Conserved Protein Domain Family
MAK32
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cd01943: MAK32 
MAK32 kinase. MAK32 is a protein found primarily in fungi that is necessary for the structural stability of L-A particles. The L-A virus particule is a specialized compartment for the transcription and replication of double-stranded RNA, known to infect yeast and other fungi. MAK32 is part of the host machinery used by the virus to multiply.
Links
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Statistics
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PSSM-Id: 238918
Aligned: 15 rows
Threshold Bit Score: 371.673
Created: 3-Sep-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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substrateATP binding
Feature 1:substrate binding site [chemical binding site]
Evidence:
  • Comment:based on homology to other members of the family
  • Citation:PMID 9519409
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                               #                                     
P23060     13 LVITNGMFIIDdierskyn------------ihyknvpGGGGTFAILGACIIs------------SGNVTskglkWIVDR 68  baker's yeast
Q09839      9 EFVTTGMFIIDeiefdgg-------------kkikdiiGGAGSFALIGARLWt-----------sEPESQql--gMIVDK 62  fission yeast
XP_328713  58 HQLSTPSDEIEyppprp---------------pstnvlGGAGSYSALGARLFs------------PAPDLs----RTVGW 106 Neurospora crassa
EAA65084   19 SFTSLGLLVLDeirlpgq-------------epltdilGGSGAYASLGARLFl-----------pTPLSRsl--gWMMNI 72  Aspergillus nidula...
EAA65566   17 EFCTLGMFILDdidfegsr------------psvknvlGGAASFAVIGARLAa-----------gKEYSRsv--sWIVDV 71  Aspergillus nidula...
EAK84269    7 RLASMGMFIIDsfqyldpttga-----dlgnrgfqdqiGGGGCYFAIGARVWlppseiqviidrgVDWSSsd--qAVLDQ 79  Ustilago maydis 521
EAK93710    3 IFTTLGMFIVDenryidsnnnplppppsssslqqtniiGGAGTYAIMGARIIcd---------grQDLIDqi--sGIIDM 71  Candida albicans S...
EAL17590   96 SGPSTPQMTLDdipvpna-------------eevyemlGGGALYAIVGARFWl-----------pPCQLR-----TLVDR 146 Cryptococcus neofo...
EAL23266   17 RVATLGMFIIDhfevhde--------------dgnpvpADEEAAAMIGARQF-------------LPPTHc---sLLVDK 66  Cryptococcus neofo...
XP_457249   7 IFTSMGMFIIDenqyppssk----------kepvhniiGGGGTYAIIGSRIIa-----------gAEKSKli--cGIIDK 63  Debaryomyces hanse...

Feature 1                                                                                     
P23060     69 ----GSDFPKev--iREIDSWgtdvrf-rddfsRLTTKGLNYYegsddlrkfkfltpkk--------------------- 120 baker's yeast
Q09839     63 ----GSDFPQvi--lDELNDLhtgivy-retpwRKTTYGYNRLrdngfrlfeyltpkk---------------------- 113 fission yeast
XP_328713 107 ivdqGSDFPQai--tDLITGWstsavf-rhdptRLTTRGWNGYvgsserrefkyttpk---------------------- 161 Neurospora crassa
EAA65084   73 ----GNDFPElr--qRYLESWgatmi--sfiyaRIKANSSSAKdfmyttsilqvd------------------------- 119 Aspergillus nidula...
EAA65566   72 ----GSDFPPev--lDVITAWdtncvi-rrdpgRLTTRAWNGYgpne--------------------------------- 111 Aspergillus nidula...
EAK84269   80 ----FNRTPSssqsqVSFSMWhyr------srpDRTTRALNIYrgdhrgfdylskkirl--------------------- 128 Ustilago maydis 521
EAK93710   72 ----GSDFPFei--kQELDTWktrgviyrenphRLTTRGVNIYqytdnnnnksfnrsidnesevepeqdairyfeyvtpk 145 Candida albicans S...
EAL17590  147 apaeNDDCPKdv--eQKLAKLgneiwvwnrgegTRMTRARIRYegdvryfqpvvkap----------------------- 201 Cryptococcus neofo...
EAL23266   67 ----GEDFPDkf--vHDLESLgkemvw-frhreGKTTRALNIYsgrrigeghqsfkylspql---------------qit 124 Cryptococcus neofo...
XP_457249  64 ----GSDFPEiv--eEEILSWnsgivw-kedlsRLTTRGLNIYdeadirhfkyktdkk---------------------- 114 Debaryomyces hanse...

