Conserved Protein Domain Family
RNaseH_like

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pfam04308: RNaseH_like 
Ribonuclease H-like
RNaseH_like is a family of uncharacterized eubacterial proteins that are distant homologs of Ribonuclease H-like. The family maintains all the core secondary structure elements of the RNase H-like fold and shares several conserved, presumably active site residues with RNase HI. This finding suggests that it functions as a nuclease.
Statistics
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PSSM-Id: 398138
Aligned: 52 rows
Threshold Bit Score: 151.522
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
zhongguo:PM3016_6663  28 DVLDRIQRFAMQD-PRAAY--DLVIGSDSQvHRGHTKLVTGIILHR-LGRGAWACCRTVVLpRELTSVKEKLSLETSLSQ 103
jgi:Tlet_1615         13 aVREIIQDFNDGN-PS-----KIYIGTDSDaRDGVVTFATALVVYK-IGIGATYFYTLKRE-RKHYDIFSRLFEETYLSL 84 
Q9X1R8                13 TVRELIKKFTEGY----KY--SVFVGTDSDvKDGKVIYATALVVYR-FGSGATYFYTVYRD-GNGKDLYSRIFKEAEMSL 84  Thermot...
O66517                 5 rdiEEVKEFIKT--TDKET--SIYVGCDSRqLRDKTIFVTVIVVHIsSKYGAKVFWNVEKV-PKINSLRQRLMEEVNRAV 79  Aquifex...
jgi:Niako_5540        15 piidAVENAIKRE-TEKGYhlKVCIGTDSQvKGVETEFATVIVFLR-EGHGGFMFIHNEKT-RKQYSIKERMLVEVAKSI 91 
WP_012683824          25 EVFSHIEHTISS--IGGPF--EIIVGADSQlKSRGTFFALVITVIR-PGHGGTFFYHKFQE-RRYSSLQQRIFQEAMYAV 98  Breviba...
WP_012813527          14 qVLLKIKEEMEKGyNHDSF--RLMVGCDSQ-TRKNTTFVTAIILHK-VGRGAIFFYHKNTV-RKIPVMQKRIFSEAAYSL 88  Desulfo...
jgi:Anamo_1832        14 QVIQRICTFMAK---EGMY--RIIIGTDSQpLSEGTLFVSAIVVHR-IGRGGIYFYRKTYE-QRPYSVKERILTETSMSL 86 
jgi:Halsa_2017        15 DTFQTIMDFVKEE--ENKY--RLIVGTDSQpGFDEAVFVTAIVIYR-VGRGGRYFYHKSSI-NFKAGMKQRIFYEVSRSL 88 
WP_015923886          15 QTYQTILDFIESE-PDNQY--RLIIGTDSQpRLEEIVFVTAIVIYR-VGRGGRFFYHKERE-KFHLSMKQRIFYEVSKSL 89  Halothe...
zhongguo:PM3016_6663 104 EAAWCLEElqaietledLLLPYv--yQGAALRTFIDIDAGTHpskNKTSLYLQEMVERVRAMGtYAVRVKPESYGASAYA 181
jgi:Tlet_1615         85 EMASFAKE---------MLQLY---------HPEIHIDVGYN---GASRDVLSSVVGYVKGMG-YSYKLKPWAFAATKVA 142
Q9X1R8                85 EMARFVEE---------ILKLG---------KPVVHLDIGYE---GLTKDLVSSVIGYVKGVG-YPYQIKPDSFAATKIA 142 Thermot...
O66517                80 YHALMLMD---------AVDGR---------HFEVHLDINPDe-nTASSVIVKEAVGYVLAQG-LTPVLKPDAIAASCAA 139 Aquifex...
jgi:Niako_5540        92 EIAYDLCHl----------------fNLYNVDMEVHADINTNp-hFKSNDALKEAMGYILGMG-FAFKAKPEAFASSSCA 153
WP_012683824          99 GLATEVRQ---------YLr-----dRHLDTPIRLHFDIGTN---GPTRKFIQSLLSLAETNH-FRAEIKPNSFCASTIA 160 Breviba...
WP_012813527          89 GVAGQLAD---------YLs-----rINLDVQVEIHVDIGEN---GETNKMLKEVIGMVAGSG-FQCRVKPYSVAASWCA 150 Desulfo...
jgi:Anamo_1832        87 TLASEVLH---------LLSQDvvlfEHYRQLLEIHLDVGEK---GLTREILNMVVGMVKGSG-YIAHIKPEAFAASCVA 153
jgi:Halsa_2017        89 KVAGELTS---------LLASEe--vLAENVELEVHIDVGEN---GPTNQIIKEVVGMVVGSG-FEAYIKPDAYAASTVA 153
WP_015923886          90 DVASKLTA---------LLAKEk--gFDEELKIEIHVDVGEK---GPTNTIIKEVVGMVVGSG-YEAMIKPDSYAASTIA 154 Halothe...
zhongguo:PM3016_6663 182 NRYTK 186
jgi:Tlet_1615        143 HRHTK 147
Q9X1R8               143 HKHTK 147 Thermotoga maritima
O66517               140 DYITE 144 Aquifex aeolicus
jgi:Niako_5540       154 NKVvn 158
WP_012683824         161 DKYTK 165 Brevibacillus
WP_012813527         151 DRFNK 155 Desulfofarcimen acetoxidans
jgi:Anamo_1832       154 DKHTK 158
jgi:Halsa_2017       154 DKFTK 158
WP_015923886         155 DKYTK 159 Halothermothrix orenii
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