Conserved Protein Domain Family
AKR_AKR12A1_B1_C1
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cd19087: AKR_AKR12A1_B1_C1 
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR)
Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Links
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Statistics
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PSSM-Id: 381313
Aligned: 33 rows
Threshold Bit Score: 450.101
Created: 19-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          ###                          #    #                           
AAD41821       3 GMYVQLGRGATLVSRLWLGTVNFSgrvpDDQAIRLMDEALDRGVNCVDTADIYGwrly------kghTEELVGRWLRgs- 75 
AAB84068       6 ATHVRLGRSALLTSRLWLGTVNFSgrveDDDALRLMDHARDRGINCLDTADMYGwrly------kghTEELVGRWLAqgg 79 
BAA84599      20 PLHTELGRTRLRISRLALGTVNIGgrveEPEARRLMDHALAQGITLFDTANTYGwrvh------kgyTEEVIGRWLAdrp 93 
OQW61312       1 MQYIHLGRSGVKVSRLCLGTMNFGpetsEADSFAIMDRALDLGINFFDTANVYGwkvg------egwTEQIVGRWLHqg- 73  Nitrospira sp. ...
O05408         1 MEYTYLGRTGLRVSRLCLGTMNFGvdtdEKTAFRIMDEALDNGIQFFDTANIYGwgkn------aglTESIIGKWFAqgg 74  Bacillus subtil...
WP_042701825   1 MKYVNLGRTGLKVSRLALGTMNFGeltdEATSFEIMDAALEAGINFFDTADVYGgpqspdmekgfgiSEEIIGRWLSqg- 79  Methanobrevibac...
ADG89976       1 MEYARLGRTGLKVSRLCLGTMNFGpqtsEEDAHAIMDRAHELGINFFDTADVYGwkkg------egvTEQIIGRWFAkgg 74  Thermobispora b...
EHI57412       1 MEYKYLGRTGMRVSSLCLGTMNFGstttEEEAFQIMDAALEAGINFFDTANNYGfltg-----dqgiTERIIGRWFAqgg 75  Clostridium hat...
ALM84250       1 MKYSHLGRTGLKVSRIALGALNFGeitdEATGFAIMDEALEAGVNLFDTADVYGgpqspdmekgfgkSEEIIGRWLAqsa 80  Bordetella sp. N
OYU69272       1 MKYRQLGRSALKVSEVCLGTMNFGprtsREDSFAILDAAVGAGVNFIDTANQYGghlg------vgtTETLLGEWLAqdr 74  Alphaproteobact...

Feature 1                  #                                            ##                       
AAD41821      76 gRRDDVVLATKVGEPMSdr----vNDRGLSARHVIRSCEASLRRLgVDHIDLYQMHRMDRtvRWDELWQAMDQLVASGKV 151
AAB84068      80 gRREDTVLATKVGGEMSer----vNDSGLSARHIIASCEGSLRRLgVDHIDVYQMHHIDRsaPWDEVWQAMDSLVASGKV 155
BAA84599      94 aRREQVVLATKVGDPMGsg----pNDHGLSVRNIVAACDASLRRLrTDWIDLYQLHHIDRraGWDEVWQAMDLLITQGKV 169
OQW61312      74 gRREKIVLATKVFGRMGnw----pNQSRLSALHIRRACEESLRRLgTDYIDLYQMHHIDResPWEEIWQAMEQLVREGKI 149 Nitrospira sp. ...
O05408        75 qRREKVVLATKVYEPISdpndgpnDMRGLSLYKIRRHLEGSLKRLqTDHIELYQMHHIDRrtPWDEIWEAFETQVRSGKV 154 Bacillus subtil...
WP_042701825  80 gRREKIVLATKVYQPMGtg----pNDRHLSAYHIRKACEESLRRLqTDHIDLYQMHHVDRntSWEEIWQAMEQLVHENKV 155 Methanobrevibac...
ADG89976      75 gRRERTVIATKVYGSMGdw----pNEDRLSALHIKRAVEGSLRRLqTDYIDLYQAHHIDRdtPFEEFWEAMEVLRQQGKI 150 Thermobispora b...
EHI57412      76 gRRERVILATKVHEDMHdendgpnTVPGLSIYKVRRHFEASLKRLqTDHVEVYYMHHVDRrvSWEEKWDAFQNLYERGMI 155 Clostridium hat...
ALM84250      81 dRRDKIVLATKVYQPMGtg----pNDKYLSAYHIRRACEASLKRLkTDHIDLYQMHHIDRatPWEEIWQAMEQLIREGKI 156 Bordetella sp. N
OYU69272      75 aRRDRLVLATKVHEPMSdd----iNDRGLSARHIQMACDASLKRLqVDHIDLYQMHHIDRsaPMDEIWQAMDRLRAQGKI 150 Alphaproteobact...