Feature 1                                                                                     
P23060    121 -qinvddwistfgqkiIDEMHAFHllcs----gsrCLDIINDLlrvk------------------------------ssk 165 baker's yeast
Q09839    114 --pirapdlletgliyAKTIHIITnpkt---fvsvCEELAKYGnl----------------------------------- 153 fission yeast
XP_328713 162 -krltaadlvgtpllkAKAVHMVCspnr---ckelVEEIITLRkrearlaaaaasnknnnnndndddcddvdddtndpna 237 Neurospora crassa
EAA65084  120 -----vsslkstplsrSKAYHFLEspan---irsrASEILALRqgf---------------------------------g 158 Aspergillus nidula...
EAA65566  112 ------------kratTRAIHAFGlpsav-knvsyVRHILQRReala------------------------------ggs 148 Aspergillus nidula...
EAK84269  129 epsdllacspsdpprlPQWIHLVCsperaletisqVDAILEQQkhkq------------------------------eqk 178 Ustilago maydis 521
EAK93710  146 lrieindileypnlkqSSNYHLICsier----cksLIDSITQFn------------------------------------ 185 Candida albicans S...
EAL17590  202 --yrtiqelstspllyAEYLHISPpyspe-nvaviVSDLKALPkd----------------------------------- 243 Cryptococcus neofo...
EAL23266  125 prdlvlppspfatpvpPEWIHVVCgvpr---mldiVDELEFLEkqrhss---------------------------tgls 174 Cryptococcus neofo...
XP_457249 115 -rieaqdivnhpylirSRTIHIISsver---cesiIDTILSNTpn----------------------------------- 155 Debaryomyces hanse...

Feature 1                                                                                     
P23060    166 gTKPIVIWEPFPDLCDFDHQNdiksvmqrNDVTVILSPNAEESSRLFGlsskeptsleecla------------------ 227 baker's yeast
Q09839    154 kNRPKIVWEPTPESCLPENWHilq---kaLKYCDIFSPNEVDSANLLGidisesksrakefv------------------ 212 fission yeast
XP_328713 238 yTRPLIIWEPVPDLCTPFELLnct---naLPLVDICSPNHAELAGFMGtdgldpetgeisveqv---------------- 298 Neurospora crassa
EAA65084  159 iPNPLIIWEPAPLSCKAENLQpci---eaTGTVNVFSPNHLELARLFGeplstrfldkekiqsma--------------- 220 Aspergillus nidula...
EAA65566  149 nERPIFVWEPVPDMCTPEEQLkfl---eaCREVDVVSPNDLELGMMFGhpcwnegsaegketv----------------- 208 Aspergillus nidula...
EAK84269  179 pSFPKLVYEPIPDSCIIENLEdcl---rvLPRLAVFSPNHEEAATLLGvfdqwqsvlerasedkeasteiilrfvsdkla 255 Ustilago maydis 521
EAK93710  186 -PTAKFIYEPLPDDCVFENLEflq--ndiLPKIHVFTPNLNEARLLLGlkdnenetnksddndel--------------- 247 Candida albicans S...
EAL17590  244 sWRPKIVFEPTPPSCHPGQKDwle---hiLPDIEVLSPNHEELFSFYSiptmatssislrptver--------------- 305 Cryptococcus neofo...
EAL23266  175 lIKSRLVWEPLPFSCVPEELNnmv---slSSRIAVFSPNLLELQSILSiphssppahshvelaaq--------------- 236 Cryptococcus neofo...
XP_457249 156 dVIPTFIYEPLPDVCVASSYDklt---llLPKIDVFTPNLNEMSNLANlarvpetmediktl------------------ 214 Debaryomyces hanse...

