6TB4


Conserved Protein Domain Family
SAGA-Tad1

?
pfam12767: SAGA-Tad1 
Transcriptional regulator of RNA polII, SAGA, subunit
The yeast SAGA complex is a multifunctional coactivator that regulates transcription by RNA polymerase II. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA. The complex can also be conceived of as consisting of two histone-fold-containing core subunits, and this family is one of these. As a family it is likely to carry binding regions for interactions with a number of the other components of the complex.
Statistics
?
Structure
?
PubMed ReferencesClick to see Conserved Features Help

pfam12767 is the only member of the superfamily cl15080
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6TB4_A         62 RIEIEPLVVDFQRRLG-KNWGRYQIAVSLFLVGKLSRRELVDELDDILDr-----------nTVKMHNQLLLGNLAN--- 126 
Q5KHJ0         55 RVDIHAIKQELHDVLG-EAGLPYWKSLNAYLVGQLGRAELEDMVRGWLKg-----------dHLHLHNKLLSSLLTN--- 119  Cryptococcus ...
KDE02672       66 RADLLSLKLKLADLLPpHLGQLYWTSLVEFMTGQINRDELQGVFERVLGkgkqg----eqdtALQLHNALLLSILYN--- 138 
XP_001729242   18 AVDPRAVKVRLFEKLG-SFADEYWQLLGALCTAAIDRAEFHNRVKAKLPs-----------eCVPLHNALVLSILAEans 85  
KIS68213       23 RADTLDLKQKLAVALG-QNGARYWQTLVQFLKGAIDRSEFEALAHKALKt-----------eHIHLHNALILGILYN--- 87  
XP_007406983   24 RSDTLSIKQSLIQLINpQDGLHYWSSFTNFIKAKIDRREFEEEVSRILNtd----------qLVGLHNSLVLSILYN--- 90  
XP_003331164   21 RADTLAIKQAIAEALSeDEGLAYWTSLVKFLTGKLDRTEFEVQTAYLLKse----------tLVGLHNALILSILYN--- 87  
OAV96244       21 RADTLAIKQAIADALSeDDGRAYWASLVKFLTGKLDRTEFEAQTARLLQse----------sLVGLHNALILSILYN--- 87  
Q54DW3         33 RIDLIPLKKQLDAVLK-DRSEDYWEWIRKYLCGRLSKRELDYYVTTNLNe-----------pNLHLHNTFFKAVIFN--- 97   Dictyostelium...
EFA77170      256 RIDLVPLKKQLNTLLA-DKTDQYWDYIKRFLQGKLSKRELDYFVLDYLTesntllsfflwisKVHVHNQFFKALIFN--- 331 
6TB4_A        127 -Slkesagdrvgsggfggsmfnkrvkdsrkssqyerlkrdilalpvrerr------------------------------ 175 
Q5KHJ0        120 -Asipthdgtssslqqrhkrqrpsvndpdfdvddtlieskrrvegwv--------------------------------- 165  Cryptococcus ...
KDE02672      139 -Ttriavppstlrhsgfqvkrrlsapndppnngsasevdplrkklktlvmslgkrerreikalvptqtgvtataasttsa 217 
XP_001729242   86 gSsasaasgtgasvraltspiqprravlndstdesddeteppvdgrasrglkrlrhlyaglsdderkrldqlskqs---- 161 
KIS68213       88 -Asadvpgpssrasrritrilpdgttiteeeeeepsrkrlrnlvaglprkerlrlknldkagklganavgg--------- 157 
XP_007406983   91 -Ttrpesppinppgrpnlyttgqgwykrkrvqipinqihqskskleesdpkkrklketilsigq---------------- 153 
XP_003331164   88 -Ttrpdpaisnplkepgpsttgegwhkrkrvpvppvppkvktkneekdpkkrklkeavmalgqre--------------- 151 
OAV96244       88 -Ttrpdpattnplkdpetppttgegwhkrkrppappvappkiktksvekdpkkrklkeavmalg---------------- 150 
Q54DW3         98 -Afysktsptiieqtkvsipsttqissstnqslpakrklssstnsitst------------------------------- 145  Dictyostelium...
