Conserved Protein Domain Family
PKc_Byr1_like

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cd06620: PKc_Byr1_like 
Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases
PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Byr1 from Schizosaccharomyces pombe, FUZ7 from Ustilago maydis, and related proteins. Byr1 phosphorylates its downstream target, the MAPK Spk1, and is regulated by the MAPKK kinase Byr2. The Spk1 cascade is pheromone-responsive and is essential for sporulation and sexual differentiation in fission yeast. FUZ7 phosphorylates and activates its target, the MAPK Crk1, which is required in mating and virulence in U. maydis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The Byr-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270792
Aligned: 7 rows
Threshold Bit Score: 478.087
Created: 16-Nov-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    #####   #            # #                               #            
P10506        60 DLDNSSLEVVRHLGEGNGGAVSLVKHr--nIFMARKTVYVGsds-klQKQILRELGVLHHCr-SPYIVGFYGAFQYk--- 132 fission yeast
Q99078       103 DLKNEDLKTLSELGAGNGGTVTKVLHeksgTVMAKKVVFIDakp-svRKQILRELQILHECn-SPYIVSFYGAYLNe--- 177 Ustilago maydis
CAB45932     174 DIRAQDLRTIQELGAGNGGSVSRVEHiptgAVMAKKVIHIGgke-avRRQILRELHIMHECd-SPYIVSFYGAFINes-s 250 Yarrowia lipoly...
AAT48729      60 DLRPEDLEIIKDLGSGNGGTVSKVKRiptnTTMARKVIHVEakr-emRKRIVRELQIMHNCh-CEHIVTFYGAFLNdn-- 135 chestnut blight...
XP_001834469  96 DLKNDDLKKLSDLGQGNGGSVEKVEHlptgTIMAKKSVLIDaks-svRKQILRELDIMHECq-SDYIISCFGSFLAe--- 170 Coprinopsis cin...
P06784       185 YIQLQDLVQLGKIGAGNSGTVVKALHvpdsKIVAKKTIPVEqnnstiINQLVRELSIVKNVkpHENIITFYGAYYNqhin 264 baker's yeast
P46599       243 KLNNKDLLTLKQLGSGNSGSVSKILHiptqKTMAKKIIHIDsks-viQTQIIRELRILHECh-SPYIIEFYGACLNnn-- 318 Candida albicans
Feature 1              ####  ##  #                                                 # #### #      
P10506       133 nNISLCMEYMdcGSLDAILre-------------gGPIPLDILGKIINSMVKGLIYLYNvLHIIHRDLKPSNVVVNsrGE 199 fission yeast
Q99078       178 pHICMCMEFMqkDSLDGIYkk-------------yGPISPEICGKIAVAVSHGLTYLYDvHRIIHRDVKPSNILVNgaGQ 244 Ustilago maydis
CAB45932     251 gDVVMCMEFMdcGHLDRIYkk-------------aGPLTEEIVGHITVAVVEGLTYLYNeHRIVHRDVKPSNILVNshGQ 317 Yarrowia lipoly...
AAT48729     136 nDVIMCMEYMdvGSLDRVSrv-------------fGPVRVDVLGKIAEATLGGLTYLYYkHHIMHRDIKPSNILVNsrGH 202 chestnut blight...
XP_001834469 171 pNICICMEFMdkGSFDGIYkk-------------lGPLQVEVVGMVALSVLEGLTYLYDvHRIMHRDIKPSNILFNsqGQ 237 Coprinopsis cin...
