Conserved Protein Domain Family
DPH2
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TIGR00272: DPH2 
diphthamide biosynthesis protein 2
This protein has been shown in Saccharomyces cerevisiae to be one of several required for the modification of a particular histidine residue of translation elongation factor 2 to diphthamide. This modified site can then become the target for ADP-ribosylation by diphtheria toxin. [Protein fate, Protein modification and repair]
Links
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Statistics
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PSSM-Id: 272990
Aligned: 3 rows
Threshold Bit Score: 717.871
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P32461        11 QSDVAFQKVETHEIDRSSYLGPCYNSDELMQLISAYYNVEPLVGYLEQHPEYQnVTLQFPDDLIKDSSLIVRLLQSkf-p 89  Saccharomyces c...
Q10206         1 MSFELSAPVPLSDNSEAILEKEIGETVKIEGDLVEVYEINRTVDFIKSGNYNS-VALQFPDEHLADSGKVASILTN---- 75  Schizosaccharom...
NP_001254257   6 PSAFFTTSTPADHVHEEESSNTGYFENLPENDIHSFFEIDATSEWIKQGNHQR-IALQFPDSLLPYSEKVTKLIESrfrs 84  Caenorhabditis ...

P32461        90 HGKIKFWVLADTAYSACCVDEVAAEHVHAEVVVHFGDACLNAIQ-NLPVVYSFGTPFLDLALVVENFQRAfpDl-SSKIC 167 Saccharomyces c...
Q10206        76 LVEANVQILADTNYGSCCVDEVAAEHMSADAIVHYGRACLSPTS-RLPVLYVFGRLPINLHKLEKCLTIP--L--DQNIL 150 Schizosaccharom...
NP_001254257  85 ESAKKTFVLADTSYRSCCVDEVAAAHADCTALVHFGEACHSAPTdKIDVKYVLGSMPIFIDQFRMEFQNVadQltAEHIV 164 Caenorhabditis ...

P32461       168 LMANAPFSKHLSQLYNILK-------GDLHYTNIIYSQvnTSAVEEKFVTILDTFHVPEDVDQVgvfEKNSVLFGQhdka 240 Saccharomyces c...
Q10206       151 LVSDTRWYYAQDSILKSLKtlgyqnvYESHLKERIEPN--LEEASTSYTIPGRTYSLPKSLSLQ---DMTLLYIGP---- 221 Schizosaccharom...
NP_001254257 165 LLMDSCFSHEQEKVAAVIKev---lpGNRHVECSLLPSedVLKQNRQNIYLGREIPSCLRNN-Q---PTDLIFCGFp--- 234 Caenorhabditis ...

P32461       241 dniSPEDYHLFHLTTPQDprllyLSTVFQSVHIFDPALPGMvTGPFPSLMRRYKYMHVARTAGCIGILVNTLSLRNTRET 320 Saccharomyces c...
Q10206       222 ---DSPTLSSILMSHYSL-----VNQFLSFDPLSNKIVEES-SFTGAKLRRRYALVQRCRDAGVIGIVIGTLGVHRYLHV 292 Schizosaccharom...
NP_001254257 235 ---NS-PLLPIWLLSYPS-----CSTVSHFNPINKTIQHEStR-SSRLLRKRLFLVEKLKDADTVGLVVGSVGVDKHREA 304 Caenorhabditis ...

P32461       321 INELVKLIKTREKKHYLFVVGKPNv-AKLANFEDIDIWCILGCSQSGIIvdQFNEFYKPIITPYELNLALSEEVTwtgkW 399 Saccharomyces c...
Q10206       293 LNQLRKMILNAGKKPYMLAVGKLNp-AKLANFQEIECFVLIACGENSLI--DSKEFYRPIVTPFELVKALSSDMS----W 365 Schizosaccharom...
NP_001254257 305 VKRMREMCKKAGKKIYVISVGKinvpKLSNFSTDIDVFVLLSCPFGVVL--DSSDYFRPVVSYFEAEIALNPAKT----W 378 Caenorhabditis ...

P32461       400 VVDFRDAIDEIEQNLGGQDTISASTTSDE----PEFDVVRGRYTSTSR-PLRALTHLELEAADDDDSKQLTTRHTASGAV 474 Saccharomyces c...
Q10206       366 NNDFILSFDEVLKLSEGKQSKEPSEVLTEesaePHFSLITGKFVNSTPmRHLDVTLETADAKNNDSSSASIEKRGMRSLA 445 Schizosaccharom...
NP_001254257 379 AADFGWSAEFAAFLEDKIETEVPD---DKa--aGDFSLISGKVR-----------VQKTEEEKNGDGPSSVAIYNPG--- 439 Caenorhabditis ...

P32461       475 IKGTVSTSASALQNRSWKGLgSDFDSTEVDntgADIEEGISGVARGYGFD 524 Saccharomyces cerevisiae S288c
Q10206       446 VNGVYSPAAAFLQSKSWSGL-DSVDEGEGP---SKLYEGQSGIAKGYVGE 491 Schizosaccharomyces pombe 972h-
NP_001254257 440 ----------YCNDRTWKGLnDGVSTAEDS---TKMGEGRSGIAQGYSGK 476 Caenorhabditis elegans
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