EFA77170      332 -Sfyaktsppvlepprpvpkkkllsfstavsnvpinsdvgspisvigesgsqgaaaaaaslgngasakekdsksq----- 405 
6TB4_A        176 -------------------------------rikaitresgkkgmvnsvitqtrqalipkvpvvtrptnvpgnsvqwaQD 224 
Q5KHJ0        166 ----------------------------------mnlgkkerarvkkalagaaekgvlgaaaaaekdmwggvgekrwsPY 211  Cryptococcus ...
KDE02672      218 aallqqqdqaqlqaikeaggvvpsalakrelerererkrdkelvrlstlaaalesgkgrgevdaigggtggktdpaltQE 297 
XP_001729242  162 -----assthtsasvwagagaellekkrkederrraveerrrareiklaigashwrlsamqtaaqtesirsrlsttmqEA 236 
KIS68213      158 ----------aaslgwagsaadmlekkrkdeekrkvaedrkkvrqyksaigakdwkgqaihgnqqiaavrsklslsaqQA 227 
XP_007406983  154 ----------------rernrikqipkekekekelyqklgnpyhsknpqfdylsreklekvtntllaskmkissstlyQD 217 
XP_003331164  152 ---------------rnrlkqiallkenelelnsnkfnpqqlaprqlsachylypertenvmntplaskmkissstlyQD 216 
OAV96244      151 ----------------hrernrlkqiaslkeeelvklnaqqplprplsacqylypertenvmstplaskmkissstlyQD 214 
Q54DW3        146 --------------------------------kekkdkkdasstsstssissssssssssssssskrkkeknptkrprRE 193  Dictyostelium...
EFA77170      406 -----lvsssskskdrdkersdkkkdkthsekskkdklssssssttntpkkkstssssssssssnskrlrsstssttqLQ 480 
6TB4_A        225 VIHG------FQALL---------ASEIYEL--------------PEMDNLRTRMTGISREHGLi----GP--VDD-SVI 268 
Q5KHJ0        212 TSNS------LIPPL---------ALPTRHL--------------PSSHQLALRLSQFAKLHDLsipstSSstAAAdDIG 262  Cryptococcus ...
KDE02672      298 YQRiiasssakDSLL---------CSTSKLL--------------PDVDGLRDRMTLIVFESGLv----GGgvVDE-RVG 349 
XP_001729242  237 LKRS------VATPN---------CIESQVL--------------PDVHSLQDRMSLSAIEAGLs----GG--VHA-HAA 280 
KIS68213      228 VMRA------MQAPL---------CVESKHL--------------PDLDGLKDRMTLLAVENGLp----GG--VQP-QAA 271 
XP_007406983  218 YMRC------QQAPL---------CSESKQL--------------PDSDTLKDRMSLIAYDSGLv----NG--VDQ-SAA 261 
XP_003331164  217 YMRC------QQAPI---------CSESKQL--------------PDFDTLKDRMSLIAYDSGLm----NG--VDK-AAS 260 
OAV96244      215 YMRC------QQAPV---------CSESKQL--------------PDFDTLKDRMSLIAYDSGLm----NG--VDK-AAS 258 
Q54DW3        194 KKD--------STPsisgssssvtiSSSLKLkqkkklfpkyslfsSQLQPLKNKMEEIASENGL-----QG--ISK-QSI 257  Dictyostelium...
EFA77170      481 KREK------RIHPk----------YSLLYC--------------PEIQALKDRMETIACESGL-----NG--VSR-QSV 522 
6TB4_A        269 EIMLIGLEQHLKGIVEAAIDIV 290 
Q5KHJ0        263 EFMAVGMDAHMGDILHGVVHLT 284  Cryptococcus neoformans
KDE02672      350 LLGVQAVETHLKNIIAHVVGLV 371 
XP_001729242  281 AVALSALHDYLQNILRRTF--L 300 
KIS68213      272 AMVLSALQSHLQNVASSIITKI 293 
XP_007406983  262 SLALIALEVHLKTILGDLLSLI 283 
XP_003331164  261 SLALIALEVHLKTLLGDLLSLI 282 
OAV96244      259 SLALIALEVHLKTLLGDLLSLI 280 
Q54DW3        258 IFMKLALEQHILNFLRktkphi 279  Dictyostelium discoideum AX4
EFA77170      523 IYMMMALEQHIREILHNTMpvf 544 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
HHS Vulnerability Disclosure