P06784       265 nEIIILMEYSdcGSLDKILsvykrfvqrgtvsskkTWFNELTISKIAYGVLNGLDHLYRqYKIIHRDIKPSNVLINskGQ 344 baker's yeast
P46599       319 nTIVICMEYCncGSLDKILplc-----------enKQFPTFVLKKLSFAILSGLTYLYTtHKIIHRDIKPNNVLMThkGE 387 Candida albicans
Feature 1           ##  #             #### #                            #        #               
P10506       200 IKLCDFGVSGELVNSVAQ--TFVGTSTYMSPERIRGg--KYTVKSDIWSLGISIIELAtqELPWSfsni----------- 264 fission yeast
Q99078       245 IKICDFGVSGELINSIAD--TFVGTSTYMSPERIQGd--QYSVKSDVWSLGVSIIELAlgRFPFAeneedddsdadnnyt 320 Ustilago maydis
CAB45932     318 IKLCDFGVSGELINSIAD--TFVGTSTYMSPERIQGg--NYTVKSDVWSLGISLLELLlgKFPFDmanga---------- 383 Yarrowia lipoly...
AAT48729     203 IKLCDFGVSGELINSVAD--TFVGTSTYMAPERIQGe--KYTVKSDVWSFGLSIMELAigKFPFAaseqlsd-------- 270 chestnut blight...
XP_001834469 238 IKLCDFGVSGEVINSIAN--TFVGTSVYMSPERIQShgdGYSVKSDVWSLGMSLVELAlgAFPFTdppddddddlsdleg 315 Coprinopsis cin...
P06784       345 IKLCDFGVSKKLINSIAD--TFVGTSTYMSPERIQGn--VYSIKGDVWSLGLMIIELVtgEFPLGghnd----------- 409 baker's yeast
P46599       388 FKLCDFGVSRELTNSLAMadTFVGTSMYMSPERIQGl--DYGVKSDVWSTGLMLIELAs-GVPVWseddnnndddedded 464 Candida albicans
Feature 1                                                                                        
P10506       265 ----------------------------------------------ddsiGILDLLHCIVqEEPPRLPSS--------FP 290 fission yeast
Q99078       321 nedlagtlsptkpap------mislgqnekqrrrkskpagvslegsshqmSILDLLQHIVnEPPPKLPEGr-------FP 387 Ustilago maydis
CAB45932     384 ----------------------------------------------vgpmGILDLLQRIVnEPPPTLPAEdt-----rFS 412 Yarrowia lipoly...
AAT48729     271 --------------------------------------------aeaapaGILDLLQQIVhEPAPKLPKSd------aFP 300 chestnut blight...
XP_001834469 316 dssspspsdaqhqrtpthrdsfllskktakraskrrskltynpdgqlstmSIFELIHQIVqEPSPRLPSDk-------FP 388 Coprinopsis cin...
P06784       410 -----------------------------------------------tpdGILDLLQRIVnEPSPRLPKDr------iYS 436 baker's yeast
P46599       465 dayvrqgsiaae-----------rngqnspsrsrknkqkgngynsyngpeGILDLLQRIVnEDAPTLTNKinpvtklpYD 533 Candida albicans
Feature 1                                                          
P10506       291 EDLRLFVDACLHKd--PTLRASp-QQLCAMPYF-QQALMi--nVDLASWA 334 fission yeast
Q99078       388 KHMEEFVNLCLLKd--PAKRPTp-KDLTKHQYV-IDADAa--kVDLQAWA 431 Ustilago maydis
CAB45932     413 PVCRRFVDRCLVK---EPERPSp-QQLHPTMPF-IITSRak-qVDMKAWA 456 Yarrowia lipolytica
AAT48729     301 QILEDMIQKCLLKt--PDDRPTp-QELYDRDPF-VQAAKrt-pVDLREWA 345 chestnut blight fungus
XP_001834469 389 ADAVDLVDICLLKn--PEERQTpkALLVRNHPW-IVAIRes-dFDIQAFA 434 Coprinopsis cinerea okayama7#130
P06784       437 KEMTDFVNRCCIKn--ERERSSi-HELLHHDLI-MKYVSpskdDKFRHWC 482 baker's yeast
P46599       534 KYLCQFIDLCLIKddsVRKTPW--QLLEDKEHFfKGVEEgvydKEHKSWA 581 Candida albicans

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