Feature 1                                                                                     
P23060    228 ----------lahrfddfmdennMCILRCGalGSISVsekf--------------------------------------- 258 baker's yeast
Q09839    213 ---------safqefqighdsqgWVVLRNGsdGCLIGactsstna----------------------------------- 248 fission yeast
XP_328713 299 -------ernceqllasmplttyTLVVRAGekGCYVAknggrrrkqppmkrgkkkkmkvgldarnfhgglqhdtdmmslf 371 Neurospora crassa
EAA65084  221 -------leflntnegigpdakgFMIVRAGeeGCLVCar----------------------------------------- 252 Aspergillus nidula...
EAA65566  209 ---------nqildsgigsrgegYLVIRAGkdGSYAYs------------------------------------------ 237 Aspergillus nidula...
EAK84269  256 ggfarhvynqmpdavkqakpfgpIICIRSGawGSVVGqa----------------------------------------- 294 Ustilago maydis 521
EAK93710  248 -------qkisqqftnhlqlsnsGTVLRCGaqGCYINtk----------------------------------------- 279 Candida albicans S...
EAL17590  306 ------lvthilhdvgigangqgIVVVRCGrlGACVGtk----------------------------------------- 338 Cryptococcus neofo...
EAL23266  237 -------qfqtlllnrssgsqipSIVVRAGelGAYTLssnw--------------------------------------- 270 Cryptococcus neofo...
XP_457249 215 ----------sskfspyltkpnsGSVVRCGplGCFIKt------------------------------------------ 242 Debaryomyces hanse...

Feature 1                                                           #  #                      
P23060    259 ---------------------------kngRTYDHFPAYhfkt---qskVLDPTGGGNSFLGGFAVSYALtks------- 301 baker's yeast
Q09839    249 ----------------------tsdavvpvREILHLPSVqmk----ngsVLDTTGAGNAFCGAAILEYYRtgn------- 295 fission yeast
XP_328713 372 agllqdmedrnneddpfgrfdveegievdsGIERWLPAYhtd----atkVVDPTGGGNTFLGGLAVALARgks------- 440 Neurospora crassa
EAA65084  253 -----------------------------hIPPTWLPPFyryg---hdkVVDPTGAGNAFLGAFTIGDLLted------- 293 Aspergillus nidula...
EAA65566  238 -----------------------------rGLRLWLPAYhqptasgsspVVDPTGAGNSFLGALAQGMVSegrdatkvis 288 Aspergillus nidula...
EAK84269  295 -----------------------------gLGFYHIPAWhts----sesIKDVTGAGNSFLGGLSAYLVHtdndnal--- 338 Ustilago maydis 521
EAK93710  280 -----------------------------sGDKFQLPAYhqd----htkVVDVTGGGNSFCGGFMMAYHLsdr------- 319 Candida albicans S...
EAL17590  339 -----------------------------kGGLKWCPAYwegd--dvknVKDVTGAGNSFLGGYVAGLSLtnd------- 380 Cryptococcus neofo...
EAL23266  271 ---------------------------tgwIPAFWTEADqg-------kIVDVTGGGNSFLGGLVAGLLIsdg------- 309 Cryptococcus neofo...
XP_457249 243 -----------------------------sKVEISLPAYhrn----qdkVVDVTGGGNLFCGGFVTGLCLskg------- 282 Debaryomyces hanse...

Feature 1                                                                           
P23060    302 ---------------------ldIASICGNIAAGAIIEQFGIPryd------piaKTWNGITFLDRLKFY 344 baker's yeast
Q09839    296 ---------------------iiEACAKATVAASFVIQQHGLPahtkn---segiDLWNGESVFQRLKEY 341 fission yeast
XP_328713 441 ---------------------ieEACAWGSVAASFAIEQVGVPelgmd---vegrETWNGERVEERLSGY 486 Neurospora crassa
EAA65084  294 ---------------------avQAACYGSIGASFALEQVGLPrltrnegasasaELWNGENVLERLSEY 342 Aspergillus nidulans FGSC A4
EAA65566  289 silaesanwqkatascgkyhsipPALILATVAASFVVEQIGVPrqsts---hegkELWNGIEFTERVRLY 355 Aspergillus nidulans FGSC A4
EAK84269  339 ----------------dpttrvkQAAMHGAVSASLVIEQLGLPsfdv----qadeEVWNGDVAVHRLDSL 388 Ustilago maydis 521
EAK93710  320 --------------------dwlASGVAGIISSGCIIEKLGMPtvs-------ddSKFNNKSLRDRLDTY 362 Candida albicans SC5314
EAL17590  381 ---------------------pyEALLYATISSSFVVEQFGLPrlmdctdpltgeEIWNADTPSRRLKEL 429 Cryptococcus neoformans var....
EAL23266  310 --------------------dirTASIYASTAASFAIQQRGPPclqq----lngeERWNGEVVWDRLNEM 355 Cryptococcus neoformans var....
XP_457249 283 --------------------dwvIGGICGNIASGCVIERLGMPrlyl----glsdEKWNGSSTSKRLKYY 328 Debaryomyces hansenii CBS767

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