Feature 1             ##                        #                           #######              
AAD41821     152 RYIGSSNFaGWHLAAGQESAarrgslGLVSEQCLYNLAVRhaELEVLPAARAyGIGVFAWSPLHGGLLSGALrklaegta 231
AAB84068     156 SYVGSSNFaGWHIAAAQENAarrhslGMVSHQCLYNLAVRhaELEVLPAAQAyGLGVFAWSPLHGGLLSGALeklaagta 235
BAA84599     170 RYVGSSNFaGWDIASAQEAArrrnalGLASEQCVYNLVTRhaELEVIPAASAyGVGVLVWSPLHGGLLGGVLrktrenta 249
OQW61312     150 LYVGSSNFaGWHLAQAQELArnrhflGLISEQSLYNLVERtiELEVIPACTAyGIGVIPWSPLARGLLAGALkpvtvgr- 228 Nitrospira sp. ...
O05408       155 DYIGSSNFaGWHLVKAQAEAekrrfmGLVTEQHKYSLLERtaEMEVLPAARDlGLGVVAWSPLAGGLLGGKAlksnag-- 232 Bacillus subtil...
WP_042701825 156 TYVGSSNFaGWDIATAQNVAksrnflGLVSEQSLYNLSARtiELEVIPALQYyGIGLIPWSPIGMGLLSGINqkktegr- 234 Methanobrevibac...
ADG89976     151 LYVGSSNFaGWHLAKAQEAArrrntlGLVSEQCHYNLLNRavELEVLPAAEDyGIGVIPWSPLAGGLLAGVLrkadkgr- 229 Thermobispora b...
EHI57412     156 DYIGASNFpAWEIARAQGEAkarhfmGISVEQDKYNLACRlpELELLPACREyGIGVTTWSPLEGGLLSGKGaetlr--- 232 Clostridium hat...
ALM84250     157 TYVGSSNFaGWDIATAQSAAasrhllGLASEQSLYNLAQRtiELEVIPALRHfGIGLIPWSPVGKGLLGGVLnqtatqg- 235 Bordetella sp. N
OYU69272     151 TYVGSSNFpGWKIAQANERAmaarqlGLICEQSLYNLVERriELEVLPACQEyGVGVIAWSPLAGGLLAGPSqdasgr-- 228 Alphaproteobact...

Feature 1                                         #                ######  #  ##                 
AAD41821     232 vksgqgraQRTLPALRDTIARYERFCARVGrdPAEVGLAWLLSRPgVSGAVIGPRTTGHLVSALRAVELELSEEEHRELE 311
AAB84068     236 vksaqgraQVLLPSLRPAIEAYEKFCRNLGedPAEVGLAWVLSRPgIAGAVIGPRTPEQLDSALKASAMTLDEQALSELD 315
BAA84599     250 vksaqgraVEALEHHRTTIAAYEDVCADHGldPAHVGMAWVLSRPgVTGLVIGPRTEQHVDGALHALRTPLPEPVLARLE 329
OQW61312     229 --radedlKKEIEKYRPKLEAYETFCQSTGeqPADVALAWLLHQPaVTSPIIGPRTIDQLNGAMRALALTLSADQLKRLD 306 Nitrospira sp. ...
O05408       233 --trtakrADLIEKHRLQLEKFSDLCKELGekEANVALAWVLANPvLTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLN 310 Bacillus subtil...
WP_042701825 235 --hatpqlQMQIEQYSSQLEEYEILCQELGeePAVIGLAWLLHNPtVTAPIIGPRTVEQLNESLRALEVSLSDETLQKLD 312 Methanobrevibac...
ADG89976     230 --saaehmVAQLEKHRDKIQRFEALCDELGeqPANVALAWLLRRPaVTSPIIGPRTVEQLDGAIRAVEITLDDKVLARLD 307 Thermobispora b...
EHI57412     233 ----kknnAALEQKYGPQLAQYKKICGEAGleEADVALAWLLHNPiVTSPIIGARTLEQMEKSIRAMEIKLDDDMLRALD 308 Clostridium hat...
ALM84250     236 -rrasprlKAQIEKFRPQLEAYEALCADFGeaPAVVALAWLLHNPvVTSVINGPRTLAQWQQRLKAPSVTLSAETLSRLN 314 Bordetella sp. N
OYU69272     229 --rsagniSEAASKRAGQLAAYADLCSSLGksPSLVAIAWLLHQKgVASAIIGPRTLDQFTSLLAAPDLQMDPDVLGRLD 306 Alphaproteobact...

Feature 1            
AAD41821     312 ALFP 315
AAB84068     316 EIFP 319
BAA84599     330 ELFP 333
OQW61312     307 EIFP 310 Nitrospira sp. ST-bin4
O05408       311 DIFP 314 Bacillus subtilis subsp. subtilis str. 168
WP_042701825 313 EIWP 316 Methanobrevibacter arboriphilus
ADG89976     308 EIFP 311 Thermobispora bispora
EHI57412     309 EVFP 312 Clostridium hathewayi
ALM84250     315 AIWP 318 Bordetella sp. N
OYU69272     307 AIFP 310 Alphaproteobacteria bacterium PA2

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