYRDIITTAEDEDLGVHFEESSKLEDLLRKVRAKETKKRVLSRLK 245 house mouse
AAC41612 168 DDKAVVKAKDLLQSGIELDLVHLKPPGDkkFRPQILYKNLVTDKENYEDG-FPEASDKMEELLLRVRMKDHKKRRLMSLP 246 Rhipicephalus appen...
BAA32018 283 LYLNKDLSFSVGVYNLIQKAYKPYPVKLYRETNEPVKTKTRVFNGKTGSLLLPSDTKRAQTYGNRQIAMEKEETEEVKRF 362 chicken
AAA36155 261 LKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRF 340 human
AAA39396 246 FKLGEDVVLMVGIYNLVQKANKPFPVRLYRETNEPVKTKTRTFNVNTGSLLLPSDTKRSLTYGTRQIVLEKEETEELKRF 325 house mouse
AAC41612 247 FWLGPEVKMSVSLYNLVRPTGKPATTRLARDNNEELLSRRITYAMDSAEALMPGDISKTQEYGGRKAYFDICEVKQIKSM 326 Rhipicephalus appen...
BAA32018 363 DSPGLFLIGFKPLSMLKQHHHIRPSQFMYPEESLVTGSTTLFNALLMKCLEKEVMALCRYIARRNTPPRIVALIPQEEEV 442 chicken
AAA36155 341 DDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEEL 420 human
AAA39396 326 DEPGLILMGFKPTVMLKKQHYLRPSLFVYPEESLVSGSSTLFSALLTKCVEKKVIAVCRYTHRKNVSPYFVALVPQEEEL 405 house mouse
AAC41612 327 APPGLQLLGFKPLSYLEKQPHVRPSHFVYPDEGSVRGSTRLFAALLQSCLRHRVAPICFWISRAAQAPKLVYLLAQEEER 406 Rhipicephalus appen...
BAA32018 443 DEQKVQIAPPGFHIIFLPYADDKRNVDFTEK--VPANREQVDKMKGIIQKLRFKYRTDSFENPVLQQHFRNLEALALDML 520 chicken
AAA36155 421 DDQKIQVTPPGFQLVFLPFADDKRKMPFTEK--IMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLEALALDLM 498 human
AAA39396 406 DDQNIQVTPGGFQLVFLPYADDKRKVPFTEK--VTANQEQIDKMKAIVQNVRFTYRSDSFENPVLQQHFRNLEALALDMM 483 house mouse
AAC41612 407 DPHGLQMVPPGFHVVQLPFSDDRRRLQALQEgtTKATPGLVALAREMAEKLRFTYHPDKFENPELQGFWSCLEALALDRD 486 Rhipicephalus appen...
BAA32018 521 EPEQAEDLTMPKTEEMSRRLGNLVEEFKQLVYPPD-YSPEGKAAKRKQAGDAQAEKRPKIEISED--SLRSYVQNGTLGK 597 chicken
AAA36155 499 EPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPD-YNPEGKVTKRKHDNEGSGSKRPKVEYSEE--ELKTHISKGTLGK 575 human
AAA39396 484 ESEQVVDLTLPKVEAIKKRLGSLADEFKELVYPPG-YNPEGKVAKRKQDDEGSTSKKPKVELSEE--ELKAHFRKGTLGK 560 house mouse
AAC41612 487 DAEHPKDYTRPDHEKMKAKAGEEMDAFLEAAFPDGcSATTAGSRKRTQAGEGGQAKKARSENQGSnvDVREEAKRGKLAS 566 Rhipicephalus appen...
BAA32018 598 LTVSALKDTCRHYGLRSGGKKQELIDALTEYFS 630 chicken
AAA36155 576 FTVPMLKEACRAYGLKSGLKKQELLEALTKHFQ 608 human
AAA39396 561 LTVPTLKDICKAHGLKSGPKKQELLDALIRHLE 593 house mouse
AAC41612 567 LTVSVLRDFCKQEGLRCPSKKAEIVDCIKKHLK 599 Rhipicephalus appendiculatus
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